Toxicant-induced leakage of germ cell-specific proteins from seminiferous tubules in the rat: Relationship to blood-testis barrier integrity and prospects for biomonitoring

Toxicological Sciences

Volumn 117, Issue 2, 2010, Pages 439-448

  Elkin, Naomi D ^a   Piner, Jacqui A ^b   Sharpe, Richard M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Biomarker; Blood testis barrier; Cadmium chloride; Fatty acid binding protein 9; Germ cell proteins; Testicular toxicology

Indexed keywords

1,3 DINITROBENZENE; CADMIUM CHLORIDE; CELL PROTEIN; FATTY ACID BINDING PROTEIN 9; METHOXYACETIC ACID; UNCLASSIFIED DRUG; VASA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MONITORING; BLOOD TESTIS BARRIER; CONTROLLED STUDY; GERM CELL; IMMUNOHISTOCHEMISTRY; INTERSTITIAL FLUID; MALE; NONHUMAN; PACHYTENE; PERMEABILITY BARRIER; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOCYTE; SPERMATOGENESIS; TOXICOLOGY;

ACETIC ACIDS; ANIMALS; BIOLOGICAL MARKERS; BLOOD-TESTIS BARRIER; CADMIUM CHLORIDE; DINITROBENZENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EXTRACELLULAR FLUID; FATTY ACID-BINDING PROTEINS; MALE; RATS; RATS, WISTAR; SEMINIFEROUS TUBULES; SERTOLI CELLS; SPERMATOZOA;

RATTUS;

EID: 77956933920     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq210     Document Type: Article

References (28)

