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Volumn 23, Issue 6, 2009, Pages 489-499

Oral antiplatelet therapy for acute and chronic management of NSTE ACS: residual ischemic risk and opportunities for improvement

Author keywords

Antiplatelet therapy. PAR 1; Bleeding; Non ST segment elevation acute coronary syndromes; Percutaneous coronary intervention

Indexed keywords

3A,4,4A,5,6,7,8,8A,9,9A DECAHYDRO N [4 [2 [5 (3 FLUOROPHENYL) 2 PYRIDYL]VINYL] 3 METHYL 1 OXO 3H BENZO[F]ISOBENZOFURAN 7 YL]CARBAMIC ACID ETHYL ESTER; ACETYLSALICYLIC ACID; CLOPIDOGREL; E 5555; HEPARIN; HIRULOG; OMEPRAZOLE; PLACEBO; PRASUGREL; PROTEINASE ACTIVATED RECEPTOR 1; PURINERGIC P2Y12 RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR BLOCKING AGENT; THROMBIN; THROMBIN RECEPTOR ANTAGONIST; TICAGRELOR; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; PURINERGIC P2 RECEPTOR; THROMBIN RECEPTOR;

EID: 77649198522     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-009-6204-5     Document Type: Review
Times cited : (7)

References (72)
  • 1
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119:e21-e181.
    • (2009) Circulation , vol.119
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3
  • 2
    • 21544467275 scopus 로고    scopus 로고
    • Pathophysiology of coronary artery disease
    • Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation. 2005;111:3481-3488
    • (2005) Circulation , vol.111 , pp. 3481-3488
    • Libby, P.1    Theroux, P.2
  • 3
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357:2482-2494
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Davi, G.1    Patrono, C.2
  • 4
    • 65849268320 scopus 로고    scopus 로고
    • Aspirin in the primary and secondary prevention of vascular disease: Collaborative metaanalysis of individual participant data from randomised trials
    • Baigent C, Blackwell L, Collins R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative metaanalysis of individual participant data from randomised trials. Lancet. 2009;373:1849-1860
    • (2009) Lancet , vol.373 , pp. 1849-1860
    • Baigent, C.1    Blackwell, L.2    Collins, R.3
  • 6
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494-502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 7
    • 0036660207 scopus 로고    scopus 로고
    • Thrombin functions during tissue factor-induced blood coagulation
    • Brummel KE, Paradis SG, Butenas S, Mann KG. Thrombin functions during tissue factor-induced blood coagulation. Blood. 2002;100:148-152
    • (2002) Blood , vol.100 , pp. 148-152
    • Brummel, K.E.1    Paradis, S.G.2    Butenas, S.3    Mann, K.G.4
  • 8
    • 0141707881 scopus 로고    scopus 로고
    • Thrombin formation
    • Mann KG. Thrombin formation. Chest. 2003;124:4S-10S.
    • (2003) Chest , vol.124
    • Mann, K.G.1
  • 9
    • 50449089925 scopus 로고    scopus 로고
    • Use of and inhospital outcomes after early clopidogrel therapy in patients not undergoing an early invasive strategy for treatment of non-ST-segment elevation myocardial infarction
    • Results from Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the American College of Cardiology/American Heart Association guidelines (CRUSADE)
    • Alexander D, Ou FS, Roe MT, et al. Use of and inhospital outcomes after early clopidogrel therapy in patients not undergoing an early invasive strategy for treatment of non-ST-segment elevation myocardial infarction: results from Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the American College of Cardiology/American Heart Association guidelines (CRUSADE). Am Heart J. 2008;156:606-612
    • (2008) Am Heart J , vol.156 , pp. 606-612
    • Alexander, D.1    Ou, F.S.2    Roe, M.T.3
  • 10
    • 34247854930 scopus 로고    scopus 로고
    • Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006
    • Fox KA, Steg PG, Eagle KA, et al. Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. JAMA. 2007;297:1892-1900
    • (2007) JAMA , vol.297 , pp. 1892-1900
    • Fox, K.A.1    Steg, P.G.2    Eagle, K.A.3
  • 11
    • 33749547685 scopus 로고    scopus 로고
    • Recent trends in the care of patients with non-ST-segment elevation acute coronary syndromes: Insights from the CRUSADE initiative
    • Mehta RH, Roe MT, Chen AY, et al. Recent trends in the care of patients with non-ST-segment elevation acute coronary syndromes: insights from the CRUSADE initiative. Arch Intern Med. 2006;166:2027-2034
    • (2006) Arch Intern Med , vol.166 , pp. 2027-2034
    • Mehta, R.H.1    Roe, M.T.2    Chen, A.Y.3
  • 12
    • 0022375287 scopus 로고
    • Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial
    • Cairns JA, Gent M, Singer J, et al. Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial. N Engl J Med. 1985;313:1369-1375
    • (1985) N Engl J Med , vol.313 , pp. 1369-1375
    • Cairns, J.A.1    Gent, M.2    Singer, J.3
  • 13
    • 0020528647 scopus 로고
    • Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina
    • Results of a Veterans Administration Cooperative Study
    • Lewis HD Jr, Davis JW, Archibald DG, et al. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study. N Engl J Med. 1983;309:396-403.
