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Volumn 13, Issue 2, 2011, Pages 147-155

Genome-wide association studies of alcohol dependence and substance use disorders

Author keywords

Addiction; Alcohol; Genome wide association study; GWAS; Heroin; Methamphetamine; Nicotine; Smoking; Substance abuse

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1C; BINDING PROTEIN; CADHERIN; CADHERIN 13; CARRIER PROTEIN; CELL ADHESION MOLECULE; CYSTEINE TRANSFER RNA SYNTHETASE; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 27; ENOYL COENZYME A HYDRATASE; METHAMPHETAMINE; NUCLEOSOME ASSEMBLY PROTEIN 1; NUCLEOSOME ASSEMBLY PROTEIN 1 LIKE 4; OXYSTEROL BINDING PROTEIN RELATED PROTEIN 5; PEROXISOMAL TRANS 2 ENOYL COA REDUCTASE; PLECKSTRIN HOMOLOGY LIKE DOMAIN FAMILY A MEMBER 2; SEMAPHORIN; SEMAPHORIN 3E; SMALL NUCLEOLAR RNA; SOLUTE CARRIER FAMILY 22 MEMBER 18; SYNTHETASE; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG;

EID: 79955886271     PISSN: 15233812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11920-011-0176-4     Document Type: Review
Times cited : (58)

References (42)
  • 1
    • 0042694131 scopus 로고    scopus 로고
    • Pharmacogenomics of alcohol response and addiction
    • Enoch MA.: Pharmacogenomics of alcohol response and addiction. Am J Pharmacogenomics. 2003;3:217-232.
    • (2003) Am J Pharmacogenomics , vol.3 , pp. 217-232
    • Enoch, M.A.1
  • 2
    • 67649985942 scopus 로고    scopus 로고
    • Alcoholism: A systems approach from molecular physiology to addictive behavior
    • Spanagel R: Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev. 2009, 89:649-705.
    • (2009) Physiol Rev , vol.89 , pp. 649-705
    • Spanagel, R.1
  • 5
    • 62549148987 scopus 로고    scopus 로고
    • New insights into the genetics of addiction
    • Li MD, Burmeister M: New insights into the genetics of addiction. Nat Rev Genet. 2009, 10:225-231.
    • (2009) Nat Rev Genet , vol.10 , pp. 225-231
    • Li, M.D.1    Burmeister, M.2
  • 6
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 1996, 273:1516-1517. (Pubitemid 26301653)
    • (1996) Science , vol.273 , Issue.5281 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 7
    • 51749102111 scopus 로고    scopus 로고
    • Addictions biology: Haplotype-based analysis for 130 candidate genes on a single array
    • Hodgkinson CA, Yuan Q, Xu K, et al.: Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol 2008, 43:505-515.
    • (2008) Alcohol Alcohol , vol.43 , pp. 505-515
    • Hodgkinson, C.A.1    Yuan, Q.2    Xu, K.3
  • 8
    • 33745659950 scopus 로고    scopus 로고
    • Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: Evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4
    • Prescott CA, Sullivan PF, Kuo PH, et al.: Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. Mol Psychiatry. 2006, 11:603-611.
    • (2006) Mol Psychiatry , vol.11 , pp. 603-611
    • Prescott, C.A.1    Sullivan, P.F.2    Kuo, P.H.3
  • 9
    • 34547433163 scopus 로고    scopus 로고
    • The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants
    • Edenberg HJ: The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 2007, 30:5-13.
    • (2007) Alcohol Res Health , vol.30 , pp. 5-13
    • Edenberg, H.J.1
  • 10
    • 38849187091 scopus 로고    scopus 로고
    • Addiction science and its genetics
    • Ball D: Addiction science and its genetics. Addiction. 2008, 103:360-367.
