Biological consequences of disturbed sleep: Important mediators of health?

Japanese Psychological Research

Volumn 53, Issue 2, 2011, Pages 163-176

  Okun, Michele L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Endocrine; Health; Immune; Sleep

Indexed keywords

EID: 79955785603     PISSN: 00215368     EISSN: 14685884     Source Type: Journal    
DOI: 10.1111/j.1468-5884.2011.00463.x     Document Type: Review

References (128)

1. Adam, K. (1980). Sleep as a restorative process and a theory to explain why. Progress in Brain Research, 53, 289-305.
2. Akerstedt, T., & Nilsson, P. M. (2003). Sleep as restitution: An introduction. Journal of Internal Medicine, 254, 6-12.
3. Alvarez, G. G., & Ayas, N. T. (2004). The impact of daily sleep duration on health: A review of the literature. Progress in Cardiovascular Nursing, 19, 56-59.
4. Ancoli-Israel, S. (2006). The impact and prevalence of chronic insomnia and other sleep disturbances associated with chronic illness. American Journal of Managed Care, 12, S221-S229.
5. Andersen, M. L., Martins, P. J., D'Almeida, V., Bignotto, M., & Tufik, S. (2005). Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats. Journal of Sleep Research, 14, 83-90.
6. Backhaus, J., Junghanns, K., & Hohagen, F. (2004). Sleep disturbances are correlated with decreased morning awakening salivary cortisol. Psychoneuroendocrinology, 29, 1184-1191.
7. Baker, F. C., Mitchell, D., & Driver, H. S. (2001). Oral contraceptives alter sleep and raise body temperature in young women. Pflugers Archives, 442, 729-737.
8. Ballieux, R. E. (1994). The mind and the immune system. Theoretical Medicine, 15, 387-395.
9. Bautista, L. E. (2003). Inflammation, endothelial dysfunction, and the risk of high blood pressure: Epidemiologic and biological evidence. Journal of Human Hypertension, 17, 223-230.
10. Benca, R., & Quintas, J. (1997). Sleep and host defenses: A review. Sleep, 20, 1027-1037.
11. Benderly, M., Haim, M., Boyko, V., Tanne, D., Behar, S., Matas, Z., Zimlichman, R., & Goldbourt, U. (2007). C-reactive protein distribution and correlates among men and women with chronic coronary heart disease. Cardiology, 107, 345-353.
12. Born, J. (1999). Sleep and immune functions. In M. Schedlowski & U. Tewes (Eds.), Psychoneuroimmunology: An interdisciplinary introduction. New York: Kluwer Academic/Plenum Publishers, pp. 417-442.
13. Born, J., & Fehm, H. L. (2000). The neuroendocrine recovery function of sleep. Noise and Health, 2, 25-38.
14. Born, J., Kern, W., Bieber, K., Fehm-Wolfsdorf, G., Schiebe, M., & Fehm, H. L. (1986). Night-time plasma cortisol secretion is associated with specific sleep stages. Biological Psychiatry, 21, 1415-1424.
15. Born, J., Lange, T., Hansen, K., Molle, M., & Fehm, H. L. (1997). Effects of sleep and circadian rhythm on human circulating immune cells. Journal of Immunology, 158, 4454-4464.
16. Born, J., Muth, S., & Fehm, H. L. (1988). The significance of sleep onset and slow wave sleep for nocturnal release of growth hormone and cortisol. Psychoneuroendocrinology, 13, 233-243.
17. Born, J., Spath-Schwalbe, E., Schwakenhofer, H., Kern, W., & Fehm, H. L. (1989). Influences of corticotropin-releasing hormone, adrenocorticotropin, and cortisol on sleep in normal man. Journal of Clinical Endocrinology and Metabolism, 68, 904-911.
18. Bryant, P. A., Trinder, J., & Curtis, N. (2004). Sick and tired: Does sleep have a vital role in the immune system? Nature Reviews Immunology, 4, 457-467.
19. Buysse, D. J., Cheng, Y., Germain, A., Moul, D. E., Franzen, P. L., Fletcher, M., & Monk, T. H. (2010). Night-to-night sleep variability in older adults with and without chronic insomnia. Sleep Medicine, 11, 56-64.