1. Anderson, R. A., and Sharpe, R. M. (2000). Regulation of inhibin production in the human male and its clinical applications. Int. J. Androl. 23, 136-144.
2. Bartlett, J. M., Kerr, J. B., and Sharpe, R. M. (1988). The selective removal of pachytene spermatocytes using methoxy acetic acid as an approach to the study in vivo of paracrine interactions in the testis. J. Androl. 9, 31-40.
3. Blackburn, D. M., Gray, A. J., Lloyd, S. C., Sheard, C. M., and Foster, P. M. D. (1988). A comparison of the effects of the 3 isomers of dinitrobenzene on the testis in the rat. Toxicol. Appl. Pharmacol. 92, 54-64.
4. Creasy, D. M. (2003). Evaluation of testicular toxicology: a synopsis and discussion of the recommendations proposed by the Society of Toxicologic Pathology. Birth Defects Res. Part B Dev. Reprod. Toxicol. 68, 408-415.
5. Draper, R. P., and Timbrell, J. A. (1998). Comparison of urinary creatine with other biomarkers for detection of cadmium-induced testicular damage. Biomarkers 3, 335-346.
6. Foster, P. M. D., Creasy, D. M., Foster, J. R., and Gray, T. J. B. (1984). Testicular toxicity produced by ethylene-glycol monomethyl and monoethyl ethers in the rat. Environ. Health Perspect. 57, 207-217.
7. Foster, P. M. D., Lloyd, S. C., and Prout, M. S. (1987). Toxicity and metabolism of 1,3-dinitrobenzene in rat testicular cell-cultures. Toxicol. In Vitro 1, 31-37.
8. Furuhashi, M., and Hotamisligil, G. S. (2008). Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat. Rev. Drug Discov. 7, 489-503.
9. Hew, K. W., Heath, G. L., Jiwa, A. H., and Welsh, M. J. (1993). Cadmium in-vivo causes disruption of tight junction-associated microfilaments in rat Sertoli cells. Biol. Reprod. 49, 840-849.
10. Kido, T., Arata, S., Suzuki, R., Hosono, T., Nakanishi, Y., Miyazaki, J., Saito, I., Kuroki, T., and Shioda, S. (2005). The testicular fatty acid binding protein PERF15 regulates the fate of germ cells in PERF15 transgenic mice. Dev. Growth Differ. 47, 15-24.
11. Kido, T., and Namiki, H. (2000). Expression of testicular fatty acid-binding protein PERF 15 during germ cell apoptosis. Dev. Growth Differ. 42, 359-366.
12. Korley, R., Pouresmaeili, F., and Oko, R. (1997). Analysis of the protein composition of the mouse sperm perinuclear theca and characterization of its major protein constituent. Biol. Reprod. 57, 1426-1432.
13. Moore, N. P., Creasy, D. M., Gray, T. J. B., and Timbrell, J. A. (1992). Urinary creatine orofiles after administration of cell-specific testicular toxicants to the rat. Arch. Toxicol. 66, 435-442.
14. Mruk, D. D., and Cheng, C. Y. (2004). Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr. Rev. 25, 747-806.
15. Oko, R., and Morales, C. R. (1994). A novel testicular protein, with sequence similarities to a family of lipid binding proteins, is a major component of the rat sperm perinuclear theca. Dev. Biol. 166, 235-245.
16. Prozialeck, W. C., Edwards, J. R., Nebert, D. W., Woods, J. M., Barchowsky, A., and Atchison, W. D. (2008). The vascular system as a target of metal toxicity. Toxicol. Sci. 102, 207-218.
17. Reader, S. C. J., Shingles, C., and Stonard, M. D. (1991). Acute testicular toxicity of 1,3-dinitrobenzene and ethylene-glycol monomethyl ether in the rat-evaluation of biochemical effect markers and hormonal responses. Fundam. Appl. Toxicol. 16, 61-70.
18. Setchell, B. P., Maddocks, S., and Brooks, D. E. (1994). Anatomy, vasculature, innervation, and fluids of the male reproductive tract. In The Physiology of Reproduction, 2nd ed. (E. Knobil and J. D. Neill, Eds.), pp. 1063-1173. Raven Press, New York.
19. Setchell, B. P., and Waites, G. M. H. (1970). Changes in the permeability of the testicular capillaries and of the "blood-testis barrier" after injection of cadmium chloride in the rat. J. Endocrinol. 47, 81-86.
20. Sharpe, R. M., and Cooper, I. (1983). Testicular interstitial fluid as a monitor for changes in the intratesticular environment in the rat. J. Reprod. Fertil. 69, 125-135.
21. Sharpe, R. M., Maddocks, S., Millar, M., Kerr, J. B., Saunders, P. T., and McKinnell, C. (1992). Testosterone and spermatogenesis. Identification of stage-specific, androgen-regulated proteins secreted by adult rat seminiferous tubules. J. Androl. 13, 172-184.
22. Siu, E. R., Mruk, D. D., Porto, C. S., and Cheng, C. Y. (2009). Cadmium-induced testicular injury. Toxicol. Appl. Pharmacol. 238, 240-249.
23. Stewart, J., and Turner, K. J. (2005). Inhibin B as a potential biomarker of testicular toxicity. Cancer Biomark. 1, 75-91.
24. Suter, L., Clemann, N., Koch, E., Bobadilla, M., and Bechter, R. (1998). New and traditional approaches for the assessment of testicular toxicity. Reprod. Toxicol. 12, 39-47.
25. Tanaka, S. S., Toyooka, Y., Akasu, R., Katoh-Fukui, Y., Nakahara, Y., Suzuki, R., Yokoyama, M., and Noce, T. (2000). The mouse homolog of Drosophila Vasa is required for the development of male germ cells. Genes Dev. 14, 841-853.
26. Tarulli, G. A., Meachem, S. J., Schlatt, S., and Stanton, P. G. (2008). Regulation of testicular tight junctions by gonadotrophins in the adult Djungarian hamster in vivo. Reproduction 135, 867-877.
27. Turner, K. J., McKinnell, C., McLaren, T. T., Qureshi, S. J., Saunders, P. T., Foster, P. M., and Sharpe, R. M. (1996). Detection of germ cell-derived proteins in testicular interstitial fluid: potential for monitoring spermatogenesis in vivo. J. Androl. 17, 127-136.
28. Yan, H. H., and Cheng, C. Y. (2005). Blood-testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors. Proc. Natl. Acad. Sci. U.S.A. 102, 11722-11727.