Expression of methylthioadenosine phosphorylase (MTAP) gene and demethylation of its promoter in human colorectal cancer

Chinese Journal of Cancer

Volumn 28, Issue 4, 2009, Pages 1-6

  Dou, Jian Xin ^a   Zhang, Wei Dong ^a   Li, Wen Tong ^a   Li, Hong Li ^a   Cai, Xiao Shan ^a   Liu, Jing ^a  

^a WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Colorectal cancer; Methylation specified PCR; Methylthioadenosine phosphorylase (MTAP); Real time PCR

Indexed keywords

5' METHYLTHIOADENOSINE PHOSPHORYLASE; DNA; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER TISSUE; COLORECTAL ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; DEMETHYLATION; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 79955774950     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Illei PB, Rusch VW, Zakowski MF, et al. Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas [J]. Clin Cancer Res, 2003, 9(6): 2108-2113.
2. Chow WA, Bedell V, Gaytan P, et al. Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas [J]. Cancer Genet Cytogenet, 2006, 166(2): 95-100.
3. Leal MF, Lima EM, Silva PN, et al. Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil [J]. World J Gastroenterol, 2007, 13(18): 2568-2574.
4. Tian ZQ, Wang XL, Wu W. Expression of metallothionein-3 in esophageal cancer and its correlations to expression of metallothionein-1 and-2 [J]. Ai Zheng, 2008, 27(2): 160-164. [in Chinese]
5. Marcé S, Balagué O, Colomo L, et al. Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy [J]. Clin Cancer Res, 2006, 12 (12): 3754-3761.
6. Ishii M, Nakazawa K, Wada H, et al. Methylthioadenosine phosphorylase gene is silenced by promoter hypermethylation in human lymphoma cell line DHL-9: another mechanism of enzyme deficiency [J]. Int J Oncol, 2005, 26(4): 985-991.
7. Hellerbrand C, Mühlbauer M, Wallner S, et al. Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma [J]. Carcinogenesis, 2006, 27 (1): 64-72.
8. Christopher SA, Diegelman P, Porter CW, et al. Methylthioadenosine phosphorylase, a gene frequently codeleted with p16 (cdkN2a/ ARF), acts as a tumor suppressor in a breast cancer cell line [J]. Cancer Res, 2002, 62 (22): 6639-6644.
9. Watanabe F, Takao M, Inoue K, et al. Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma [J]. Lung Cancer, 2009, 63(1): 39-44.
10. Miyazaki S, Nishioka J, Shiraishi T, et al. Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients [J]. Int J Oncol, 2007, 31 (5): 1069-1076.
11. Bataille F, Rogler G, Modes K, et al. Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin [J]. Lab Invest, 2005, 85(1): 124-136.