An animal model to investigate effectiveness and safety of conducted energy weapons (Including TASER® Devices)

Journal of Forensic Sciences

Volumn 55, Issue 2, 2010, Pages 521-526

  Jauchem, James R ^a  

^a AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

Animal model; Conducted energy weapon; Electro muscular disruption; Electronic control device; Forensic pathophysiology; Forensic science; Swine; TASER

Indexed keywords

INTRAVENOUS ANESTHETIC AGENT; PROPOFOL;

ANIMAL; ANIMAL MODEL; ARTICLE; ELECTRIC SHOCK; FORENSIC MEDICINE; INSTRUMENTATION; SAFETY; SUPINE POSITION; SWINE;

ANESTHETICS, INTRAVENOUS; ANIMALS; ELECTROSHOCK; FORENSIC MEDICINE; MODELS, ANIMAL; PROPOFOL; SAFETY; SUPINE POSITION; SWINE;

EID: 77649246453     PISSN: 00221198     EISSN: 15564029     Source Type: Journal    
DOI: 10.1111/j.1556-4029.2009.01308.x     Document Type: Article

References (95)

1. Allen TB. Discussion of "effects of the taser in fatalities involving police confrontation." J Forensic Sci 1992 37 : 956 958.
2. Sherry CJ, Brown GC, Beason CW, Jauchem JR, Dayton TE, Ross JA, et al. An evaluation of the electrical properties and bio-behavioral effects of four commercially available TASERs and the Jaycor Sticky Shocker. Brooks City-Base, TX : U.S. Air Force Research Laboratory 2003 June. Technical Report No.: AFRL-HE-BR-TR-2003-0089. Available at: http://handle.dtic.mil/100.2/ADA416553 (accessed March 15, 2009).
3. Jauchem JR. Effectiveness and health effects of electro-muscular incapacitating devices. 6th Annual Non-Lethal Technology and Academic Research Symposium; 16 November 2004; Winston-Salem, North Carolina. Available at: http://ecow.engr.wisc.edu/cgi-bin/getbig/bme/762/webster/hw1-25-07/ jauchem-effectivenesshealtheffects.pdf (accessed March 15, 2009).
4. Sherry CJ, Beason CW, Brown GC, Simonds JL, Ross JA, Cook MC, et al. Variable TASER parameters: effectiveness (muscle contraction) and cardiac safety (ventricular fibrillation). Brooks City-Base, TX : U.S. Air Force Research Laboratory 2004 July. Technical Report No.: AFRL-HE-BR-TR-2004-0094.
5. Jauchem JR, Sherry CJ, Fines DA, Cook MC. Acidosis, lactate, electrolytes, muscle enzymes, and other factors in the blood of Sus scrofa following repeated TASER® exposures. Forensic Sci Int 2006 161 : 20 30.
6. Jauchem JR, Cook MC, Beason CW. Blood factors of Sus scrofa following a series of three TASER® electronic control device exposures. Forensic Sci Int 2008 175 : 166 170.
7. Jauchem JR, Seaman RL, Fines DA. Survival of anesthetized Sus scrofa after cycling (7 s on/3 s off) exposures to an electronic control device for three min. Am J Forensic Med Pathol. In press.
8. Beason CW, Jauchem JR, Clark CD III., Parker JE, Fines DA. Pulse variations of a conducted energy weapon (similar to the TASER® X26 device): effects on muscle contraction and threshold for ventricular fibrillation. J Forensic Sci 2009 54 (5 1113 1118.
9. Jauchem JR, Beason CW, Cook MC. Acute effects of an alternative electronic-control-device waveform in swine. Forensic Sci Med Pathol 2009 5 (1 2 10.
10. Stratbucker RA, Kroll MW, McDaniel W, Panescu D. Cardiac current density distribution by electrical pulses from TASER devices. Conf Proc IEEE Eng Med Biol Soc 2006 1 : 6305 6307.
11. Bozeman WP, Hauda WE, Heck JJ, Graham DD Jr., Martin BP, Winslow JE. Safety and injury profile of conducted electrical weapons used by law enforcement officers against criminal suspects. Ann Emerg Med 2009 53 (4 480 489.
12. Williams HE. TASER electronic control devices and sudden in-custody death: separating evidence from conjecture. Springfield, IL : Charles C. Thomas Publishers, 2008.
