Simvastatin induces heme oxygenase-1 expression but fails to reduce inflammation in the capsule surrounding a silicone shell implant in rats

Journal of Surgical Research

Volumn 168, Issue 2, 2011, Pages 272-280

  Hsieh, Ching Hua ^a   Sun, Cheuk Kwan ^a   Lu, Tsu Hsiang ^a   Chen, Yi Chun ^a   Lin, Chia Jung ^a   Wu, Chia Jung ^a   Rau, Cheng Shyuan ^a   Jeng, Seng Feng ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

B; cyclooxygenase 2; heme oxygenase 1; inflammation; nuclear factor ; periprosthetic capsule; silicone shell implant; simvastatin

Indexed keywords

CD68 ANTIGEN; CYCLOOXYGENASE 2; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PROTOPORPHYRIN ZINC; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPSULAR TISSUE; CELL LEVEL; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INDUCTION; EXPERIMENTAL RAT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMPLANTATION; INFLAMMATION; MACROPHAGE; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SILICONE PROSTHESIS; TISSUE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BREAST IMPLANTS; CYCLOOXYGENASE 2; FOREIGN-BODY REACTION; HEME OXYGENASE (DECYCLIZING); HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; NF-KAPPA B; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

EID: 79955870169     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.07.048     Document Type: Article

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