    • (1983) N Engl J Med , vol.309 , pp. 396-403
    • Lewis Jr., H.D.1    Davis, J.W.2    Archibald, D.G.3
  • 14
    • 0025090942 scopus 로고
    • Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease
    • The RISC Group
    • The RISC Group. Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet. 1990;336:827-830
    • (1990) Lancet , vol.336 , pp. 827-830
  • 15
    • 34547655744 scopus 로고    scopus 로고
    • ACC/AHA 2007 guidelines for the management of patients with unstable angina/ non-ST-Elevation myocardial infarction
    • a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
    • Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/ non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol. 2007;50:e1-e157.
    • (2007) J Am Coll Cardiol , vol.50
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3
  • 16
    • 34547772153 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes
    • Bassand JP, Hamm CW, Ardissino D, et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J. 2007;28:1598-1660
    • (2007) Eur Heart J , vol.28 , pp. 1598-1660
    • Bassand, J.P.1    Hamm, C.W.2    Ardissino, D.3
  • 18
    • 0141919739 scopus 로고    scopus 로고
    • Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: Observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study
    • Peters RJ, Mehta SR, Fox KA, et al. Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Circulation. 2003;108:1682-1687
    • (2003) Circulation , vol.108 , pp. 1682-1687
    • Peters, R.J.1    Mehta, S.R.2    Fox, K.A.3
  • 19
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative metaanalysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Antithrombotic Trialists' Collaboration
    • Antithrombotic Trialists' Collaboration. Collaborative metaanalysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324:71-86.
    • (2002) BMJ , vol.324 , pp. 71-86
  • 20
    • 77951023316 scopus 로고    scopus 로고
    • CURRENT OASIS 7: A 2×2 factorial randomized trial of optimal clopidogrel and aspirin dosing in patients with ACS undergoing an early invasive strategy with intent for PCI
    • Presented at: August 29-September 2, Barcelona, Spain
    • Mehta SR. CURRENT OASIS 7: a 2×2 factorial randomized trial of optimal clopidogrel and aspirin dosing in patients with ACS undergoing an early invasive strategy with intent for PCI. Presented at: European Society of Cardiology (ESC) 2009 Congress. August 29-September 2, 2009. Barcelona, Spain.
    • (2009) European Society of Cardiology (ESC) 2009 Congress
    • Mehta, S.R.1
  • 21
    • 0020692577 scopus 로고
    • Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man
    • FitzGerald GA, Oates JA, Hawiger J, et al. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest. 1983;71:676-688
    • (1983) J Clin Invest , vol.71 , pp. 676-688
    • Fitzgerald, G.A.1    Oates, J.A.2    Hawiger, J.3
  • 22
    • 57049165937 scopus 로고    scopus 로고
    • Platelet ADP-receptor antagonists for cardiovascular disease: Past, present and future
    • Raju NC, Eikelboom JW, Hirsh J. Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future. Nat Clin Pract Cardiovasc Med. 2008;5:766-780
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 766-780
    • Raju, N.C.1    Eikelboom, J.W.2    Hirsh, J.3
  • 23
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527-533
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3
  • 24
    • 20144373281 scopus 로고    scopus 로고
    • Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation
    • Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med. 2005;352:1179-1189
    • (2005) N Engl J Med , vol.352 , pp. 1179-1189
    • Sabatine, M.S.1    Cannon, C.P.2    Gibson, C.M.3
  • 25
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • Steinhubl SR, Berger PB, Mann JT 3rd, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002;288: 2411-2420
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann III, J.T.3
  • 26
    • 65649145705 scopus 로고    scopus 로고
    • Effect of clopidogrel added to aspirin in patients with atrial fibrillation
    • Connolly S, Pogue J, Hart R, et al. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med. 2009;360: 1-13.