13. Somogyi E, Tedeschi CG. Injury by electrical force. In : Tedeschi CG, Eckert WG, Tedeschi LG, editors. Forensic medicine: a study in trauma and environmental hazards. Vol. I. Mechanical trauma. Chapter 17. Philadelphia, PA : W.B. Saunders Company, 1977 645 676.
14. Meyer W, Schwartz R, Neurand K. The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig. Curr Probl Dermatol 1978 7 : 39 52.
15. Pippin JJ. Taser research in pigs not helpful [letter]. J Am Coll Cardiol 2007 49 : 731 732.
16. Pippin JJ. PLoS takes a step backward [letter]. PLoS Med 2005 2 : e278.
17. Hearing before the Committee on Environment and Public Works. United States Senate, One Hundred Ninth Congress, First Session, May 18, 2005. Washington, DC : U.S. Government Printing Office, 2007. Available at: http://bulk.resource.org/gpo.gov/hearings/109s/32209.txt (accessed March 15, 2009).
18. O'Neil BJ, Kline JA, Burkhart K, Younger J. Research fundamentals: V. The use of laboratory animal models in research. Acad Emerg Med 1999 6 : 75 82.
19. Tchou PJ. Electronic control devices and the clinical milieu. Reply [letter]. J Am Coll Cardiol 2007 49 : 733.
20. Hopewell JW, Rezvani M, Moustafa HF. The pig as a model for the study of radiation effects on the lung [review]. Int J Radiat Biol 2000 76 : 447 452.
21. Detweiler DK. Swine in comparative cardiovascular research. In : Bustad LK, McClellan RO, editors. Swine in biomedical research. Seattle, WA : Batelle Memorial Institute, Pacific Northwest Laboratory, 1966 301 306.
22. Pluth JR. What is the status of coronary revascularization for acute myocardial infarction? Cardiovasc Clin 1983 13 : 183 190.
23. Kong Y, Chen JT, Zeft HJ, Whalen RE, McIntosh HD. Natural history of experimental coronary occlusion in pigs: a serial cineangiographic study. Am Heart J 1969 77 : 45 54.
24. Christensen GC, Competi FL. Anatomic and functional studies of the coronary circulation in the dog and pig. Am J Vet Res 1959 30 : 18 26.
25. Bowman TA, Hughes HC. Ventriculoatrial conduction in swine during cardiac pacing: animal model for retrograde conduction. Am Heart J 1984 108 : 337 341.
26. Bowman TA, Hughes HC. Swine as an in vivo model for electrophysiologic evaluation of cardiac pacing parameters. Pacing Clin Electrophysiol 1984 7 : 187 194.
27. Verdouw PD, Wolffenbuttel BH, van der Giessen WJ. Domestic pigs in the study of myocardial ischemia. Eur Heart J 1983 4 (Suppl. C 61 7.
28. Hearse DJ, Sutherland FJ. Experimental models for the study of cardiovascular function and disease [review]. Pharmacol Res 2000 41 : 597 603.
29. Riquet M, Souilamas R, Hubsch JP, Brière J, Colomer S, Hidden G. Lymphatic drainage of heart and lungs: comparison between pig and man. Surg Radiol Anat 2000 22 : 47 50.
30. Balcombe J. Beyond animal research. Washington, DC : Physicians Committee for Responsible Medicine, 2005. Available at: http://www.pcrm.org/resch/anexp/ beyond/stungun-0506.html (accessed March 15, 2009).
31. California Office of Environmental Health Hazard Assessment. Air toxics hot spots program risk assessment guidelines. Part IV: technical support document for exposure assessment and stochastic analysis. Oakland, CA : California Environmental Protection Agency, 2000, Available at: http://www.oehha.org/air/hot-spots/pdf/Stoch4f.pdf (accessed March 15, 2009).
32. Burmaster DE, Crouch EA. Log normal distributions for body weight as a function of age for males and females in the United States, 1976-1980. Risk Anal 1997 17 : 499 505.
33. Mesloh C, Henych M, Thompson LF, Wolf R. A qualitative & quantitative analysis of conducted energy weapons: TASER X26 vs. Stinger S200. A report to the National Institute of Justice. January 25, 2008. Fort Myers, FL : Florida Gulf Coast University, 2008. Available at: http://www.ncjrs.gov/pdffiles1/nij/ grants/222769.pdf (accessed March 15, 2009).
34. ® exposures [letter]. Forensic Sci Int 2007 168 : e19.
