Genetic and pharmacogenomic data on smoking: The bigger sample size, the less reliable phenotype? A critical review;A dohányzással kapcsolatos genetikai és farmakogenomikai vizsgálatok összefoglalása: A nagy elemszám ára a pontatlan fenotipizálás? - Áttekintő tanulmány

Neuropsychopharmacologia Hungarica

Volumn 13, Issue 1, 2011, Pages 7-13

  Lazary, Judit ^a   Dome, Peter ^a   Faludi, Gabor ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Genetic epidemiological studies; Nicotine dependence; Pharmacogenomics; Smoking; Smoking related phenotypes

Indexed keywords

AMFEBUTAMONE; ANKYRIN; CLONIDINE; COTININE; CYTOCHROME P450 2A6; DOPAMINE 2 RECEPTOR; NERVE CELL ADHESION MOLECULE; NICOTINE; NICOTINIC RECEPTOR; NORTRIPTYLINE; TETRATRICOPEPTIDE REPEAT PROTEIN; VARENICLINE;

ALLELE; GENE CLUSTER; HUMAN; HUNGARY; NICOTINE REPLACEMENT THERAPY; PATHOPHYSIOLOGY; PHARMACOGENOMICS; PHENOTYPE; REVIEW; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SMOKING CESSATION; TETRATRICOPEPTIDE REPEAT; TOBACCO DEPENDENCE;

EID: 79955883318     PISSN: 14198711     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (55)