    • (2008) Addiction , vol.103 , pp. 360-367
    • Ball, D.1
  • 14
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • International HapMap Consortium
    • International HapMap Consortium: The International HapMap Project. Nature. 2003, 426:789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 15
    • 42249087793 scopus 로고    scopus 로고
    • Estimation of significance thresholds for genomewide association scans
    • Dudbridge F, Gusnanto A: Estimation of significance thresholds for genomewide association scans. Genet. Epidemiol. 2008, 32:227-234.
    • (2008) Genet. Epidemiol. , vol.32 , pp. 227-234
    • Dudbridge, F.1    Gusnanto, A.2
  • 16
    • 39649108872 scopus 로고    scopus 로고
    • Genome-wide significance for dense SNP and resequencing data
    • Hoggart CJ, Clark TG, De Iorio M et al.: Genome-wide significance for dense SNP and resequencing data. Genet. Epidemiol. 2008, 32:179-185.
    • (2008) Genet. Epidemiol. , vol.32 , pp. 179-185
    • Hoggart, C.J.1    Clark, T.G.2    De Iorio, M.3
  • 17
    • 43249125992 scopus 로고    scopus 로고
    • Estimation of the multiple testing burden for genome-wide association studies of nearly all common variants
    • Pe'er I, Yelensky R, Altshuler D, et al. Estimation of the multiple testing burden for genome-wide association studies of nearly all common variants. Genet. Epidemiol. 2008, 32:381-385.
    • (2008) Genet. Epidemiol. , vol.32 , pp. 381-385
    • Pe'Er, I.1    Yelensky, R.2    Altshuler, D.3
  • 18
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff LA, Sethupathy P, Junkins HA, et al.: Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A. 2009, 106:9362-9367.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 19
    • 58049217860 scopus 로고    scopus 로고
    • Available at The comprehensive online catalog for SNP-trait associations from published GWAS at the National Institutes of Health is the central resource in which findings from GWAS are collected and reported
    • Hindorff LA, Junkins HA, Hall PN, et al.: A Catalog of Published Genome-Wide Association Studies. Available at http:// www.genome.gov/gwastudies. The comprehensive online catalog for SNP-trait associations from published GWAS at the National Institutes of Health is the central resource in which findings from GWAS are collected and reported.
    • A Catalog of Published Genome-Wide Association Studies
    • Hindorff, L.A.1    Junkins, H.A.2    Hall, P.N.3
  • 20
    • 33845465213 scopus 로고    scopus 로고
    • Pooled association genome scanning for alcohol dependence using 104,268 SNPs: Validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism
    • DOI 10.1002/ajmg.b.30346
    • Johnson C, Drgon T, Liu QR, Walther D, Edenberg H, Rice J, Foroud T, Uhl GR. Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53. (Pubitemid 44905437)
    • (2006) American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics , vol.141 , Issue.8 , pp. 844-853
    • Johnson, C.1    Drgon, T.2    Liu, Q.-R.3    Walther, D.4    Edenberg, H.5    Rice, J.6    Foroud, T.7    Uhl, G.R.8
  • 21
    • 67650422591 scopus 로고    scopus 로고
    • Genome-wide association study of alcohol dependence. *indicates co-primary authorship
    • This GWAS was conducted on a case sample of individuals of male gender and with an early age at onset. In a follow-up study, in addition to top-down hits, nominally significant SNPs from the initial scan were considered that were located in genes that had shown expression changes in rat brains after long-term alcohol consumption. Fifteen SNPs showed significant association with the same allele as in the initial scan, two of which had genomewide significance in a combined analysis
    • Treutlein J*, Cichon S*, Ridinger M*, et al.: Genome-wide association study of alcohol dependence. *indicates co-primary authorship. Arch Gen Psychiatry. 2009, 66:773-784. This GWAS was conducted on a case sample of individuals of male gender and with an early age at onset. In a follow-up study, in addition to top-down hits, nominally significant SNPs from the initial scan were considered that were located in genes that had shown expression changes in rat brains after long-term alcohol consumption. Fifteen SNPs showed significant association with the same allele as in the initial scan, two of which had genomewide significance in a combined analysis.
