Pathophysiologic changes due to TASER® devices versus excited delirium: Potential relevance to deaths-in-custody?

Journal of Forensic and Legal Medicine

Volumn 18, Issue 4, 2011, Pages 145-153

  Jauchem, James R ^a  

^a AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

Conducted energy weapon; Electric shocking device; Electric stimulation; Electronic control device; Excited delirium; TASER

Indexed keywords

MUSCLE ENZYME;

ACIDOSIS; BODY TEMPERATURE; BREATHING; CARDIOVASCULAR SYSTEM; DEATH; DELIRIUM; DEVICE; ELECTRONICS; HEMATOCRIT; HUMAN; HYPERGLYCEMIA; HYPERKALEMIA; LAW ENFORCEMENT; PATHOPHYSIOLOGY; REVIEW; RHABDOMYOLYSIS;

ACIDOSIS; ANIMALS; BLOOD GLUCOSE; BODY TEMPERATURE; CATECHOLAMINES; CHANNELOPATHIES; CONDUCTED ENERGY WEAPON INJURIES; CREATINE KINASE; DELIRIUM; ELECTRIC STIMULATION; ELECTROCARDIOGRAPHY; FEVER; FORENSIC MEDICINE; HEART RATE; HEMATOCRIT; HUMANS; HYPERGLYCEMIA; HYPERKALEMIA; LACTIC ACID; LAW ENFORCEMENT; PRISONERS; RESPIRATION; RHABDOMYOLYSIS; SUBSTANCE-RELATED DISORDERS; VENTRICULAR FIBRILLATION;

EID: 79955836459     PISSN: 1752928X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jflm.2011.01.014     Document Type: Review

References (155)

1. Jauchem JR. Deaths in custody: are some due to electronic control devices (including TASER® devices) or excited delirium? J Forensic Leg Med 2010;17:1-7 [review].
2. Pearson SS. TASER use is 'organized bullying.' Emerg Med News 2008;30(4):3 [letter].
3. Hall C. Excited delirium: a real medical condition. Can Police Assoc Express 2008;71:14-5 (Winter).
4. Hall CA. Sudden death proximal to police restraint: medical issues. Canadian Association for Civilian Oversight of Law Enforcement. Conference. Montreal, Quebec, Canada: Current Issues in Police Accountability; October 3-5, 2005.
5. Hall C, Butler C. National study on neck restraints in policing. Technical report TR-03-2007. Ottawa, Ontario, Canada: Canadian Police Research Centre; June 2007.
6. Stuart B, Lawrence C, Hall C. Report on conducted energy weapons and excited delirium syndrome. Ottawa, Ontario, Canada: Royal Canadian Mounted Police; October 29, 2007.
7. Leong GB, Leisenring SE, Dean MD. Commentary: intoxication and settled insanity d unsettled matters. J Am Acad Psychiatry Law 2007;35:183-7. (Pubitemid 47104727)
8. Samuel E, Williams RB, Ferrell RB. Excited delirium: consideration of selected medical and psychiatric issues. Neuropsychiatr Dis Treat 2009;5:61-6.
9. Detweiler MB, Mehra A, Rowell T, Kim KY, Bader G. Delirious mania and malignant catatonia: a report of 3 cases and review. Psychiatr Q 2009;80:23-40.
10. DiMaio VJM, DiMaio TG. Excited delirium syndrome. In: Kroll MW, Ho JD, editors. TASER® conducted electrical weapons: physiology, pathology, and law. New York: Springer Science+Business Media; 2009. p. 347-63.
11. Hoffman L. ACEP recognizes excited delirium syndrome. Emerg Med News 2009;31(10) (October 5).
12. Jauchem JR, Seaman RL, Fines DA. Survival of anesthetized Sus scrofa after cycling (7 s on / 3 s off) exposures to a TASER® X26 electronic control device for three minutes. Am J Forensic Med Pathol; in press.
13. Jauchem JR, Beason CW, Cook MC. Acute effects of an alternative electronic-control- device waveform in swine. Forensic Sci Med Pathol 2009;5:2-10.
14. Jauchem JR, Seaman RL, Klages CM. Physiological effects of the TASER® C2 conducted energy weapon. Forensic Sci Med Pathol 2009;5:189-98.
