S-CMC-Lys protective effects on human respiratory cells during oxidative stress

Cellular Physiology and Biochemistry

Volumn 22, Issue 5-6, 2008, Pages 455-464

  Garavaglia, Maria Lisa ^a   Bononi, Elena ^a   Dossena, Silvia ^b   Mondini, Anna ^a   Bazzini, Claudia ^a   Lanata, Luigi ^c   Balsamo, Rossella ^c   Bagnasco, Michela ^c   Conese, Massimo ^d   Bottà, Guido ^a   Paulmichl, Markus ^b   Meyer, Giuliano ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b PARACELSUS MEDICAL UNIVERSITY   (Austria)

^c Chemistry Section   (Italy)

^d UNIVERSITY OF FOGGIA   (Italy)

Author keywords

CFTR; Glutathione; Oxidative stress; S carbocysteine lysine salt monohydrate

Indexed keywords

CARBOCISTEINE; CARBOCYSTEINE LYSINE SALT MONOHYDRATE; CHLORIDE; GLUTATHIONE; HYDROXYL RADICAL; REACTIVE OXYGEN METABOLITE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL PROTECTION; CELL STIMULATION; CELL STRESS; CHLORIDE CURRENT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLUOROMETRY; HUMAN; HUMAN CELL; ION CURRENT; LUNG ALVEOLUS CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; WHOLE CELL;

EID: 57649202581     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000185494     Document Type: Article

References (40)

