Antioxidative and hepatoprotective effect of CGX, an herbal medicine, against toxic acute injury in mice

Journal of Ethnopharmacology

Volumn 120, Issue 1, 2008, Pages 51-55

  Hu, Xiao Ping ^a   Shin, Jang Woo ^a   Wang, Jing Hua ^a   Cho, Jung Hyo ^a   Son, Jin Young ^a   Cho, Chong Kwan ^a   Son, Chang Gue ^a  

^a Daejeon University   (South Korea)

Author keywords

Carbon tetrachloride; CGX; Hepatoprotective; Herbal drug; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALISMA ORIENTALE EXTRACT; AMOMUM VILLOSUM EXTRACT; AMYDA MAACKII EXTRACT; ARTEMISIA CAPILLARIS EXTRACT; ASPARTATE AMINOTRANSFERASE; ATRACTYLODES EXTRACT; ATRACTYLODES MACROCEPHALA EXTRACT; AUCKLANDIA LAPPA EXTRACT; CARBON TETRACHLORIDE; CATALASE; FREE RADICAL; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PLANT EXTRACT; POLYPORUS UMBELLATUS EXTRACT; PONCIRUS TRIFOLIATA EXTRACT; RAPHANUS SATIVUS EXTRACT; SALVIA MILTIORRHIZA EXTRACT; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALISMA ORIENTALE; AMOMUM VILLOSUM; AMYDA MAACKII; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AUCKLANDIA LAPPA; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVITY; LIVER INJURY; LIVER PROTECTION; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; POLYPORUS UMBELLATUS; PROTEIN EXPRESSION; RADISH; RHIZOME; TRIFOLIATE ORANGE;

ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE; CATALASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION; GLUTATHIONE; HEPATITIS, TOXIC; LIVER; LIVER FUNCTION TESTS; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE SYNTHASE TYPE II; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 53649110538     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.07.042     Document Type: Article

References (31)

