Clinical challenges in the management of premature ejaculation

European Urological Review

Volumn 5, Issue 2, 2010, Pages 48-54

  Jannini, Emmanuele A ^a   Di Tommaso, Silvia ^a   Limoncin, Erika ^a   Carosa, Eleonora ^a   Gravina, Giovanni Luca ^a   Romanelli, Francesco ^b   Lombardo, Francesco ^b   Pepe, Mario ^b   Lenzi, Andrea ^b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Antidepressants; Dapoxetine; Ejaculation; Erectile dysfunction (ED); Erection; Fluoxetine; Hyperthyroidism; Impotence; Paroxetine; Premature ejaculation (PE); Prostatitis; Selective serotonin re uptake inhibitor (SSRI)

Indexed keywords

EID: 79955817642     PISSN: 17583829     EISSN: 1758406X     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Jannini EA, Simonelli C, Lenzi A, Disorders of ejaculation, J Endocrinol Invest, 2002;25:1006-19.
2. Jannini EA, Lenzi A, Ejaculatory disorders: epidemiology and current approaches to definition, classification and subtyping, World J Urol, 2005;23:68-75.
3. Jannini EA, Lombardo F, Lenzi A, Correlation between ejaculatory and erectile dysfunction, Int J Androl, 2005;28(Suppl. 2):40-5.
4. McMahon CG, Althof SE, Waldinger MD, et al., An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation, J Sex Med, 2008;5:1590-606.
5. Laumann EO, Nicolosi A, Glasser DB, et al., Sexual problems among women and men aged 40-80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors, Int J Impot Res,2005;17:39-57.
6. Corona G, Petrone L, Mannucci E, et al., Psychobiological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions, Eur Urol, 2004;46:615-22.
7. Rosen RC, Riley A, Wagner G, et al., The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction, Urology, 1997;49:822-30.
8. Rosen RC, Cappelleri JC, Smith MD, et al., Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction, Int J Impot Res, 1999;11:319-26.
9. McMahon CG, Screening for erectile dysfunction in men with lifelong premature ejaculation - Is the Sexual Health Inventory for Men (SHIM) reliable? J Sex Med, 2009;6:567-73.
10. Jannini EA, Simonelli C, Lenzi A, Sexological approach to ejaculatory dysfunction, Int J Androl, 2002;25:317-23.
11. Bieber I, The psychoanalytic treatment of sexual disorders, J Sex Marital Ther, 1974;1:5-15.
12. Kaplan H, The New Sex Therapy: Active Treatment of Sexual Dysfunction, New York, Brunner/Mazel, 1974.
13. Dunn KM, Croft PR, Hackett GI, Association of sexual problems with social, psychological, and physical problems in men and women: a cross sectional population survey, J Epidemiol Community Health,1999;53:144-8.
14. Jannini EA, Carosa E, Pepe M, et al., Update on pathophysiology of premature ejaculation: the bases for new pharmacological treatments, EAU-EBU Updates Series, 2006;4:141-9.
15. Jannini EA, McCabe MP, Salonia A, et al., Organic vs. psychogenic? The Manichean diagnosis in sexual medicine, J Sex Med, 2010;7:1726-33.
16. Masters W, Johnson VE, Human Sexual Inadequacy, Boston, Little, Brown & Co, 1970.
17. Hawton K, Catalan J, Prognostic factors in sex therapy, Behav Res Ther, 1986;24:377-85.
18. Heiman JR, Meston CM, Empirically validated treatment for sexual dysfunction, Annu Rev Sex Res, 1997;8:148-94.
19. Leiblum SR, Rosen RC, Couples therapy for erectile disorders: conceptual and clinical considerations, J Sex Marital Ther, 1991;17:147-59.
20. Screponi E, Carosa E, Di Stasi SM, et al., Prevalence of chronic prostatitis in men with premature ejaculation, Urology, 2001;58:198-202.
21. Liang CZ, Zhang XJ, Hao ZY, et al., Prevalence of sexual dysfunction in Chinese men with chronic prostatitis, BJU Int, 2004;93:568-70.
22. Shamloul R, el-Nashaar A, Chronic prostatitis in premature ejaculation: a cohort study in 153 men, J Sex Med, 2006;3:150-4.
23. Lotti F, Corona G, Mancini M, et al., The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms, J Sex Med, 2009;6:2878-87.
24. Carani C, Isidori AM, Granata A, et al., Multicenter study on the prevalence of sexual symptoms in male hypoand hyperthyroid patients, J Clin Endocrinol Metab,2005;90:6472-9.
25. Corona G, Jannini EA, Lotti F, et al., Premature and delayed ejaculation: two ends of a single continuum influenced by hormonal milieu, Int J Androl, 2011;34(1):41-8.