20. Cakirbay, H., Bilici, M., Kavakci, O., Cebi, A., Guler, M., & Tan, U. (2004). Sleep quality and immune functions in rheumatoid arthritis patients with and without major depression. International Journal of Neuroscience, 114, 245-256.
21. Carrier, J., Land, S., Buysse, D. J., Kupfer, D. J., & Monk, T. H. (2001). The effects of age and gender on sleep EEG power spectral density in the middle years of life (ages 20-60 years old). Psychophysiology, 38, 232-242.
22. Carskadon, M., & Dement, W. C. (2005). Normal human sleep: An overview. In M. H. T. Roth & W. C. Dement (Eds.), Principles and practice of sleep medicine. 4th ed. Philadelphia: Elsevier Saunders, pp. 13-23.
23. Cesari, M., Penninx, B. W., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Tracy, R. P., Rubin, S. M., Harris, T. B., & Pahor, M. (2003). Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study). American Journal of Cardiology, 92, 522-528.
24. Chang, F. C., & Opp, M. R. (2001). Corticotropin-releasing hormone (CRH) as a regulator of waking. Neuroscience and Biobehavioral Reviews, 25, 445-453.
25. Chen, H. Y., Chiang, C. K., Wang, H. H., Hung, K. Y., Lee, Y. J., Peng, Y. S., Wu, K. D., & Tsai, T. J. (2008). Cognitive-behavioral therapy for sleep disturbance in patients undergoing peritoneal dialysis: A pilot randomized controlled trial. American Journal of Kidney Disease, 52, 314-323.
26. Cohen, S., Doyle, W. J., Alper, C. M., Janicki-Deverts, D., & Turner, R. B. (2009). Sleep habits and susceptibility to the common cold. Archives of Internal Medicine, 169, 62-67.
27. Cruess, D. G., Antoni, M. H., Gonzalez, J., Fletcher, M. A., Klimas, N., Duran, R., Ironson, G., & Schneiderman, N. (2003). Sleep disturbance mediates the association between psychological distress and immune status among HIV-positive men and women on combination antiretroviral therapy. Journal of Psychosomatic Research, 54, 185-189.
28. Davidson, J. R. (2009). Insomnia treatment options for women. Obstetrics and Gynecology Clinics of North America, 36, 831-841.
29. Diamanti-Kandarakis, E., Alexandraki, K., Piperi, C., Protogerou, A., Katsikis, I., Paterakis, T., Lekakis, J., & Panidis, D. (2006). Inflammatory and endothelial markers in women with polycystic ovary syndrome. European Journal of Clinical Investigations, 36, 691-697.
30. Dimitrov, S., Lange, T., Tieken, S., Fehm, H. L., & Born, J. (2004). Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Brain, Behavior, and Immunity, 18, 341-348.
31. Dinges, D. F., Douglas, S. D., Zaugg, L., Campbell, D. E., McMann, J. M., Whitehouse, W. G., Orne, E. C., Kapoor, S. C., Icaza, E., & Orne, M. T. (1994). Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation. Journal of Clinical Investigation, 93, 1930-1939.
32. Dockray, S., Bhattacharyya, M. R., Molloy, G. J., & Steptoe, A. (2008). The cortisol awakening response in relation to objective and subjective measures of waking in the morning. Psychoneuroendocrinology, 33, 77-82.
33. Driscoll, H. C., Serody, L., Patrick, S., Maurer, J., Bensasi, S., Houck, P. R., Mazumdar, S., Nofzinger, E. A., Bell, B., Nebes, R. D., Miller, M. D., & Reynolds, C. F., III (2008). Sleeping well, aging well: A descriptive and cross-sectional study of sleep in "successful agers" 75 and older. American Journal of Geriatric Psychiatry, 16, 74-82.
34. Driver, H. S., & Baker, F. C. (1998). Menstrual factors in sleep. Sleep Medicine Reviews, 2, 213-229.
35. Edinger, J. D., Olsen, M. K., Stechuchak, K. M., Means, M. K., Lineberger, M. D., Kirby, A., & Carney, C. E. (2009). Cognitive behavioral therapy for patients with primary insomnia or insomnia associated predominantly with mixed psychiatric disorders: A randomized clinical trial. Sleep, 32, 499-510.