15. Valentino DJ, Walter RJ, Nagy K, Dennis AJ, Winners J, Bokhari F, et al. Repeated thoracic discharges from a stun device. J Trauma 2007;62:1134-42. (Pubitemid 46742965)
16. Valentino DJ, Walter RJ, Dennis AJ, Nagy K, Loor MM, Winners J, et al. Neuromuscular effects of stun device discharges. J Surg Res 2007;143:78-87. (Pubitemid 47562441)
17. Valentino DJ, Walter RJ, Dennis AJ, Nagy K, Loor MM, Winners J, et al. Acute effects of MK63 stun device discharges in miniature swine. Milit Med 2008;173:167-73. (Pubitemid 351238681)
18. Dennis AJ, Valentino DJ, Walter RJ, Nagy KK, Winners J, Bokhari F, et al. Acute effects of TASER X26 discharges in a swine model. J Trauma 2007;63:581-90.
19. Walter RJ, Dennis AJ, Valentino DJ, Margeta B, Nagy KK, Bokhari F, et al. TASER X26 discharges in swine produce potentially fatal ventricular arrhythmias. Acad Emerg Med 2008;15:66-73.
20. Vilke GM, Sloane CM, Bouton KD, Kolkhorst FW, Levine SD, Neuman TS, et al. Physiological effects of a conducted electrical weapon on human subjects. Ann Emerg Med 2007;50:569-75. (Pubitemid 47600387)
21. Ho JD, Dawes DM, Lapine AL, Heegaard WG, Bultman LL, Johnson MA, et al. Prolonged TASER® "drive stun" exposure in humans does not cause worrisome biomarker changes. Abstracts for the 2008 National Association of EMS Physicians (NAEMSP) Scientific Assembly. Prehosp Emerg Care 2008;12:128 [abstract].
22. Jauchem JR. Muscle stimulation by TASER® conducted energy weapons: similarities with voluntary muscle contractions during exercise. Adv Med Biol 2010;7:169-79.
23. Knochel JP, Blachley JD, Johnson JH, Carter NW. Muscle cell electrical hyperpolarization and reduced exercise hyperkalemia in physically conditioned dogs. J Clin Invest 1985;75:740-5. (Pubitemid 15142088)
24. Marcos E, Ribas J. Kinetics of plasma potassium concentrations during exhausting exercise in trained and untrained men. Eur J Appl Physiol Occup Physiol 1995;71:207-14.
25. Medbø JI, Sejersted OM. Plasma potassium changes with high intensity exercise. J Physiol 1990;421:105-22. (Pubitemid 20050156)
26. Mahoney BA, Smith WA, Lo DS, Tsoi K, Tonelli M, Clase CM. Emergency interventions for hyperkalaemia. Cochrane Database Syst Rev 2005;(2). CD003235 [review].
27. Mohaupt MG. Rhabdomyolysis. Ther Umsch 2003;60:391-7 [German].
28. Jauchem JR, Vick RL. Phenylephrine-induced hyperkalemia: role of the liver. Proc Soc Exp Biol Med 1980;163:478-81. (Pubitemid 10037455)
29. Martinez-Vea A, Bardaji A, Garcia C, Oliver JA. Severe hyperkalemia with minimal electrocardiographic manifestations: a report of seven cases. J Electrocardiol 1999;32:45-9.
30. Diercks DB, Shumaik GM, Harrigan RA, Brady WJ, Chan TC. Electrocardiographic manifestations: electrolyte abnormalities. J Emerg Med 2004; 27:153-60 [review].
31. Freeman K, Feldman JA, Mitchell P, Donovan J, Dyer KS, Eliseo L, et al. Effects of presentation and electrocardiogram on time to treatment of hyperkalemia. Acad Emerg Med 2008;15:239-49.
32. Coulter DB, Swenson MJ. Effects of potassium intoxication on porcine electrocardiograms. J Vet Res 1970;31:2001-11.
33. Geddes LA, Roeder RA, Rundell AE, Otlewski MP, Kemeny AE, Lottes AE. The natural biochemical changes during ventricular fibrillation with cardiopulmonary resuscitation and the onset of postdefibrillation pulseless electrical activity. Am J Emerg Med 2006;24:577-81. (Pubitemid 44287269)
34. Parks JM, Reed G, Knochel JP. Cocaine-associated rhabdomyolysis. Am J Med Sci 1989;297:334-6. (Pubitemid 19129021)
35. Kambam J, Mets B, Hickman R, Janicki P, James MF, Kirsch R. The effects of inhibition of plasma cholinesterase activity on systemic toxicity and blood catecholamine levels from cocaine infusion in pigs. J Lab Clin Med 1993;122: 188-96. (Pubitemid 23239150)
36. Chan P, Chen JH, Lee MH, Deng JF. Fatal and nonfatal methamphetamine intoxication in the intensive care unit. J Toxicol Clin Toxicol 1994;32:147-55. (Pubitemid 24133759)
37. Siddiqui F, Slater R, Ashraf S. Life threatening hyperkalemia following cocaine ingestion: a case report. Cases J 2009;2:7355.
