Screening of formulation variables for the preparation of poly(ε-caprolactone) nanocapsules containing the local anesthetic benzocaine

Journal of Nanoscience and Nanotechnology

Volumn 11, Issue 3, 2011, Pages 2450-2457

  Moraes, Carolina Morales ^a   De Matos, Angélica Prado ^a   Grillo, Renato ^b   De Melo, Nathalie F S ^a,b   De Paula, Eneida ^a   Filho, Newton Luiz Dias ^c   Rosa, André Henrique ^b   Fraceto, Leonardo Fernandes ^a,b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c Campus Ilha Solteira ^*  (Brazil)

Author keywords

2 4 1 factorial experimental; Experimental design; Local anesthetic; Nanoparticles; Polymeric nanocapsules

Indexed keywords

2 4-1 FACTORIAL EXPERIMENTAL; ASSOCIATION EFFICIENCY; CAPROLACTONE; CLINICAL STUDY; COLLOIDAL SYSTEM; DRUG CARRIER SYSTEMS; DRUG LOADING; FACTORIAL EXPERIMENTAL DESIGN; INDEPENDENT VARIABLES; LOCAL ANESTHETIC; LOCAL ANESTHETICS; NANOPRECIPITATION; POLYDISPERSIONS; TWEEN 80;

ANESTHETICS; DESIGN OF EXPERIMENTS; NANOPARTICLES; POLYDISPERSITY; POLYMERS; STATISTICS; ZETA POTENTIAL;

NANOCAPSULES;

BENZOCAINE; NANOCAPSULE; POLYCAPROLACTONE; POLYESTER;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG FORMULATION; MATERIALS TESTING; METHODOLOGY; SURFACE PROPERTY; ULTRASTRUCTURE;

BENZOCAINE; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG COMPOUNDING; MATERIALS TESTING; NANOCAPSULES; POLYESTERS; SURFACE PROPERTIES;

EID: 79955851521     PISSN: 15334880     EISSN: None     Source Type: Journal    
DOI: 10.1166/jnn.2011.3547     Document Type: Conference Paper

References (36)

