메뉴 건너뛰기




Volumn 5, Issue 4, 2011, Pages

HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: Implications for progression to neurological complications

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; HLA A ANTIGEN; MEMBRANE PROTEIN; PROGRAMMED DEATH 1 RECEPTOR; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING PROTEIN 3; TAX PROTEIN; UNCLASSIFIED DRUG; HAVCR2 PROTEIN, HUMAN; TAX PROTEIN, HUMAN T LYMPHOTROPHIC VIRUS 1; TAX PROTEIN, HUMAN T-LYMPHOTROPHIC VIRUS 1;

EID: 79955863018     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001030     Document Type: Article
Times cited : (22)

References (56)
  • 1
    • 0033006448 scopus 로고    scopus 로고
    • Rapid quantification of HTLV-I provirus load: detection of monoclonal proliferation of HTLV-I-infected cells among blood donors
    • Etoh K, Yamaguchi K, Tokudome S, Watanabe T, Okayama A, et al. (1999) Rapid quantification of HTLV-I provirus load: detection of monoclonal proliferation of HTLV-I-infected cells among blood donors. Int J Cancer 81: 859-864.
    • (1999) Int J Cancer , vol.81 , pp. 859-864
    • Etoh, K.1    Yamaguchi, K.2    Tokudome, S.3    Watanabe, T.4    Okayama, A.5
  • 2
    • 10744227482 scopus 로고    scopus 로고
    • Prevalence and clinical features of HTLV neurologic disease in the HTLV Outcomes Study
    • Orland JR, Engstrom J, Fridey J, Sacher RA, Smith JW, et al. (2003) Prevalence and clinical features of HTLV neurologic disease in the HTLV Outcomes Study. Neurology 61: 1588-1594.
    • (2003) Neurology , vol.61 , pp. 1588-1594
    • Orland, J.R.1    Engstrom, J.2    Fridey, J.3    Sacher, R.A.4    Smith, J.W.5
  • 3
    • 0022578349 scopus 로고
    • HTLV-I associated myelopathy, a new clinical entity
    • Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, et al. (1986) HTLV-I associated myelopathy, a new clinical entity. Lancet 1: 1031-1032.
    • (1986) Lancet , vol.1 , pp. 1031-1032
    • Osame, M.1    Usuku, K.2    Izumo, S.3    Ijichi, N.4    Amitani, H.5
  • 4
    • 0021995980 scopus 로고
    • Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
    • Gessain A, Barin F, Vernant JC, Gout O, Maurs L, et al. (1985) Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 2: 407-410.
    • (1985) Lancet , vol.2 , pp. 407-410
    • Gessain, A.1    Barin, F.2    Vernant, J.C.3    Gout, O.4    Maurs, L.5
  • 5
    • 0019781211 scopus 로고
    • Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera
    • Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, et al. (1981) Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A 78: 6476-6480.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 6476-6480
    • Hinuma, Y.1    Nagata, K.2    Hanaoka, M.3    Nakai, M.4    Matsumoto, T.5
  • 6
    • 0017708061 scopus 로고
    • Adult T-cell leukemia: clinical and hematologic features of 16 cases
    • Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H, (1977) Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 50: 481-492.
    • (1977) Blood , vol.50 , pp. 481-492
    • Uchiyama, T.1    Yodoi, J.2    Sagawa, K.3    Takatsuki, K.4    Uchino, H.5
  • 7
    • 0021418424 scopus 로고
    • Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease
    • Yoshida M, Seiki M, Yamaguchi K, Takatsuki K, (1984) Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A 81: 2534-2537.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 2534-2537
    • Yoshida, M.1    Seiki, M.2    Yamaguchi, K.3    Takatsuki, K.4
  • 8
    • 0035863547 scopus 로고    scopus 로고
    • Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load
    • Nagai M, Kubota R, Greten TF, Schneck JP, Leist TP, et al. (2001) Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load. J Infect Dis 183: 197-205.
    • (2001) J Infect Dis , vol.183 , pp. 197-205
    • Nagai, M.1    Kubota, R.2    Greten, T.F.3    Schneck, J.P.4    Leist, T.P.5
  • 9
    • 0033622479 scopus 로고    scopus 로고
    • Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I
    • Hanon E, Stinchcombe JC, Saito M, Asquith BE, Taylor GP, et al. (2000) Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity 13: 657-664.