26. Jannini EA, Ulisse S, D'Armiento M, Thyroid hormone and male gonadal function, Endocr Rev, 1995;16:443-59.
27. Carosa E, Di Sante S, Rossi S, et al., Ontogenetic profile of the expression of thyroid hormone receptors in rat and human corpora cavernosa of the penis, J Sex Med,2010;7:1381-90.
28. Mancina R, Filippi S, Marini M, et al., Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens, Mol Hum Reprod, 2005;11:107-15.
29. Fein RL, Intracavernous medication for treatment of premature ejaculation, Urology, 1990;35:301-3.
30. Abdel-Hamid IA, El Naggar EA, El Gilany AH, Assessment of as needed use of pharmacotherapy and the pausesqueeze technique in premature ejaculation, Int J Impot Res, 2001;13:41-5.
31. Salonia A, Maga T, Colombo R, et al., A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation, J Urol, 2002;168:2486-9.
32. Chen J, Mabjeesh NJ, Matzkin H, et al., Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation, Urology, 2003;61:197-200.
33. Dresser MJ, Desai D, Gidwani S, et al., Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors, Int J Impot Res, 2006;18:104-10.
34. Marson L, McKenna KE, Serotonergic neurotoxic lesions facilitate male sexual reflexes, Pharmacol Biochem Behav, 1994;47:883-8.
35. McIntosh TK, Barfield RJ, Brain monoaminergic control of male reproductive behavior. II. Dopamine and the postejaculatoryrefractory period, Behav Brain Res,1984;12:267-73.
36. Heaton JP, Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine, Neurosci Biobehav Rev, 2000;24:561-9.
37. Xin ZC, Chung WS, Choi YD, et al., Penile sensitivity in patients with primary premature ejaculation, J Urol, 1996;156:979-81.
38. Colpi GM, Fanciullacci F, Beretta G, et al., Evoked sacral potentials in subjects with true premature ejaculation, Andrologia, 1986;18:583-6.
39. Rowland DL, Haensel SM, Blom JH, et al., Penile sensitivity in men with premature ejaculation and erectile dysfunction, J Sex Marital Ther, 1993;19:189-97.
40. Waldinger MD, The neurobiological approach to premature ejaculation, J Urol, 2002;168:2359-67.
41. St Lawrence JS, Madakasira S, Evaluation and treatment of premature ejaculation: a critical review, Int J Psychiatry Med, 1992;22:77-97.
42. Jannini EA, Lenzi, A, Couple therapy for premature ejaculation. In: Kandeel RF, Lue T, Pryor JL, et al., (eds), Male Sexual Dysfunction: Pathophysiology and Treatment, New York, Informa, 2007:351-62.
43. Goodman RE, An assessment of clomipramine (Anafranil) in the treatment of premature ejaculation, J Int Med Res, 1980;8(Suppl. 3):53-9.
44. Waldinger MD, Zwinderman AH, Olivier B, Antidepressants and ejaculation: a double-blind,randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone, J Clin Psychopharmacol, 2001;21:293-7.
45. Althof SE, Evidence based assessment of rapid ejaculation, Int J Impot Res, 1998;10(Suppl. 2):S74-6,discussion S77-9.
46. Rowland D, McMahon CG, Abdo C, et al., Disorders of orgasm and ejaculation in men, J Sex Med, 2010;7 (4 Pt 2):1668-86.
47. Salonia A, Rocchini L, Sacca A, et al., Acceptance of and discontinuation rate from paroxetine treatment in patients with lifelong premature ejaculation, J Sex Med, 2009;6(10):2868-77.
48. Hamilton CL, Cornpropst JD, Determination of dapoxetine, an investigational agent with the potential for treating depression, and its mono- and di-desmethyl metabolites in human plasma using column-switching high-performance liquid chromatography, J Chromatogr,1993;612:253-61.
49. Andersson KE, Mulhall JP, Wyllie MG, Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for 'on-demand' treatment of premature ejaculation, BJU Int, 2006;97:311-5.
50. Pryor JL, Althof SE, Steidle C, et al., Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials, Lancet, 2006;368:929-37.
51. Buvat J, Tesfaye F, Rothman M, et al., Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries, Eur Urol, 2009;55:957-67.
52. Berkovitch M, Keresteci AG, Koren G, Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation, J Urol, 1995;154:1360-1.
53. Choi HK, Jung GW, Moon KH, et al., Clinical study of SScream in patients with lifelong premature ejaculation, Urology, 2000;55:257-61.