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 773-784
    • Treutlein, J.1    Cichon, S.2    Ridinger, M.3
  • 24
    • 40349091515 scopus 로고    scopus 로고
    • Genome-wide association for methamphetamine dependence: Convergent results from 2 samples
    • Uhl GR, Drgon T, Liu QR, Johnson C et al.: Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry. 2008, 65:345-355.
    • (2008) Arch Gen Psychiatry , vol.65 , pp. 345-355
    • Uhl, G.R.1    Drgon, T.2    Liu, Q.R.3    Johnson, C.4
  • 25
    • 77953247314 scopus 로고    scopus 로고
    • A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    • This GWAS analyzed alcohol dependence and nicotine dependence and comorbid alcohol/nicotine dependence in a sample from Australia (QIMR). A meta-analysis was conducted with a second GWAS sample from The Netherlands. Genes for ion channels and cell adhesion molecules were overrepresented, as revealed by a gene network diagram
    • Lind PA, Macgregor S, Vink JM, et al.: A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. Twin Res Hum Genet. 2010, 13:10-29. This GWAS analyzed alcohol dependence and nicotine dependence and comorbid alcohol/nicotine dependence in a sample from Australia (QIMR). A meta-analysis was conducted with a second GWAS sample from The Netherlands. Genes for ion channels and cell adhesion molecules were overrepresented, as revealed by a gene network diagram.
    • (2010) Twin Res Hum Genet , vol.13 , pp. 10-29
    • Lind, P.A.1    Macgregor, S.2    Vink, J.M.3
  • 26
    • 77950497675 scopus 로고    scopus 로고
    • A genome-wide association study of alcohol dependence
    • -5 in the initial study, but none passed a replication P<0.05 in 2 independent replication series. Five SNPs at the GABRA2 locus yielded nominal (uncorrected) significance (P<0.05)
    • -5 in the initial study, but none passed a replication P<0.05 in 2 independent replication series. Five SNPs at the GABRA2 locus yielded nominal (uncorrected) significance (P<0.05).
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5082-5087
    • Bierut, L.J.1    Agrawal, A.2    Bucholz, K.K.3
  • 27
    • 77951557173 scopus 로고    scopus 로고
    • Genome-wide association study of alcohol dependence implicates a region on chromosome 11
    • This study conducted a GWAS on a sample of cases and controls drawn from the families in COGA and a family-based replication study. Strongest support was received for a cluster of genes on chromosome 11
    • Edenberg HJ, Koller DL, Xuei X, et al.: Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res. 2010, 34:840-852. This study conducted a GWAS on a sample of cases and controls drawn from the families in COGA and a family-based replication study. Strongest support was received for a cluster of genes on chromosome 11.
    • (2010) Alcohol Clin Exp Res , vol.34 , pp. 840-852
    • Edenberg, H.J.1    Koller, D.L.2    Xuei, X.3
  • 28
    • 41649103052 scopus 로고    scopus 로고
    • Avariant associated with nicotine dependence, lung cancer and peripheral arterial disease
    • This GWAS was the first to yield genome-wide significance on chromosome 15q for smoking quantity
    • Thorgeirsson TE, Geller F, Sulem P, et al.: Avariant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 2008, 452:638-642. This GWAS was the first to yield genome-wide significance on chromosome 15q for smoking quantity.
    • (2008) Nature , vol.452 , pp. 638-642
    • Thorgeirsson, T.E.1    Geller, F.2    Sulem, P.3
  • 29
    • 77951751034 scopus 로고    scopus 로고
    • Meta-analysis and imputation refines the association of 15q25 with smoking quantity
    • This GWAS is one of the three meta-analyses published in the May 2010 edition of Nature Genetics. The authors analyzed the number of cigarettes smoked per day and all found the strongest association in the 15q25 region. This region harbors genes for subunits of cholinergic nicotinic receptors
    • Liu JZ, Tozzi F, Waterworth DM, et al.: Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet. 2010, 42:436-440. This GWAS is one of the three meta-analyses published in the May 2010 edition of Nature Genetics. The authors analyzed the number of cigarettes smoked per day and all found the strongest association in the 15q25 region. This region harbors genes for subunits of cholinergic nicotinic receptors.
