Multidrug resistance in breast cancer cells during epithelial-mesenchymal transition is modulated by breast cancer resistant protein

Chinese Journal of Cancer

Volumn 29, Issue 2, 2010, Pages 151-157

  Chen, Wei Juan ^a   Wang, Hui ^a   Tang, Yong ^b   Liu, Chuan Liang ^b   Li, Hong Li ^a   Li, Wen Tong ^a  

^a WEIFANG MEDICAL UNIVERSITY   (China)

^b WEIFANG PEOPLE'S HOSPITAL   (China)

Author keywords

Breast cancer; Epithelial mesenchymal transition; Multidrug resistance

Indexed keywords

BETA ACTIN; BREAST CANCER RESISTANCE PROTEIN; MITOXANTRONE; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CELL ASSAY; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; E CADHERIN GENE; EPITHELIAL MESENCHYMAL TRANSITION; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MARKER GENE; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; VIMENTIN GENE; WESTERN BLOTTING;

EID: 79955822249     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.009.10447     Document Type: Article

References (14)

1. Huber MA, Beug H, Wirth T. Epithelial-mesenchymal transition: NF-KB takes center stage[J]. Cell Cycle, 2004, 3(12): 1477-1480.
2. Yang JM, Xu Z, Wu H, et al. Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells [J]. Mol Cancer Res, 2003, 1(6): 420-427.
3. Li QQ, Xu JD, Wang WJ, et al.Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells [J]. Clin Cancer Res, 2009, 15(8): 2657-2665.
4. Dou JX, Zhang WD, Li WT, et al. Expression of methylthioadenosine phosphorylase (MTAP) gene and demethylation of its promoter in human colorectal cancer [J]. Chin J Cancer, 2009, 28(4):390-394. [in Chinese].
5. Arumugam T, Ramachandran V, Fournier KF, et al. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer [J]. Cancer Res, 2009, 69(14):5820-5828.
6. Ni J, Liu X, Zha Y, et al.Effects of Snail gene modification on CXCR4 expression of human bone mesenchymal stem cells and their capacity of migration to SDF-1 in vitro[J]. Sheng Wu Gong Cheng Xue Bao, 2009, 25 (2):242-250.
7. Sullivan NJ, Sasser AK, Axel AE, et al. Interleukin-6 induces an epithelialmesenchymal transition phenotype in human breast cancer cells [J]. Oncogene, 2009, 28(33):2940-2947.
8. Franci C, Gallen M, Alameda F, et al. Snaill protein in the stroma as a new putative prognosis marker for colon tumours [J]. PLoS One, 2009, 4 (5):e5595.
9. Zhang AL, Wang QS, Zhong YH, et al. Effect of transcriptional factor snail on epithelial-mesenchymal transition and tumor metastasis [J]. Chin J Cancer, 2005, 24(11):1301-1305. [in Chinese].
10. Davies M, Robinson M, Smith E, et al. Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways [J]. J Cell Biochem, 2005, 95(5):918-931
11. Meyer Zu, Schwabedissen HE, Grube M, et al. Epidermal growth factor- mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP) [J]. Drug Metab Dispos, 2006, 34(4):524-533.
12. Jechlinger M, Grunert S, Tamir IH, et al. Expression profiling of epithelial plasticity in tumor progression [J]. Oncogene, 2003, 22(46):7155-7169.
13. Yan W, Fu Y, Tian D, et al. PI3 kinase/Akt signaling mediates epithelial- mesenchymal transition in hypoxic hepatocellular carcinoma cells [J]. Biochem Biophys Res Commun, 2009, 382(3):631-636.
14. Takada T, Suzuki H, Gotoh Y, et al. Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells [J]. Drug Metab Dispos, 2005, 33(7):905-909.