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Volumn 8, Issue 4, 2009, Pages 364-370

Hepatoprotective effect of pentoxifylline against D-galactosamine-induced hepatotoxicity in rats

Author keywords

Antioxidant; D galactosamine; Hepatotoxicty; Pentoxifylline

Indexed keywords

ALBUMIN; ALKALINE PHOSPHATASE; CATALASE; GALACTOSAMINE; MALONALDEHYDE; NITRITE; PENTOXIFYLLINE; SILYMARIN; SUPEROXIDE DISMUTASE; LIPID PEROXIDE; PHOSPHODIESTERASE INHIBITOR; PROTECTIVE AGENT; SERUM ALBUMIN;

EID: 77953462213     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31751-x     Document Type: Article
Times cited : (26)

References (42)
  • 1
    • 0033014916 scopus 로고    scopus 로고
    • Teas and other beverages suppress D-galactosamine-induced liver injury in rats
    • Sugiyama K, He P, Wada S, Saeki S. Teas and other beverages suppress D-galactosamine-induced liver injury in rats. J Nutr 1999; 129(7): 1361-1367.
    • (1999) J Nutr , vol.129 , Issue.7 , pp. 1361-1367
    • Sugiyama, K.1    He, P.2    Wada, S.3    Saeki, S.4
  • 2
    • 33749346484 scopus 로고    scopus 로고
    • Protective effect of Lygodium flexuo-sum (L.) Sw. (Lygodiaceae) against D-galactosamine induced liver injury in rats
    • Wills PJ, Asha VV. Protective effect of Lygodium flexuo-sum (L.) Sw. (Lygodiaceae) against D-galactosamine induced liver injury in rats. J Ethnopharmacol 2006; 108(1): 116-123.
    • (2006) J Ethnopharmacol , vol.108 , Issue.1 , pp. 116-123
    • Wills, P.J.1    Asha, V.V.2
  • 3
    • 0026504084 scopus 로고
    • Im-munohistochemical study of extracellular matrix in acute galactosamine hepatitis in rats
    • Jonker AM, Dijkhuis FW, Boes A, Hardonk MJ, Grond J. Im-munohistochemical study of extracellular matrix in acute galactosamine hepatitis in rats. Hepatology 1992; 15(3): 423-431.
    • (1992) Hepatology , vol.15 , Issue.3 , pp. 423-431
    • Jonker, A.M.1    Dijkhuis, F.W.2    Boes, A.3    Hardonk, M.J.4    Grond, J.5
  • 4
    • 0015963597 scopus 로고
    • Selective uridine triphos-phate deficiency induced by D-galactosamine in liver and reversed by pyrimidine nucleotide precursors. Effect on ribonucleic acid synthesis
    • Keppler DO, Pausch J, Decker K. Selective uridine triphos-phate deficiency induced by D-galactosamine in liver and reversed by pyrimidine nucleotide precursors. Effect on ribonucleic acid synthesis. J Biol Chem 1974; 249(1): 211-216.
    • (1974) J Biol Chem , vol.249 , Issue.1 , pp. 211-216
    • Keppler, D.O.1    Pausch, J.2    Decker, K.3
  • 5
    • 0027175996 scopus 로고
    • Protection by phospho-diesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice
    • Fischer W, Schudt C, Wendel A. Protection by phospho-diesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice. Biochem Pharmacol 1993; 45(12): 2399-404.
    • (1993) Biochem Pharmacol , vol.45 , Issue.12 , pp. 2399-2404
    • Fischer, W.1    Schudt, C.2    Wendel, A.3
  • 6
    • 0033162727 scopus 로고    scopus 로고
    • Protection by a cyclic AMP-specific phosphodieste-rase inhibitor, rolipram, and dibutyryl cyclic AMP against Propionibacterium acnes and lipopolysaccharide-induced mouse hepatitis
    • Taguchi I, Oka K, Kitamura K, Sugiura M, Oku A, Matsumo-to M. Protection by a cyclic AMP-specific phosphodieste-rase inhibitor, rolipram, and dibutyryl cyclic AMP against Propionibacterium acnes and lipopolysaccharide-induced mouse hepatitis. Inflamm Res 1999; 48(7): 380-385.
    • (1999) Inflamm Res , vol.48 , Issue.7 , pp. 380-385
    • Taguchi, I.1    Oka, K.2    Kitamura, K.3    Sugiura, M.4    Oku, A.5    Matsumo-To, M.6
