Interference RNA-based silencing of endogenous SMAD4 in porcine granulosa cells resulted in decreased FSH-mediated granulosa cells proliferation and steroidogenesis

Reproduction

Volumn 141, Issue 5, 2011, Pages 643-651

  Wang, Wei ^a   Chen, Xia ^a   Li, Xinxiu ^a   Wang, Li ^a   Zhang, Haiyan ^a   He, Yu ^a   Wang, Jingjing ^a   Zhao, Yongyan ^a   Zhang, Baole ^a   Xu, Yinxue ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYCLIN D2; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; ESTRADIOL; FOLLITROPIN; MESSENGER RNA; SMAD4 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSFECTION; GRANULOSA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEROIDOGENESIS;

ANIMALS; AROMATASE; CELL PROLIFERATION; CELLS, CULTURED; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DOWN-REGULATION; ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE; GENES, CDC; GRANULOSA CELLS; PROGESTERONE; RECEPTORS, FSH; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; SWINE; TRANSFECTION;

SUS;

EID: 79955823868     PISSN: 14701626     EISSN: 17417899     Source Type: Journal    
DOI: 10.1530/REP-10-0098     Document Type: Article

References (38)

1. Biondi CA, Das D, Howell M, Islam A, Bikoff EK, Hill CS & Robertson EJ 2007 Mice develop normally in the absence of SMAD4 nucleocytoplasmic shuttling. Biochemical Journal 404 235-245. (doi:10.1042/BJ20061830)
2. Brown KA, Pietenpol JA & Moses HL 2007 A tale of two proteins: differential roles and regulation of SMAD2 and SMAD3 in TGF-β signaling. Journal of Cellular Biochemistry 101 9-33. (doi:10.1002/jcb.21255)
3. Chang H, Lau AL & Matzuk MM 2001 Studying TGF-beta superfamily signaling by knockouts and knockins. Molecular and Cellular Endocrinology 180 39-46. (doi:10.1016/S0303-7207(01)00513-5)
4. Dai F, Lin X, Chang C & Feng XH 2009 Nuclear export of SMAD2 and SMAD3 by RanBP3 facilitates termination of TGF-beta signaling. Developmental Cell 16 345-357. (doi:10.1016/j.devcel.2009.01.022)
5. ten Dijke P & Hill CS 2004 New insights into TGF-beta-Smad signalling. Trends in Biochemical Sciences 29 265-273. (doi:10.1016/j.tibs.2004. 03.008)
6. Dorsett Y & Tuschl T 2004 siRNAs: applications in functional genomics and potential as therapeutics. Nature Reviews. Drug Discovery 3 318-329. (doi:10.1038/nrd1345)
7. Findlay JK, Drummond AE, Dyson ML, Baillie AJ, Robertson DM & Ethier JF 2002 Recruitment and development of the follicle; the roles of the transforming growth factor-beta superfamily. Molecular and Cellular Endocrinology 191 35-43. (doi:10.1016/S0303-7207(02) 00053-9)
8. Fraser M, Braems GA & Challis JR 2001 Developmental regulation of corticotrophin receptor gene expression in the adrenal gland of the ovine fetus and newborn lamb: effects of hypoxia during late pregnancy. Journal of Endocrinology 169 1-10. (doi:10.1677/joe.0.1690001)
9. Gong X & McGee EA 2009 Smad3 is required for normal follicular follicle-stimulating hormone responsiveness in the mouse. Biology of Reproduction 81 730-738. (doi:10.1095/biolreprod.108.070086)
10. Guéripel X, Benahmed M & Gougeon A 2004 Sequential gonadotropin treatment of immature mice leads to amplification of transforming growth factor beta action, via upregulation of receptor-type 1, Smad2 and 4, and downregulation of Smad6. Biology of Reproduction 70 640-648. (doi:10.1095/biolreprod.103.021162)
11. Juengel JL & McNatty KP 2005 The role of proteins of the transforming growth factor-beta superfamily in the intraovarian regulation of follicular development. Human Reproduction Update 11 143-160. (Pubitemid 40439508)
12. Kaivo-oja N, Jeffery LA, Ritvos O & Mottershead DG 2006 Smad signalling in the ovary. Reproductive Biology and Endocrinology 4 21. (doi:10.1186/1477-7827-4-21)
13. Kawabata M, Imamura T & Miyazono K 1998 Signal transduction by bone morphogenetic proteins. Cytokine and Growth Factor Reviews 9 49-61. (doi:10.1016/S1359-6101(97)00036-1)
14. Knight PG & Glister C 2006 TGF-beta superfamily members and ovarian follicle development. Reproduction 132 191-206. (doi:10.1530/rep.1.01074)
15. Lee WS, Otsuka F, Moore RK & Shimasaki S 2001 Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat. Biology of Reproduction 65 994-999. (doi:10.1095/biolreprod65.4.994)