    • (2009) N Engl J Med , vol.360 , pp. 1-13
    • Connolly, S.1    Pogue, J.2    Hart, R.3
  • 27
    • 33645861080 scopus 로고    scopus 로고
    • Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006;354:1706-1717
    • (2006) N Engl J Med , vol.354 , pp. 1706-1717
    • Bhatt, D.L.1    Fox, K.A.2    Hacke, W.3
  • 28
    • 34247869852 scopus 로고    scopus 로고
    • Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial
    • Bhatt DL, Flather MD, Hacke W, et al. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol. 2007;49:1982-1988
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1982-1988
    • Bhatt, D.L.1    Flather, M.D.2    Hacke, W.3
  • 30
    • 34047096264 scopus 로고    scopus 로고
    • Variability in individual responsiveness to clopidogrel: Clinical implications, management, and future perspectives
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol. 2007;49:1505-1516
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1505-1516
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 31
    • 33748948717 scopus 로고    scopus 로고
    • Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting
    • Cuisset T, Frere C, Quilici J, et al. Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol. 2006;48:1339-1345
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1339-1345
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 32
    • 33750479499 scopus 로고    scopus 로고
    • Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement
    • Hochholzer W, Trenk D, Bestehorn HP, et al. Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol. 2006;48:1742-1750
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1742-1750
    • Hochholzer, W.1    Trenk, D.2    Bestehorn, H.P.3
  • 33
    • 8344221349 scopus 로고    scopus 로고
    • Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    • Matetzky S, Shenkman B, Guetta V, et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation. 2004;109:3171-3175
    • (2004) Circulation , vol.109 , pp. 3171-3175
    • Matetzky, S.1    Shenkman, B.2    Guetta, V.3
  • 34
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • Collet JP, Hulot JS, Pena A, et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet. 2009;373:309-317
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.P.1    Hulot, J.S.2    Pena, A.3
  • 35
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360:354-362
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 36
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Simon T, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 2009;360:363-375
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 37
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • Gilard M, Arnaud B, Cornily JC, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol. 2008;51:256-260
    • (2008) J Am Coll Cardiol , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3
  • 38
    • 61549124132 scopus 로고    scopus 로고
    • Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome
    • Ho PM, Maddox TM, Wang L, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA. 2009;301: 937-944
    • (2009) JAMA , vol.301 , pp. 937-944
    • Ho, P.M.1    Maddox, T.M.2    Wang, L.3
  • 39
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: An analysis of two randomised trials
    • O'Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet. 2009;374:989-997
    • (2009) Lancet , vol.374 , pp. 989-997
    • O'Donoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 40
    • 33646732608 scopus 로고    scopus 로고
    • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of nonresponders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease
    • Jernberg T, Payne CD, Winters KJ, et al. Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of nonresponders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J. 2006;27:1166-1173
    • (2006) Eur Heart J , vol.27 , pp. 1166-1173
    • Jernberg, T.1    Payne, C.D.2    Winters, K.J.3
  • 41
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
    • Wallentin L, Varenhorst C, James S, et al. Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease. Eur Heart J. 2008;29:21-30.
    • (2008) Eur Heart J , vol.29 , pp. 21-30
    • Wallentin, L.1    Varenhorst, C.2    James, S.3
  • 42
    • 60649112469 scopus 로고    scopus 로고
    • Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): Double-blind, randomised controlled trial
    • Montalescot G, Wiviott SD, Braunwald E, et al. Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial. Lancet. 2009;373:723-731
    • (2009) Lancet , vol.373 , pp. 723-731
    • Montalescot, G.1    Wiviott, S.D.2    Braunwald, E.3
  • 43
    • 55949103494 scopus 로고    scopus 로고
    • Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38
    • Wiviott SD, Braunwald E, Angiolillo DJ, et al. Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38. Circulation. 2008;118:1626-1636
    • (2008) Circulation , vol.118 , pp. 1626-1636
