Rat pachytene spermatocytes down-regulate a pololike kinase and up- regulate a thiol-specific antioxidant protein, whereas sertoli cells down- regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and methoxyacetic acid

Endocrinology

Volumn 139, Issue 8, 1998, Pages 3503-3511

  Syed, Viqae ^a   Hecht, Norman B ^a,b  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b Center for Research on Reproduction and Women's Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHER DERIVATIVE; METHOXYACETIC ACID;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; DOWN REGULATION; DRUG PROTEIN BINDING; MALE; MALE INFERTILITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; SERTOLI CELL; SPERMATOCYTE; TESTIS DISEASE;

EID: 0031760758     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.8.6123     Document Type: Article

References (52)

1. Hardin BD 1983 Reproductive toxicity of glycol ethers. Toxicology 27:91-102
2. Rao KS, Cobel-Geard SR, Young TJ, Hanley TR, Hayes WC, John JA, Miller RR 1983 Ethylene glycol monomethyl ether II. Reproductive and dominant lethal studies in rats. Fundam Appl Toxicol 3:80-85
3. Chapin RE, Dutton SC, Ross MD, Sumrell BM, Lamb JC 1984 The effect of ethylene glycol monomethyl ether on testicular histology. J Androl 5:369-380
4. Foster PMD, Creasy DM, Foster JR, Thomas LV, Cook MV, Gangolli SD 1983 Testicular toxicity of ethylene glycol monomethyl and monoethyl ethers in the rat. Toxicol Appl Pharmacol 69:385-399
5. Moss EJ, Thomas LV, Cook MV, Walters DG, Foster PMD, Creasy DM, Gray TJB 1985 The role of metabolism in 2 methoxyethanol-induced testicular toxicity. Toxicol Appl Pharmacol 79:480-489
6. Creasy DM, Flynn JC, Gray TJB, Butler WH 1985 A quantitative study of stage-specific spermatocyte damage following administration of ethylene glycol monomethyl ether in the rat. Exp Mol Pathol 43:321-339
7. Bartlett JMS, Kerr JB, Sharp RM 1988 The selective removal of pachytene spermatocytes using methoxyacetic acid as an approach to the study in vivo of interactions in the testis. J Androl 9:31-40
8. Sharpe RM, Bartlett JM, Allenby G 1991 Evidence for control of testicular interstitial fluid volume in the rat by specific germ cell types. J Endocrinol 128:359-367
9. Ku WW, Chapin RE 1994 Spermatocyte toxicity of 2-methoxyethanol in vivo and in vitro, requirement for an intact seminiferous tubule structure for germ cell degeneration. Toxicol In Vitro 8:1191-1202
10. Clark AM, Maguire SM, Griswold MD 1997 Accumulation of clustrin/sulfated glycoprotein-2 in degenerating pachytene spermatocytes of adult rats treated with methoxyacetic acid. Biol Reprod 57:837-846
11. Gray TJB, Moss EJ, Creasy DM, Gangolli SD 1985 Studies on the toxicity of some glycol ethers and alkoxyacetic acids in primary testicular cell cultures. Toxicol Appl Pharmacol 79:490-501
12. Cook WM, Worell NR, Gray TJB 1989 The toxicity of methoxyacetic acid (MAA) to rat pachytene spermatocytes. Toxicologist 9:66-70
13. Skinner MK 1991 Cell-cell interactions in the testis. Endocr Rev 12:45-77
14. Jegou B 1995 Current aspects of autocrine and paracrine regulation of spermatogenesis. Adv Exp Med Biol 377:67-86
15. Robinson R, Fritz IB 1981 Metabolism of glucose by Sertoli cells in culture. Biol Reprod 24:1032-1041
16. Jutte NHPM, Grootegoed JA, Rommerts FFG, Van der Molen HJ 1981 Exogenous lactate is essential for metabolic activities in isolated rat spermatocytes and spermatids. J Reprod Fertil 62:399-405
17. Jutte NHPM, Jensen R, Grootegoed JA, Rommerts FFG, Clausen OPF, Van der Molen HJ 1982 Regulation of survival of rat pachytene spermatocytes by lactate supply from Sertoli cells. J Reprod Fertil 65:431-438
18. Beattie PJ, Welsh MJ, Brabec MJ 1984 The effect of 2-methoxyethanol and methoxyacetic acid and Sertoli cells lactate production and protein synthesis in vitro. Toxicol Appl Pharmacol 76:56-61
19. Maguire SM, Millar MR, Sharpe RM, Saunder PT 1993 Stage-specific expression of mRNA for cyclic protein-2 during spermatogenesis is modulated by elongated spermatids. Mol Cell Endocrinol 94:79-88
20. Syed V, Gu W, Hecht NB 1997 Sertoli cells in culture and mRNA differential display provide a sensitive early warning assay system to detect changes induced by xenobiotics. J Androl 18:264-273
21. Syed V, Hecht NB 1997 Up-regulation and down-regulation of genes expressed in cocultures of rat Sertoli cells and germ cells. Mol Reprod Dev 47:1-10
22. Galdieri M, Ziparo E, Polombi F, Russo MA, Stefanini M 1981 Pure Sertoli cell cultures: a new model for the study of somatic germ cell interactions. J Androl 5:249-259
23. Le Magueresse B, Jegou B 1988 In vitro effects of germ cells on the secretory activities of Sertoli cells recovered from rats of different ages. Endocrinology 122:1672-1680