38. Eede HV, Montenij LJ, Touw DJ, Norris EM, Rhabdomyolysis in MDMA intoxication: a rapid and underestimated killer. "Clean" ecstasy: a safe party drug? J Emerg Med; in press. doi:10.1016/j.jemermed.2009.04.057.
39. Ho JD, Dawes DM, Heegaard WG, Calkins HG, Moscati RM, Miner JR. Absence of electrocardiographic change after prolonged application of a conducted electrical weapon in physically exhausted adults. J Emerg Med; in press. doi: 10.1016/j.jemermed.2009.03.023.
40. Bozeman WP, Barnes Jr DG, Winslow 3rd JE, Johnson 3rd JC, Phillips CH, Alson R. Immediate cardiovascular effects of the Taser X26 conducted electrical weapon. Emerg Med J 2009;26:567-70.
41. Vilke GM, Sloane CM, Suffecool A, Kolkhorst FW, Neuman TS, Castillo EM, et al. Physiologic effects of the TASER after exercise. Acad Emerg Med 2009;16:704-10.
42. Dawes DM, Ho JD, Reardon RF, Miner JR. Echocardiographic evaluation of TASER X26 probe deployment into the chests of human volunteers. Am J Emerg Med 2010;28:49-55.
43. Ho JD, Dawes DM, Reardon RF, Strote SR, Kunz SN, Nelson RS, et al. Human cardiovascular effects of a new generation conducted electrical weapon. Forensic Sci Int 2011;204:50-7.
44. Swerdlow CD, Fishbein MC, Chaman L, Lakkireddy DR, Tchou P. Presenting rhythm in sudden deaths temporally proximate to discharge of TASER conducted electrical weapons. Acad Emerg Med 2009;16:1-13.
45. Valentino DJ, Walter RJ, Dennis AJ, Margeta B, Starr F, Nagy KK, et al. Taser X26 discharges in swine: ventricular rhythm capture is dependent on discharge vector. J Trauma 2008;65:1478-85.
46. Jauchem JR. An animal model to investigate effectiveness and safety of electronic control devices (including TASER® devices). J Forensic Sci 2010;55:521-6.
47. Jauchem JR. Repeated or long-duration TASER® electronic control device exposures: acidemia and lack of respiration. Forensic Sci Med Pathol 2010;6:46-53 [review].
48. Richardson ES. Intrapericardial delivery of anti-arrhythmic agents. PhD Dissertation. University Of Minnesota; May 2009.
49. Ho J, Dawes D, Cole J, Reardon RF, Lundin EJ, Terwey KS, et al. Effect of an electronic control device exposure on a methamphetamine intoxicated animal model. Acad Emerg Med 2010;17:436-43.
50. Beason CW, Jauchem JR, Clark III CD, Parker JE, Fines DA. Pulse variations of a conducted energy weapon (similar to the TASER® X26 device): effects on muscle contraction and threshold for ventricular fibrillation. J Forensic Sci 2009;54:1113-8.
51. Skogvoll E, Eftestøl T, Gundersen K, Kvaløy JT, Kramer-Johansen J, Olasveengen TM, et al. Dynamics and state transitions during resuscitation in out-of-hospital cardiac arrest. Resuscitation 2008;78:30-7.
52. Cevik C, Otahbachi M, Miller E, Bagdure S, Nugent KM. Acute stress cardiomyopathy and deaths associated with electronic weapons. Int J Cardiol 2009;132:312-7.
53. Holden SJ, Sheridan RD, Coffey TJ, Scaramuzza RA, Diamantopoulos P. Electromagnetic modelling of current flow in the heart from TASER devices and the risk of cardiac dysrhythmias. Phys Med Biol 2007;52:7193-209. (Pubitemid 350242835)
54. Nair K, Umapathy K, Downar E, Nanthakumar K. Aborted sudden death from sustained ventricular fibrillation. Heart Rhythm 2008;5:1198-200.
