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Volumn 6, Issue 5, 2011, Pages

Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; CASPASE 3; CYTOKERATIN 19; KI 67 ANTIGEN; MYC PROTEIN; RETINOBLASTOMA PROTEIN; MESSENGER RNA;

EID: 79955866426     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019758     Document Type: Article
Times cited : (10)

References (83)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The Hallmarks of Cancer
    • Hanahan D, Weinberg RA, (2000) The Hallmarks of Cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 4744344066 scopus 로고    scopus 로고
    • Epigenetics and cancer
    • Lund AH, van Lohuizen M, (2004) Epigenetics and cancer. Genes Dev 18: 2315-2335.
    • (2004) Genes Dev , vol.18 , pp. 2315-2335
    • Lund, A.H.1    van Lohuizen, M.2
  • 3
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA, (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 4
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr CJ, McCormick F, (2002) The RB and p53 pathways in cancer. Cancer Cell 2: 103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 5
    • 33750923736 scopus 로고    scopus 로고
    • The retinoblastoma protein in osteoblast differentiation and osteosarcoma
    • Deshpande A, Hinds PW, (2006) The retinoblastoma protein in osteoblast differentiation and osteosarcoma. Curr Mol Med 6: 809-817.
    • (2006) Curr Mol Med , vol.6 , pp. 809-817
    • Deshpande, A.1    Hinds, P.W.2
  • 6
    • 33748060945 scopus 로고    scopus 로고
    • Regulation of cell lineage specification by the retinoblastoma tumor suppressor
    • Skapek SX, Pan YR, Lee EY, (2006) Regulation of cell lineage specification by the retinoblastoma tumor suppressor. Oncogene 25: 5268-5276.
    • (2006) Oncogene , vol.25 , pp. 5268-5276
    • Skapek, S.X.1    Pan, Y.R.2    Lee, E.Y.3
  • 7
    • 33748065310 scopus 로고    scopus 로고
    • RB, the conductor that orchestrates life, death and differentiation
    • Khidr L, Chen PL, (2006) RB, the conductor that orchestrates life, death and differentiation. Oncogene 25: 5210-5219.
    • (2006) Oncogene , vol.25 , pp. 5210-5219
    • Khidr, L.1    Chen, P.L.2
  • 8
    • 24344507918 scopus 로고    scopus 로고
    • Role of the retinoblastoma tumor suppressor protein in cellular differentiation
    • Nguyen DX, McCance DJ, (2005) Role of the retinoblastoma tumor suppressor protein in cellular differentiation. J Cell Biochem 94: 870-879.
    • (2005) J Cell Biochem , vol.94 , pp. 870-879
    • Nguyen, D.X.1    McCance, D.J.2
  • 9
    • 0141907407 scopus 로고    scopus 로고
    • Role of the retinoblastoma protein in differentiation and senescence
    • Thomas DM, Yang HS, Alexander K, Hinds PW, (2003) Role of the retinoblastoma protein in differentiation and senescence. Cancer Biol Ther 2: 124-130.
    • (2003) Cancer Biol Ther , vol.2 , pp. 124-130
    • Thomas, D.M.1    Yang, H.S.2    Alexander, K.3    Hinds, P.W.4
  • 10
    • 0036884829 scopus 로고    scopus 로고
    • The retinoblastoma tumour suppressor in development and cancer
    • Classon M, Harlow E, (2002) The retinoblastoma tumour suppressor in development and cancer. Nature Rev Cancer 2: 910-917.
    • (2002) Nature Rev Cancer , vol.2 , pp. 910-917
    • Classon, M.1    Harlow, E.2
  • 11
    • 11144248047 scopus 로고    scopus 로고
    • Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
    • Iavarone A, (2004) Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature 432: 1040-1045.
    • (2004) Nature , vol.432 , pp. 1040-1045
    • Iavarone, A.1
  • 12
    • 0036569924 scopus 로고    scopus 로고
    • Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability
    • Zheng L, Flesken-Nikitin A, Chen PL, Lee WH, (2002) Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Res 62: 2498-2502.