24. Le Magueresse B, Le Gac F, Loir M, Jegou B 1988 Stimulation of rat Sertoli cell secretory activity in vitro by germ cells and residual bodies. J Reprod Fertil 77:489-498
25. Alcivar AA, Hake LE, Millette CF, Trasler JM, Hecht NB 1989 Mitochondrial gene expression in male germ cells of the mouse. Dev Biol 135:263-271
26. Hake LE, Alcivar AA, Hecht NB 1990 Changes in mRNA length accompany translational regulation of the somatic and testicular specific cy tochrome genes during spermatogensis in the mouse. Development 110:249-257
27. Nagano K, Nakayama E, Kogano M, Oobayashi H, Adachi H, Yamada T 1979 Testicular atrophy of mice induced by ethylene glycol mono alkyl ethers. Jpn J Sangyo lgaku 21:29-35
28. Foster PMD, Lloyd SC, Blackburn DM 1987 Comparison of the in vivo and in vitro testicular effects produced by methoxy-ethoxy and N-butoxyacetic acids in the rat. Toxicology 43:17-30
29. Ku WW, Wine RN, Chac BY, Ghanayem BI, Chapin RE 1995 Spermatocyte toxicity of 2-methoxyethanol (ME) in rats and guinea pigs: evidence for the induction of apoptosis.Toxicol. Appl Pharmacol 134:100-110
30. Li LH, Wein RN, Chapin RE 1996 2-Methoxyacetic acid (MAA)-induced spermatocyte apoptosis in human and rat testes: an in vitro comparison. J Androl 17:538-549
31. Norbury C, Nurse P 1992 Animal cell cycles and their control. Annu Rev Biochem 61:441-470
32. Guan KL 1994 The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. Cell Signal 6:581-589
33. Pelech SL, Sanghera JS 1992 Mitogen-activated protein kinases: versatile transducers for cell signaling. Trends Biochem 71:233-238
34. Clay FJ, Stephan JM, Ivan B, Wilks AF, Dunn AR 1993 Identification and cloning of a protein kinase-encoding mouse gene, Plk. Proc Natl Acad Sci USA 90:4882-4886
35. Matsubara N, Yanagisawa M, Nishimune Y, Obinata M, Matsui Y 1995 Murine polo-like kinase 1 gene is expressed in meiotic testicular cells and oocytes. Mol Reprod Dev 41:407-415
36. Fenton B, Glover DM 1993 A conserved mitotic active site at late anaphasetelophase in syncytical Drosophila embryos. Nature 363:637-640
37. Sies H 1993 Strategies of antioxidant defense. Eur J Biochem 215:213-219
38. Femandaz V, Videla LA 1996 Biochemical aspects of cellular antioxidant systems. Biol Res 29:177-182
39. Gu W, Hecht NB 1996 Developmental expression of glutathione peroxidase, catalase, and manganese superoxide dismutase mRNAs during spermatogenesis in the mouse. J Androl 17:256-262
40. Gu W, Hecht NB 1997 The enzymatic activity of Cu/Zn superoxide dismutase does not fluctuate in mouse spermatogenic cells despite mRNA changes. Exp Cell Res 232:371-375
41. Piper PW, Curran B, Davies MW, Lockheart A, Reid 1986 Transcription of the phosphoglycerate kinase gene of Soccharomyces cerevisiae increases when fermentative cultures are stressed by heat-shock. Eur J Biochem 161:525-531
42. Morgan RW, Christman MF, Jacobson FS, Storz G, Ames BN 1986 Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins. Proc Natl Acad Sci USA 83:8059-8083
43. Beavo JA 1988 Multiple isozymes of cyclic nucleotide phosphodiesterase. In: Greengard P, Robison GA (eds) Raven Press, New York, vol 22:1-38
44. Swinnen JV, Joseph DR, Conti M 1989 Molecular cloning of rat homologues of the Drosophilia melanogaster dunce cAMP phosphodiesterase. evidence for a family of genes. Proc Natl Acad Sci USA 86:5325-5329
45. Geremia R, Ropssi P, Pezzotti R, Conti M 1982 Cyclic nucleotide phosphodiesterase in developing rat testis. Identification of somatic and germ cell forms. Mol Cell Endocrinol 28:37-53
46. Morena AR, Boitani C, Grossi SD, Stefanini M, Conti M 1995 Stage and cell-specific expression of adenylate 3′, 5′ monophosphate-phosphodiesterase genes in rat seminiferous epithelium. Endocrinology 136:687-695
47. Sette C, Iona S, Conti M 1994 The short-term activation of rolipram-sensitive cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by cAMP-dependent phosphorylation. J Biol Chem 269:9245-9252
48. Ishii T, Yanagawa T, Kawane T, Yuki K, Seita J, Yoshida H, Bannai S 1996 Murine peritoneal macrophages induce a novel 60 kDa protein with structural similarity to a tyrosine kinase p56-associated protein in response to oxidative stress. Biochem Biophys Res Commun 226:456-460
49. Schlessinger J 1994 SH2/SH3 signaling proteins. Curr Opin Genet Dev 4:25-30
50. Xanthopoulos KG, Mirkovitch J, Decker T, Kau CF, Damell Jr JE 1989 Cell-specific transcriprional control of the mouse DNA-binding protein mC/ EBP. Proc Natl Acad Sci USA 86:4117-4121
51. Lau LF, Nathans D 1987 Expression of a set of growth-related immediate early genes in BALB/C 3T3 cells: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci USA 84:1182-1186
52. Alcivar AA, Hake LE, Hardy MP, Hecht NB 1990 Increased levels of jun B and c jun mRNAs in male germ cells following testicular cell dissociation. Maximal stimulation in prepuberal animals. J Biol Chem 265:20160-20165