    • (2000) Immunity , vol.13 , pp. 657-664
    • Hanon, E.1    Stinchcombe, J.C.2    Saito, M.3    Asquith, B.E.4    Taylor, G.P.5
  • 10
    • 6344240449 scopus 로고    scopus 로고
    • The role of CTLs in persistent viral infection: cytolytic gene expression in CD8+ lymphocytes distinguishes between individuals with a high or low proviral load of human T cell lymphotropic virus type 1
    • Vine AM, Heaps AG, Kaftantzi L, Mosley A, Asquith B, et al. (2004) The role of CTLs in persistent viral infection: cytolytic gene expression in CD8+ lymphocytes distinguishes between individuals with a high or low proviral load of human T cell lymphotropic virus type 1. J Immunol 173: 5121-5129.
    • (2004) J Immunol , vol.173 , pp. 5121-5129
    • Vine, A.M.1    Heaps, A.G.2    Kaftantzi, L.3    Mosley, A.4    Asquith, B.5
  • 11
    • 0034651545 scopus 로고    scopus 로고
    • Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes
    • Hanon E, Hall S, Taylor GP, Saito M, Davis R, et al. (2000) Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes. Blood 95: 1386-1392.
    • (2000) Blood , vol.95 , pp. 1386-1392
    • Hanon, E.1    Hall, S.2    Taylor, G.P.3    Saito, M.4    Davis, R.5
  • 12
    • 0036891343 scopus 로고    scopus 로고
    • Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease
    • Jacobson S, (2002) Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease. J Infect Dis 186 (Suppl 2): S187-192.
    • (2002) J Infect Dis , vol.186 , Issue.SUPPL. 2 , pp. 187-192
    • Jacobson, S.1
  • 13
    • 0742324486 scopus 로고    scopus 로고
    • Loss of the ex vivo but not the reinducible CD8+ T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia/lymphoma
    • Arnulf B, Thorel M, Poirot Y, Tamouza R, Boulanger E, et al. (2004) Loss of the ex vivo but not the reinducible CD8+ T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia/lymphoma. Leukemia 18: 126-132.
    • (2004) Leukemia , vol.18 , pp. 126-132
    • Arnulf, B.1    Thorel, M.2    Poirot, Y.3    Tamouza, R.4    Boulanger, E.5
  • 14
    • 55249117798 scopus 로고    scopus 로고
    • Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease
    • Sabouri AH, Usuku K, Hayashi D, Izumo S, Ohara Y, et al. (2008) Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease. Blood 112: 2411-2420.
    • (2008) Blood , vol.112 , pp. 2411-2420
    • Sabouri, A.H.1    Usuku, K.2    Hayashi, D.3    Izumo, S.4    Ohara, Y.5
  • 15
    • 0032560535 scopus 로고    scopus 로고
    • Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients
    • Greten TF, Slansky JE, Kubota R, Soldan SS, Jaffee EM, et al. (1998) Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients. Proc Natl Acad Sci U S A 95: 7568-7573.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7568-7573
    • Greten, T.F.1    Slansky, J.E.2    Kubota, R.3    Soldan, S.S.4    Jaffee, E.M.5
  • 16
    • 0034671992 scopus 로고    scopus 로고
    • The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection
    • Jeffery KJ, Siddiqui AA, Bunce M, Lloyd AL, Vine AM, et al. (2000) The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection. J Immunol 165: 7278-7284.
    • (2000) J Immunol , vol.165 , pp. 7278-7284
    • Jeffery, K.J.1    Siddiqui, A.A.2    Bunce, M.3    Lloyd, A.L.4    Vine, A.M.5
  • 17
    • 13044249147 scopus 로고    scopus 로고
    • HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy
    • Jeffery KJ, Usuku K, Hall SE, Matsumoto W, Taylor GP, et al. (1999) HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci U S A 96: 3848-3853.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3848-3853
    • Jeffery, K.J.1    Usuku, K.2    Hall, S.E.3    Matsumoto, W.4    Taylor, G.P.5
  • 19
    • 0030942013 scopus 로고    scopus 로고
    • HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP): a chronic progressive neurologic disease associated with immunologically mediated damage to the central nervous system
    • Levin MC, Jacobson S, (1997) HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP): a chronic progressive neurologic disease associated with immunologically mediated damage to the central nervous system. J Neurovirol 3: 126-140.
    • (1997) J Neurovirol , vol.3 , pp. 126-140
    • Levin, M.C.1    Jacobson, S.2
  • 20
    • 0027173969 scopus 로고
    • High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease
    • Elovaara I, Koenig S, Brewah AY, Woods RM, Lehky T, et al. (1993) High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease. J Exp Med 177: 1567-1573.