    • (2002) Cancer Res , vol.62 , pp. 2498-2502
    • Zheng, L.1    Flesken-Nikitin, A.2    Chen, P.L.3    Lee, W.H.4
  • 13
    • 0036386059 scopus 로고    scopus 로고
    • Retinoblastoma tumor suppressor and genome stability
    • Zheng L, Lee WH, (2002) Retinoblastoma tumor suppressor and genome stability. Adv Cancer Res 85: 13-50.
    • (2002) Adv Cancer Res , vol.85 , pp. 13-50
    • Zheng, L.1    Lee, W.H.2
  • 14
    • 34548246559 scopus 로고    scopus 로고
    • RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors
    • Srinivasan SV, Mayhew CN, Schwemberger S, Zagorski W, Knudsen ES, (2007) RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors. J Biol Chem 282: 23867-23877.
    • (2007) J Biol Chem , vol.282 , pp. 23867-23877
    • Srinivasan, S.V.1    Mayhew, C.N.2    Schwemberger, S.3    Zagorski, W.4    Knudsen, E.S.5
  • 15
    • 4043093341 scopus 로고    scopus 로고
    • Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
    • Hernando E, (2004) Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 430: 797-802.
    • (2004) Nature , vol.430 , pp. 797-802
    • Hernando, E.1
  • 16
    • 33750906287 scopus 로고    scopus 로고
    • Role of the retinoblastoma tumor suppressor in the maintenance of genome integrity
    • Knudsen ES, Sexton CR, Mayhew CN, (2006) Role of the retinoblastoma tumor suppressor in the maintenance of genome integrity. Curr Mol Med 6: 749-757.
    • (2006) Curr Mol Med , vol.6 , pp. 749-757
    • Knudsen, E.S.1    Sexton, C.R.2    Mayhew, C.N.3
  • 17
    • 0032578407 scopus 로고    scopus 로고
    • pRB plays an essential role in cell cycle arrest induced by DNA damage
    • Harrington EA, Bruce JL, Harlow E, Dyson N, (1998) pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci USA 95: 11945-11950.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11945-11950
    • Harrington, E.A.1    Bruce, J.L.2    Harlow, E.3    Dyson, N.4
  • 18
    • 50149120366 scopus 로고    scopus 로고
    • Cellular mechanisms of tumour suppression by the retinoblastoma gene
    • Burkhart DL, Sage J, (2008) Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 8: 671-682.
    • (2008) Nat Rev Cancer , vol.8 , pp. 671-682
    • Burkhart, D.L.1    Sage, J.2
  • 19
    • 50149084928 scopus 로고    scopus 로고
    • Tailoring to RB: tumour suppressor status and therapeutic response
    • Knudsen ES, Knudsen KE, (2008) Tailoring to RB: tumour suppressor status and therapeutic response. Nat Rev Cancer 8: 714-724.
    • (2008) Nat Rev Cancer , vol.8 , pp. 714-724
    • Knudsen, E.S.1    Knudsen, K.E.2
  • 22
    • 0036781812 scopus 로고    scopus 로고
    • c-MYC: more than just a matter of life and death
    • Pelengaris S, Khan M, Evan G, (2002) c-MYC: more than just a matter of life and death. Nat Rev Cancer 2: 764-776.
    • (2002) Nat Rev Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1    Khan, M.2    Evan, G.3
  • 23
    • 0032905924 scopus 로고    scopus 로고
    • c?Myc target genes involved in cell growth, apoptosis, and metabolism
    • Dang CV, (1999) c?Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 19: 1-11.
    • (1999) Mol Cell Biol , vol.19 , pp. 1-11
    • Dang, C.V.1
  • 24
    • 0036781812 scopus 로고    scopus 로고
    • c-MYC: more than just a matter of life and death
    • Pelengaris S, Khan M, Evan G, (2002) c-MYC: more than just a matter of life and death. Nat Rev Cancer 2: 764-776.
