Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells

Respirology

Volumn 14, Issue 7, 2009, Pages 1027-1034

  Yoshida, Motoki ^a   Nakayama, Katsutoshi ^b   Yasuda, Hiroyasu ^c   Kubo, Hiroshi ^b   Kuwano, Kazuyoshi ^b   Arai, Hiroyuki ^a   Yamaya, Mutsuo ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Antioxidant; Apoptosis; Chronic obstructive pulmonary disease; Emphysema; Infection and inflammation; Mucolytic

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CARBOCISTEINE; CASPASE 3; CASPASE 9; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; PROTEIN KINASE B; WORTMANNIN;

AGED; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY EPITHELIUM; TRACHEA MUCOSA; WESTERN BLOTTING;

APOPTOSIS; CARBOCYSTEINE; CASPASE 3; CASPASE 9; CELLS, CULTURED; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPECTORANTS; HUMANS; HYDROGEN PEROXIDE; PROTO-ONCOGENE PROTEINS C-AKT; RESPIRATORY MUCOSA; TIME FACTORS; TRACHEA;

EID: 70049107547     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2009.01594.x     Document Type: Article

References (39)

1. Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of n-acetylcysteine actions. Cell. Mol. Life Sci. 2003 60 : 6 20.
2. Balansky RB, D'Agostini F, Zanacchi P, De Flora S. Protection by N-acetylcysteine of the histopathological and cytogenetical damage produced by exposure of rats to cigarette smoke. Cancer Lett. 1992 64 : 123 131.
3. Hauber HP, Goldmann T, Vollmer E, Wollenberg B, Zabel P. Effect of dexamethasone and ACC on bacteria-induced mucin expression in human airway mucosa. Am. J. Respir. Cell Mol. Biol. 2007 37 : 606 616.
4. Demedts M, Behr J, Buhl R, Costabel U, Dekhuijzen R et al. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N. Engl. J. Med. 2005 353 : 2229 2242.
5. British Thoracic Society Research Committee. Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airway obstruction. Thorax 1985 40 : 832 835.
6. Decramer M, Rutten-van Molken M, Dekhuijzen PN, Troosters T, van Herwaarden C et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet 2005 365 : 1552 1560. (Pubitemid 40615404)
7. Sakakura Y, Majima Y, Saida S, Ukai K, Miyoshi Y. Reversibility of reduced mucociliary clearance in chronic sinusitis. Clin. Otolaryngol. Alli. Sci. 1985 10 : 79 83.
8. Ishii Y, Kimura T, Morishima Y, Mochizuki M, Nomura A et al. S-carboxymethylcysteine inhibits neutrophil activation mediated by N-formyl-methionyl-leucyl-phenylalanine. Eur. J. Pharmacol. 2002 449 : 183 189.
9. Yasuda H, Yamaya M, Sasaki T, Inoue D, Nakayama K et al. Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells. Eur. Respir. J. 2006 28 : 51 8.
10. Sueyoshi S, Miyata Y, Masumoto Y, Ishibashi Y, Matsuzawa S et al. Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide. Int. Arch. Allergy Immunol. 2004 134 : 273 280.
11. Yang B, Yao DF, Ohuchi M, Ide M, Yano M et al. Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. Eur. Respir. J. 2002 19 : 952 958.
12. Zheng JP, Kang J, Huang SG, Chen P, Yao WZ et al. Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study. Lancet 2008 371 : 2013 2018.
13. Sethi S. New developments in the pathogenesis of acute exacerbations of chronic obstructive pulmonary disease. Curr. Opin. Infect. Dis. 2004 17 : 113 119.
14. Tao F, Gonzalez-Flecha B, Kobzik L. Reactive oxygen species in pulmonary inflammation by ambient particulates. Free Radic. Biol. Med. 2003 35 : 327 340.
15. Dekhuijzen PN, Aben KK, Dekker I, Aarts LP, Wielders PL et al. Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1996 154 : 813 816.
16. Montuschi P, Kharitonov SA, Barnes PJ. Exhaled carbon monoxide and nitric oxide in COPD. Chest 2001 120 : 496 501.