    • (1993) J Exp Med , vol.177 , pp. 1567-1573
    • Elovaara, I.1    Koenig, S.2    Brewah, A.Y.3    Woods, R.M.4    Lehky, T.5
  • 21
    • 0027942152 scopus 로고
    • Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-I-associated myelopathy: a possible mechanism to control viral infection in the central nervous system
    • Umehara F, Nakamura A, Izumo S, Kubota R, Ijichi S, et al. (1994) Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-I-associated myelopathy: a possible mechanism to control viral infection in the central nervous system. J Neuropathol Exp Neurol 53: 617-624.
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 617-624
    • Umehara, F.1    Nakamura, A.2    Izumo, S.3    Kubota, R.4    Ijichi, S.5
  • 22
    • 0027245937 scopus 로고
    • Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy
    • Umehara F, Izumo S, Nakagawa M, Ronquillo AT, Takahashi K, et al. (1993) Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy. J Neuropathol Exp Neurol 52: 424-430.
    • (1993) J Neuropathol Exp Neurol , vol.52 , pp. 424-430
    • Umehara, F.1    Izumo, S.2    Nakagawa, M.3    Ronquillo, A.T.4    Takahashi, K.5
  • 23
    • 0031802995 scopus 로고    scopus 로고
    • Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by intracellular cytokine detection
    • Kubota R, Kawanishi T, Matsubara H, Manns A, Jacobson S, (1998) Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by intracellular cytokine detection. J Immunol 161: 482-488.
    • (1998) J Immunol , vol.161 , pp. 482-488
    • Kubota, R.1    Kawanishi, T.2    Matsubara, H.3    Manns, A.4    Jacobson, S.5
  • 24
    • 0031571256 scopus 로고    scopus 로고
    • Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase
    • Biddison WE, Kubota R, Kawanishi T, Taub DD, Cruikshank WW, et al. (1997) Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase. J Immunol 159: 2018-2025.
    • (1997) J Immunol , vol.159 , pp. 2018-2025
    • Biddison, W.E.1    Kubota, R.2    Kawanishi, T.3    Taub, D.D.4    Cruikshank, W.W.5
  • 25
    • 0032416085 scopus 로고    scopus 로고
    • Viral immune evasion due to persistence of activated T cells without effector function
    • Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJ, Suresh M, et al. (1998) Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 188: 2205-2213.
    • (1998) J Exp Med , vol.188 , pp. 2205-2213
    • Zajac, A.J.1    Blattman, J.N.2    Murali-Krishna, K.3    Sourdive, D.J.4    Suresh, M.5
  • 26
    • 0032482176 scopus 로고    scopus 로고
    • Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes
    • Gallimore A, Glithero A, Godkin A, Tissot AC, Pluckthun A, et al. (1998) Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med 187: 1383-1393.
    • (1998) J Exp Med , vol.187 , pp. 1383-1393
    • Gallimore, A.1    Glithero, A.2    Godkin, A.3    Tissot, A.C.4    Pluckthun, A.5
  • 27
    • 35349014587 scopus 로고    scopus 로고
    • Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    • Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, et al. (2007) Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27: 670-684.
    • (2007) Immunity , vol.27 , pp. 670-684
    • Wherry, E.J.1    Ha, S.J.2    Kaech, S.M.3    Haining, W.N.4    Sarkar, S.5
  • 28
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, et al. (2006) PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443: 350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3    Brown, J.A.4    Moodley, E.S.5
  • 29
    • 58149277359 scopus 로고    scopus 로고
    • Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
    • Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, et al. (2008) Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med 205: 2763-2779.
    • (2008) J Exp Med , vol.205 , pp. 2763-2779
    • Jones, R.B.1    Ndhlovu, L.C.2    Barbour, J.D.3    Sheth, P.M.4    Jha, A.R.5
  • 30
    • 77954492467 scopus 로고    scopus 로고
    • Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors
    • Takamura S, Tsuji-Kawahara S, Yagita H, Akiba H, Sakamoto M, et al. (2010) Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors. J Immunol 184: 4696-4707.
    • (2010) J Immunol , vol.184 , pp. 4696-4707
    • Takamura, S.1    Tsuji-Kawahara, S.2    Yagita, H.3    Akiba, H.4    Sakamoto, M.5
  • 31
    • 58149291895 scopus 로고    scopus 로고
    • TIMs: central regulators of immune responses
    • Hafler DA, Kuchroo V, (2008) TIMs: central regulators of immune responses. J Exp Med 205: 2699-2701.