55. Michaud A, Dupuis JY. Echocardiographic evaluation of TASER X26 in healthy volunteers. Am J Emerg Med 2010;28:521-3 [letter].
56. Weinstock J, Maron BJ, Song C, Mane PP, Estes 3rd NA, Link MS. Failure of commercially available chest wall protectors to prevent sudden cardiac death induced by chest wall blows in an experimental model of commotio cordis. Pediatrics 2006;117:e656-62.
57. VanMeenen KM, Cherniack NS, Bergen MT, Gleason LA, Teichman R, Servatius RJ. Cardiovascular evaluation of electronic control device exposure in law enforcement trainees: a multisite study. J Occup Environ Med 2010;52:197-201.
58. Roberts JR. Acute agitated delirium from cocaine: a medical emergency. Emerg Med News 2007;29(10):18-20.
59. Karch SB. Stimulant abuse and sudden cardiac death. In: Kroll MW, Ho JD, editors. TASER® conducted electrical weapons: physiology, pathology, and law. New York: Springer Science+Business Media; 2009. p. 315-25.
60. Aslibekyan S, Levitan EB, Mittleman MA. Prevalent cocaine use and myocardial infarction. Am J Cardiol 2008;102:966-9.
61. Vasica G, Tennant CC. Cocaine use and cardiovascular complications. Med J Aust 2002;177:260-2 [review].
62. Afonso L, Mohammad T, Thatai D. Crack whips the heart: a review of the cardiovascular toxicity of cocaine. Am J Cardiol 2007;100:1040-3. (Pubitemid 47368115)
63. Roxin LE, Venge P, Friman G. Variations in serum myoglobin after a 2-min isokinetic exercise test and the effects of training. Eur J Appl Physiol Occup Physiol 1984;53:43-7. (Pubitemid 14003845)
64. Sanford JM, Jacobs GJ, Roe EJ, Terndrup TE. Two patients subdued with a TASER® device: cases and review of complications. J Emerg Med 2011;40:28-32.
65. Ho JD, Dawes DM. TASER device-induced rhabdomyolysis is unlikely. J Emerg Med 2011;40:68-9.
66. Yamin C, Oliveira J, Meckel Y, Eynon N, Sagiv M, Ayalon M, et al. CK-MM gene polymorphism does not influence the blood CK activity levels after exhaustive eccentric exercise. Int J Sports Med 2010;31:213-7.
67. Jauchem JR, Cook MC, Beason CW. Blood factors of Sus scrofa following a series of three TASER® electronic control device exposures. Forensic Sci Int 2008;175:166-70. (Pubitemid 351199970)
68. Sloane C. Vilke GM.Riot control agents, tasers, and other less lethal weapons. In: Ross DL, Chan TC, editors. Forensic science and medicine: sudden deaths in custody. Totowa, New Jersey: Humana Press, Inc; 2006. p. 113-38.
69. Dawes DM, Ho JD, Miner JR. A meta-analysis of the effect of an electronic control device on muscle injury as determined by creatine kinase enzyme. Australasian Coll for Emerg Med Scientific Assembly. Poster available at http:// www.ipicd.com/docs/Med%2520Poster%2520CK.pdf; November 15, 2009.
70. Tóth AR, Varga T. Myocardium and striated muscle damage caused by licit or illicit drugs. Leg Med (Tokyo) 2009;11(Suppl 1):S484-7.
71. Berrens Z, Lammers J, White C. Rhabdomyolysis after LSD ingestion. Psychosomatics 2010;51:356-3563. e3.
72. Shkrum MJ, Ramsay DA. Asphyxia. Chapter 3. Forensic science and medicine: forensic pathology of trauma: common problems for the pathologist. Totowa, New Jersey, USA: Humana Press Inc; 2007. pp. 65-179.
73. Gill JR. The medicolegal evaluation of excited delirium. Chapter 6. In: Tsokos M, editor. Forensic pathology Reviews. Volume 5. Totowa, New Jersey, USA: Humana Press Inc; 2008. p. 91-111.
74. Dawes DM, Ho JD, Reardon RF, Sweeney JD, Miner JR. The physiologic effects of multiple simultaneous electronic control device discharges. West J Emerg Med 2010;11:49-56.