    • (2010) Nat Genet , vol.42 , pp. 436-440
    • Liu, J.Z.1    Tozzi, F.2    Waterworth, D.M.3
  • 30
    • 77951711343 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify multiple loci associated with smoking behavior
    • Tobacco and Genetics Consortium: This GWAS is one of the three metaanalyses published in the May 2010 edition of Nature Genetics. The authors analyzed the number of cigarettes smoked per day and all found the strongest association in the 15q25 region. This region harbors genes for subunits of cholinergic nicotinic receptors
    • Tobacco and Genetics Consortium: Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet. 2010, 42:441-447. This GWAS is one of the three metaanalyses published in the May 2010 edition of Nature Genetics. The authors analyzed the number of cigarettes smoked per day and all found the strongest association in the 15q25 region. This region harbors genes for subunits of cholinergic nicotinic receptors.
    • (2010) Nat Genet , vol.42 , pp. 441-447
  • 31
    • 77951748276 scopus 로고    scopus 로고
    • Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
    • This GWAS is one of the three meta-analyses published in the May 2010 edition of Nature Genetics. The authors analyzed the number of cigarettes smoked per day and all found the strongest association in the 15q25 region. This region harbors genes for subunits of cholinergic nicotinic receptors
    • Thorgeirsson TE, Gudbjartsson DF, Surakka I, et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet. 2010, 42:448-453. This GWAS is one of the three meta-analyses published in the May 2010 edition of Nature Genetics. The authors analyzed the number of cigarettes smoked per day and all found the strongest association in the 15q25 region. This region harbors genes for subunits of cholinergic nicotinic receptors.
    • (2010) Nat Genet , vol.42 , pp. 448-453
    • Thorgeirsson, T.E.1    Gudbjartsson, D.F.2    Surakka, I.3
  • 32
    • 77957366301 scopus 로고    scopus 로고
    • Multiple independent loci at chromosome 15q25.1 affect smoking quantity: A meta-analysis and comparison with lung cancer and COPD
    • This study presented evidence that at least two distinct SNPs at 15q25 affect smoking behavior. The authors performed a meta-analysis of 34 datasets containing individuals of European ancestry and confirmed the previous findings at the 15q25 region with genome-wide significance. In their dataset, they additionally analyzed the phenotypes lung cancer and chronic obstructive pulmonary disease
    • Saccone NL, Culverhouse RC, Schwantes-An T-H, et al.: Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet 2010, 6(8): e1001053. This study presented evidence that at least two distinct SNPs at 15q25 affect smoking behavior. The authors performed a meta-analysis of 34 datasets containing individuals of European ancestry and confirmed the previous findings at the 15q25 region with genome-wide significance. In their dataset, they additionally analyzed the phenotypes lung cancer and chronic obstructive pulmonary disease.
    • (2010) PLoS Genet , vol.6 , Issue.8
    • Saccone, N.L.1    Culverhouse, R.C.2    Schwantes-An, T.-H.3
  • 33
    • 0036890804 scopus 로고    scopus 로고
    • Cellular and synaptic mechanisms of nicotine addiction
    • DOI 10.1002/neu.10148
    • Mansvelder HD, McGehee DS: Cellular and synaptic mechanisms of nicotine addiction. J Neurobiol. 2002, 53:606-617. (Pubitemid 35375590)
    • (2002) Journal of Neurobiology , vol.53 , Issue.4 , pp. 606-617
    • Mansvelder, H.D.1    McGehee, D.S.2
  • 34
    • 51349156208 scopus 로고    scopus 로고
    • Variants in nicotinic receptors and risk for nicotine dependence
    • Bierut LJ, Stitzel JA, Wang JC, et al.: Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 2008, 165:1163-1171.
