Carbocisteine protects against emphysema induced by cigarette smoke extract in rats

Chest

Volumn 139, Issue 5, 2011, Pages 1101-1108

  Hanaoka, Masayuki ^a   Droma, Yunden ^a   Chen, Yan ^a   Agatsuma, Toshihiko ^a   Kitaguchi, Yoshiaki ^a   Voelkel, Norbert F ^b   Kubo, Keishi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOCISTEINE; CASPASE 3; CIGARETTE SMOKE; GELATINASE A; GELATINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; EMPHYSEMA; ENZYME ACTIVITY; LOW DRUG DOSE; LUNG HOMOGENATE; LUNG HYPERTROPHY; LUNG INJURY; LUNG PARENCHYMA; LUNG PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RAT; TREATMENT DURATION; TUBE FEEDING;

EID: 79955758951     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.10-0920     Document Type: Article

References (29)

1. Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet. 2007;370(9589):765-773. (Pubitemid 47321908)
2. Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol. 2009;4:435-459.
3. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 2004;364(9435):709-721. (Pubitemid 39140629)
4. Churg A, Wright JL. Proteases and emphysema. Curr Opin Pulm Med. 2005;11(2):153-159. (Pubitemid 40279924)
5. Rahman I. Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms. Cell Biochem Biophys. 2005;43(1):167-188. (Pubitemid 41095282)
6. Repine JE, Bast A, Lankhorst I; Oxidative Stress Study Group. Oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1997;156(2 Pt 1):341-357. (Pubitemid 27351964)
7. Demedts IK, Demoor T, Bracke KR, Joos GF, Brusselle GG. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res. 2006;7:53.
8. Dekhuijzen PN, Aben KK, Dekker I, et al. Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1996;154(3 Pt 1):813-816. (Pubitemid 26327310)
9. Montuschi P, Kharitonov SA, Barnes PJ. Exhaled carbon monoxide and nitric oxide in COPD. Chest. 2001;120(2):496-501. (Pubitemid 32881266)
10. Yasuda H, Yamaya M, Nakayama K, et al. Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005;171(11):1246-1251. (Pubitemid 40740731)
11. Evans MD, Pryor WA. Cigarette smoking, emphysema, and damage to alpha 1-proteinase inhibitor. Am J Physiol. 1994;266(6 Pt 1):L593-L611.
12. Heffner JE, Repine JE. Pulmonary strategies of antioxidant defense. Am Rev Respir Dis. 1989;140(2):531-554. (Pubitemid 19218371)
13. Halliwell B. Antioxidants in human health and disease. Annu Rev Nutr. 1996;16:33-50. (Pubitemid 26286845)
14. Hooper C, Calvert J. The role for S-carboxymethylcysteine (carbocisteine) in the management of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008;3(4):659-669.
15. Pinamonti S, Venturoli L, Leis M, et al. Antioxidant activity of carbocysteine lysine salt monohydrate. Panminerva Med. 2001;43(3):215-220. (Pubitemid 33642146)
16. Nogawa H, Ishibashi Y, Ogawa A, et al. Carbocisteine can scavenge reactive oxygen species in vitro. Respirology. 2009;14(1):53-59.
17. Yoshida M, Nakayama K, Yasuda H, et al. Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells. Respirology. 2009;14(7):1027-1034.
18. Chen Y, Hanaoka M, Chen P, Droma Y, Voelkel NF, Kubo K. Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema. Am J Physiol Lung Cell Mol Physiol. 2009;296(4):L648-L656.
19. Ishibashi Y, Okamura T, Masumoto Y, Tachiiri T, Momo K. Effects of carbocisteine on airway inflammation and related events in SO2-exposed rats [in Japanese]. Nihon Kokyuki Gakkai Zasshi. 2001;39(1):17-23.
20. Ishibashi Y, Kobayashi F, Idesawa A, Taniguchi A, Matsuzawa S. Effects of carbocisteine on altered activities of glycosidase and glycosyltransferase and expression of Muc5ac in SO2- exposed rats. Eur J Pharmacol. 2004;487(1-3):7-15. (Pubitemid 38368977)
21. Saetta M, Shiner RJ, Angus GE, et al. Destructive index: a measurement of lung parenchymal destruction in smokers. Am Rev Respir Dis. 1985;131(5):764-769. (Pubitemid 15066865)
22. van Antwerpen L, Theron AJ, Myer MS, et al. Cigarette smoke-mediated oxidant stress, phagocytes, vitamin C, vitamin E, and tissue injury. Ann N Y Acad Sci. 1993;686:53-65. (Pubitemid 23204415)
23. Slater AF, Nobel CS, Orrenius S. The role of intracellular oxidants in apoptosis. Biochim Biophys Acta. 1995;1271(1):59-62.
24. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apop tosis. Cell. 1993;75(2):241-251. (Pubitemid 23320288)
25. Zheng JP, Kang J, Huang SG, et al. Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study. Lancet. 2008;371(9629):2013-2018. (Pubitemid 351799858)
26. Yasuda H, Yamaya M, Sasaki T, et al. Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease. J Am Geriatr Soc. 2006;54(2):378-380.
27. Brandolini L, Allegretti M, Berdini V, et al. Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs). Eur Cytokine Netw. 2003;14(1):20-26. (Pubitemid 36683627)
28. Garavaglia ML, Bononi E, Dossena S, et al. S-CMC-Lys protective effects on human respiratory cells during oxidative stress. Cell Physiol Biochem. 2008;22(5-6):455-464.
29. Stockley RA. alpha-1-antitrypsin and the pathogenesis of emphysema. Lung. 1987;165(2):61-77.