    • (2002) Nat Rev Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1    Khan, M.2    Evan, G.3
  • 25
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • Meyer N, Penn LZ, (2008) Reflecting on 25 years with MYC. Nat Rev Cancer 8: 976-990.
    • (2008) Nat Rev Cancer , vol.8 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 26
    • 0033616602 scopus 로고    scopus 로고
    • Transient excess of MYC activity can elicit genomic instability and tumorigenesis
    • Felsher DW, Bishop JM, (1999) Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci USA 96: 3940-3944.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3940-3944
    • Felsher, D.W.1    Bishop, J.M.2
  • 27
    • 58849143425 scopus 로고    scopus 로고
    • The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology
    • Caldwell S, Park SH, (2009) The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J Gastroenterol 44 (Suppl 19): 96-101.
    • (2009) J Gastroenterol , vol.44 , Issue.SUPPL. 19 , pp. 96-101
    • Caldwell, S.1    Park, S.H.2
  • 28
    • 66149175804 scopus 로고    scopus 로고
    • The natural history of chronic hepatitis B virus infection
    • McMahon BJ, (2009) The natural history of chronic hepatitis B virus infection. Hepatology 49: S45-55.
    • (2009) Hepatology , vol.49 , pp. 45-55
    • McMahon, B.J.1
  • 29
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi PA, DePinho RA, (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6: 674-687.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 30
    • 77957603190 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting
    • Thomas MB, Jaffe D, Choti MM, Belghiti J, Curley S, et al. (2010) Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting. J Clin Oncol 28: 3994-4005.
    • (2010) J Clin Oncol , vol.28 , pp. 3994-4005
    • Thomas, M.B.1    Jaffe, D.2    Choti, M.M.3    Belghiti, J.4    Curley, S.5
  • 31
    • 77349084899 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis
    • Sherman M, (2010) Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis. Semin Liver Dis 30: 3-16.
    • (2010) Semin Liver Dis , vol.30 , pp. 3-16
    • Sherman, M.1
  • 32
  • 33
    • 0029874206 scopus 로고    scopus 로고
    • c-myc amplification in hepatocellular carcinoma predicts unfavorable prognosis
    • Abou-Elella AGT, Fritsch C, Gansler T, (1996) c-myc amplification in hepatocellular carcinoma predicts unfavorable prognosis. Modern Pathology 9: 95-98.
    • (1996) Modern Pathology , vol.9 , pp. 95-98
    • Abou-Elella, A.G.T.1    Fritsch, C.2    Gansler, T.3
  • 34
    • 0032820507 scopus 로고    scopus 로고
    • Amplification of c-Myc in Hepatocellular Carcinoma: Correlation with Clinicopathologic Features, Proliferative Activity and p53 Overexpression
    • Kawate S, Fukusato T, Ohwada S, Watanuki A, Morishita Y, (1999) Amplification of c-Myc in Hepatocellular Carcinoma: Correlation with Clinicopathologic Features, Proliferative Activity and p53 Overexpression. Oncology 57: 157-163.
    • (1999) Oncology , vol.57 , pp. 157-163
    • Kawate, S.1    Fukusato, T.2    Ohwada, S.3    Watanuki, A.4    Morishita, Y.5
  • 35
    • 33745532794 scopus 로고    scopus 로고
    • Genetics of hepatocellular tumors
    • Laurent-Puig P, Zucman-Rossi J, (2006) Genetics of hepatocellular tumors. Oncogene 25: 3778-3786.
    • (2006) Oncogene , vol.25 , pp. 3778-3786
    • Laurent-Puig, P.1    Zucman-Rossi, J.2
  • 36
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi PA, DePinho RA, (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6: 674-687.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 38
    • 48549088066 scopus 로고    scopus 로고
    • Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance
    • Shachaf CM, Gentles AJ, Elchuri S, Sahoo D, Soen Y, et al. (2008) Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res 68: 5132-5142.