75. Reilly JP. Testimony at the Thomas R. Braidwood, Q.C., Commissions of Inquiry under the public Inquiry Act. SBC 2007, c. 9. British Columbia, Canada: Vancouver. Available at, http://www.braidwoodinquiry.ca/transcripts/08-05-05. pdf; 2008.
76. Moscati R, Ho JD, Dawes DM, Miner JR. Physiologic effects of prolonged conducted electrical weapon discharge in ethanol-intoxicated adults. Am J Emerg Med 2010;28:582-7.
77. Ho JD, Dawes DM, Bultman LL, Moscati RM, Janchar TA, Miner JR. Prolonged TASER use on exhausted humans does not worsen markers of acidosis. Am J Emerg Med 2009;27:413-8.
78. Ho JD, Dawes DM, Cole JB, Hottinger JC, Overton KG, Miner JR. Lactate and pH evaluation in exhausted humans with prolonged TASER X26 exposure or continued exertion. Forensic Sci Int 2009;190:80-6.
79. Dawes DM, Ho JD, Reardon RF, Miner JR. The cardiovascular, respiratory, and metabolic effects of a long duration electronic control device exposure in human volunteers. Forensic Sci Med Pathol 2010;6:268-74.
80. Eken C. Acidosis is a life-threatening condition regardless of the underlying condition. Am J Emerg Med 2008;26:721 [letter].
81. Byard RW, Wick R, Gilbert JD. Conditions and circumstances predisposing to death from positional asphyxia in adults. J Forensic Leg Med 2008;15:415-9.
82. Takeichi S, Wakasugi C, Shikata I. Fluidity of cadaveric blood after sudden death: Part I. Postmortem fibrinolysis and plasma catecholamine level. Am J Forensic Med Pathol 1984;5:223-7. (Pubitemid 14027938)
83. Hirvonen J, Kortelainen ML, Huttunen P. Pulmonary and serum surfactant phospholipids and serum catecholamines in strangulation. An experimental study on rats. Forensic Sci Int 1997;90:17-24. (Pubitemid 28000105)
84. Barton M, Lake CR, Rainey TG, Chernow B. Is catecholamine release pH mediated? Crit Care Med 1982;10:751-3.
85. Lim EC, Seet RC. TASER usage and neurological sequelae. J Emerg Med 2009;37:170-1 [letter].
86. Bui ET, Sourkes M, Wennberg R. Generalized tonic-clonic seizure after a taser shot to the head. CMAJ 2009;180:625-6.
87. Eastman AL, Metzger JC, Pepe PE, Benitez FL, Decker J, Rinnert KJ, et al. Conductive electrical devices: a prospective, population-based study of the medical safety of law enforcement use. J Trauma 2008;64:1567-72.
88. Mash DC. Biochemical brain markers in excited delirium deaths. In: Kroll MW, Ho JD, editors. TASER® conducted electrical weapons: physiology, pathology, and law. New York: Springer Science?Business Media; 2009. p. 365-77.
89. Bunai Y, Akaza K, Jiang WX, Nagai A. Fatal hyperthermia associated with excited delirium during an arrest. Leg Med (Tokyo) 2008;10:306-9.
90. Menaker J, Farcy DA, Boswell SA, Stein DM, Dutton RP, Hess JR, et al. Cocaine-induced agitated delirium with associated hyperthermia: a case report. J Emerg Med; in press. doi:10.1016/j.jemermed.2008.02.055.
91. Tsokos M. Postmortem changes and artifacts occurring during the early postmortem interval. Chapter 5. In: Tsokos M, editor. Forensic pathology Reviews. Volume 3. Totowa, New Jersey, USA: Humana Press Inc.; 2006. p. 183-237.
92. Jauchem JR, Sherry CJ, Fines DA, Cook MC. Acidosis, lactate, electrolytes, muscle enzymes, and other factors in the blood of Sus scrofa following repeated TASER® exposures. Forensic Sci Int 2006;161:20-30. (Pubitemid 44107678)
93. Jauchem JR. Increased hematocrit after applications of conducted energy weapons (including TASER® devices) to sus scrofa. J Forensic Sci 2011; 56(Suppl 1):S229-33.
94. Brun J-F, Varlet-Marie E, Connes P, Aloulou I. Hemorheological alterations related to training and overtraining. Biorheology 2010;47:95-115 [review].