1. Albano E. Alcohol, oxidative stress and free radical damage. Proceedings of the Nutrition Society 65 (2006) 278-290
2. Beers R.F., and Siezer I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. Journal of Biological Chemistry 195 (1952) 133-140
3. Boll M., Weber L.W., Becker E., and Stampfl A. Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites. Zeitschrift für Naturforschung C 56 (2001) 649-659
4. Cho J.H., Lee Y.Y., Seo S.H., Yoo H.S., Choi W.J., Lee Y.W., Son C.G., and Cho C.K. A clinical report about 57 patients with chronic liver disease. Korean Journal of Oriental Medicine 21 (2001) 112-121
5. Choi W.J., Shin J.W., Son J.Y., Seo D.S., Park H.S., Han S.H., Sung H.J., Cho J.H., Cho C.K., Yoo H.S., Lee Y.W., and Son C.G. Toxicological study of the hepatotherapeutic herbal formula, chunggan extract in beagle dogs. World Journal of Gastroenterology 14 (2006) 7497-7502
6. Das S.K., and Vasudevan D.M. Protective effects of silymarin, a milk thistle (Silybium marianum) derivative on ethanol-induced oxidative stress in liver. Indian Journal of Biochemistry & Biophysics 43 (2006) 306-311
7. Ellman G.L. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics 82 (1959) 70-77
8. Farghali H., Kamenikova L., Hynie S., and Kmonickova E. Silymarin effects on intracellular calcium and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury. Pharmacological Research 41 (2000) 231-237
9. Kurata M., Suzuki M., and Agar N.S. Antioxidant systems and erythrocyte life-span in mammals. Comparative Biochemistry and Physiology B 106 (1993) 477-487
10. Levent G., Ali A., Ahmet A., Polat E.C., Aytac C., Ayse E., and Ahmet S. Oxidative stress and antioxidant defense in patients with chronic hepatitis C patients before and after pegylated interferon alfa-2b plus ribavirin therapy. Journal of Translational Medicine 4 (2006) 25
11. Ljubuncic P., Azaizeh H., Portnaya I., Cogan U., Said O., Saleh K.A., and Bomzon A. Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel. Journal of Ethnopharmacology 99 (2005) 43-47
12. Lucena M.I., Andrade R.J., de la Cruz J.P., Rodriguez-Mendizaba M., Blanco E., and Sánchez de la Cuesta F. Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis. Results of a randomized, double-blind, placebo-controlled clinical study. International Journal of Clinical Pharmacology and Therapeutics 40 (2002) 2-8
13. Marston A. Role of advances in chromatographic techniques in phytochemistry. Phytochemistry 68 (2007) 2786-2798
14. Medina J., and Moreno-Otero R. Pathophysiological basis for antioxidant therapy in chronic liver disease. Drugs 65 (2005) 2445-2461
15. Mihara M., and Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analytical Biochemistry 86 (1978) 271-278
16. Parke D.V., and Sapota A. Chemical toxicity and reactive oxygen species. International Journal of Occupational Medicine and Environmental Health 9 (1996) 331-340
17. Pradhan S.C., and Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. The Indian Journal of Medical Research 124 (2006) 491-504
18. Qian G.S., Wang Q., Leung K.S., Qin Y., Zhao Z., and Jiang Z.H. Quality assessment of Rhizoma et Radix Notopterygii by HPTLC and HPLC fingerprinting and HPLC quantitative analysis. Journal of pharmaceutical and biomedical analysis 44 (2007) 812-817
19. Raja S., Ahamed K.F., Kumar V., Mukherjee K., Bandyopadhyay A., and Mukherjee P.K. Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. Journal of Ethnopharmacology 109 (2007) 41-47
20. Shin J.W., Son J.Y., Oh S.M., Han S.H., Wang J.H., Cho J.H., Cho C.K., Yoo H.S., Lee Y.W., Lee M.M., Hu X.P., and Son C.G. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. World Journal of Gastroenterology 14 (2006) 6142-6148
21. Son C.G., Choi B.L., Shin J.W., Choi W.J., Cho J.H., and Cho C.K. Effect of Gamichunggantang on alcoholic metabolism and alcoholic liver disease. Korean Journal of Oriental Medicine 2 (2001) 89-98
22. Son C.G., Choi W.J., Shin J.W., Han S.H., Cho J.H., Song K.C., and Cho C.K. Effects of gamichunggantang on hyperlipidemia. Acta Pharmacologica Sinica 24 (2003) 133-139
23. Stoyanovsky D.A., and Cederbaum A.I. Metabolism of carbon tetrachloride to trichloromethyl radical: An ESR and HPLC-EC study. Chemical Research in Toxicology 12 (1999) 730-736
24. Tomasi A., Albano E., Banni S., Botti B., Corongiu F., Dessi M.A., Iannone A., Vannini A., and Dianzani M.U. Free-radical metabolism of carbon tetrachloride in rat liver mitochondria. A study of the mechanism of activation. The Biochemical Journal 1 (1987) 313-317
25. Videla L.A., Fernandez V., Tapia G., and Varela P. Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells. Biometals 16 (2003) 103-111
26. Wang C.Y., Ma F.L., Liu J.T., Tian J.W., and Fu F.H. Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats. Biological and Pharmaceutical Bulletin 30 (2007) 44-47
27. Wang T., and Weinman S.A. Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C. Journal of Gastroenterology and Hepatology 21 (2006) 34-37
28. Weber L.W., Boll M., and Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Critical Reviews in Toxicology 33 (2003) 105-136
29. Wu Y., Li L., Wen T., and Li Y.Q. Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats. Toxicology 232 (2007) 50-56
30. Yong E.L., Wong S.P., Shen P., Gong Y.H., Li J., and Hong Y. Standardization and evaluation of botanical mixtures: lessons from a traditional Chinese herb, epimedium, with oestrogenic properties. Novartis Foundation symposium 282 (2007) 173-188
31. Yuan G.J., Zhou X.R., Gong Z.J., Zhang P., Sun X.M., and Zheng S.H. Expression and activity of inducible nitric oxide synthase and endothelial nitric oxide synthase correlate with ethanol-induced liver injury. World Journal of Gastroenterology 21 (2006) 2375-2381