1. Dome P., Lazary J., Kalapos MP., Rihmer Z. (2010) Smoking, nicotine and neuropsychiatric disorders. Neurosci Biobehav Rev 34, 3, 295-342.
2. Mokdad, A.H. et al. (2004) Actual causes of death in the United States, 2000. Jama 291, 1238-1245.
3. Youlden, D.R. et al. (2008) The International Epidemiology of Lung Cancer: geographical distribution and secular trends. J Thorac Oncol 3, 819-831.
4. Tombor, I. et al. [Epidemiology of smoking in Hungary-a representative national study]. Orv Hetil 151, 330-337.
5. Keating, G.M., Lyseng-Williamson, K.A. Varenicline: a pharmacoeconomic review of its use as an aid to smoking cessation. Pharmacoeconomics 28, 231-254.
6. Tombor, I. et al. Denial of smoking-related risk among pregnant smokers. Acta Obstet Gynecol Scand 89, 524-530.
7. Dome, P., Kapitany, B., Rihmer, Z. (2010) A dohánytermékek ára, a dohányfogyasztás és az öngyilkossági ráta közötti összefüggések vizsgálata Magyarországon. Med Thor 63, 403-411.
8. Li, M.D. et al. (2003) A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genet 4 Suppl 1, S103.
9. Maes, H.H. et al. (2004) A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence. Psychol Med 34, 1251-1261.
10. Vink, J.M. et al. (2005) Heritability of smoking initiation and nicotine dependence. Behav Genet 35, 397-406.
11. Dani, J.A., Heinemann, S. (1996) Molecular and cellular aspects of nicotine abuse. Neuron 16, 905-908.
12. Kortmann, G.L. et al. Pharmacogenetics of smoking cessation therapy. Am J Med Genet B Neuropsychiatr Genet 153B, 17-28.
13. Nakajima, M. et al. (1996) Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos 24, 1212-1217.
14. Messina, E.S. et al. (1997) A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. J Pharmacol Exp Ther 282, 1608-1614.
15. Bierut, L.J. et al. (2008) Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 165, 1163-1171.
16. Stevens, V.L. et al. (2008) Nicotinic receptor gene variants influence susceptibility to heavy smoking. Cancer Epidemiol Biomarkers Prev 17, 3517-3525.
17. Weiss, R.B. et al. (2008) A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet 4, e1000125.
18. Breitling, L.P. et al. (2009) Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans. Pharmacogenomics J 9, 219-224.
19. Breitling, L.P. et al. (2009) Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes. Biol Psychiatry 65, 691-695.
20. Etter, J.F. et al. (2009) Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. Addict Behav 34, 772-775.
21. Keskitalo, K. et al. (2009) Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Hum Mol Genet 18, 4007-4012.
22. Hoft, N.R. et al. (2009) Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. Neuropsychopharmacology 34, 698-706.
23. Wessel, J. et al. Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstrom test for nicotine dependence. Neuropsychopharmacology 35, 2392-2402.
24. Saccone, N.L. et al. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav 9, 741-750.
25. Johnson, E.O. et al. Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence. Addiction 105, 2014-2022.
26. Culverhouse, R.C. et al. Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Hum Genet 129, 177-188.
27. Berrettini, W. et al. (2008) Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry 13, 368-373.
28. Ray, R. et al. (2009) Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes. J Neurogenet 23, 252-261.
29. David, S.P., Munafo, M.R. (2008) Genetic variation in the dopamine pathway and smoking cessation. Pharmacogenomics 9, 1307-1321.
30. Uhl, G.R. et al. (2008) Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Arch Gen Psychiatry 65, 683-693.
31. Katoh, M., Katoh, M. (2003) Identification and characterization of TPARM gene in silico. Int J Oncol 23, 1213-1217.
32. Nguyen, C. et al. (1986) Localization of the human NCAM gene to band q23 of chromosome 11: the third gene coding for a cell interaction molecule mapped to the distal portion of the long arm of chromosome 11. J Cell Biol 102, 711-715.
33. Bierut, L.J. et al. (2007) Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 16, 24-35.
34. Saccone, S.F. et al. (2007) Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 16, 36-49.
35. Schlaepfer, I.R. et al. (2008) The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biol Psychiatry 63, 1039-1046.
36. Liu, J.Z. et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 42, 436-440.
37. Thorgeirsson, T.E. et al. (2008) A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452, 638-642.
38. Hung, R.J. et al. (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452, 633-637.
39. Amos, C.I. et al. (2008) Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 40, 616-622.
40. Thorgeirsson, T.E. et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 42, 448-453.
41. Minna, J.D. (2003) Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. J Clin Invest 111, 31-33.
42. Ho, M.K., Tyndale, R.F. (2007) Overview of the pharmacogenomics of cigarette smoking. Pharmacogenomics J 7, 81-98.
43. Stead, L.F. et al. (2008) Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev CD000146.
44. Hughes, J.R. et al. (2007) Antidepressants for smoking cessation. Cochrane Database Syst Rev CD000031.
45. Aubin, H.J. et al. (2008) Varenicline versus transdermal nicotine patch for smoking cessation: results from a randomised open-label trial. Thorax 63, 717-724.
46. Critchley, J.A., Capewell, S. (2003) Prospective cohort studies of coronary heart disease in the UK: a systematic review of past, present and planned studies. J Cardiovasc Risk 10, 111-119.
47. Xian, H. et al. (2003) The heritability of failed smoking cessation and nicotine withdrawal in twins who smoked and attempted to quit. Nicotine Tob Res 5, 245-254.
48. Uhl, G.R. et al. Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. Mol Med 16, 513-526.
49. Drgon, T. et al. (2009) Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. Mol Med 15, 21-27.
50. Perkins, K.A. et al. (2009) Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch. Cancer Epidemiol Biomarkers Prev 18, 2608-2612.
51. Ray, R. et al. Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence. Neuropsychopharmacology 35, 1374-1382.
52. Conti, D.V. et al. (2008) Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Hum Mol Genet 17, 2834-2848.
53. Breitling, L.P. et al. Prospective association of dopamine-related polymorphisms with smoking cessation in general care. Pharmacogenomics 11, 527-536.
54. Fagerstrom, K.O. (1978) Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. Addict Behav 3, 235-241.
55. Heatherton, T.F. et al. (1991) The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict 86, 1119-1127.