95. Dawes DM, Ho JD, Reardon RF, Strote SR, Nelson RS, Lundin EJ, et al. The respiratory, metabolic, and neuroendocrine effects of a new generation electronic control device. Forensic Sci Int; in press. doi:10.1016/j.forsciint. 2010.08.028.
96. Penttilä A, Laiho K. Autolytic changes in blood cells of human cadavers. II. Morphological studies. Forensic Sci Int 1981;17:121-32.
97. Cadroy Y, Pillard F, Sakariassen KS, Thalamas C, Boneu B, Riviere D. Strenuous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers. J Appl Physiol 2002;93:829-33. (Pubitemid 34919651)
98. Ikarugi H, Shibata M, Shibata S, Ishii H, Taka T, Yamamoto J. High intensity exercise enhances platelet reactivity to shear stress and coagulation during and after exercise. Pathophysiol Haemost Thromb 2003;33:127-33. (Pubitemid 38698113)
99. Ribeiro J, Almeida-Dias A, Oliveira AR, Mota J, Appell HJ, Duarte JA. Exhaustive exercise with high eccentric components induces prothrombotic and hypofibrinolytic responses in boys. Int J Sports Med 2007;28:193-6. (Pubitemid 46423570)
100. Kaufman MJ, Siegel AJ, Mendelson JH, Rose SL, Kukes TJ, Sholar MB, et al. Cocaine administration induces human splenic constriction and altered hematologic parameters. J Appl Physiol 1998;85:1877-83. (Pubitemid 28516425)
101. Jepson JH. Polycythemia: diagnosis, pathophysiology and therapy. II. Can Med Assoc J 1969;100:327-34 [review].
102. Nolte KB. Rhabdomyolysis associated with cocaine abuse. Hum Pathol 1991;22:1141-5.
103. Roth D, Alarcón FJ, Fernandez JA, Preston RA, Bourgoignie JJ. Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med 1988;319:673-7.
104. Asadollahi K, Hastings IM, Beeching NJ, Gill GV. Laboratory risk factors for hospital mortality in acutely admitted patients. QJM 2007;100:501-7. (Pubitemid 47241916)
105. Kreutziger J, Wenzel V, Kurz A, Constantinescu MA. Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients. Intensive Care Med 2009;35:1234-9.
106. Babu N, Singh M. Influence of hyperglycemia on aggregation, deformability and shape parameters of erythrocytes. Clin Hemorheol Microcirc 2004;31:273-80. (Pubitemid 40916682)
107. Lieber CS. Ethanol metabolism, cirrhosis and alcoholism. Clin Chim Acta 1997;257:59-84. (Pubitemid 27055895)
108. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev 2010;31:98-132.
109. Molina DK, Hargrove VM. Fatal cocaine interactions: a review of cocaine-related deaths in Bexar County, Texas. Am J Forensic Med Pathol 2010; in press. doi:10.1097/PAF.0b013e3181ed79fe.
110. Mets B, Jamdar S, Landry D. The role of catecholamines in cocaine toxicity: a model for cocaine sudden death. Life Sci 1996;59:2021-31. (Pubitemid 26401601)
111. Pilgrim JL, Gerostamoulos D, Drummer OH, Bollmann M. Involvement of amphetamines in sudden and unexpected death. J Forensic Sci 2009;54:478-85.
112. Karch SB, Stephens BG, Ho CH. Methamphetamine-relateddeaths in San Francisco: demographic, pathologic, and toxicologic profiles. J Forensic Sci 1999;44:359-68.
113. Paterson DJ. Antiarrhythmic mechanisms during exercise. J Appl Physiol 1996;80:1853-62 [review].
114. O'Neill M, Paterson DJ. Role of the sympathetic nervous system in cardiac performance during hyperkalaemia in the anaesthetized pig. Acta Physiol Scand 1995;153:1-11.
115. Paterson DJ, Rogers J, Powell T, Brown HF. Effect of catecholamines on the ventricular myocyte action potential in raised extracellular potassium. Acta Physiol Scand 1993;148:177-86. (Pubitemid 23179946)
116. Dawes D, Ho J, Miner J. The neuroendocrine effects of the TASER® X26: a brief report. Forensic Sci Int 2009;183:14-9.
117. DiMaio V. Deaths in custody investigations. Chapter 10. In: Ross DL, Chan TC, editors. Sudden deaths in custody. 1st ed. Totawa, New Jersey: Humana Press; 2006. p. 167-72.