1. Braga PC, Allegra L, Rampoldi C, Ornaghi A, Beghi G: Long-lasting effects on rheology and clearance of bronchial mucus after short-term administration of high doses of carbocysteine-lysine to patients with chronic bronchitis. Respiration 1990;57:353-358.
2. Macnee W, Rahman I: Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999;160:S58-S65.
3. Asti C, Melillo G, Caselli GF, Daffonchio L, Hernandez A, Clavenna G, Omini C: Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness. Pharmacol Res 1995;31:387-392.
4. Carpagnano GE, Resta O, Foschino-Barbaro MP, Spanevello A, Stefano A, Di GG, Serviddio G, Gramiccioni E: Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys). Eur J Pharmacol 2004;505:169-175.
5. Pinamonti S, Venturoli L, Leis M, Chicca M, Barbieri A, Sostero S, Ravenna F, Daffonchio L, Novellini R, Ciaccia A: Antioxidant activity of carbocysteine lysine salt monohydrate. Panminerva Med 2001;43:215-220.
6. Brandolini L, Allegretti M, Berdini V, Cervellera MN, Mascagni P, Rinaldi M, Melillo G, Ghezzi P, Mengozzi M, Bertini R: Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (rois). Eur Cytokine Netw 2003;14:20-26.
7. Guizzardi F, Rodighiero S, Binelli A, Saino S, Bononi E, Dossena S, Garavaglia ML, Bazzini C, Botta G, Conese M, Daffonchio L, Novellini R, Paulmichl M, Meyer G: S-CMC-Lys-dependent stimulation of electrogenic glutathione secretion by human respiratory epithelium. J Mol Med 2006;84:97-107.
8. Rahman I, macnee W: Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic Biol Med 2000;28:1405-1420.
9. Meyer G, Doppierio S, Daffonchio L, Cremaschi D: S-carbocysteine-lysine salt monohydrate and camp cause non-additive activation of the cystic fibrosis transmembrane regulator channel in human respiratory epithelium. FEBS Lett 1997;404:11-14.
10. Yoshimura K, Nakamura H, Trapnell BC, Chu CS, Dalemans W, Pavirani A, Lecocq JP, Crystal RG: Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin. Nucleic Acids Res 1991;19:5417-5423.
11. Yankaskas JR, Haizlip JE, Conrad M, Koval D, Lazarowski E, Paradiso AM, Rinehart CA, Jr., Sarkadi B, Schlegel R, Boucher RC: Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype. Am J Physiol 1993;264:C1219-C1230.
12. Olsen JC, Johnson LG, Stutts MJ, Sarkadi B, Yankaskas JR, Swanstrom R, Boucher RC: Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer. Hum Gene Ther 1992;3:253-266.
13. Becq F, Jensen TJ, Chang XB, Savoia A, Rommens JM, Tsui LC, Buchwald M, Riordan JR, Hanrahan JW: Phosphatase inhibitors activate normal and defective CFTR chloride channels. Proc Natl Acad Sci U S A 1994;91:9160-9164.
14. Becq F: Ionic channel rundown in excised membrane patches. Biochim Biophys Acta 1996;1286:53-63.
15. Luo J, Pato MD, Riordan JR, Hanrahan JW: Differential regulation of single CFTR channels by PP2C, PP2A, and other phosphatases. Am J Physiol 1998;274:C1397-C1410.
16. Graf E, Mahoney JR, Bryant RG, Eaton JW: Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. J Biol Chem 1984;259:3620-3624.
17. Jeulin C, Fournier J, Marano F, Dazy AC: Effects of hydroxyl radicals on outwardly rectifying chloride channels in a cultured human bronchial cell line (16HBE 14o-). Pflugers Arch 2000;439:331-338.
18. Rojanasakul Y, Wang L, Hoffman AH, Shi X, Dalal NS, Banks DE, Ma JK: Mechanisms of hydroxyl free radical-induced cellular injury and calcium overloading in alveolar macrophages. Am J Respir Cell Mol Biol 1993;8:377-383.
19. Fernandez-Checa JC, Kaplowitz N: The use of monochlorobimane to determine hepatic GSH levels and synthesis. Anal Biochem 1990;190:212-219.
20. Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB: CFTR inhibition mimics the cystic fibrosis inflammatory profile. Am J Physiol Lung Cell Mol Physiol 2007;292:L383-L395.
21. Shanker G, Aschner JL, Syversen T, Aschner M: Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury. Brain Res Mol Brain Res 2004;128:48-57.
22. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS: Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest 2002;110:1651-1658.
23. Rahman I, Biswas SK, Kode A: Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol 2006;533:222-239.
24. Cantin AM, Bilodeau G, Ouellet C, Liao J, Hanrahan JW: Oxidant stress suppresses CFTR expression. Am J Physiol Cell Physiol 2006;290:C262-C270.
25. Cowley EA, Linsdell P: Oxidant stress stimulates anion secretion from the human airway epithelial cell line Calu-3: implications for cystic fibrosis lung disease. J Physiol 2002;543:201-209.
26. Jeulin C, Guadagnini R, Marano F: Oxidant stress stimulates Ca2+-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells. Am J Physiol Lung Cell Mol Physiol 2005;289:L636-L646.
27. Jiao JD, Xu CQ, Yue P, Dong DL, Li Z, Du ZM, Yang BF: Volume-sensitive outwardly rectifying chloride channels are involved in oxidative stress-induced apoptosis of mesangial cells. Biochem Biophys Res Commun 2006;340:277-285.
28. Kourie JI: Interaction of reactive oxygen species with ion transport mechanisms. Am J Physiol 1998;275:C1-24.
29. Shimizu T, Numata T, Okada Y: A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel. Proc Natl Acad Sci U S A 2004;101:6770-6773.
30. Uc A, Reszka KJ, Buettner GR, Stokes JB: Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes. Am J Physiol Cell Physiol 2007;292:C1906-C1914.
31. Weng TX, Godley BF, Jin GF, Mangini NJ, Kennedy BG, Yu AS, Wills NK: Oxidant and antioxidant modulation of chloride channels expressed in human retinal pigment epithelium. Am J Physiol Cell Physiol 2002;283:C839-C849.
32. Kottgen M, Busch AE, Hug MJ, Greger R, Kunzelmann K: N-Acetyl-L-cysteine and its derivatives activate a Cl- conductance in epithelial cells. Pflugers Arch 1996;431:549-555.
33. Soodvilai S, Jia Z, Yang T: Hydrogen peroxide stimulates chloride secretion in primary inner medullary collecting duct cells via mpges-1-derived PGE2. Am J Physiol Renal Physiol 2007;293:F1571-F1576.
34. Blouquit-Laye S, Chinet T: Ion and liquid transport across the bronchiolar epithelium. Respir Physiol Neurobiol 2007;159:278-282.
35. Adler KB, Holden-Stauffer WJ, Repine JE: Oxygen metabolites stimulate release of high-molecular-weight glycoconjugates by cell and organ cultures of rodent respiratory epithelium via an arachidonic acid-dependent mechanism. J Clin Invest 1990;85:75-85.
36. Rahman I, Mulier B, Gilmour PS, Watchorn T, Donaldson K, Jeffery PK, Macnee W: Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappab. Biochem Pharmacol 2001;62:787-794.
37. Sadowska AM, Manuel YK, De Backer WA: Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm Pharmacol Ther 2007;20:9-22.
38. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND: Glutathione metabolism and its implications for health. J Nutr 2004;134:489-492.
39. Cantin AM, White TB, Cross CE, Forman HJ, Sokol RJ, Borowitz D: Antioxidants in cystic fibrosis. Conclusions from the CF antioxidant workshop, Bethesda, Maryland, November 11-12, 2003. Free Radic Biol Med 2007;42:15-31.
40. Velsor LW, Kariya C, Kachadourian R, Day BJ: Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. Am J Respir Cell Mol Biol 2006;35:579-586.