In Vitro characterization of the cytochrome P450 isoforms involved in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 5, 2011, Pages 734-739

  Matsumoto, Kaori ^a   Nemoto, Eiichi ^a,b   Hasegawa, Tetsuya ^a   Akimoto, Masayuki ^a   Sugibayashi, Kenji ^b  

^a JOSAI INTERNATIONAL UNIVERSITY   (Japan)

^b JOSAI UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Human; Liver microsome; Metabolite; Nabumetone; Rat

Indexed keywords

6 HYDROXY 2 NAPHTHYLACETIC ACID; 6 METHOXY 2 NAPHTHYLACETIC ACID; 6 O DEMETHYLASE; ARYLACETIC ACID DERIVATIVE; CIMETIDINE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B1; CYTOCHROME P450 2B6; CYTOCHROME P450 2C11; CYTOCHROME P450 2C6; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; DAPSONE; DICLOFENAC; DIETHYLDITHIOCARBAMIC ACID; FURAFYLLINE; KETOCONAZOLE; NABUMETONE; NORMEPHENYTOIN; O DEMETHYLASE; PROTEIN ANTIBODY; QUINIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; SULFAPHENAZOLE; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG INHIBITION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME REPRESSION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; PROTEIN ANALYSIS; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; BUTANONES; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; MICROSOMES, LIVER; NAPHTHALENEACETIC ACIDS; PRODRUGS; RATS;

EID: 79955670192     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.734     Document Type: Article

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