118. DiMaio TG, DiMaio VJM. Excited delirium syndrome: cause of death and prevention. Boca Raton, Florida: CRC/Taylor & Francis; 2006.
119. Ross DL, Chan TC. Sudden deaths in custody. 1st ed. Totawa, New Jersey: Humana Press; 2006.
120. Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Quan L, et al. Postmortem serum catecholamine levels in relation to the cause of death. Forensic Sci Int 2007;173:122-9. (Pubitemid 47588739)
121. Kernbach-Wighton G, Friedrich E, Risser D, Niedmann PD, Saternus K- S. Postmortem biochemical estimations in cases of lethal high excitation. Rom J Leg Med 2006;14:251-61. (Pubitemid 46479148)
122. Howlett K, Galbo H, Lorentsen J, Bergeron R, Zimmerman-Belsing T, Bülow J, et al. Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans. J Physiol 1999;519(Pt 3):911-21. (Pubitemid 29462452)
123. Zilg B, Alkass K, Berg S, Druid H. Postmortem identification of hyperglycemia. Forensic Sci Int 2009;185:89-95.
124. Madea B, Musshoff F. Postmortem biochemistry. Forensic Sci Int 2007;165:165e71 [review].
125. Glatter KA, Chiamvimonvat N, He Y, Chevalier P, Turillazzi E. Postmortem analysis for inherited ion channelopathies. Chapter 2. In: Rutty GN, editor. Essentials of autopsy practice. London, UK: Springer-Verlag; 2006. p. 15-37.
126. Tester DJ, Ackerman MJ. The role of molecular autopsy in unexplained sudden cardiac death. Curr Opin Cardiol 2006;21:166-72. (Pubitemid 44315078)
127. Kauferstein S, Kiehne N, Neumann T, Pitschner HF, Bratzke H. Cardiac gene defects can cause sudden cardiac death in young people. Dtsch Arztebl Int 2009;106:41-7 [review].
128. Cerretani D, Riezzo I, Fiaschi AI, Centini F, Giorgi G, D'Errico S, et al. Cardiac oxidative stress determination and myocardial morphology after a single ecstasy (MDMA) administration in a rat model. Int J Leg Med 2008;122:461-9.
129. Hua YS, Liang R, Liang L, Huang GZ. Contraction band necrosis in two ecstasy abusers: a latent lethal lesion associated with ecstasy. Am J Forensic Med Pathol 2009;30:295-7.
130. Mash DC, Duque L, Pablo J, Qin Y, Adi N, Hearn WL, et al. Brain biomarkers for identifying excited delirium as a cause of sudden death. Forensic Sci Int 2009;190:e13-9.
131. Maeda H, Zhu BL, Bessho Y, Ishikawa T, Quan L, Michiue T, et al. Postmortem serum nitrogen compounds and C-reactive protein levels with special regard to investigation of fatal hyperthermia. Forensic Sci Med Pathol 2008;4:175-80.
132. Nixdorf-Miller A, Hunsaker DM, Hunsaker 3rd JC. Hypothermia and hyperthermia medicolegal investigation of morbidity and mortality from exposure to environmental temperature extremes. Arch Pathol LabMed 2006;130:1297-304 [review].
133. Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Oritani S, et al. Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 1. Analysis with special regard to traumatic causes of death. Leg Med (Tokyo) 2006;8:86-93.
134. Maeda H, Michiue T, Zhu BL, Ishikawa T, Quan L. Analysis of cardiac troponins and creatine kinase MB in cerebrospinal fluid in medicolegal autopsy cases. Leg Med (Tokyo) 2009;11(Suppl. 1):S266-8.
135. Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Quan L, et al. Evaluation of postmortem urea nitrogen, creatinine and uric acid levels in pericardial fluid in forensic autopsy. Leg Med (Tokyo) 2005;7:287-92. (Pubitemid 41262177)
136. Li DR, Quan L, Zhu BL, Ishikawa T, Michiue T, Zhao D, et al. Evaluation of postmortem calcium and magnesium levels in the pericardial fluid with regard to the cause of death in medicolegal autopsy. Leg Med (Tokyo) 2009; 11(Suppl. 1):S276-8.
137. Ishikawa T, Quan L, Li DR, Zhao D, Michiue T, Hamel M, et al. Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia. Forensic Sci Int 2008; 179:147-51.