    • (2008) Cancer Res , vol.68 , pp. 5132-5142
    • Shachaf, C.M.1    Gentles, A.J.2    Elchuri, S.3    Sahoo, D.4    Soen, Y.5
  • 39
    • 34548771087 scopus 로고    scopus 로고
    • Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
    • Wu CH, van Riggelen J, Yetil A, Fan AC, Bachireddy P, et al. (2007) Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. Proc Natl Acad Sci U S A 104: 13028-13033.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13028-13033
    • Wu, C.H.1    van Riggelen, J.2    Yetil, A.3    Fan, A.C.4    Bachireddy, P.5
  • 40
    • 33750800316 scopus 로고    scopus 로고
    • Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch
    • Giuriato S, Ryeom S, Fan AC, Bachireddy P, Lynch RC, et al. (2006) Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci U S A 103: 16266-16271.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16266-16271
    • Giuriato, S.1    Ryeom, S.2    Fan, A.C.3    Bachireddy, P.4    Lynch, R.C.5
  • 41
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T, (2003) Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424: 223-228.
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 42
    • 7744220635 scopus 로고    scopus 로고
    • MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
    • Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, et al. (2004) MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 431: 1112-1117.
    • (2004) Nature , vol.431 , pp. 1112-1117
    • Shachaf, C.M.1    Kopelman, A.M.2    Arvanitis, C.3    Karlsson, A.4    Beer, S.5
  • 43
    • 0027968207 scopus 로고
    • Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences
    • Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, et al. (1994) Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. Embo J 13: 4251-4259.
    • (1994) Embo J , vol.13 , pp. 4251-4259
    • Williams, B.O.1    Schmitt, E.M.2    Remington, L.3    Bronson, R.T.4    Albert, D.M.5
  • 44
    • 21144441497 scopus 로고    scopus 로고
    • Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy
    • Mayhew CN, Bosco EE, Fox SR, Okaya T, Tarapore P, et al. (2005) Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer Res 65: 4568-4577.
    • (2005) Cancer Res , vol.65 , pp. 4568-4577
    • Mayhew, C.N.1    Bosco, E.E.2    Fox, S.R.3    Okaya, T.4    Tarapore, P.5
  • 45
    • 33745533559 scopus 로고    scopus 로고
    • Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    • Roskams T, (2006) Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 25: 3818-3822.
    • (2006) Oncogene , vol.25 , pp. 3818-3822
    • Roskams, T.1
  • 46
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • Yamashita T, Forgues M, Wang W, Kim JW, Ye Q, et al. (2008) EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res 68: 1451-1461.
    • (2008) Cancer Res , vol.68 , pp. 1451-1461
    • Yamashita, T.1    Forgues, M.2    Wang, W.3    Kim, J.W.4    Ye, Q.5
  • 48
    • 70450195105 scopus 로고    scopus 로고
    • Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway
    • Machida K, Liu JC, McNamara G, Levine A, Duan L, et al. (2009) Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway. J Virol.
    • (2009) J Virol
    • Machida, K.1    Liu, J.C.2    McNamara, G.3    Levine, A.4    Duan, L.5
  • 49
    • 34548246559 scopus 로고    scopus 로고
    • RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors
    • Srinivasan SV, Mayhew CN, Schwemberger S, Zagorski W, Knudsen ES, (2007) RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors. J Biol Chem 282: 23867-23877.
    • (2007) J Biol Chem , vol.282 , pp. 23867-23877
    • Srinivasan, S.V.1    Mayhew, C.N.2    Schwemberger, S.3    Zagorski, W.4    Knudsen, E.S.5
  • 50
    • 34548483149 scopus 로고    scopus 로고
    • RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis
    • Mayhew CN, Carter SL, Fox SR, Sexton CR, Reed CA, et al. (2007) RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology 133: 976-984.
    • (2007) Gastroenterology , vol.133 , pp. 976-984
    • Mayhew, C.N.1    Carter, S.L.2    Fox, S.R.3    Sexton, C.R.4    Reed, C.A.5
  • 53
    • 0027245446 scopus 로고
    • Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis
    • Murakami H, (1993) Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res 53: 1719-1723.
