Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for 'on-demand' treatment of premature ejaculation

BJU International

Volumn 97, Issue 2, 2006, Pages 311-315

  Andersson, Karl Erik ^a   Mulhall, John P ^b   Wyllie, Michael G ^c,d  

^a LUND UNIVERSITY   (Sweden)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Urodoc Ltd   (United Kingdom)

^d Urodoc Ltd   (United Kingdom)

Author keywords

Dapoxetine; Premature ejaculation; Serotonin transport inhibitor

Indexed keywords

DAPOXETINE; SEROTONIN UPTAKE INHIBITOR; BENZYLAMINE DERIVATIVE; NAPHTHALENE DERIVATIVE;

ARTICLE; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG MECHANISM; DRUG SAFETY; DRUG TISSUE LEVEL; DRUG TOLERABILITY; EJACULATION; ERECTILE DYSFUNCTION; HUMAN; LATENT PERIOD; LIBIDO DISORDER; NAUSEA; NONHUMAN; PREMATURE EJACULATION; PRIORITY JOURNAL; SEXUAL INTERCOURSE; SEXUAL SATISFACTION; TISSUE DISTRIBUTION; VALIDATION STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; SEXUAL DYSFUNCTION;

BENZYLAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; EJACULATION; HUMANS; MALE; NAPHTHALENES; SEROTONIN UPTAKE INHIBITORS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 33644867499     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2006.05911.x     Document Type: Article

References (19)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th edn Text Revision. Washington DC American Psychiatric Association 2000 552 4
2. Laumann EO Paik A Rosen RC. Sexual dysfunction in the United States: prevalence and predictors JAMA 1999 281 537 44
3. Laumann EO Nicolosi A Glasser DB et al. Sexual problems among women and men aged 40-80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors Int J Impot Res 2005 17 39 57
4. Simons JS Carey MP. Prevalence of sexual dysfunctions: results from a decade of research Arch Sex Behav 2001 30 177 219
5. Waldinger MD. Lifelong premature ejaculation: from authority-based to evidence-based medicine BJU Int 2004 93 201 7
6. McMahon CG Abdo C Incrocci L et al. Disorders of orgasm and ejaculation in men Lue TF Basson R Rosen R et al. Sexual Medicine: Sexual Dysfunctions in Men and Women2nd International Consultation on Sexual Dysfunctions Paris Health Publications 2004
7. Waldinger MD Berendsen HH Blok BF Olivier B Holstege G. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system Behav Brain Res 1998 92 111 8
8. Patrick DL Althof SE Pryor JL et al. Premature ejaculation: an observational study of men and their partners J Sex Med 2005 2 358 67
9. Aschka C Himmel W Ittner E Kochen MM. Sexual problems of male patients in family practice J Fam Pract 2001 50 773 8
10. Rosen R Porst H Montorsi F. The premature ejaculation prevalence and attitudes (PEPA) survey: a multinational survey J Sex Med 2004 1 Suppl. 1 57
11. Gengo PJ Giuliano F McKenna KE et al. Monoaminergic transporter binding and inhibition profile of dapoxetine, a medication for the treatment of premature ejaculation J Urol 2005 173 Suppl. 239
12. Modi N Dresser M Desai D. Single- and multiple-dose pharmacokinetics of dapoxetine, a new treatment for premature ejaculation. Submitted to SMSNA meeting, New York November 2005 in press
13. Ronfeld RA Tremaine LM Wilner KD. Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers Clin Pharmacokinet 1997 32 Suppl. 1 22 30
14. McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study J Urol 1998 159 1935 8
15. McMahon CG Touma K. Treatment of premature ejaculation with paroxetine hydrochloride Int J Impot Res 1999 11 241 6
16. Pryor JL Althof SE Steidle C Kell S. Efficacy and tolerability of dapoxetine in the treatment of premature ejaculation J Urol 2005 173 Suppl. 201
17. Waldinger MD Schweitzer DH Olivier B. On-demand SSRI treatment of premature ejaculation: pharmacodynamic limitations for relevant ejaculation delay and consequent solutions J Sex Med 2005 2 121 31
18. Golden RN. Making advances where it matters: improving outcomes in mood and anxiety disorders CNS Spectr 2004 9 Suppl. 4 14 22
19. Keltner NL McAfee KM Taylor CL. Mechanisms and treatments of SSRI-induced sexual dysfunction Perspect Psychiatr Care 2002 38 111 6