36. Epstein, D. R., & Dirksen, S. R. (2007). Randomized trial of a cognitive-behavioral intervention for insomnia in breast cancer survivors. Oncology Nursing Forum, 34, E51-E59.
37. Everson, C. A. (2005). Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats. American Journal of Physiology, Regulatory, and Integrative Comparative Physiology, 289, R1054-R1063.
38. Faraut, B., Boudjeltia, K. Z., Dyzma, M., Rousseau, A., David, E., Stenuit, P., Franck, T., Van, A. P., Vanhaeverbeek, M., & Kerkhofs, M. (2011). Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction. Brain, Behavior, and Immunity, 25, 16-24.
39. Federenko, I., Wust, S., Hellhammer, D. H., Dechoux, R., Kumsta, R., & Kirschbaum, C. (2004). Free cortisol awakening responses are influenced by awakening time. Psychoneuroendocrinology, 29, 174-184.
40. Frey, D. J., Fleshner, M., & Wright, K. P., Jr. (2007). The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults. Brain, Behavior, and Immunity, 21, 1050-1057.
41. Fuller, P. M., Gooley, J. J., & Saper, C. B. (2006). Neurobiology of the sleep-wake cycle: Sleep architecture, circadian regulation, and regulatory feedback. Journal of Biological Rhythms, 21, 482-493.
42. Gangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2006). Short sleep duration as a risk factor for hypertension: Analyses of the first National Health and Nutrition Examination Survey. Hypertension, 47, 833-839.
43. Garcia, R. G., Celedon, J., Sierra-Laguado, J., Alarcon, M. A., Luengas, C., Silva, F., Arenas-Mantilla, M., & Lopez-Jaramillo, P. (2007). Raised C-reactive protein and impaired flow-mediated vasodilation precede the development of preeclampsia. American Journal of Hypertension, 20, 98-103.
44. Germain, A., Moul, D. E., Franzen, P. L., Miewald, J. M., Reynolds, C. F., III, Monk, T. H., & Buysse, D. J. (2006). Effects of a brief behavioral treatment for late-life insomnia: Preliminary findings. Journal of Clinical Sleep Medicine, 2, 403-406.
45. Griefahn, B., & Robens, S. (2008). The cortisol awakening response: A pilot study on the effects of shift work, morningness and sleep duration. Psychoneuroendocrinology, 33, 981-988.
46. Guggisberg, A. G., Hess, C. W., & Mathis, J. (2007). The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep. Sleep, 30, 755-766.
47. Haack, M., Sanchez, E., & Mullington, J. M. (2007). Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep, 30, 1145-1152.
48. Hachul, H., Bittencourt, L. R., Andersen, M. L., Haidar, M. A., Baracat, E. C., & Tufik, S. (2008). Effects of hormone therapy with estrogen and/or progesterone on sleep pattern in postmenopausal women. International Journal of Gynaecology and Obstetrics, 103, 207-212.
49. Haimov, I., & Lavie, P. (1997). Melatonin: A chronobiotic and soporific hormone. Archives of Gerontology and Geriatrics, 24, 167-173.
50. Haimov, I., Shochat, T., & Lavie, P. (1997). Melatonin: A possible link between sleep and the immune system. Israel Journal of Medical Sciences, 33, 246-250.
51. Hall, M. (2010). Behavioral medicine and sleep: Concepts, measures and methods. In A. Steptoe (Ed.), Handbook of behavioral medicine: Methods and applications. Berlin: Springer, pp. 749-768.
52. Hall, M., Baum, A., Buysse, D. J., Prigerson, H. G., Kupfer, D. J., & Reynolds, C. F. (1998). Sleep as a mediator of the stress-immune relationship. Psychosomatic Medicine, 60, 48-51.
53. Hall, M. H., Matthews, K. A., Kravitz, H. M., Gold, E. B., Buysse, D. J., Bromberger, J. T., Owens, J. F., & Sowers, M. (2009). Race and financial strain are independent correlates of sleep in midlife women: The SWAN sleep study. Sleep, 32, 73-82.
54. Hall, M., Okun, M. L., Atwood, C. W., Buysse, D. J., & Strollo, P. J. (2008). Measurement of sleep by polysomnography. In L. L. Luecken & L. C. Gallo (Eds.), Handbook of physiological research methods in health psychology. London: Sage Publications, pp. 341-367.
