Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2

Journal of Cancer Research and Clinical Oncology

Volumn 137, Issue 5, 2011, Pages 779-787

  Kitagawa, Junichi ^a   Hara, Takeshi ^a   Tsurumi, Hisashi ^a   Ninomiya, Soranobu ^a   Ogawa, Kengo ^a   Adachi, Seiji ^a   Kanemura, Nobuhiro ^a   Kasahara, Senji ^a   Shimizu, Masahito ^a   Moriwaki, Hisataka ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

Apoptosis; HL 60; p RXR ; Retinoic acid (RA); Vitamin K2 (VK2)

Indexed keywords

FARNOQUINONE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; PERETINOIN; RETINOID X RECEPTOR ALPHA;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; DRUG SYNERGISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HL-60 CELLS; HUMANS; RETINOID X RECEPTOR ALPHA; RETINOIDS; VITAMIN K 2;

EID: 79955703348     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-010-0938-0     Document Type: Article

References (37)

1. Adachi S, Okuno M, Matsushima-Nishiwaki R, Takano Y, Kojima S, Friedman SL, Moriwaki H, Okano Y (2002) Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma. Hepatology 35:332-340 (Pubitemid 34106372)
2. Altucci L, Gronemeyer H (2001) The promise of retinoid to fight against cancer. Nat Rev Cancer 1:181-193 (Pubitemid 33741893)
3. Breitman TR, Selonick SE, Collins SJ (1980) Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA 77:2936-2940 (Pubitemid 10049852)
4. Chmbon P (1996) A decade of molecular biology of retinoid acid receptors. Faseb J 10:940-954
5. Collins SJ, Robertson KA, Mueller L (1990) Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha). Mol Cel Biol 10:2154-2163
6. Dean PN, Dolbeare F, Grantzer H, Rice GC, Gray JW (1984) Cellcycle analysis using a monoclonal antibody to BrdUrd. Cell Tissue Kinet 17:427-436 (Pubitemid 14051025)
7. Fujita H, Tomiyama J, Tanaka T (1998) Vitamin K2 combined with all-trans retinoic acid induced complete remission of relapsing acute promyelocytic leukemia. Br J Haematol 103:584-585
8. Hitomi M, Yokoyama F, Mita Y, Nonomura T, Masaki T, Yoshiji H, Inoue H, Kinikawa F, Kurokohchi K, Uchida N, Watanabe S, Kuriyama S (2005) Antitumor effects of vitamins K1, K2, and K3 on hepatocellular carcinoma in vitro and in vivo. Int J Oncol 26:713-720
9. Kanamori T, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Tsurumi H, Kojima S, Moriwaki H (2007) Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells. Cancer Sci 98:431-437 (Pubitemid 46195617)
10. Kanemura N, Tsurumi H, Okuno M, Matsushima-Nishiwaki R, Shimizu M, Moriwaki H (2008) Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells. Leuk Res 32:884-892
11. Kuriyama S, Hitomi M, Yoshiji H, Nonomura T, Tsujimoto T, Mitoro A, Akahane T, Ogawa M, Nakai S, Deguchi A, Masaki T, Uchida N (2005) Vitamins K2, K3, and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules. Int J Oncol 27:505-511
12. Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y (1996) Aberrant metabolism of retinoid X receptor proteins in human hepatocellular carcinoma. Mol Cell Endocrinol 121:179-190 (Pubitemid 26394727)
13. Matsushima-Nishiwaki R, Okuno M, Adachi S, Sano T, Akita K, Moriwaki H, Friedman SL, Kojima S (2001) Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res 61:7675-7682 (Pubitemid 32995065)
14. Matsushima-Nishiwaki R, Okuno M, Takano Y, Kojima S, Friedman SL, Moriwaki H (2003) Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid. Carcinogenesis 24:1353-1359 (Pubitemid 37038825)
15. Mehta K, McQueen T, Neamati N, Collins S, Andreeff M (1996) Activation of retinoid receptors RAR alpha and RXR alpha induces differentiation and apoptosis, respectively, in HL-60 cells. Cell Growth Differ 7:179-186 (Pubitemid 26049826)
16. Miyazawa K, Nishimaki J, Ohyashiki K, Enomoto S, Kuriya S, Fukuda R, Hotta T, Teramura M, Mizoguchi H, Uchiyama T, Omine M (2000) Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-center pilot studies in Japan. Leukemia 14:1156-1157 (Pubitemid 30389524)
17. Miyazawa K, Yaguchi M, Funato K, Gotoh A, Kawanishi Y, Nishizawa Y, You A, Ohyashiki K (2001) Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells. Leukemia 15:1111-1117 (Pubitemid 32717282)
18. Mizuta T, Ozaki I, Eguchi Y, Yasutake T, Kawazoe S, Fujimoto K, Yamamoto K (2006) The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study. Cancer 106:867-872 (Pubitemid 43238454)
