Herbal formula CGX ameliorates LPS/d-galactosamine-induced hepatitis

Food and Chemical Toxicology

Volumn 49, Issue 6, 2011, Pages 1329-1334

  Shin, Jang Woo ^a   Wang, Jing Hua ^a   Park, Hye Jung ^a   Choi, Min Kyeong ^a   Kim, Hyeong Geug ^a   Son, Chang Gue ^a  

^a Daejeon University   (South Korea)

Author keywords

Antioxidant; CGX; D Galactosamine; Liver injury; LPS; Traditional Korean medicine

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CASPASE 7; CATALASE; CGX; GLUTATHIONE PEROXIDASE; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; LIVER PROTECTIVE AGENT; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CELL COUNT; CONTROLLED STUDY; DISEASE MARKER; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME ACTIVITY; IMMUNOMODULATION; LIPID PEROXIDATION; LIVER HISTOLOGY; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; CASPASES; DRUG-INDUCED LIVER INJURY; GALACTOSAMINE; HERBAL MEDICINE; IMMUNOLOGIC FACTORS; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; LIVER; LYMPHOCYTES; MALE; MICE; MICE, INBRED BALB C; NEUTROPHILS; OXIDOREDUCTASES; PLANT EXTRACTS; TRANSAMINASES;

MUS;

EID: 79955664274     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2011.03.015     Document Type: Article

References (37)