55. Hogan, D., Morrow, J. D., Smith, E. M., & Opp, M. R. (2003). Interleukin-6 alters sleep of rats. Journal of Neuroimmunology, 137, 59-66.
56. Irwin, M. (2002). Effects of sleep and sleep loss on immunity and cytokines. Brain, Behavior, and Immunity, 16, 503-512.
57. Irwin, M., Clark, C., Kennedy, B., Christian, G. J., & Ziegler, M. (2003). Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects. Brain, Behavior, and Immunity, 17, 365-372.
58. Irwin, M. R., Wang, M., Campomayor, C. O., Collado-Hidalgo, A., & Cole, S. (2006). Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Archives of Internal Medicine, 166, 1756-1762.
59. Kapsimalis, F., Basta, M., Varouchakis, G., Gourgoulianis, K., Vgontzas, A., & Kryger, M. (2007). Cytokines and pathological sleep. Sleep Medicine, 9, 603-614.
60. Kilroy, G. E., Foster, S. J., Wu, X., Ruiz, J., Sherwood, S., Heifetz, A., Ludlow, J. W., Stricker, D. M., Potiny, S., Green, P., Halvorsen, Y. D., Cheatham, B., Storms, R. W., & Gimble, J. M. (2007). Cytokine profile of human adipose-derived stem cells: Expression of angiogenic, hematopoietic, and pro-inflammatory factors. Journal of Cell Physiology, 212, 702-709.
61. Knutson, K. L., Rathouz, P. J., Yan, L. L., Liu, K., & Lauderdale, D. S. (2007). Intra-individual daily and yearly variability in actigraphically recorded sleep measures: The CARDIA study. Sleep, 30, 793-796.
62. Koenig, W. (2003). Update on C-reactive protein as a risk marker in cardiovascular disease. Kidney International Supplement, 84, S58-S61.
63. Kunz, D., Mahlberg, R., Muller, C., Tilmann, A., & Bes, F. (2004). Melatonin in patients with reduced REM sleep duration: Two randomized controlled trials. Journal of Clinical and Endocrinological Metabolism, 89, 128-134.
64. Lancel, M., Faulhaber, J., Holsboer, F., & Rupprecht, R. (1996). Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators. American Journal of Physiology, 271, E763-E772.
65. Lancel, M., Faulhaber, J., Schiffelholz, T., Romeo, E., Di Michele, F., Holsboer, F., & Rupprecht, R. (1997). Allopregnanolone affects sleep in a benzodiazepine-like fashion. Journal of Pharmacology and Experimental Therapeutics, 282, 1213-1218.
66. Landis, C. A., Lentz, M. J., Tsuji, J., Buchwald, D., & Shaver, J. L. (2004). Pain, psychological variables, sleep quality, and natural killer cell activity in midlife women with and without fibromyalgia. Brain, Behavior, and Immunity, 18, 304-313.
67. Lange, T., Dimitrov, S., & Born, J. (2010). Effects of sleep and circadian rhythm on the human immune system. Annals of the New York Academy of Sciences, 1193, 48-59.
68. Lange, T., Perras, B., Fehm, H. L., & Born, J. (2003). Sleep enhances the human antibody response to hepatitis A vaccination. Psychosomatic Medicine, 65, 831-835.
69. Lappas, M., Permezel, M., & Rice, G. E. (2004). Release of proinflammatory cytokines and 8-isoprostane from placenta, adipose tissue, and skeletal muscle from normal pregnant women and women with gestational diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 89, 5627-5633.
70. Leproult, R., Copinschi, G., Buxton, O., & Van Cauter, E. (1997). Sleep loss results in an elevation of cortisol levels the next evening. Sleep, 20, 865-870.
71. Lichstein, K. L. (2006). Behavioral intervention for special insomnia populations: Hypnotic-dependent insomnia and comorbid insomnia. Sleep Medicine, 7 (Suppl. 1), S27-S31.
72. Lim, J., & Dinges, D. F. (2008). Sleep deprivation and vigilant attention. Annals of the New York Academy of Sciences, 1129, 305-322.
73. Lissoni, P., Rovelli, F., Brivio, F., Brivio, O., & Fumagalli, L. (1998). Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans. Natural Immunity, 16, 1-5.