    • (1993) Cancer Res , vol.53 , pp. 1719-1723
    • Murakami, H.1
  • 54
    • 0032899817 scopus 로고    scopus 로고
    • Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-[alpha] in the liver
    • Sargent LM, (1999) Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-[alpha] in the liver. Am J Pathol 154: 1047-1055.
    • (1999) Am J Pathol , vol.154 , pp. 1047-1055
    • Sargent, L.M.1
  • 55
    • 0031963692 scopus 로고    scopus 로고
    • Disruption of the pRb/E2F Pathway and Inhibition of Apoptosis Are Major Oncogenic Events in Liver Constitutively Expressing c-myc and Transforming Growth Factor alpha
    • Santoni-Rugiu E, Jensen MR, Thorgeirsson SS, (1998) Disruption of the pRb/E2F Pathway and Inhibition of Apoptosis Are Major Oncogenic Events in Liver Constitutively Expressing c-myc and Transforming Growth Factor alpha. Cancer Research 58: 123-134.
    • (1998) Cancer Research , vol.58 , pp. 123-134
    • Santoni-Rugiu, E.1    Jensen, M.R.2    Thorgeirsson, S.S.3
  • 56
    • 2142812377 scopus 로고    scopus 로고
    • Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice
    • Calvisi DF, Factor VM, Ladu S, Conner EA, Thorgeirsson SS, (2004) Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice. Gastroenterology 126: 1374-1386.
    • (2004) Gastroenterology , vol.126 , pp. 1374-1386
    • Calvisi, D.F.1    Factor, V.M.2    Ladu, S.3    Conner, E.A.4    Thorgeirsson, S.S.5
  • 57
    • 66149152693 scopus 로고    scopus 로고
    • Central role of c-Myc during malignant conversion in human hepatocarcinogenesis
    • Kaposi-Novak P, Libbrecht L, Woo HG, Lee YH, Sears NC, et al. (2009) Central role of c-Myc during malignant conversion in human hepatocarcinogenesis. Cancer Res 69: 2775-2782.
    • (2009) Cancer Res , vol.69 , pp. 2775-2782
    • Kaposi-Novak, P.1    Libbrecht, L.2    Woo, H.G.3    Lee, Y.H.4    Sears, N.C.5
  • 58
    • 70349739285 scopus 로고    scopus 로고
    • Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    • Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, et al. (2009) Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res 69: 7385-7392.
    • (2009) Cancer Res , vol.69 , pp. 7385-7392
    • Hoshida, Y.1    Nijman, S.M.2    Kobayashi, M.3    Chan, J.A.4    Brunet, J.P.5
  • 59
    • 0030849451 scopus 로고    scopus 로고
    • Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination
    • Mateyak MK, Obaya AJ, Adachi S, Sedivy JM, (1997) Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ 8: 1039-1048.
    • (1997) Cell Growth Differ , vol.8 , pp. 1039-1048
    • Mateyak, M.K.1    Obaya, A.J.2    Adachi, S.3    Sedivy, J.M.4
  • 60
    • 77953745129 scopus 로고    scopus 로고
    • Myc-induced microRNAs integrate Myc-mediated cell proliferation and cell fate
    • Kim JW, Mori S, Nevins JR, (2010) Myc-induced microRNAs integrate Myc-mediated cell proliferation and cell fate. Cancer Res 70: 4820-4828.
    • (2010) Cancer Res , vol.70 , pp. 4820-4828
    • Kim, J.W.1    Mori, S.2    Nevins, J.R.3
  • 61
    • 0034014307 scopus 로고    scopus 로고
    • Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway
    • Santoni-Rugiu E, Falck J, Mailand N, Bartek J, Lukas J, (2000) Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway. Mol Cell Biol 20: 3497-3509.
    • (2000) Mol Cell Biol , vol.20 , pp. 3497-3509
    • Santoni-Rugiu, E.1    Falck, J.2    Mailand, N.3    Bartek, J.4    Lukas, J.5
  • 62
    • 0037023755 scopus 로고    scopus 로고
    • Signaling networks that link cell proliferation and cell fate
    • Sears RC, Nevins JR, (2002) Signaling networks that link cell proliferation and cell fate. J Biol Chem 277: 11617-11620.