35. Jennings M, Silcock S. Benefits, necessity and justification in animal research. Altern Lab Anim 1995 23 : 828 836.
36. Ko JC, Williams BL, Smith VL, McGrath CJ, Jacobson JD. Comparison of Telazol, Telazol-ketamine, Telazol-xylazine, and Telazol-ketamine-xylazine as chemical restraint and anesthetic induction combination in swine. Lab Anim Sci 1993 43 : 476 480.
37. Alam HB, Shults C, Ahuja N, Velmahos GC, de Moya M, Rhee P, et al. Impact of resuscitation strategies on the acetylation status of cardiac histones in a swine model of hemorrhage. Resuscitation 2008 76 : 299 310.
38. TASER International. Potential autopsy errors with in-custody-deaths: the Ronald Hasse case study. Henderson, NV : Institute for the prevention of in-custody deaths, 2007. Available at: http://www.ipicd.com/docs/Hasse-Case- Study.pdf (accessed March 15, 2009).
39. Lagutchik MS, Januszkiewicz AJ, Dodd KT, Martin DG. Cardiopulmonary effects of a tiletamine-zolazepam combination in sheep. Am J Vet Res 1991 52 : 1441 1447.
40. Savvas I, Plevraki K, Raptopoulos D, Koutinas AF. Blood gas and acid-base status during tiletamine/zolazepam anaesthesia in dogs. Vet Anaesth Analg 2005 32 : 94 100.
41. Dockery MP, Drummond GB. Respiratory response to skin incision during anaesthesia with infusions of propofol and alfentanil. Br J Anaesth 2002 88 : 649 652.
42. Eastwood PR, Platt PR, Shepherd K, Maddison K, Hillman DR. Collapsibility of the upper airway at different concentrations of propofol anesthesia. Anesthesiology 2005 103 : 470 477.
43. Lakoski J, Murray WB, Kenny JM. The advantages and limitations of calmatives for use as a non-lethal technique. Hershey, PA : Pennsylvania State University College of Medicine, 2000, October 2000. Available at: http://nldt2.arl.psu.edu/publications.php (link to "calamative-report. pdf") (accessed March 15, 2009).
44. Urban BW, Bleckwenn M, Barann M. Interactions of anesthetics with their targets: non-specific, specific or both? Pharmacol Ther 2006 111 : 729 770.
45. Qadeer MA, Vargo JJ, Khandwala F, Lopez R, Zuccaro G. Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. Clin Gastroenterol Hepatol 2005 3 : 1049 1056.
46. Tendillo FJ, Mascias A, Santos M, de Segura IA, Castillo-Olivares JL. [Cardiorespiratory and analgesic effects of continuous infusion of propofol in swine as experimental animals] [Spanish]. Rev Esp Anestesiol Reanim 1996 43 : 126 129.
47. Boyd JJ, Kyttä JV, Aittomäki JV, Rosenberg PH, Seppälä TA, Randell TT. Cardiovascular changes after naloxone administration in propofol-sedated piglets during opioid overdose. Acta Anaesthesiol Scand 2006 50 : 1271 1276.
48. Goodman NW, Black AMS, Carter JA. Some ventilatory effects of propofol as sole anaesthetic agent. Br J Anaesth 1987 59 : 1497 1503.
49. Servin F, Huot O, Desmonts JM. [Use of a continuous infusion of propofol in maintaining anesthesia] [French]. Ann Fr Anesth Reanim 1987 6 : 29 32.
50. Fabbri LP, Tozzi F, Batacchi S, Bucciardini L, Fontanari P, Linden M, et al. Haemodynamic and haemoximetric aspects of experimental orthotopic liver transplantation: comparison between two different doses of propofol. Minerva Anestesiol 1995 61 : 441 450.
51. Ginz HF, Zorzato F, Iaizzo PA, Urwyler A. Effect of three anaesthetic techniques on isometric skeletal muscle strength. Br J Anaesth 2004 92 : 367 372.
52. Maleque MA, Warnick JE, Albuquerque EX. The mechanism and site of action of ketamine on skeletal muscle. J Pharmacol Exp Ther 1981 219 : 638 645.
53. Lapointe BM, Côté CH. Anesthetics can alter subsequent in vitro assessment of contractility in slow and fast skeletal muscles of rat. Am J Physiol 1999 277 : R917 21.
54. Ingalls CP, Warren GL, Lowe DA, Boorstein DB, Armstrong RB. Differential effects of anesthetics on in vivo skeletal muscle contractile function in the mouse. J Appl Physiol 1996 80 : 332 340.