74. Lissoni, P., Rovelli, F., Meregalli, S., Fumagalli, L., Musco, F., Brivio, F., Brivio, O., & Esposti, G. (1997). Melatonin as a new possible anti-inflammatory agent. Journal of Biological Regulators and Homeostatic Agents, 11, 157-159.
75. Liukkonen, T., Rasanen, P., Ruokonen, A., Laitinen, J., Jokelainen, J., Leinonen, M., Meyer-Rochow, V. B., & Timonen, M. (2007). C-reactive protein levels and sleep disturbances: Observations based on the Northern Finland 1966 Birth Cohort study. Psychosomatic Medicine, 69, 756-761.
76. Maestroni, G. J. (1993). The immunoneuroendocrine role of melatonin. Journal of Pineal Research, 14, 1-10.
77. Maestroni, G. J., Hertens, E., Galli, P., Conti, A., & Pedrinis, E. (1996). Melatonin-induced T-helper cell hematopoietic cytokines resembling both interleukin-4 and dynorphin. Journal of Pineal Research, 21, 131-139.
78. Majde, J. A., & Krueger, J. M. (2005). Links between the innate immune system and sleep. Journal of Allergy and Clinical Immunology, 116, 1188-1198.
79. van Mark, A., Weiler, S. W., Schroder, M., Otto, A., Jauch-Chara, K., Groneberg, D. A., Spallek, M., Kessel, R., & Kalsdorf, B. (2010). The impact of shift work induced chronic circadian disruption on IL-6 and TNF-alpha immune responses. Journal of Occupational Medicine and Toxicology, 5, 18.
80. McDade, T. W., Hawkley, L. C., & Cacioppo, J. T. (2006). Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: The Chicago health, aging, and social relations study. Psychosomatic Medicine, 68, 376-381.
81. McEwen, B. S. (2006). Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. Metabolism: Clinical and Experimental, 55, S20-S23.
82. Meerlo, P., Sgoifo, A., & Suchecki, D. (2008). Restricted and disrupted sleep: Effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Medicine Reviews, 12, 197-210.
83. Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Price, N., Dinges, D. F., & Mullington, J. M. (2001). Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clinical Chemistry, 47, 426-430.
84. Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004). Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. Journal of the American College of Cardiology, 43, 678-683.
85. Meisinger, C., Heier, M., Lowel, H., Schneider, A., & Doring, A. (2007). Sleep duration and sleep complaints and risk of myocardial infarction in middle-aged men and women from the general population: The MONICA/KORA Augsburg cohort study. Sleep, 30, 1121-1127.
86. Mezick, E. J., Matthews, K. A., Hall, M., Kamarck, T. W., Buysse, D. J., Owens, J. F., & Reis, S. E. (2009). Intra-individual variability in sleep duration and fragmentation: Associations with stress. Psychoneuroendocrinology, 34, 1346-1354.
87. Miller, M. A., Kandala, N. B., Kivimaki, M., Kumari, M., Brunner, E. J., Lowe, G. D., Marmot, M. G., & Cappuccio, F. P. (2009). Gender differences in the cross-sectional relationships between sleep duration and markers of inflammation: Whitehall II study. Sleep, 32, 857-864.
88. Moldofsky, H., Lue, F. A., Shahal, B., Jiang, C. G., & Gorczynski, R. M. (1995). Diurnal sleep/wake-related immune functions during the menstrual cycle of healthy young women. Journal of Sleep Research, 4, 150-159.
89. Ohayon, M. M., Carskadon, M. A., Guilleminault, C., & Vitiello, M. V. (2004). Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: Developing normative sleep values across the human lifespan. Sleep, 27, 1255-1273.
90. Okun, M. L., & Coussons-Read, M. E. (2007). Sleep disruption during pregnancy: How does it influence serum cytokines? Journal of Reproductive Immunology, 73, 158-165.
91. Okun, M. L., Coussons-Read, M., & Hall, M. (2009). Disturbed sleep is associated with increased C-reactive protein in young women. Brain, Behavior, and Immunity, 23, 351-354.
92. Okun, M. L., Hall, M., & Coussons-Read, M. E. (2007). Sleep disturbances increase interleukin-6 production during pregnancy: Implications for pregnancy complications. Reproductive Sciences, 14, 560-567.