    • (2002) J Biol Chem , vol.277 , pp. 11617-11620
    • Sears, R.C.1    Nevins, J.R.2
  • 63
    • 72449178334 scopus 로고    scopus 로고
    • Division and apoptosis of E2f-deficient retinal progenitors
    • Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, et al. (2009) Division and apoptosis of E2f-deficient retinal progenitors. Nature 462: 925-929.
    • (2009) Nature , vol.462 , pp. 925-929
    • Chen, D.1    Pacal, M.2    Wenzel, P.3    Knoepfler, P.S.4    Leone, G.5
  • 64
    • 46949111496 scopus 로고    scopus 로고
    • Insights from mouse models into human retinoblastoma
    • Macpherson D, (2008) Insights from mouse models into human retinoblastoma. Cell Div 3: 9.
    • (2008) Cell Div , vol.3 , pp. 9
    • Macpherson, D.1
  • 65
    • 0038505659 scopus 로고    scopus 로고
    • Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis
    • Edamoto Y, Hara A, Biernat W, Terracciano L, Cathomas G, et al. (2003) Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. Int J Cancer 106: 334-341.
    • (2003) Int J Cancer , vol.106 , pp. 334-341
    • Edamoto, Y.1    Hara, A.2    Biernat, W.3    Terracciano, L.4    Cathomas, G.5
  • 66
    • 50149084928 scopus 로고    scopus 로고
    • Tailoring to RB: tumour suppressor status and therapeutic response
    • Knudsen ES, Knudsen KE, (2008) Tailoring to RB: tumour suppressor status and therapeutic response. Nat Rev Cancer 8: 714-724.
    • (2008) Nat Rev Cancer , vol.8 , pp. 714-724
    • Knudsen, E.S.1    Knudsen, K.E.2
  • 67
    • 33745532794 scopus 로고    scopus 로고
    • Genetics of hepatocellular tumors
    • Laurent-Puig P, Zucman-Rossi J, (2006) Genetics of hepatocellular tumors. Oncogene 25: 3778-3786.
    • (2006) Oncogene , vol.25 , pp. 3778-3786
    • Laurent-Puig, P.1    Zucman-Rossi, J.2
  • 68
    • 33751264911 scopus 로고    scopus 로고
    • Gankyrin, the 26 S proteasome, the cell cycle and cancer
    • Mayer RJ, Fujita J, (2006) Gankyrin, the 26 S proteasome, the cell cycle and cancer. Biochem Soc Trans 34: 746-748.
    • (2006) Biochem Soc Trans , vol.34 , pp. 746-748
    • Mayer, R.J.1    Fujita, J.2
  • 69
    • 35948946094 scopus 로고    scopus 로고
    • Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1
    • Hsieh YH, Su IJ, Wang HC, Tsai JH, Huang YJ, et al. (2007) Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1. Mol Cancer Res 5: 1063-1072.
    • (2007) Mol Cancer Res , vol.5 , pp. 1063-1072
    • Hsieh, Y.H.1    Su, I.J.2    Wang, H.C.3    Tsai, J.H.4    Huang, Y.J.5
  • 70
    • 33845995100 scopus 로고    scopus 로고
    • Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter
    • Park SG, Chung C, Kang H, Kim JY, Jung G, (2006) Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter. J Biol Chem 281: 31770-31777.
    • (2006) J Biol Chem , vol.281 , pp. 31770-31777
    • Park, S.G.1    Chung, C.2    Kang, H.3    Kim, J.Y.4    Jung, G.5
  • 71
    • 54449091313 scopus 로고    scopus 로고
    • Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis
    • Wang WH, Hullinger RL, Andrisani OM, (2008) Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. J Biol Chem 283: 25455-25467.
    • (2008) J Biol Chem , vol.283 , pp. 25455-25467
    • Wang, W.H.1    Hullinger, R.L.2    Andrisani, O.M.3
  • 72
    • 79955870527 scopus 로고    scopus 로고
    • Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation
    • Kim YJ, Jung JK, Lee SY, Jang KL, (2009) Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation. Cancer Lett.
