Formulation optimization for the nanoparticles-in-microsphere hybrid oral delivery system using factorial design

Journal of Controlled Release

Volumn 110, Issue 2, 2006, Pages 422-430

  Bhavsar, Mayank D ^a   Tiwari, Sandip B ^a   Amiji, Mansoor M ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Factorial design; Nanoparticles in microsphere hybrid delivery system; Oral delivery; Response surface plot

Indexed keywords

ANTIGENS; BIOTECHNOLOGY; MACROMOLECULES; NANOSTRUCTURED MATERIALS; OPTIMIZATION; PROTEINS; REGRESSION ANALYSIS;

FACTORIAL DESIGN; NANOPARTICLES-IN-MICROSPHERE HYBRID ORAL DELIVERY SYSTEMS; ORAL DELIVERY; RESPONSE SURFACE PLOT;

DRUG THERAPY;

ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; GELATIN; MICROSPHERE; NANOPARTICLE;

ARTICLE; CONCENTRATION (PARAMETERS); DRUG DELIVERY SYSTEM; DRUG FORMULATION; EMULSION; ENCAPSULATION; FLUORESCENCE MICROSCOPY; HYBRID; MACROMOLECULE; MATHEMATICAL MODEL; PARTICLE SIZE; PREDICTION; PRIORITY JOURNAL; REGRESSION ANALYSIS; STATISTICAL MODEL; STUDENT T TEST; TECHNIQUE; VALIDATION PROCESS;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; FLUORESCEINS; FLUORESCENT DYES; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, FLUORESCENCE; MICROSPHERES; MOLECULAR WEIGHT; NANOSTRUCTURES; PARTICLE SIZE;

EID: 29244442282     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.11.001     Document Type: Article

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