    • (2008) J Exp Med , vol.205 , pp. 2699-2701
    • Hafler, D.A.1    Kuchroo, V.2
  • 32
    • 64849111809 scopus 로고    scopus 로고
    • Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators
    • Sehrawat S, Suryawanshi A, Hirashima M, Rouse BT, (2009) Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J Immunol 182: 3191-3201.
    • (2009) J Immunol , vol.182 , pp. 3191-3201
    • Sehrawat, S.1    Suryawanshi, A.2    Hirashima, M.3    Rouse, B.T.4
  • 34
    • 77956459371 scopus 로고    scopus 로고
    • HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression
    • Vali B, Jones RB, Sakhdari A, Sheth PM, Clayton K, et al. (2010) HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression. Eur J Immunol.
    • (2010) Eur J Immunol
    • Vali, B.1    Jones, R.B.2    Sakhdari, A.3    Sheth, P.M.4    Clayton, K.5
  • 35
    • 77954053238 scopus 로고    scopus 로고
    • Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response
    • Sehrawat S, Reddy PB, Rajasagi N, Suryawanshi A, Hirashima M, et al. (2010) Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response. PLoS Pathog 6: e1000882.
    • (2010) PLoS Pathog , vol.6
    • Sehrawat, S.1    Reddy, P.B.2    Rajasagi, N.3    Suryawanshi, A.4    Hirashima, M.5
  • 36
    • 69449091993 scopus 로고    scopus 로고
    • Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
    • Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, et al. (2009) Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol 83: 9122-9130.
    • (2009) J Virol , vol.83 , pp. 9122-9130
    • Golden-Mason, L.1    Palmer, B.E.2    Kassam, N.3    Townshend-Bulson, L.4    Livingston, S.5
  • 37
    • 33750691709 scopus 로고    scopus 로고
    • PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    • Urbani S, Amadei B, Tola D, Massari M, Schivazappa S, et al. (2006) PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol 80: 11398-11403.
    • (2006) J Virol , vol.80 , pp. 11398-11403
    • Urbani, S.1    Amadei, B.2    Tola, D.3    Massari, M.4    Schivazappa, S.5
  • 38
    • 33947407689 scopus 로고    scopus 로고
    • Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
    • Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, et al. (2007) Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 81: 2545-2553.
    • (2007) J Virol , vol.81 , pp. 2545-2553
    • Radziewicz, H.1    Ibegbu, C.C.2    Fernandez, M.L.3    Workowski, K.A.4    Obideen, K.5
  • 39
    • 33749338938 scopus 로고    scopus 로고
    • PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
    • Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, et al. (2006) PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 203: 2281-2292.
    • (2006) J Exp Med , vol.203 , pp. 2281-2292
    • Petrovas, C.1    Casazza, J.P.2    Brenchley, J.M.3    Price, D.A.4    Gostick, E.5
  • 40
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L, Janbazian L, Chomont N, Said EA, Gimmig S, et al. (2006) Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 12: 1198-1202.
    • (2006) Nat Med , vol.12 , pp. 1198-1202
    • Trautmann, L.1    Janbazian, L.2    Chomont, N.3    Said, E.A.4    Gimmig, S.5
  • 41
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3    Zhu, B.4    Allison, J.P.5
  • 42
    • 34548191951 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction
    • Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, et al. (2007) Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 81: 9249-9258.
    • (2007) J Virol , vol.81 , pp. 9249-9258
    • Golden-Mason, L.1    Palmer, B.2    Klarquist, J.3    Mengshol, J.A.4    Castelblanco, N.5
  • 43
    • 35648968689 scopus 로고    scopus 로고
    • PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients
    • Peng G, Li S, Wu W, Tan X, Chen Y, et al. (2008) PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol 45: 963-970.
    • (2008) Mol Immunol , vol.45 , pp. 963-970
    • Peng, G.1    Li, S.2    Wu, W.3    Tan, X.4    Chen, Y.5
  • 44
    • 34547931898 scopus 로고    scopus 로고
    • SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    • Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, et al. (2007) SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110: 928-936.
    • (2007) Blood , vol.110 , pp. 928-936
    • Petrovas, C.1    Price, D.A.2    Mattapallil, J.3    Ambrozak, D.R.4    Geldmacher, C.5
  • 46
    • 0024511485 scopus 로고
    • Monoclonal antibody defining tax protein of human T-cell leukemia virus type-I
    • Lee B, Tanaka Y, Tozawa H, (1989) Monoclonal antibody defining tax protein of human T-cell leukemia virus type-I. Tohoku J Exp Med 157: 1-11.