16. Li Q, Pangas SA, Jorgez CJ, Graff JM, Weinstein M & Matzuk MM 2008 Redundant roles of Smad2 and Smad3 in ovarian granulosa cells in vivo. Molecular and Cellular Biology 28 7001-7011. (doi:10.1128/MCB.00732-08)
17. Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC et al. 2006 PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell 125 915-928. (doi:10.1016/j.cell.2006.03.044)
18. Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(KDelta Delta C(T)) method. Methods 25 402-408. (doi:10.1006/meth.2001.1262)
19. Massague J 1992 Receptors for the TGF-beta family. Cell 69 1067-1070. (doi:10.1016/0092-8674(92)90627-O)
20. Massague J 2000 How cells read TGF-beta signals. Nature Reviews. Molecular Cell Biology 1 169-178. (doi:10.1038/35043051)
21. Matsuura I, Denissova NG, Wang G, He D, Long J & Liu F 2004 Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430 226-231. (doi:10.1038/nature02650)
22. Mehra A & Wrana JL 2002 TGF-beta and the Smad signal transduction pathway. Biochemistry and Cell Biology 80 605-622. (doi:10.1139/o02-161)
23. Mittal V 2004 Improving the efficiency of RNA interference in mammals. Nature Reviews. Genetics 5 355-365. (doi:10.1038/nrg1323)
24. Miyoshi T, Otsuka F, Suzuki J, Takeda M, Inagaki K, Kano Y, Otani H, Mimura Y, Ogura T & Makino H 2006 Mutual regulation of follicle-stimulating hormone signaling and bone morphogenetic protein system in human granulosa cells. Biology of Reproduction 74 1073-1082. (doi:10.1095/biolreprod.105.047969)
25. Moustakas A, Souchelnytskyi S & Heldin CH 2001 Smad regulation in TGF-beta signal transduction. Journal of Cell Science 114 4359-4369.
26. Otsuka F, Yao Z, Lee T, Yamamoto S, EricksonGF & Shimassaki S 2000 Bone morphogenetic protein-15. Identification of target cells and biological functions. Journal of Biological Chemistry 275 39523-39528. (doi:10.1074/jbc. M007428200)
27. Otsuka F, Moore RK & Shimassaki S 2001a Biological function and cellular mechanism of bone morphogenetic protein-6 in the ovary. Journal of Biological Chemistry 276 32889-32895. (doi:10.1074/jbc.M103212200)
28. Otsuka F, Yamamoto S, Erickson GF & Shimasaki S 2001b Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression. Journal of Biological Chemistry 276 11387-11392. (doi:10.1074/jbc.M010043200)
29. Pangas SA 2007 Growth factors in ovarian development. Seminars in Reproductive Medicine 25 225-234. (doi:10.1055/s-2007-980216)
30. Pangas SA, Li X, Robertson EJ & Matzuk MM 2006 Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice. Molecular Endocrinology 20 1406-1422. (doi:10.1210/me.2005-0462)
31. Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, Wang D, Martin JF, Jamin SP, Behringer RR et al. 2008 Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Molecular and Cellular Biology 28 248-257. (doi:10.1128/MCB.01404-07)
32. Paterson IC, Davies M, Stone A, Huntley S, Smith E, Pring M, Eveson JW, Robinson CM, Parkinson EK & Prime SS 2002 TGF-beta1 acts as a tumor suppressor of human malignant keratinocytes independently of Smad4 expression and ligand-induced G(1) arrest. Oncogene 21 1616-1624. (doi:10.1038/sj.onc. 1205217)
33. Picton HM, Campbell BK & Hunter MG 1999 Maintenance of oestradiol production and expression of cytochrome P450 aromatase enzyme mRNA in long-term serum-free cultures of pig granulosa cells. Journal of Reproduction and Fertility 115 67-77. (doi:10.1530/jrf.0.1150067)
34. Schmierer B & Hill CS 2007 TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nature Reviews. Molecular Cell Biology 8 970-982. (doi:10.1038/nrm2297)
35. Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N & Sampath K 1999 A functional bone morphogenetic protein system in the ovary. PNAS 96 7282-7287. (doi:10.1073/pnas.96.13.7282)
36. Shimasaki S, Moore RK, Erickson GF & Otsuka F 2003 The role of bone morphogenetic proteins in ovarian function. Reproduction Supplement 61 323-337.
37. Shimasaki S, Moore RK, Otsuka F & Erickson GF 2004 The bone morphogenetic protein system in mammalian reproduction. Endocrine Reviews 25 72-101. (doi:10.1210/er.2003-0007)
38. Vitt UA, Hayashi M, Klein C & Hsueh AJ 2000 Growth differentiation factor-9 stimulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulosa cells from small antral and preovulatory rat follicles. Biology of Reproduction 62 370-377. (doi:10.1095/biolreprod62.2.370)