55. Dennis AJ, Valentino DJ, Walter RJ, Nagy KK, Winners J, Bokhari F, et al. Acute effects of TASER X26 discharges in a swine model. J Trauma 2007 63 : 581 590.
56. Lee L. Ruminant & swine anesthesia. Veterinary surgery I. Stillwater, OK : Oklahoma State University Center for Veterinary Health Sciences, 2006. Available at: http://instruction.cvhs.okstate.edu/vmed5412/pdf/ 24RuminantAnesthesia2006.pdf (accessed March 15, 2009).
57. Jasani MS, Salzman SK, Tice LL, Ginn A, Nadkarni VM. Anesthetic regimen effects on a pediatric porcine model of asphyxial arrest. Resuscitation 1997 35 : 69 75.
58. White PF, Way WL, Trevor AJ. Ketamine - its pharmacology and therapeutic uses. Anesthesiology 1982 56 : 119 136.
59. Trim CM, Gilroy BA. Cardiopulmonary effects of a xylazine and ketamine combination in pigs. Res Vet Sci 1985 38 : 30 4.
60. Dittmar MS, Fehm NP, Vatankhah B, Horn M. Ketamine/xylazine anesthesia for radiologic imaging of neurologically impaired rats: dose response, respiratory depression, and management of complications. Comp Med 2004 54 : 652 655.
61. Joly LM, Benhamou D. Ventilation during total intravenous anaesthesia with ketamine. Can J Anaesth 1994 41 : 227 231.
62. Kim CY, Lee HS, Han SC, Heo JD, Kwon MS, Ha CS, et al. Hematological and serum biochemical values in cynomolgus monkeys anesthetized with ketamine hydrochloride. J Med Primatol 2005 34 : 96 100.
63. Kleinsasser A, Lindner KH, Hoermann C, Schaefer A, Keller C, Loeckinger A. Isoflurane and sevoflurane anesthesia in pigs with a preexistent gas exchange defect. Anesthesiology 2001 95 : 1422 1426.
64. Puglisi F, Crovace A, Staffieri F, Capuano P, Carravetta G, De Fazio M, et al. Comparison of hemodynamic and respiratory effects of propofol and sevoflurane during carbon dioxide pneumoperitoneum in a swine model. Chir Ital 2007 59 : 105 111.
65. Grasshoff C, Drexler B, Hentschke H, Thiermann H, Antkowiak B. Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro. Anesthesiology 2007 106 : 1147 1155. (Pubitemid 46828168)
66. Lawrence C. The varied faces of excited delirium. Police One, 2006 January 21. Available at: http://www.policeone.com/writers/columnists/ ChrisLawrence/articles/120458/ (accessed March 15, 2009).
67. Robinson MN, Brooks CG, Renshaw GD. Electric shock devices and their effects on the human body. Med Sci Law 1990 30 : 285 300.
68. Kenny JM, Murray WB, Sebastianelli WJ, Kraemer WJ, Fish RM, Mauger DT, et al. Human Effects Advisory Panel Report of Findings: Sticky Shocker Assessment (National Institute of Justice Cooperative Agreement 98-IJ-CX-K006). State College, PA : Pennsylvania State University Applied Research Laboratory, 1999. Available at: http://www.ncjrs.gov/pdffiles1/nij/grants/188262.pdf (accessed March 15, 2009).
69. Miller K. EMS & law enforcement custody patients. Irvine, CA : Base Hospital Medical Director's Newsletter, University of California at Irvine Medical Center, January 2000. Available at: http://www.healthaffairs.uci.edu/ emergmed/-ems%5Ccustody.htm (accessed March 15, 2009).
70. Manojlovic D, Hall C, Laur D, Goodkey S, Lawrence C, Shaw R, et al. Review of conducted energy devices. Technical report TR-01-2006. Ottawa, Canada : Canadian Police Research Centre, 2005, http://www.css.drdc-rddc.gc.ca/cprc/ publications/index-eng.asp (link to "TR-01-2006") (accessed March 15, 2009).
71. Esquivel AO, Dawe EJ, Sala-Mercado JA, Hammond RL, Bir CA. The physiologic effects of a conducted electrical weapon in swine. Ann Emerg Med 2007 50 : 576 583.
72. Spitz WU. Asphyxia. In : Spitz WU, editor. Spitz and Fisher's medicolegal investigation of death: guidelines for the application of pathology to crime investigation, 3rd edn. Springfield, IL : Charles C. Thomas, 1993 444 497.