93. Okun, M. L., Hanusa, B. H., Hall, M., & Wisner, K. L. (2009). Sleep complaints in late pregnancy and the recurrence of postpartum depression. Behavioral Sleep Medicine, 7, 106-117.
94. Okun, M. L., Krafty, R. T., Buysse, D. J., Monk, T. H., Reynolds, C. F., III, Begley, A., & Hall, M. (2009). What constitutes too long of a delay? Determining the cortisol awakening response (CAR) using self-report and PSG-assessed wake time. Psychoneuroendocrinology, 3, 460-468.
95. Okun, M. L., Reynolds, C. F., III, Buysse, D. J., Monk, T. H., Mazumdar, S., Begley, A., & Hall, M. (2011). Sleep variability, health-related practices, and inflammatory markers in a community dwelling sample of older adults. Psychosomatic Medicine, 73, 142-150.
96. Olivadoti, M. D., & Opp, M. R. (2008). Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice. Neuroscience, 153, 338-348.
97. Opp, M. R. (2006). Sleep and psychoneuroimmunology. Neurologic Clinics, 24, 493-506.
98. Opp, M. R. (2009). Sleep and psychoneuroimmunology. Immunology and Allergy Clinics of North America, 29, 295-307.
99. Opp, M., Born, J., & Irwin, M. (2006). Sleep and the immune system. In R. Ader (Ed.), Psychoneuroimmunology. 4th ed. New York: Academic Press, Inc, pp. 539-578.
100. Papanicolaou, D. A., & Vgontzas, A. N. (2000). Interleukin-6: The endocrine cytokine. Journal of Clinical Endocrinology and Metabolism, 85, 1331-1333.
101. Patel, S. R., Zhu, X., Storfer-Isser, A., Mehra, R., Jenny, N. S., Tracy, R., & Redline, S. (2009). Sleep duration and biomarkers of inflammation. Sleep, 32, 200-204.
102. Pollmacher, T., Schuld, A., Kraus, T., Haack, M., Hinze-Selch, D., & Mullington, J. (2000). Experimental immunomodulation, sleep, and sleepiness in humans. Annals of the New York Academy of Sciences, 917, 488-499.
103. Polo-Kantola, P., Erkkola, R., Helenius, H., Irjala, K., & Polo, O. (1998). When does estrogen replacement therapy improve sleep quality? American Journal of Obstetrics and Gynecology, 178, 1002-1009.
104. Redwine, L., Hauger, R. L., Gillin, J. C., & Irwin, M. (2000). Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. Journal of Clinical Endocrinology and Metabolism, 85, 3597-3603.
105. Roehrs, T., Carskadon, M. A., Dement, W. C., & Roth, T. (2005). Daytime sleepiness and alertness. In M. H. Kryger, T. Roth, & W. C. Dement (Eds.), Principles and practice of sleep medicine. 4th ed. Philadelphia: Elsevier Saunders, pp. 39-50.
106. Ruiz, F. S., Andersen, M. L., Martins, R. C., Zager, A., Lopes, J. D., & Tufik, S. (2010). Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers. Innate Immunity, Nov. 18 [Epub ahead of print].
107. Sakami, S., Ishikawa, T., Kawakami, N., Haratani, T., Fukui, A., Kobayashi, F., Fujita, O., Araki, S., & Kawamura, N. (2002). Coemergence of insomnia and a shift in the Th1/Th2 balance toward Th2 dominance. Neuroimmunomodulation, 10, 337-343.
108. Saletu-Zyhlarz, G., Anderer, P., Gruber, G., Mandl, M., Gruber, D., Metka, M., Huber, J., Oettel, M., Graser, T., Abu-Bakr, M. H., Gratzhofer, E., & Saletu, B. (2003). Insomnia related to postmenopausal syndrome and hormone replacement therapy: Sleep laboratory studies on baseline differences between patients and controls and double-blind, placebo-controlled investigations on the effects of a novel estrogen-progesterone combination (Climodien, Lafamme) versus estrogen alone. Journal of Sleep Research, 12, 239-254.