17. Yasuda H, Yamaya M, Nakayama K, Ebihara S, Sasaki T et al. Increased arterial carboxyhemoglobin concentrations in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2005 171 : 1246 1251.
18. Yasuda H, Yamaya M, Sasaki T, Inoue D, Nakayama K et al. Carbocisteine reduces frequency of common colds and exacerbations in COPD patients. J. Am. Geriatr. Soc. 2006 54 : 378 380.
19. Brandolini L, Allegretti M, Berdini V, Cervellera MN, Mascagni P et al. Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs). Eur. Cytokine Netw. 2003 14 : 20 6.
20. Yamaya M, Finkbeiner WE, Chun SY, Widdicombe JH. Differentiated structure and function of cultures from human tracheal epithelium. Am. J. Physiol. 1992 262 : L713 24.
21. Nakajoh M, Fukushima T, Suzuki T, Yamaya M, Nakayama K et al. Retinoic acid inhibits elastase-induced injury in human lung epithelial cells. Am. J. Respir. Cell Mol. Biol. 2003 28 : 296 304.
22. Fortenberry JD, Owens ML, Brown LA. S-nitrosoglutathione enhances neutrophil DNA fragmentation and cell death. Am. J. Physiol. 1999 276 : L435 42.
23. Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T et al. NF-kB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 2003 22 : 3898 3909.
24. Hughes G, Murphy MP, Ledgerwood EC. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. Biochem. J. 2005 389 : 83 9.
25. Amador E, Dorfman LE, Wacker EC. Serum lactic dehydrogenase activity: an analytical assessment of current assays. Clin. Chem. 1963 9 : 391 399.
26. Pinamonti S, Venturoli L, Leis M, Chicca M, Barbieri A et al. Antioxidant activity of carbocysteine lysine salt monohydrate. Panminerva Med. 2001 43 : 215 220.
27. Gillissen A, Nowak D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy. Respir. Med., 1998 92, 609 623.
28. Nogawa H, Ishibashi Y, Ogawa A, Masuda K, Tsubuki T et al. Carbocisteine can scavenge reactive oxygen species in vitro. Respirology 2009 14 : 53 9.
29. Ishiura Y, Fujimura M, Yamamori C, Nobata K, Myou S et al. Effect of carbocysteine on cough reflex to capsaicin in asthmatic patients. Br. J. Clin. Pharmacol. 2003 55 : 504 510.
30. Bylin G, Hendenstierna G, Lagerstrand L, Wagner PD. No influence of acetylcysteine on gas exchange and spirometry in chronic asthma. Eur. J. Respir. Dis. 1987 71 : 102 107.
31. Zhuang S, Yan Y, Daubert RA, Han J, Schnellmann RG. ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Am. J. Physiol. Ren. Physiol. 2007 292 : F440 7.
32. Zhang H, Forman HJ. Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 2008 38 : 483 490.
33. Yang JY, Michod D, Walicki J, Widmann C. Surviving the kiss of death. Biochem. Pharmacol. 2004 68 : 1027 1031.
34. Verma A, Mehta K. Tissue transglutaminase-mediated chemoresistance in cancer cells. Drug Resist. Updat. 2007 10 : 144 151. (Pubitemid 47446401)
35. Inoue A, Muranaka S, Fujita H, Kanno T, Tamai H et al. Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. Free Radic. Biol. Med. 2004 37. 1290 1299.
36. Smyrniotis V, Arkadopoulos N, Kostopanagiotou G, Theodoropoulos T, Theodoraki K et al. Attenuation of ischemic injury by N-acetylcysteine preconditioning of the liver. J. Surg. Res. 2005 129 : 31 7.
37. Guizzardi F, Rodighiero S, Binelli A, Saino S, Bononi E et al. S-CMC-Lys-dependent stimulation of electrogenic glutathione secretion by human respiratory epithelium. J. Mol. Med. 2006 84 : 97 107.
38. Mantovani G, Maccio A, Madeddu C, Gramignano G, Lusso MR et al. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol. Biomarkers Prev. 2006 15 : 1030 1034.
39. Takano T, Sada K, Yamamura H. Role of protein-tyrosine kinase syk in oxidative stress signaling in B cells. Antioxid. Redox Signal. 2002 4 : 533 541. (Pubitemid 34753393)