73. Hallstrom A, Rea TD, Mosesso VN Jr., Cobb LA, Anton AR, Van Ottingham L, et al. The relationship between shocks and survival in out-of-hospital cardiac arrest patients initially found in PEA or asystole. Resuscitation 2007 74 : 418 426.
74. Ho JD, Miner JR, Lakireddy DR, Bultman LL, Heegaard WG. Cardiovascular and physiologic effects of conducted electrical weapon discharge in resting adults. Acad Emerg Med 2006 13 : 589 595.
75. Ho JD, Dawes DM, Bultman LL, Thacker JL, Skinner LD, Bahr JM, et al. Respiratory effect of prolonged electrical weapon application on human volunteers. Acad Emerg Med 2007 14 : 197 201.
76. Peters M. Can a Taser kill? Greeley, CO : Tribune, 2006, July 9.
77. ® devices) or excited delirium? [review]. J Forensic Leg Med 2010 17 : 1 7
78. Reilly JP. Testimony at the Thomas R. Braidwood, Q.C., commissions of inquiry under the Public Inquiry Act, SBC 2007, c. 9. Vancouver, British Columbia, Canada, 2008, Available at: http://www.braidwoodinquiry.ca/ transcripts/08-05-05.pdf (accessed March 15, 2009).
79. Vilke GM, Sloane CM, Bouton KD, Kolkhorst FW, Levine SD, Neuman TS, et al. Physiological effects of a conducted electrical weapon on human subjects. Ann Emerg Med 2007 50 : 569 575.
80. Ho J, Lapine A, Joing S, Reardon R, Dawes D. Confirmation of respiration during trapezial conducted electrical weapon application. Acad Emerg Med 2008 15 : 398.
81. ® conference. Police & Security News 22(4), 2006 July/August.
82. Smotherman M, Kobayasi K, Ma J, Zhang S, Metzner W. A mechanism for vocal-respiratory coupling in the mammalian parabrachial nucleus. J Neurosci 2006 26 : 4860 4869.
83. Connaghan KP, Moore CA, Higashakawa M. Respiratory kinematics during vocalization and nonspeech respiration in children from 9 to 48 months. J Speech Lang Hear Res 2004 47 : 70 84.
84. Jurgens U. Neural pathways underlying vocal control [review]. Neurosci Biobehav Rev 2002 26 : 235 258.
85. Heightman AJ. Don't be shocked [editorial]. JEMS 2005 30 (5 12.
86. Peters JG Jr. Sudden death, "excited" delirium, and issues of force: part II. Police & Security News 22(3), 2006 May/June.
87. Dreyfuss D, Saumon G. Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 1998 157 : 294 323. (Pubitemid 28071297)
88. Meier TR. Swine anesthesia & analgesia guidelines. Standard operating procedure. Ann Arbor, Michigan : Unit for laboratory animal medicine, the University of Michigan, Veterinary Division, 2006, http://www.ulam.umich.edu/ sops/ULAM%20SOP%20Swine%20AnesthesiaSept2006.doc (accessed March 15, 2009).
89. Steinberg JM, Schiller HJ, Halter JM, Gatto LA, Lee HM, Pavone LA, et al. Alveolar instability causes early ventilator-induced lung injury independent of neutrophils. Am J Respir Crit Care Med 2004 169 : 57 63.
90. Kerger H, Saltzman DJ, Gonzales A, Tsai AG, van Ackern K, Winslow RM, et al. Microvascular oxygen delivery and interstitial oxygenation during sodium pentobarbital anesthesia. Anesthesiology 1997 86 : 372 386.
91. Altemeier WA, McKinney S, Krueger M, Glenny RW. Effect of posture on regional gas exchange in pigs. J Appl Physiol 2004 97 : 2104 2111.
92. Altemeier WA, McKinney S, Glenny RW. Fractal nature of regional ventilation distribution. J Appl Physiol 2000 88 : 1551 1557.
93. Winter WC, Gampper T, Gay SB, Suratt PM. Lateral pharyngeal fat pad pressure during breathing in anesthetized pigs. J Appl Physiol 1997 83 : 688 694.
94. Miles MP, Clarkson PM. Exercise-induced muscle pain, soreness, and cramps [review]. J Sports Med Phys Fitness 1994 34 : 203 216.
95. Horita T, Komi PV, Nicol C, Kyröläinen H. Effect of exhausting stretch-shortening cycle exercise on the time course of mechanical behaviour in the drop jump: possible role of muscle damage. Eur J Appl Physiol Occup Physiol 1999 79 : 160 167.