Surprises of the Genome and "Personalized" Medicine**Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

Journal of the American College of Cardiology

Volumn 51, Issue 4, 2008, Pages 456-458

  Marian, Ali J ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PRAVASTATIN;

CORONARY ARTERY ATHEROSCLEROSIS; DNA POLYMORPHISM; DNA SEQUENCE; EDITORIAL; EPIGENETICS; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENETIC VARIABILITY; GENOME ANALYSIS; HEART INFARCTION PREVENTION; HUMAN; HUMAN GENOME; METABOLOMICS; PHARMACOGENOMICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS;

CORONARY DISEASE; GENOME, HUMAN; HISTORY, 21ST CENTURY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINESIN; MOLECULAR BIOLOGY;

EID: 38349166997     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2007.10.020     Document Type: Editorial

References (21)

1. Miersky A.E. The discovery of DNA. Sci Am 218 (1968) 78-88
2. Hershey A.D., and Chase M. Independent function of viral protein and nucleic acid in growth of bacteriophage. J Gen Physiol 36 (1952) 39-56
3. Care A., Catalucci D., Felicetti F., et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med 13 (2007) 613-618
4. Zhao Y., Ransom J.F., Li A., et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129 (2007) 303-317
5. van Rooij E., Sutherland L.B., Qi X., Richardson J.A., Hill J., and Olson E.N. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316 (2007) 575-579
6. Jiang Y.H., Bressler J., and Beaudet A.L. Epigenetics and human disease. Annu Rev Genomics Hum Genet 5 (2004) 479-510
7. Lander E.S., Linton L.M., Birren B., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
8. Venter J.C., Adams M.D., Myers E.W., et al. The sequence of the human genome. Science 291 (2001) 1304-1351
9. Levy S., Sutton G., Ng P.C., et al. The diploid genome sequence of an individual human. PLoS Biol 5 (2007) e254
10. Marian A.J., Brugada R., and Roberts R. Cardiovascular diseases due to genetic abnormalities. In: Fuster V. (Ed). Hurst's The Heart (2004), McGraw-Hill, New York, NY 1747-1783
11. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007) 661-678
12. McPherson R., Pertsemlidis A., Kavaslar N., et al. A common allele on chromosome 9 associated with coronary heart disease. Science 316 (2007) 1488-1491
13. Samani N.J., Erdmann J., Hall A.S., et al. Genomewide association analysis of coronary artery disease. N Engl J Med 357 (2007) 443-453
14. Helgadottir A., Thorleifsson G., Manolescu A., et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316 (2007) 1491-1493
15. NCI-NHGRI Working Group on Replication in Association Studies. Replicating genotype phenotype associations. Nature 447 (2007) 655-660
16. Morrison A.C., Bare L.A., Chambless L.E., et al. Prediction of coronary heart disease risk using a genetic risk score: the atherosclerosis risk in communities study. Am J Epidemiol 166 (2007) 28-35
17. Iakoubova O.A., Tong C.H., Rowland C.M., et al. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol 51 (2008) 435-443
18. Shiffman D., Chasman D.J., Zee R.Y., et al. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. J Am Coll Cardiol 51 (2008) 444-448
19. Iakoubova O.A., Sabatine M.S., Rowland C.M., et al. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. J Am Coll Cardiol 51 (2008) 449-455
20. Miki H., Okada Y., and Hirokawa N. Analysis of the kinesin superfamily: insights into structure and function. Trends Cell Biol 15 (2005) 467-476
21. Koshland J. Philosophy of science: the cha-cha-cha theory of scientific discovery. Science 317 (2007) 761-762