    • Wiviott, S.D.1    Braunwald, E.2    Angiolillo, D.J.3
  • 44
    • 42149119040 scopus 로고    scopus 로고
    • Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: A subanalysis of a randomised trial
    • Wiviott SD, Braunwald E, McCabe CH, et al. Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial. Lancet. 2008;371:1353-1363
    • (2008) Lancet , vol.371 , pp. 1353-1363
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 46
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361:1045-1057
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 47
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost. 2005;3:1800-1814
    • (2005) J Thromb Haemost , vol.3 , pp. 1800-1814
    • Coughlin, S.R.1
  • 48
    • 0037310962 scopus 로고    scopus 로고
    • Blockade of the thrombin receptor protease-activated receptor-1 with a smallmolecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates
    • Derian CK, Damiano BP, Addo MF, et al. Blockade of the thrombin receptor protease-activated receptor-1 with a smallmolecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates. J Pharmacol Exp Ther. 2003;304:855-861
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 855-861
    • Derian, C.K.1    Damiano, B.P.2    Addo, M.F.3
  • 49
    • 12444304462 scopus 로고    scopus 로고
    • Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig
    • Kato Y, Kita Y, Hirasawa-Taniyama Y, et al. Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur J Pharmacol. 2003;473:163-169
    • (2003) Eur J Pharmacol , vol.473 , pp. 163-169
    • Kato, Y.1    Kita, Y.2    Hirasawa-Taniyama, Y.3
  • 50
    • 33846095378 scopus 로고    scopus 로고
    • Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis
    • Vandendries ER, Hamilton JR, Coughlin SR, Furie B, Furie BC. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A. 2007;104:288-292
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 288-292
    • Vandendries, E.R.1    Hamilton, J.R.2    Coughlin, S.R.3    Furie, B.4    Furie, B.C.5
  • 51
    • 36448986049 scopus 로고    scopus 로고
    • Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage
    • Kai Y, Hirano K, Maeda Y, Nishimura J, Sasaki T, Kanaide H. Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage. Stroke. 2007;38:3259-3265
    • (2007) Stroke , vol.38 , pp. 3259-3265
    • Kai, Y.1    Hirano, K.2    Maeda, Y.3    Nishimura, J.4    Sasaki, T.5    Kanaide, H.6
  • 52
    • 36448931550 scopus 로고    scopus 로고
    • Antithrombotic and bleeding time effects of E5555, an orally active proteaseactivated receptor-1 antagonist, in guinea pigs
    • Kogushi M, Kobayashi H, Matsuoka T. Antithrombotic and bleeding time effects of E5555, an orally active proteaseactivated receptor-1 antagonist, in guinea pigs. Circulation. 2003;108:280.
    • (2003) Circulation , vol.108 , pp. 280
    • Kogushi, M.1    Kobayashi, H.2    Matsuoka, T.3
  • 53
    • 67749086022 scopus 로고    scopus 로고
    • The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease
    • Serebruany VL, Kogushi M, Dastros-Pitei D, Flather M, Bhatt DL. The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease. Thromb Haemost. 2009;102:111-119
    • (2009) Thromb Haemost , vol.102 , pp. 111-119
    • Serebruany, V.L.1    Kogushi, M.2    Dastros-Pitei, D.3    Flather, M.4    Bhatt, D.L.5
  • 58
    • 44949114152 scopus 로고    scopus 로고
    • Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
    • Chackalamannil S, Wang Y, Greenlee WJ, et al. Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. J Med Chem. 2008;51:3061-3064
    • (2008) J Med Chem , vol.51 , pp. 3061-3064
    • Chackalamannil, S.1    Wang, Y.2    Greenlee, W.J.3
  • 59
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study
    • Becker RC, Moliterno DJ, Jennings LK, et al. Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study. Lancet. 2009;373: 919-928
    • (2009) Lancet , vol.373 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 60
    • 58649097954 scopus 로고    scopus 로고
    • Thrombin receptor antagonist (TRA;SCH530348) is a selective potent inhibitor of PAR1 activity with predictable pharmacokinetics. [abstract]
    • Jennings LK, Earhart A, Becker RC, et al. Thrombin receptor antagonist (TRA;SCH530348) is a selective, potent inhibitor of PAR1 activity with predictable pharmacokinetics. [abstract]. Circulation. 2007;116:11-674.
    • (2007) Circulation , vol.116 , pp. 11-674
    • Jennings, L.K.1    Earhart, A.2    Becker, R.C.3
  • 61
    • 70349202648 scopus 로고    scopus 로고
    • Phase II trial of the novel antiplatelet agent, SCH 530348, in Japanese patients with non-ST segment elevation acute coronary syndromes (NSTE ACS). [abstract]
    • Goto S, Yamaguchi T, Ikeda Y, Yamaguchi H, Shimizu K, Jensen P. Phase II trial of the novel antiplatelet agent, SCH 530348, in Japanese patients with non-ST segment elevation acute coronary syndromes (NSTE ACS). [abstract]. Eur Heart J. 2008;29:829.
