Antidepressants and ejaculation: A double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone

Journal of Clinical Psychopharmacology

Volumn 21, Issue 3, 2001, Pages 293-297

  Waldinger, Marcel D ^a,b   Zwinderman, Aeilko H ^c   Olivier, Berend ^b,d  

^a LEYENBURG HOSPITAL   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEFAZODONE; PAROXETINE; PLACEBO; SERTRALINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; LATENT PERIOD; MALE; PREMATURE EJACULATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEXUAL FUNCTION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS; CHI-SQUARE DISTRIBUTION; DOUBLE-BLIND METHOD; EJACULATION; HUMANS; MALE; MIDDLE AGED; PAROXETINE; PLACEBOS; RECEPTORS, SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; TRIAZOLES;

EID: 0035005565     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004714-200106000-00007     Document Type: Article

References (22)

1. Meston CM, Gorzalka BB. Psychoactive drugs and human sexual behavior: the role of serotonergic activity. J Psychoactive Drugs 1992;24:1-40.
2. Olivier B, van Oorschot R, Waldinger MD. Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. Int Clin Psychopharmacol 1998;13[suppl 6]:S9-S14.
3. Waldinger MD, Berendsen HHG, Blok BFM, et al. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res 1998;92:111-8.
4. Mendels J, Camera A, Sikes C. Sertraline treatment for premature ejaculation. J Clin Psychopharmacol 1995;15:341-6.
5. Kara H, Aydin S, Agargun Y, et al. The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind, placebo controlled study. J Urol 1996;156:1631-2.
6. Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 1994;151:1377-9.
7. Waldinger MD. Use of psychoactive agents in the treatment of sexual dysfunction. CNS Drugs 1996;6:204-16.
8. Waldinger MD, Hengeveld MW, Zwinderman AH. Ejaculation retarding properties of paroxetine in patients with primary premature ejaculation: a double-blind, randomized, dose-response study. Br J Urol 1997;79:592-5.
9. Waldinger MD, Hengeveld MW, Zwinderman AH, et al. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine and sertraline. J Clin Psychopharmacol 1998:18:274-°81.
10. Waldinger MD, Olivier B. Selective serotonin reuptake inhibitor-induced sexual dysfunction: clinical and research considerations. Int Clin Psychopharmacol 1998;13[suppl 6]:S27-S33.
11. Eison A, Eison M, Torrente J, et al. Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacol Bull 1990; 26:311-5.
12. Feiger A, Kiev A, Shrivastava RK, et al. Nefazodone versus sertraline in outpatients with major depression: focus on efficacy, tolerability, and effects on sexual function and satisfaction. J Clin Psychiatry 1996;57[suppl 2]:53-62.
13. Ferguson JM, Shrivastava RK, Stahl SM, et al. Effects of double-blind treatment with nefazodone or sertraline on re-emergence of sexual dysfunction in depressed patients [abstract]. Washington, DC: American Psychiatric Association, 1996.
14. Matuscyk JV, Larsson K, Eriksson E. The selective serotonin re-uptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 1998;60:527-32.
15. Waldinger MD, van de Plas A, van Oorschot R, et al. SSRIs and sexual behavior in male rats: differential effects of paroxetine and fluvoxamine [abstract NR713, p. 270]. In: New Research Program and Abstracts of the 152nd Annual Meeting of the American Psychiatric Association. Washington, DC, May 20, 1999.
16. Foreman MM, Hall JL, Love RL. The role of the 5-HT2 receptor in the regulation of sexual performance of male rats. Life Sci 1989; 45:1263-70.
17. Waldinger MD, Hengeveld MW, Zwinderman AH, et al. An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation. Int J Psychiatry Clin Pract 1998;2: 287-93.
18. Derogatis LR. SCL-90, Handleiding bij een Multidimensionele Psychopathologie-indicator. Lisse, Holland: Swets and Zeitlinger B.V., 1986.
19. Lingjaerde O, Ahlfors UG, Bech P, et al. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand 1987;76[suppl 334]:1-100.
20. Ahlenius S, Larsson K, Svensson L, et al. Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmacol Biochem Behav 1981;15:785-92.
21. Coolen LM. The neuronal organization of sexual behavior in the rat. A functional neuroanatomical Fos-study [PhD thesis]. Nijmegen, The Netherlands: University of Nijmegen, 1995:1-143.
22. Veening J, Coolen LM, Spooren WJPM, et al. Patterns of c-fos expression induced by fluvoxamine are different after acute vs. chronic oral administration. Eur Neuropsychopharmacol 1998;8: 213-26.