1. Beers R.F., Sizer I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J. Biol. Chem. 1952, 195:133-140.
2. Bernal W., Auzinger G., Dhawan A., Wendon J. Acute liver failure. Lancet 2010, 376:190-201.
3. Bernuau J., Rueff B., Benhamou J.P. Fulminant and subfulminant liver failure: definitions and causes. Semin. Liver Dis. 1986, 6:97-106.
4. Brown A.P., Harkema J.R., Schultze A.E., Roth R.A., Ganey P.E. Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration. Shock 1997, 7:186-192.
5. Cho J.H., Lee Y.Y., Seo S.H., Yoo H.S., Choi W.J., Lee Y.W., Son C.G., Cho C.K. A clinical report about 57 patients with chronic liver disease. J. Korean Orien. Med. 2000, 21:112-121.
6. Choi J., Ou J.H. Mechanisms of liver injury III oxidative stress in the pathogenesis of hepatitis C virus. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G847-851.
7. Chosay J.G., Essani N.A., Dunn C.J., Jaeschke H. Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury. Am. J. Physiol. 1997, 272:G1195-1200.
8. Decker K., Keppler D. Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmacol. 1974, 77-106.
9. Dejager L., Libert C. Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I:C) in d-galactosamine-sensitized mice. Cytokine 2008, 42:55-61.
10. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
11. Essani N.A., Fisher M.A., Farhood A., Manning A.M., Smith C.W., Jaeschke H. Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 1995, 21:1632-1639.
12. Fu W., Chen J., Cai Y., Lei Y., Chen L., Pei L., Zhou D., Lang X., Ruan J. Antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch. et Sav.) Ching. J. Ethnopharmacol. 2010, 130:521-528.
13. Han D., Hanawa N., Saberi B., Kaplowitz N. Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic. Biol. Med. 2006, 41:627-639.
14. Han D.W. Intestinal endotoxemia as a pathogenetic mechanism in liver failure. World J. Gastroenterol. 2002, 8:961-965.
15. Hu X.P., Shin J.W., Wang J.H., Cho J.H., Son J.Y., Cho C.K., Son C.G. Antioxidative and hepatoprotective effect of CGX, an herbal medicine, against toxic acute injury in mice. J. Ethnopharmacol. 2008, 120:51-55.
16. Kambayashi Y., Binh N.T., H W.A., Hibino Y., Hitomi Y., Nakamura H., Ogino K. Efficient assay for total antioxidant capacity in human plasma using a 96-well microplate. J. Clin. Biochem. Nutr. 2009, 44:46-51.
17. Kudo H., Takahara T., Yata Y., Kawai K., Zhang W., Sugiyama T. Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model. J. Hepatol. 2009, 51:168-175.
18. Luster M.I., Simeonova P.P., Gallucci R., Matheson J. Tumor necrosis factor alpha and toxicology. Crit. Rev. Toxicol. 1999, 29:491-511.
19. Miethke T., Wahl C., Heeg K., Echtenacher B., Krammer P.H., Wagner H. T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J. Exp. Med. 1992, 175:91-98.
20. Nagaki M., Tanaka M., Sugiyama A., Ohnishi H., Moriwaki H. Interleukin-10 inhibits hepatic injury and tumor necrosis factor-alpha and interferon-gamma mRNA expression induced by staphylococcal enterotoxin B or lipopolysaccharide in galactosamine-sensitized mice. J. Hepatol. 1999, 31:815-824.
21. Ng K.K., Lo C.M. Liver transplantation in Asia: past, present and future. Ann. Acad. Med. Singapore 2009, 38:310-322.
22. Nolan J.P. The role of intestinal endotoxin in liver injury: a long and evolving history. Hepatology 2010, 52:1829-1835.
23. Olaleye M.T., Akinmoladun A.C., Ogunboye A.A., Akindahunsi A.A. Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats. Food Chem. Toxicol. 2010, 48:2200-2205.
24. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70:158-169.
25. Rahman T.M., Hodgson H.J. Animal models of acute hepatic failure. Int. J. Exp. Pathol. 2000, 81:145-157.
26. Seki E., De Minicis S., Osterreicher C.H., Kluwe J., Osawa Y., Brenner D.A., Schwabe R.F. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat. Med. 2007, 13:1324-1332.
27. Shin J.W., Kim H.G., Park H.J., Sung N.W., Son C.G. Safety of the traditional Korean herbal medicine CGX: a 6-month repeated-dose study in rats. J. Ethnopharmacol. 2010, 128:221-229.
28. Shin J.W., Park H.J., Kwon M., Son C.G. Scientific evaluation of the chronic toxicity of the herbal medicine CGX in beagle dogs. Food Chem. Toxicol. 2010, 48:743-749.
29. Shin J.W., Son J.Y., Oh S.M., Han S.H., Wang J.H., Cho J.H., Cho C.K., Yoo H.S., Lee Y.W., Lee M.M., Hu X.P., Son C.G. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. World J. Gastroenterol. 2006, 12:6142-6148.
30. Silverstein R., Christoffersen C.A., Morrison D.C. Modulation of endotoxin lethality in mice by hydrazine sulfate. Infect. Immun. 1989, 57:2072-2078.
31. Taye A., El-Moselhy M.A., Hassan M.K., Ibrahim H.M., Mohammed A.F. Hepatoprotective effect of pentoxifylline against d-galactosamine-induced hepatotoxicity in rats. Ann. Hepatol. 2009, 8:364-370.
32. van Deuren M., Dofferhoff A.S., van der Meer J.W. Cytokines and the response to infection. J. Pathol. 1992, 168:349-356.
33. Uchiyama M., Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analyt. Biochem. 1978, 86:271-278.
34. Wang G.S., Liu G.T. Influences of Kupffer cell stimulation and suppression on immunological liver injury in mice. Zhongguo Yao Li Xue Bao 1997, 18:173-176.
35. Wang J.H., Shin J.W., Son J.Y., Cho J.H., Son C.G. Antifibrotic effects of CGX, a traditional herbal formula, and its mechanisms in rats. J. Ethnopharmacol. 2010, 127:534-542.
36. Xu H., Gonzalo J.A., St Pierre Y., Williams I.R., Kupper T.S., Cotran R.S., Springer T.A., Gutierrez-Ramos J.C. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J. Exp. Med. 1994, 180:95-109.
37. Zou W., Roth R.A., Younis H.S., Burgoon L.D., Ganey P.E. Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment. Toxicology 2010, 272:32-38.