109. Salin-Pascual, R. J., Ortega-Soto, H., Huerto-Delgadillo, L., Camacho-Arroyo, I., Roldan-Roldan, G., & Tamarkin, L. (1988). The effect of total sleep deprivation on plasma melatonin and cortisol in healthy human volunteers. Sleep, 11, 362-369.
110. Sari, I., Davutoglu, V., Ozbala, B., Ozer, O., Baltaci, Y., Yavuz, S., & Aksoy, M. (2008). Acute sleep deprivation is associated with increased electrocardiographic P-wave dispersion in healthy young men and women. Pacing and Clinical Electrophysiology, 31, 438-442.
111. Savard, J., Laroche, L., Simard, S., Ivers, H., & Morin, C. M. (2003). Chronic insomnia and immune functioning. Psychosomatic Medicine, 65, 211-221.
112. Savard, J., Simard, S., Ivers, H., & Morin, C. M. (2005). Randomized study on the efficacy of cognitive-behavioral therapy for insomnia secondary to breast cancer, part II: Immunologic effects. Journal of Clinical Oncology, 23, 6097-6106.
113. Schmid, D. A., Wichniak, A., Uhr, M., Ising, M., Brunner, H., Held, K., Weikel, J. C., Sonntag, A., & Steiger, A. (2006). Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine. Neuropsychopharmacology, 31, 832-844.
114. Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Van Cauter, E. (2005). Sleep loss: A novel risk factor for insulin resistance and Type 2 diabetes. Journal of Applied Physiology, 99, 2008-2019.
115. Spiegel, K., Leproult, R., & Van Cauter, E. (1999). Impact of sleep debt on metabolic and endocrine function. Lancet, 354, 1435-1439.
116. Spiegel, K., Sheridan, J. F., & Van Cauter, E. (2002). Effect of sleep deprivation on response to immunization. Journal of the American Medical Association, 12, 1471-1472.
117. Spiegel, K., Tasali, E., Penev, P., & Van Cauter, E. (2004). Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Annals of Internal Medicine, 141, 846-850.
118. Steiger, A. (2003). Sleep and endocrinology. Journal of Internal Medicine, 254, 13-22.
119. Stricker, J. L., Brown, G. G., Wetherell, L. A., & Drummond, S. P. (2006). The impact of sleep deprivation and task difficulty on networks of fMRI brain response. International Neuropsychological Society, 12, 591-597.
120. Van Cauter, E., Leproult, R., & Kupfer, D. J. (1996). Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. Journal of Clinical Endocrinology and Metabolism, 81, 2468-2473.
121. Vgontzas, A. N., & Chrousos, G. P. (2002). Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: Multiple interactions and disturbances in sleep disorders. Endocrinology and Metabolism Clinics of North America, 31, 15-36.
122. Vgontzas, A. N., Pejovic, S., Zoumakis, E., Lin, H. M., Bixler, E. O., Basta, M., Fang, J., Sarrigiannidis, A., & Chrousos, G. P. (2007). Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion. American Journal of Physiology Endocrinology and Metabolism, 292, E253-E261.
123. Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H. M., Follett, H., Kales, A., & Chrousos, G. P. (2004). Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. Journal of Clinical Endocrinology and Metabolism, 89, 2119-2126.
124. Vgontzas, A. N., Zoumakis, M., Bixler, E. O., Lin, H. M., Prolo, P., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2003). Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: Physiologic and therapeutic implications. Journal of Clinical Endocrinology and Metabolism, 88, 2087-2095.
125. Vgontzas, A. N., Zoumakis, M., Papanicolaou, D. A., Prolo, P., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2002). Chronic insomnia is associated with a shift in interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism: Clinical and Experimental, 51, 887-892.
126. Williams, E., Magid, K., & Steptoe, A. (2005). The impact of time of waking and concurrent subjective stress on the cortisol response to awakening. Psychoneuroendocrinology, 30, 139-148.
127. Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002). Cytokines and cognition: The case for a head-to-toe inflammatory paradigm. Journal of the American Geriatrics Society, 50, 2041-2056.
128. Wright, C. E., Erblich, J., Valdimarsdottir, H. B., & Bovbjerg, D. H. (2006). Poor sleep the night before an experimental stressor predicts reduced NK cell mobilization and slowed recovery in healthy women. Brain, Behavior, and Immunity, 21, 358-363.