Effects of high-whey-protein intake and resistance training on renal, bone and metabolic parameters in rats

British Journal of Nutrition

Volumn 105, Issue 6, 2011, Pages 836-845

  Aparicio, Virginia A ^a,b   Nebot, Elena ^a   Porres, Jesús M ^a   Ortega, Francisco B ^a,b   Heredia, Jose M ^a   López Jurado, María ^a   Ramírez, Pilar Aranda ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Bone status; High protein diets; Rats; Renal status; Resistance training

Indexed keywords

CALCIUM; CITRIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; MILK PROTEIN; PROTEIN HYDROLYSATE; TRIACYLGLYCEROL; CHOLESTEROL; WHEY PROTEIN;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY WEIGHT; BONE; BONE MINERAL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FOOD INTAKE; KIDNEY MASS; METABOLIC PARAMETERS; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN DIET; RAT; RESISTANCE TRAINING; URINARY EXCRETION; URINE VOLUME; WEIGHT GAIN; ANIMAL; BLOOD; BONE DENSITY; CALORIC INTAKE; CHEMISTRY; DRUG EFFECT; KIDNEY; MALE; METABOLISM; ORGAN SIZE; PH; PHYSIOLOGY; PROTEIN INTAKE; RANDOMIZATION; URINE; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; BODY COMPOSITION; BODY WEIGHT; BONE DENSITY; CALCIUM; CHOLESTEROL; CITRIC ACID; DIETARY PROTEINS; ENERGY INTAKE; HYDROGEN-ION CONCENTRATION; KIDNEY; MALE; MILK PROTEINS; ORGAN SIZE; PHYSICAL CONDITIONING, ANIMAL; PROTEIN HYDROLYSATES; RANDOM ALLOCATION; RATS; RATS, WISTAR; RESISTANCE TRAINING; TRIGLYCERIDES; URINE;

EID: 79955866014     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510004393     Document Type: Article

References (55)