19. Muto Y, Moriwaki H (1984) Antitumor activity of vitamin A and its derivatives. J Natl Cancer Inst 73:1389-1393 (Pubitemid 15243582)
20. Muto Y, Moriwaki H, Ninomiya M, Adachi S, Saito A, Takasaki KT, Tanaka T, Tsurumi K, Okuno M, Tomita E, Nakamura T, Kojima T (1996) Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. N Engl J Med 334:1561-1567 (Pubitemid 26177483)
21. Muto Y, Moriwaki H, Saito A (1999) Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. N Engl J Med 340:1046-1047 (Pubitemid 29157643)
22. Nagy L, Thomazy VA, Shipley GL, Fresus L, Lamph W, Heyman RA, Chandraratna RA, Davies PJ (1995) Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. Mol Cell Biol 15:3540-3551
23. Nakamura N, Shidoji Y, Yamada Y, Hatakeyama H, Moriwaki H, Muto Y (1995) Induction of apoptosis by acyclic retinoid in the human hepatoma-derived cell line, HuH-7. Biochem Biophy Res Commun 207:382-388
24. Sakai I, Hashimoto S, Yoda M, Hida T, Ohsawa S, Nakajo S, Nakaya K (1994) Novel role of vitamin K2: a potent inducer of differentiation of various human myeloid leukemia cell lines. Biochem Biophys Res Commun 205:1305-1310
25. Shimizu M, Suzui M, Deguchi A, Lim JT, Xiao D, Hayes JH, Papadopoulos KP, Weinstein IB (2004) Synergistic effect of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells. Clin Cancer 10:6710-6721 (Pubitemid 39346569)
26. Soriano AF, Helfrich B, Chan DC, Heasley LE, Bunn PA, Chou JR (1999) Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Cancer Res 59:6178-6184 (Pubitemid 30035640)
27. Suzui M, Masuda M, Lim JT, Albanese C, Pestell RG, Weinstein IB (2002) Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21 (CIP1) and inhibition of expression of cyclin D1. Cancer Res 62:3997-4006 (Pubitemid 34791066)
28. Takai K, Okuno M, Yasuda L, Matsushima-Nishiwaki R, Uematsu T, Tsurumi H, Shiratori Y, Muto Y, Moriwaki H (2005) Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. Updated analysis of the long-term follow-up data. Intervirology 48:39-45 (Pubitemid 40529209)
29. Takami A, Nakao S, Ontachi Y, Yamauchi H, Matsuda T (1999) Successful therapy of myelodysplastic syndrome with menatetrenone, a vitamin K2 analog. Int J Hematol 69:24-26
30. Tsurumi H, Tojo A, Takahashi T, Ozawa K, Moriwaki H, Asano S, Muto Y (1993) Differentiation induction of human promyelocytic leukemia cells by acyclic retinoid (polyprenoic acid). Int J Hematol 59:9-15 (Pubitemid 24033345)
31. van den Eijnde SM, Luijsterburg AJ, Boshart L, De Zeeuw CI, van Dierendonck JH, Reutelingsperger CP, Vermeji-Keers C (1997) In situ detection of apoptosis during embryogenesis with annexin V: from whole mount to ultrastructure. Cytometry 29:313-320
32. Watanabe M, Hitomi M, van der Wee K, Rothenberg F, Fisher SA, Zucker R, Svoboda KK, Goldsmith EC, Heiskanen KM, Nieminen AL (2002) The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs. Microsc Microanal 8:375-391 (Pubitemid 35456712)
33. Yaguchi M, Miyazawa K, Katagiri T, Nishimaki J, Kizaki M, Tohyama K, Toyama K (1997) Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of alltrans retinoic acid. Leukemia 11:779-787 (Pubitemid 27279724)
34. Yaguchi M, Miyazawa K, Otawa M, Katagiri T, Nishiwaki J, Ushida Y, Iwase O, Gotoh A, Kawanishi Y, Toyama K (1998) Vitamin K2 selectively induces apoptosis of blastic cells in myelodysplastic syndrome: flow cytometric detection of apoptotic cells using APO2.7 monoclonal antibody. Leukemia 12:1392-1397 (Pubitemid 28442385)
35. Yaguchi M, Miyazawa K, Otawa M, Ito Y, Kawanishi Y, Toyama K (1999) Vitamin K2 therapy for a patient with myelodysplastic syndrome. Leukemia 13:144-145 (Pubitemid 29043731)
36. Yamazaki K, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Kanemura N, Araki H, Tsurumi H, Kojima S, Weinstein IB, Moriwaki H (2007) Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells - phosphorylated RXR alpha is a critical target for colon cancer management. Gut 56:1557-1563 (Pubitemid 350033194)
37. Yasuda I, Shiratori Y, Adachi S, Obora A, Takemura M, Okuno M, Shidoji Y, Seishima M, Muto Y, Moriwaki H (2002) Acyclic retinoid induces partial differentiation, down-regulates telomerase reverse transcriptase mRNA expression and telomerase activity, and induces apoptosis in human hepatoma-derived cell lines. J Hepatol 36:660-671 (Pubitemid 34499404)