    • (2008) Am J Psychiatry , vol.165 , pp. 1163-1171
    • Bierut, L.J.1    Stitzel, J.A.2    Wang, J.C.3
  • 35
    • 68049090045 scopus 로고    scopus 로고
    • Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5
    • Wang JC, Cruchaga C, Saccone NL, et al.: Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum Mol Genet. 2009, 18:3125-3135.
    • (2009) Hum Mol Genet , vol.18 , pp. 3125-3135
    • Wang, J.C.1    Cruchaga, C.2    Saccone, N.L.3
  • 36
    • 77957586481 scopus 로고    scopus 로고
    • Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction
    • Jun 1. (Epub ahead of print)
    • Nielsen DA, Ji F, Yuferov V, Ho A, et al.: Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. Psychiatr Genet. 2010, Jun 1. (Epub ahead of print).
    • (2010) Psychiatr Genet
    • Nielsen, D.A.1    Ji, F.2    Yuferov, V.3    Ho, A.4
  • 37
    • 10444280098 scopus 로고    scopus 로고
    • Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis
    • DOI 10.1196/annals.1316.035
    • Ujike H, Sato M: Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis. Ann N Y Acad Sci. 2004, 1025:279-287. (Pubitemid 39643873)
    • (2004) Annals of the New York Academy of Sciences , vol.1025 , pp. 279-287
    • Ujike, H.1    Sato, M.2
  • 38
    • 33845434956 scopus 로고    scopus 로고
    • Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes
    • Liu QR, Drgon T, Johnson C, et al.: Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes. Am J Med Genet B Neuropsychiatr Genet. 2006, 141B:918-25.
    • (2006) Am J Med Genet B Neuropsychiatr Genet , vol.141 B , pp. 918-925
    • Liu, Q.R.1    Drgon, T.2    Johnson, C.3
  • 39
    • 59849090159 scopus 로고    scopus 로고
    • Genome wide association for substance dependence: Convergent results from epidemiologic and research volunteer samples
    • Johnson C, Drgon T, Liu QR, et al.: Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. BMC Med Genet. 2008, 9:113.
    • (2008) BMC Med Genet , vol.9 , pp. 113
    • Johnson, C.1    Drgon, T.2    Liu, Q.R.3
  • 40
    • 77749249653 scopus 로고    scopus 로고
    • Genome wide association for addiction: Replicated results and comparisons of two analytic approaches
    • Drgon T, Zhang PW, Johnson C, et al. Genome wide association for addiction: replicated results and comparisons of two analytic approaches. PLoS One. 2010, 5(1):e8832.
    • (2010) PLoS One , vol.5 , Issue.1
    • Drgon, T.1    Zhang, P.W.2    Johnson, C.3
  • 41
    • 78650517351 scopus 로고    scopus 로고
    • Identification of blood biomarkers for psychosis using convergent functional genomics
    • Nov 24 (Epub ahead of print)
    • Kurian SM, Le-Niculescu H, Patel SD et al.: Identification of blood biomarkers for psychosis using convergent functional genomics. Mol Psychiatry. 2009, Nov 24 (Epub ahead of print).
    • (2009) Mol Psychiatry
    • Kurian, S.M.1    Le-Niculescu, H.2    Patel, S.D.3
  • 42
    • 80053562429 scopus 로고    scopus 로고
    • Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate
    • *equally contributed Jun 29. (Epub ahead of print)
    • Kiefer F*, Witt SH*, Frank J, et al.: Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. *equally contributed Pharmacogenomics J. 2010, Jun 29. (Epub ahead of print).
    • (2010) Pharmacogenomics J
    • Kiefer, F.1    Witt, S.H.2    Frank, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.