    • (2009) Cancer Lett
    • Kim, Y.J.1    Jung, J.K.2    Lee, S.Y.3    Jang, K.L.4
  • 73
    • 66149135640 scopus 로고    scopus 로고
    • Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer
    • McGivern DR, Lemon SM, (2009) Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer. Annu Rev Pathol 4: 399-415.
    • (2009) Annu Rev Pathol , vol.4 , pp. 399-415
    • McGivern, D.R.1    Lemon, S.M.2
  • 74
    • 62249217189 scopus 로고    scopus 로고
    • The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras
    • Ho VM, Schaffer BE, Karnezis AN, Park KS, Sage J, (2009) The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras. Oncogene.
    • (2009) Oncogene
    • Ho, V.M.1    Schaffer, B.E.2    Karnezis, A.N.3    Park, K.S.4    Sage, J.5
  • 75
    • 78649492693 scopus 로고    scopus 로고
    • Selective activation of p53-mediated tumour suppression in high-grade tumours
    • Junttila MR, Karnezis AN, Garcia D, Madriles F, Kortlever RM, et al. (2010) Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature 468: 567-571.
    • (2010) Nature , vol.468 , pp. 567-571
    • Junttila, M.R.1    Karnezis, A.N.2    Garcia, D.3    Madriles, F.4    Kortlever, R.M.5
  • 76
    • 78649491016 scopus 로고    scopus 로고
    • Stage-specific sensitivity to p53 restoration during lung cancer progression
    • Feldser DM, Kostova KK, Winslow MM, Taylor SE, Cashman C, et al. (2010) Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature 468: 572-575.
    • (2010) Nature , vol.468 , pp. 572-575
    • Feldser, D.M.1    Kostova, K.K.2    Winslow, M.M.3    Taylor, S.E.4    Cashman, C.5
  • 77
    • 77954522274 scopus 로고    scopus 로고
    • Loss of pRB causes Centromere Dysfunction and Chromosomal Instability
    • Manning AL, Longworth MS, Dyson NJ, (2010) Loss of pRB causes Centromere Dysfunction and Chromosomal Instability. Genes Dev.
    • (2010) Genes Dev
    • Manning, A.L.1    Longworth, M.S.2    Dyson, N.J.3
  • 78
    • 77954526477 scopus 로고    scopus 로고
    • RB's original CIN?
    • Sage J, Straight AF, (2010) RB's original CIN? Genes Dev 24: 1329-1333.
    • (2010) Genes Dev , vol.24 , pp. 1329-1333
    • Sage, J.1    Straight, A.F.2
  • 79
    • 77958569435 scopus 로고    scopus 로고
    • Induced pluripotency: history, mechanisms, and applications
    • Stadtfeld M, Hochedlinger K, (2010) Induced pluripotency: history, mechanisms, and applications. Genes Dev 24: 2239-2263.
    • (2010) Genes Dev , vol.24 , pp. 2239-2263
    • Stadtfeld, M.1    Hochedlinger, K.2
  • 80
    • 77954516489 scopus 로고    scopus 로고
    • Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling
    • van Harn T, Foijer F, van Vugt M, Banerjee R, Yang F, et al. (2010) Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling. Genes Dev.
    • (2010) Genes Dev
    • van Harn, T.1    Foijer, F.2    van Vugt, M.3    Banerjee, R.4    Yang, F.5
  • 81
    • 51649083703 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation, aneuploidy, and cancer
    • Cimini D, (2008) Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim Biophys Acta 1786: 32-40.
    • (2008) Biochim Biophys Acta , vol.1786 , pp. 32-40
    • Cimini, D.1
  • 82
    • 27144507868 scopus 로고    scopus 로고
    • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    • Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, et al. (2005) Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437: 1043-1047.
    • (2005) Nature , vol.437 , pp. 1043-1047
    • Fujiwara, T.1    Bandi, M.2    Nitta, M.3    Ivanova, E.V.4    Bronson, R.T.5


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