No impact of KIF6 Genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study

Journal of the American College of Cardiology

Volumn 57, Issue 20, 2011, Pages 2000-2007

  Hopewell, Jemma C ^a   Parish, Sarah ^a   Clarke, Robert ^a   Armitage, Jane ^a   Bowman, Louise ^a   Hager, Jorg ^b   Lathrop, Mark ^b   Collins, Rory ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CENTRE NATIONAL DE GÉNOTYPAGE   (France)

Author keywords

KIF6; pharmacogenetics; statin response; vascular risk

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KINESIN LIKE PROTEIN 6; MEMBRANE PROTEIN; PLACEBO; SIMVASTATIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HEART PROTECTION; HUMAN; KIF6 GENE; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RANDOMIZED CONTROLLED TRIAL; REVASCULARIZATION; STROKE; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; FEMALE; GENOTYPE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINESIN; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS; TREATMENT OUTCOME;

EID: 79955875125     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.02.015     Document Type: Article

References (38)

1. Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial Lancet 360 2002 7 22
2. Cholesterol Treatment Trialists' (CTT) Collaboration Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins Lancet 366 2005 1267 1278
3. Cholesterol Treatment Trialists' (CTT) Collaboration Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials Lancet 376 2010 1670 1681
4. W.E. Evans, and H.L. McLeod Pharmacogenomicsdrug disposition, drug targets, and side effects N Engl J Med 348 2003 538 549 (Pubitemid 36159890)
5. W. Kalow, B.K. Tang, and L. Endrenyi Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research Pharmacogenetics 8 1998 283 289 (Pubitemid 28372321)
6. M.P. de Maat, J.W. Jukema, and S. Ye Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis Am J Cardiol 83 1999 852 856 (Pubitemid 29143120)
7. L.U. Gerdes, C. Gerdes, and K. Kervinen The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction: a substudy of the Scandinavian simvastatin survival study Circ Cardiovasc Genet 101 2000 1366 1371 (Pubitemid 30169856)
8. J.A. Kuivenhoven, J.W. Jukema, A.H. Zwinderman Regression Growth Evaluation Statin Study Group The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis N Engl J Med 338 1998 86 93 (Pubitemid 28042271)
9. A.J. Marian, F. Safavi, L. Ferlic, J.K. Dunn, A.M. Gotto, and C.M. Ballantyne Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study J Am Coll Cardiol 35 2000 89 95 (Pubitemid 30061265)
10. G. Schmitz, A. Schmitz-Madry, and P. Ugocsai Pharmacogenetics and pharmacogenomics of cholesterol-lowering therapy Curr Opin Lipidol 18 2007 164 173 (Pubitemid 46412087)
11. M.V. Holmes, T. Shah, C. Vickery, L. Smeeth, A.D. Hingorani, and J.P. Casas Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies PLoS One 4 2009 e7960
12. A.C. Morrison, L.A. Bare, and L.E. Chambless Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study Am J Epidemiol 166 2007 28 35 (Pubitemid 47234300)
13. O.A. Iakoubova, C.H. Tong, and C.M. Rowland Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials J Am Coll Cardiol 51 2008 435 443
14. L.A. Bare, A.C. Morrison, and C.M. Rowland Five common gene variants identify elevated genetic risk for coronary heart disease Genet Med 9 2007 682 689 (Pubitemid 350287153)
15. M.M. Luke, W. Lalouschek, and C.M. Rowland Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: Vienna stroke registry Cerebrovasc Dis 28 2009 499 504
16. D. Shiffman, D.I. Chasman, and R.Y. Zee A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study J Am Coll Cardiol 51 2008 444 448
17. D. Shiffman, E.S. O'Meara, and L.A. Bare Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study Arterioscler Thromb Vasc Biol 28 2008 173 179
18. O.A. Iakoubova, M. Robertson, and C.H. Tong KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study Eur J Cardiovasc Prev Rehabil 17 2010 455 461
19. O.A. Iakoubova, M.S. Sabatine, and C.M. Rowland Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study J Am Coll Cardiol 51 2008 449 455
20. D. Shiffman, M.S. Sabatine, and J.Z. Louie Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial Am J Cardiol 105 2010 1300 1305
21. N. Hirokawa Kinesin and dynein superfamily proteins and the mechanism of organelle transport Science 279 1998 519 526 (Pubitemid 28067273)
22. H. Miki, Y. Okada, and N. Hirokawa Analysis of the kinesin superfamily: insights into structure and function Trends Cell Biol 15 2005 467 476 (Pubitemid 41253466)
23. A.J. Marian Surprises of the genome and "personalized" medicine J Am Coll Cardiol 51 2008 456 458
24. Y. Li, O.A. Iakoubova, D. Shiffman, J.J. Devlin, J.S. Forrester, and H.R. Superko KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy Am J Cardiol 106 2010 994 998
25. KIF6 Genotype: Personalize Your Patient's Therapy http://www.bhlinc.com/ pdf/KIF6-Overview.pdf Accessed July 17, 2010
26. Celera Publishes Data Extending the Association Between the KIF6 Gene Variant and Differential Reduction of Coronary Events from Statin Therapy to the Elderly with Prior Vascular Disease https://www.celera.com/celera/pr-1269391715 Accessed July 17, 2010
27. Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience Eur Heart J 20 1999 725 741
28. A.F. Stewart, S. Dandona, and L. Chen Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study J Am Coll Cardiol 53 2009 1471 1472
29. T.L. Assimes, H. Holm, and S. Kathiresan Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies J Am Coll Cardiol 56 2010 1552 1563
30. S.S. Anand, C. Xie, and G. Pare Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: the INTERHEART Genetics Study Circ Cardiovasc Genet 2 2009 16 25
31. S. Kathiresan, B.F. Voight, and S. Purcell Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants Nat Genet 41 2009 334 341
32. N.J. Samani, P. Deloukas, and J. Erdmann Large scale association analysis of novel genetic loci for coronary artery disease Arterioscler Thromb Vasc Biol 29 2009 774 780
33. N.J. Samani, J. Erdmann, and A.S. Hall Genomewide association analysis of coronary artery disease N Engl J Med 357 2007 443 453 (Pubitemid 47204873)
34. J. Erdmann, A. Grosshennig, and P.S. Braund New susceptibility locus for coronary artery disease on chromosome 3q22.3 Nat Genet 41 2009 280 282
35. M.M. Luke, E.S. O'Meara, and C.M. Rowland Gene variants associated with ischemic stroke: the cardiovascular health study Stroke 40 2009 363 368
36. A.C. Morrison, L.A. Bare, and M.M. Luke Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study Cerebrovasc Dis 26 2008 420 424
37. C.J. Willer, S. Sanna, and A.U. Jackson Newly identified loci that influence lipid concentrations and risk of coronary artery disease Nat Genet 40 2008 161 169 (Pubitemid 351171403)
38. J.F. Thompson, C.L. Hyde, and L.S. Wood Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort Circ Cardiovasc Genet 2 2009 173 181