    • (1989) Tohoku J Exp Med , vol.157 , pp. 1-11
    • Lee, B.1    Tanaka, Y.2    Tozawa, H.3
  • 47
    • 49449114030 scopus 로고    scopus 로고
    • The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis
    • Michaelsson J, Barbosa HM, Jordan KA, Chapman JM, Brunialti MK, et al. (2008) The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis. BMC Immunol 9: 41.
    • (2008) BMC Immunol , vol.9 , pp. 41
    • Michaelsson, J.1    Barbosa, H.M.2    Jordan, K.A.3    Chapman, J.M.4    Brunialti, M.K.5
  • 48
    • 0026666288 scopus 로고
    • HTLV-I DNA sequences in CNS tissue of a patient with tropical spastic paraparesis and HTLV-I-associated myelopathy
    • Iannone R, Sherman MP, Rodgers-Johnson PE, Beilke MA, Mora CA, et al. (1992) HTLV-I DNA sequences in CNS tissue of a patient with tropical spastic paraparesis and HTLV-I-associated myelopathy. J Acquir Immune Defic Syndr 5: 810-816.
    • (1992) J Acquir Immune Defic Syndr , vol.5 , pp. 810-816
    • Iannone, R.1    Sherman, M.P.2    Rodgers-Johnson, P.E.3    Beilke, M.A.4    Mora, C.A.5
  • 49
    • 0027296048 scopus 로고
    • Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease
    • Koenig S, Woods RM, Brewah YA, Newell AJ, Jones GM, et al. (1993) Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease. J Immunol 151: 3874-3883.
    • (1993) J Immunol , vol.151 , pp. 3874-3883
    • Koenig, S.1    Woods, R.M.2    Brewah, Y.A.3    Newell, A.J.4    Jones, G.M.5
  • 50
    • 0035469884 scopus 로고    scopus 로고
    • In vitro spontaneous lymphoproliferation in patients with human T-cell lymphotropic virus type I-associated neurologic disease: predominant expansion of CD8+ T cells
    • Sakai JA, Nagai M, Brennan MB, Mora CA, Jacobson S, (2001) In vitro spontaneous lymphoproliferation in patients with human T-cell lymphotropic virus type I-associated neurologic disease: predominant expansion of CD8+ T cells. Blood 98: 1506-1511.
    • (2001) Blood , vol.98 , pp. 1506-1511
    • Sakai, J.A.1    Nagai, M.2    Brennan, M.B.3    Mora, C.A.4    Jacobson, S.5
  • 51
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, et al. (2008) Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10: 29-37.
    • (2008) Nat Immunol , vol.10 , pp. 29-37
    • Blackburn, S.D.1    Shin, H.2    Haining, W.N.3    Zou, T.4    Workman, C.J.5
  • 52
    • 79955825217 scopus 로고    scopus 로고
    • PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients
    • Kozako T, Yoshimitsu M, Fujiwara H, Masamoto I, Horai S, et al. (2008) PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. Leukemia.
    • (2008) Leukemia
    • Kozako, T.1    Yoshimitsu, M.2    Fujiwara, H.3    Masamoto, I.4    Horai, S.5
  • 53
    • 0036095943 scopus 로고    scopus 로고
    • Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP)
    • Yamano Y, Nagai M, Brennan M, Mora CA, Soldan SS, et al. (2002) Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP). Blood 99: 88-94.
    • (2002) Blood , vol.99 , pp. 88-94
    • Yamano, Y.1    Nagai, M.2    Brennan, M.3    Mora, C.A.4    Soldan, S.S.5
  • 54
    • 0033991921 scopus 로고    scopus 로고
    • HTLV-I specific IFN-gamma+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals
    • Kubota R, Kawanishi T, Matsubara H, Manns A, Jacobson S, (2000) HTLV-I specific IFN-gamma+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals. J Neuroimmunol 102: 208-215.
    • (2000) J Neuroimmunol , vol.102 , pp. 208-215
    • Kubota, R.1    Kawanishi, T.2    Matsubara, H.3    Manns, A.4    Jacobson, S.5
  • 55
    • 74549164139 scopus 로고    scopus 로고
    • High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease
    • Enose-Akahata Y, Matsuura E, Oh U, Jacobson S, (2009) High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease. PLoS Pathog 5: e1000682.
    • (2009) PLoS Pathog , vol.5
    • Enose-Akahata, Y.1    Matsuura, E.2    Oh, U.3    Jacobson, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.