    • (2008) Eur Heart J , vol.29 , pp. 829
    • Goto, S.1    Yamaguchi, T.2    Ikeda, Y.3    Yamaguchi, H.4    Shimizu, K.5    Jensen, P.6
  • 62
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • Eikelboom JW, Mehta SR, Anand SS, Xie C, Fox KA, Yusuf S. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation. 2006;114:774-782
    • (2006) Circulation , vol.114 , pp. 774-782
    • Eikelboom, J.W.1    Mehta, S.R.2    Anand, S.S.3    Xie, C.4    Fox, K.A.5    Yusuf, S.6
  • 63
    • 33947575142 scopus 로고    scopus 로고
    • Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: An analysis from the ACUITY Trial
    • Manoukian SV, Feit F, Mehran R, et al. Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY Trial. J Am Coll Cardiol. 2007;49:1362-1368
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1362-1368
    • Manoukian, S.V.1    Feit, F.2    Mehran, R.3
  • 64
    • 38949179203 scopus 로고    scopus 로고
    • Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: Appropriateness of including bleeding as a component of a quadruple end point
    • Ndrepepa G, Berger PB, Mehilli J, et al. Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: appropriateness of including bleeding as a component of a quadruple end point. J Am Coll Cardiol. 2008;51:690-697
    • (2008) J Am Coll Cardiol , vol.51 , pp. 690-697
    • Ndrepepa, G.1    Berger, P.B.2    Mehilli, J.3
  • 65
    • 4644350897 scopus 로고    scopus 로고
    • Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes
    • Rao SV, Jollis JG, Harrington RA, et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA. 2004;292:1555-1562
    • (2004) JAMA , vol.292 , pp. 1555-1562
    • Rao, S.V.1    Jollis, J.G.2    Harrington, R.A.3
  • 66
    • 27144475755 scopus 로고    scopus 로고
    • Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes
    • Rao SV, O'Grady K, Pieper KS, et al. Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. Am J Cardiol. 2005;96:1200-1206
    • (2005) Am J Cardiol , vol.96 , pp. 1200-1206
    • Rao, S.V.1    O'Grady, K.2    Pieper, K.S.3
  • 67
    • 65649119646 scopus 로고    scopus 로고
    • Bleeding, blood transfusion, and increased mortality after percutaneous coronary intervention: Implications for contemporary practice
    • Doyle BJ, Rihal CS, Gastineau DA, Holmes DR Jr. Bleeding, blood transfusion, and increased mortality after percutaneous coronary intervention: implications for contemporary practice. J Am Coll Cardiol. 2009;53:2019-2027
    • (2009) J Am Coll Cardiol , vol.53 , pp. 2019-2027
    • Doyle, B.J.1    Rihal, C.S.2    Gastineau, D.A.3    Holmes Jr., D.R.4
  • 68
    • 0037967316 scopus 로고    scopus 로고
    • Early use of glycoprotein IIb/IIIa inhibitors in non-ST-elevation acute myocardial infarction: Observations from the National Registry of Myocardial Infarction 4
    • Peterson ED, Pollack CV Jr, Roe MT, et al. Early use of glycoprotein IIb/IIIa inhibitors in non-ST-elevation acute myocardial infarction: observations from the National Registry of Myocardial Infarction 4. J Am Coll Cardiol. 2003;42:45-53.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 45-53
    • Peterson, E.D.1    Pollack Jr., C.V.2    Roe, M.T.3
  • 69
    • 20144374536 scopus 로고    scopus 로고
    • Racial variations in treatment and outcomes of black and white patients with high-risk non-ST-elevation acute coronary syndromes: Insights from CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelines?)
    • Sonel AF, Good CB, Mulgund J, et al. Racial variations in treatment and outcomes of black and white patients with high-risk non-ST-elevation acute coronary syndromes: insights from CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines?). Circulation. 2005;111:1225-1232
    • (2005) Circulation , vol.111 , pp. 1225-1232
    • Sonel, A.F.1    Good, C.B.2    Mulgund, J.3
  • 70
    • 33645749663 scopus 로고    scopus 로고
    • Clopidogrel to treat patients with non-ST-segment elevation acute coronary syndromes after hospital discharge
    • Tricoci P, Roe MT, Mulgund J, et al. Clopidogrel to treat patients with non-ST-segment elevation acute coronary syndromes after hospital discharge. Arch Intern Med. 2006;166:806-811
    • (2006) Arch Intern Med , vol.166 , pp. 806-811
    • Tricoci, P.1    Roe, M.T.2    Mulgund, J.3
  • 72
    • 0142041382 scopus 로고    scopus 로고
    • Predictors of major bleeding in acute coronary syndromes: The Global Registry of Acute Coronary Events (GRACE)
    • Moscucci M, Fox KA, Cannon CP, et al. Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE). Eur Heart J. 2003;24:1815-1823
    • (2003) Eur Heart J , vol.24 , pp. 1815-1823
    • Moscucci, M.1    Fox, K.A.2    Cannon, C.P.3


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