138. Quan L, Ishikawa T, Michiue T, Li DR, Zhao D, Zhu BL, et al. Quantitative analysis of ubiquitin-immunoreactivity in the midbrain periaqueductal gray matter with regard to the causes of death in forensic autopsy. Leg Med (Tokyo) 2005;7:151-6. (Pubitemid 40545077)
139. Nishio H, Suzuki K. Three cases of suspected hyperthermia with remarkable elevation of serum mast cell tryptase. Forensic Sci Int 2005;149:51-5. (Pubitemid 40289083)
140. Yoshida C, Ishikawa T, Michiue T, Quan L, Maeda H. Postmortem biochemistry and immunohistochemistry of chromogranin A as a stress marker with special regard to fatal hypothermia and hyperthermia. Int J Leg Med 2011;125:11-20.
141. Ishikawa T, Yoshida C, Michiue T, Perdekamp MG, Pollak S, Maeda H. Immunohistochemistry of catecholamines in the hypothalamic-pituitary-adrenal system with special regard to fatal hypothermia and hyperthermia. Leg Med (Tokyo) 2010;12:121-7.
142. Payne-James J. History and development of clinical forensicmedicine. Chapter 1. In: Stark MM, editor. Clinical forensic medicine: a physician's guide. Totowa, New Jersey, USA: Humana Press Inc.; 2005. p. 1-36.
143. Hall CA. [Les pistolets Taser, un risque inacceptablement élevé ou suffisamment bas pour être acceptable?] Taser guns, an unacceptably high risk or sufficiently low to be acceptable? CJEM 2009;11:84e6. 87-9 [French, English] [editorial].
144. Kroll MW, Panescu D, Brewer JE, Lakkireddy DJ, Graham M. Weight-adjusted meta-analysis of fibrillation risk from TASER® conducted electrical weapons. American Academy of Forensic Sciences. Proceedings of the 61st Annual Meeting ("Forensic science: envisioning and creating the future"), Denver, Colorado; February 16e21, 2009. pp. 177-8.
145. Southall P, Grant J, Fowler D, Scott S. Police custody deaths in Maryland, USA: an examination of 45 cases. J Forensic Leg Med 2008;15:227-30.
146. Bozeman WP, Hauda 2nd WE, Heck JJ, Graham Jr DD, Martin BP, Winslow JE. Safety and injury profile of conducted electrical weapons used by law enforcement officers against criminal suspects. Ann Emerg Med 2009;53:480-9.
147. Calgary Police Commission. Minutes of open meeting. Calgary, Alberta, Canada. Available at http://www.calgary.ca/docgallery/bu/cpc/meetings/2006/ september-minutes.pdf; September 19, 2006.
148. Bozeman WP, Winslow JE. Medical aspects of less lethal weapons. Internet J Rescue Disaster Med(1), http://www.ispub.com/ostia/index.php?xmlFilePath? journals/ ijrdm/vol5n1/lethal.xml, 2005;5.
149. Glick J. 'Excited delirium' cited in deaths. Police One, http://www.policeone.com/ edp/articles/1179873-Excited-Delirium-cited-in-deaths/ , September 2006;25.
150. Ho JD. Some more food for thought on the current TASER device literature. Am Coll Emerg Physicians Web Page, http://www.acep.org/content.aspx?id=31840; 2008.
151. Young JG, Chiasson DA, Cairns JT, Carter EJ, Payne-James J. Custody and restraint deaths. In: Payne-James J, Busuttil A, Smock W, editors. Forensic medicine: clinical and pathological aspects. San Francisco, London: Greenwich Medical Media Ltd; 2003. p. 115-31.
152. Grant JR, Southall PE, Mealey J, Scott SR, Fowler DR. Excited delirium deaths in custody: past and present. Am J Forensic Med Pathol 2009;30:1-5.
153. Stratton SJ, Rogers C, Brickett K, Gruzinski G. Factors associated with sudden death of individuals requiring restraint for excited delirium. Am J Emerg Med 2001;19:187-91. (Pubitemid 32381017)
154. Sathyavagiswaran L, Rogers C, Noguchi TT. Restraint asphyxia in in-custody deaths Medical examiner's role in prevention of deaths. Leg Med (Tokyo) 2007;9:88-93. (Pubitemid 46274464)
155. Cina SJ, Davis GJ. Cardiac dysrhythmia during restraint. Am J Forensic Med Pathol 2010;31:e4 [letter].