1. Lowery LM & Devia L (2009) Dietary protein safety and resistance exercise: what do we really know? J Int Soc Sports Nutr 6, 3.
2. JHJ Otten and L Meyers (editors) (2006) Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington, DC: The National Academies Press.
3. Campbell B, Kreider RB, Ziegenfuss T, et al. (2007) International Society of Sports Nutrition position stand: protein and exercise. J Int Soc Sports Nutr 4, 8.
4. Tipton KD & Witard OC (2007) Protein requirements andrecommendations for athletes: relevance of ivory towerarguments for practical recommendations. Clin Sports Med26, 17-36.
5. Rodriguez NR, Di Marco NM & Langley S (2009) American College of Sports Medicine position stand. Nutrition and athletic performance. Med Sci Sports Exerc 41, 709-731.
6. Innocencio da Silva Gomes A, Goncalves Ribeiro B & de Abreu Soares E (2006) Nutritional profile of the Brazilian Amputee Soccer Team during the precompetition period for the world championship. Nutrition 22, 989-995.
7. Lacroix M, Gaudichon C, Martin A, et al. (2004) A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats. Am J Physiol Regul Integr Comp Physiol 287, R934-R942.
8. Pichon L, Potier M, Tome D, et al. (2008) High-protein diets containing different milk protein fractions differently influence energy intake and adiposity in the rat. Br J Nutr 99, 39-748.
9. Cribb PJ, Williams AD, Stathis CG, et al. (2007) Effects of whey isolate, creatine, and resistance training on muscle hypertrophy. Med Sci Sports Exerc 39, 298-307.
10. Hayes A & Cribb PJ (2008) Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care 11, 40-44.
11. Belobrajdic DP, McIntosh GH & Owens JA (2004) A highwhey- protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in wistar rats. J Nutr 134, 1454-1458.
12. Cribb P (2005) Whey Proteins in Sports Nutrition. Arlington, TX: US Dairy Export Council.
13. Jia Y, Hwang SY, House JD, et al. (2010) Long-term high intake of whole proteins results in renal damage in pigs. J Nutr 140, 1646-1652.
14. Friedman AN (2004) High-protein diets: potential effects on the kidney in renal health and disease. Am J Kidney Dis 44, 950-962.
15. Martin WF, Armstrong LE & Rodriguez NR (2005) Dietary protein intake and renal function. Nutr Metab (Lond) 2, 25.
16. Frank H, Graf J, Amann-Gassner U, et al. (2009) Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men. Am J Clin 90, 1509-1516.
17. Pak CY (2008) Pharmacotherapy of kidney stones. Expert Opin Pharmacother 9, 1509-1518.
18. Amanzadeh J, Gitomer WL, Zerwekh JE, et al. (2003) Effect of high protein diet on stone-forming propensity and bone loss in rats. Kidney Int 64, 2142-2149.
19. Barzel US & Massey LK (1998) Excess dietary protein can adversely affect bone. J Nutr 128, 1051-1053.
20. Lowe DT (1998) Comment on recent symposium overview: does excess dietary protein adversely affect bone. J Nutr 128, 2529.
21. Weiss RE, Gorn A, Dux S, et al. (1981) Influence of high protein diets on cartilage and bone formation in rats. J Nutr 111,804-816.
22. Massey LK (2003) Dietary animal and plant protein and human bone health: a whole foods approach. J Nutr 133, 862S-865S.
23. Talbott SM, Cifuentes M, Dunn MG, et al. (2001) Energy restriction reduces bone density and biomechanical properties in aged female rats. J Nutr 131, 2382-2387.
24. Sellmeyer DE, Stone KL, Sebastian A, et al. (2001) A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr 73, 118-122.
25. Kerstetter JE, Mitnick ME, Gundberg CM, et al. (1999) Changes in bone turnover in young women consuming different levels of dietary protein. J Clin Endocrinol Metab 84, 1052-1055.
26. Mardon J, Habauzit V, Trzeciakiewicz A, et al. (2008) Longterm intake of a high-protein diet with or without potassium citrate modulates acid-base metabolism, but not bone status, in male rats. J Nutr 138, 718-724.
27. Alexy U, Remer T, Manz F, et al. (2005) Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children. Am J Clin Nutr 82, 1107-1114.
28. Promislow JH, Goodman-Gruen D, Slymen DJ, et al. (2002) Protein consumption and bone mineral density in the elderly: the Rancho Bernardo Study. Am J Epidemiol 155, 636-644.\
29. Kerstetter JE, O'Brien KO & Insogna KL (2003) Low protein intake: the impact on calcium and bone homeostasis in humans. J Nutr 133, 855S-861S.
30. de Salles BF, Simao R, Miranda F, et al. (2009) Rest interval between sets in strength training. Sports Med 39, 765-777.
31. Wolfe RR (2006) The underappreciated role of muscle in health and disease. Am J Clin Nutr 84, 475-482.
32. Williams MA, Haskell WL, Ades PA, et al. (2007) Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation 116, 572-584.
33. Houston MC, Fazio S, Chilton FH, et al. (2009) Nonpharmacologic treatment of dyslipidemia. Prog Cardiovasc Dis 52, 61-94.
34. Borer KT (2005) Physical activity in the prevention and amelioration of osteoporosis in women: interaction of mechanical, hormonal and dietary factors. Sports Med 35, 779-830.
35. Mosley PE (2009) Bigorexia: bodybuilding and muscle dysmorphia. Eur Eat Disord Rev 17, 191-198.
36. Knoesen N, Thai Vo S & Castle D (2009) To be superman - the male looks obsession. Aust Fam Physician 38, 131-133.
37. Pye KM, Wakefield AP, Aukema HM, et al. (2009) A high mixed protein diet reduces body fat without altering the mechanical properties of bone in female rats. J Nutr 139, 2099-2105.
38. Reeves PG, Nielsen FH, Fahey GC Jr, et al. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939-1951.
39. Bouthegourd JC, Roseau SM, Makarios-Lahham L, et al. (2002) A preexercise alpha-lactalbumin-enriched whey protein meal preserves lipid oxidation and decreases adiposity in rats. Am J Physiol Endocrinol Metab 283, E565-E572.
40. Moinuddin I & Leehey DJ (2008) A comparison of aerobicexercise and resistance training in patients with and without chronic kidney disease. Adv Chronic Kidney Dis 15, 83-96.
41. Bianchi C, Penno G, Romero F, et al. (2007) Treating the metabolic syndrome. Expert Rev Cardiovasc Ther 5, 491-506.
42. Bankir L, Bouby N, Trinh-Trang-Tan MM, et al. (1996) Direct and indirect cost of urea excretion. Kidney Int 49, 1598-1607.
43. Hammond KA & Janes DN (1998) The effects of increased protein intake on kidney size and function. J Exp Biol 201, 2081-2090.
44. Walrand S, Short KR, Bigelow ML, et al. (2008) Functional impact of high protein intake on healthy elderly people. Am J Physiol Endocrinol Metab 295, E921-E928.
45. Poortmans JR & Ouchinsky M (2006) Glomerular filtration rate and albumin excretion after maximal exercise in aging sedentary and active men. J Gerontol A Biol Sci Med Sci 61, 1181-1185.
46. Matsuo T, Nozaki T, Okamura K, et al. (2003) Effects of voluntary resistance exercise and high-protein snack on bone mass, composition, and strength in rats given glucocorticoid injections. Biosci Biotechnol Biochem 67, 2518-2523.
47. Heaney RP (2009) Dairy and bone health. J Am Coll Nutr 28, Suppl. 1, 82S-90S.
48. Hannan MT, Tucker KL, Dawson-Hughes B, et al. (2000) Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 15, 2504-2512.
49. Heaney RP (1998) Excess dietary protein may not adversely affect bone. J Nutr 128, 1054-1057.
50. Tylavsky FA, Spence LA & Harkness L (2008) The importance of calcium, potassium, and acid-base homeostasis in bone health and osteoporosis prevention. J Nutr 138, 164S-165S.
51. Remer T (2000) Influence of diet on acid-base balance. Semin Dial 13, 221-226.
52. Remer T (2001) Influence of nutrition on acid-base balance - metabolic aspects. Eur J Nutr 40, 214-220.
53. Bennell K, Page C, Khan K, et al. (2000) Effects of resistance training on bone parameters in young and mature rats. Clin Exp Pharmacol Physiol 27, 88-94.
54. Burr DB, Robling AG & Turner CH (2002) Effects of biomechanical stress on bones in animals. Bone 30, 781-786.
55. Elango R, Humayun MA, Ball RO, et al. (2009) Evidence that protein requirements have been significantly underestimated. Curr Opin Clin Nutr Metab 13, 52-57.