1. B. G. Covino and H. G. Vassalo, Anestésicos locais: mecanismos de ação e uso clínico, Colina, Rio de Janeiro (1985).
2. R. H. de Jong, Local Anesthesics, Springfield, C. C. Thomas, Illinois (1994).
3. T. So and E. Farrington, J. Pediatric Health Care 22, 335 (2008).
4. S. V. P. Malheiros, L. M. A. Pinto, L. Gottardo, D. K. Yokaichiya, L. F. Fraceto, N. C. Meirelles, and E. de Paula, Biophys. Chem. 110, 213 (2004).
5. L. F Fraceto, S. Oyama Junior, C. R. Nakaie, A. Spisni, E. de Paula, and T. A. Pertinhez, Biophys. Chem. 1213, 29 (2006).
6. C. M. Moraes, P. Abrami, D. R. de Araújo, A. A. Braga, M. G. Issa, H. G. Ferraz, E. de Paula, and L. F Fraceto, J. Incl. Phenom. Macrocycl. Chem. 57, 313 (2007).
7. N. F S. de Melo, R. Grillo, A. H. Rosa, and L. F Fraceto, J. Pharm. Biomed. Anal. 47, 865 (2008).
8. R. Grillo, N. F S. de Melo, C. M. Moraes, R. de Lima, C. M. S. Menezes, E. I. Ferreira, A. H. Rosa, and L. F. Fraceto, J. Pharm. Biomed. Anal. 47, 265 (2008).
9. V. R. Sinha, K. Bansal, R. Kaushik, R. Kumria, and A. Trehan, Int. J. Pharm. 278, 1 (2008).
10. H. Fessi, F. Puisieux, J. P. Devissaguet, N. Ammoury, and S. Benita, Int. J. Pharm. 55, R1 (1989).
11. H. Fessi, F. Puisieux, and J. P. Devissaguet, European Patent 0274961 A1 (1988).
12. A. Budhian, S. J. Siegel, and K. Winey, Int. J. Pharm. 336, 367 (2007).
13. H. Murakami, M. Kobayashi, H. Takeuchi, and Y. Kawashima, Int. J. Pharm. 187, 143 (1999).
14. S. Galindo-Rodriguez, E. Allémann, H. Fessi, and E. Doelker, Pharm. Res. 21, 1428 (2004).
15. K. Derakhshandeh, M. Erfan, and S. Dadashzadeh, Eur J. Pharm. Biopharm. 66, 34 (2007).
16. D. Quintanar-Guerrero, H. Fessi, E. Allémann, and E. Doelker, Int. J. Pharm. 143, 133 (1996).
17. B. Barros Neto, I. S. Scarminio, and R. E. Bruns, Como fazer experimentos, Unicamp, Campinas (2007).
18. F. S. Polletto, R. S. Silveira, L. A. Fiel, B. Donida, M. Rizzi, S. S. Guterres, and A. R. Pohlmann, J. Nanosci. Nanotechnol. 9, 4933 (2009).
19. C. M. Moraes, A. P. Matos, E. de Paula, A. H. Rosa, and L. F. Fraceto, Materials Science and Engineering B, Solid State Materials for Advanced Technology 165, 243 (2009).
20. C. B. Woitiski, F. Veiga, A. Ribeiro, and R. Neufeld, Eur. J. Pharm. Biopharm. 73, 25 (2009).
21. J. A. M. Namur, E. C. M. Cabral-Albuquerque, W. Quintilio, M. H. A. Santana, M. J. Politi, P. S. de Araújo, A. C. Lopes, and M. H. B. Costa, J. Nanosci. Nanotechnol. 6, 2403 (2006).
22. K. Dillen, J. Vandervoort, G. V. Mooter, L. Verheyden, and A. Ludwiga, Int. J. Pharm. 275, 171 (2007).
23. M. Chacon, L. Berges, J. Molpeceres, M. R. Aberturas, and M. Guzman, Int. J. Pharm. 141, 81 (1996).
24. T. Riley, T. Govender, S. Stolnik, C. D. Xiong, M. C. Garnett, L. Illum, and S. S. Davis, Colloids and Surfaces B: Biointerfaces 16, 147 (1999).
25. P. Jie, S. S. Venkatraman, F. Min, B. Y. C. Freddy, and G. L. Huat, J. Control. Release 110, 20 (2005).
26. Brasil, ANVISA, Resolution RE no 899, de 29 de Maio de 2003.
27. Y Duan, X. Sun, T. Gong, Q. Wang, and Z. Zhang, J. Mater. Sci. 17, 509 (2006).
28. J. Vandervoort and A. Ludwig, Int. J. Pharm. 238, 77 (2002).
29. D. M. Bhavsar, S. B. Tiwari, and M. M. Amiji, J. Control. Release 110, 422 (2006).
30. N. Mondal, A. Samanta, T. K. Pal, and S. K. Ghosal, Pharm. Soc. Japan 128, 595 (2008).
31. M. D. Blanco and M. J. Alonso, Eur J. Pharm. Biopharm. 43, 287 (1997).
32. K. Bouchemal, S. Briançon, E. Perrier, and E. Fessi, Int. J. Pharm. 280, 241 (2004).
33. S. R. Schaffazick, S. S. Guterres, L. L. Freitas, and A. R. Pohlmann, Química Nova 26, 726 (2003).
34. T. Görner, R. Gref, D. Michenot, F. Sommer, M. N. Tran, and E. Dellacherie, J. Control. Release 57, 259 (1999).
35. R. C. Mundargi, V R. Babu, V Rangaswamy, P. Patel, and T. M. Aminabhavi, J. Control. Release 125, 193 (2008).
36. A. M. Pense, C. Vauthier-Holtzscherer, and J. P. Benoit, Microen-capsulation of Drugs, edited by T. L. Whateley, Harwood Academic Publishers, Switzerland (1992), Vol. 1, p. 1.