  • 7
    • 0033288126 scopus 로고    scopus 로고
    • The effects of pentoxi-fylline on spinal cord blood flow after experimental spinal cord injury
    • Thompson MK, Tuma RF, Young WF. The effects of pentoxi-fylline on spinal cord blood flow after experimental spinal cord injury. J Assoc Acad Minor Phys 1999; 10(1): 23-26.
    • (1999) J Assoc Acad Minor Phys , vol.10 , Issue.1 , pp. 23-26
    • Thompson, M.K.1    Tuma, R.F.2    Young, W.F.3
  • 8
    • 0025535738 scopus 로고
    • In vivo effect of free radical scavenger hepatoprotective agents on superoxide dismutase (SOD) activity in patients
    • Feher J, Lang I, Nekam K, Gergely P, Muzes G. In vivo effect of free radical scavenger hepatoprotective agents on superoxide dismutase (SOD) activity in patients. Tokai J Exp Clin Med 1990; 15(2-3): 129-134.
    • (1990) Tokai J Exp Clin Med , vol.15 , Issue.2-3 , pp. 129-134
    • Feher, J.1    Lang, I.2    Nekam, K.3    Gergely, P.4    Muzes, G.5
  • 9
    • 0018832431 scopus 로고
    • Silybin inhibition of ama-toxin uptake in the perfused rat liver
    • Faulstich H, Jahn W, Wieland T. Silybin inhibition of ama-toxin uptake in the perfused rat liver. Arzneimittelfors-chuns 1980; 30(3): 452-454.
    • (1980) Arzneimittelfors-chuns , vol.30 , Issue.3 , pp. 452-454
    • Faulstich, H.1    Jahn, W.2    Wieland, T.3
  • 10
    • 0037376374 scopus 로고    scopus 로고
    • The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat
    • Abdel-Salam OM, Baiuomy AR, El-Shenawy SM, Arbid MS. The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat. Pharmacol Res 2003; 47(4): 331-340.
    • (2003) Pharmacol Res , vol.47 , Issue.4 , pp. 331-340
    • Abdel-Salam, O.M.1    Baiuomy, A.R.2    El-Shenawy, S.M.3    Arbid, M.S.4
  • 11
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-310.
    • (1978) Methods Enzymol , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 12
    • 0028013154 scopus 로고
    • Lipid peroxide and reactive oxygen species generating systems of the crystalline lens
    • Babizhayev MA, Costa EB. Lipid peroxide and reactive oxygen species generating systems of the crystalline lens. Biochimica et biophysica acta 1994; 1225(3): 326-337.
    • (1994) Biochimica Et Biophysica Acta , vol.1225 , Issue.3 , pp. 326-337
    • Babizhayev, M.A.1    Costa, E.B.2
  • 13
    • 41849139003 scopus 로고    scopus 로고
    • Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxi-dant Mechanism
    • Yoo YM, Nam JH, Kim MY, Choi J, Park HJ. Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxi-dant Mechanism. Biol Pharm Bull 2008; 31(4): 760-764.
    • (2008) Biol Pharm Bull , vol.31 , Issue.4 , pp. 760-764
    • Yoo, Y.M.1    Nam, J.H.2    Kim, M.Y.3    Choi, J.4    Park, H.J.5
  • 14
    • 0022583887 scopus 로고
    • Biochemical effects of the flavono-lignane silibinin on RNA, protein and DNA synthesis in rat livers
    • Sonnenbichler J, Zetl I. Biochemical effects of the flavono-lignane silibinin on RNA, protein and DNA synthesis in rat livers. Pros Clin Biol Res 1986; 213: 319-331.
    • (1986) Pros Clin Biol Res , vol.213 , pp. 319-331
    • Sonnenbichler, J.1    Zetl, I.2
  • 15
    • 0032059231 scopus 로고    scopus 로고
    • Protective and therapeutic effect of silymarin on the development of latent liver damage
    • Kropacova K, Misurova E, Hakova H. Protective and therapeutic effect of silymarin on the development of latent liver damage. Radiats Biol Radioecol 1998; 38(3): 411-415.
    • (1998) Radiats Biol Radioecol , vol.38 , Issue.3 , pp. 411-415
    • Kropacova, K.1    Misurova, E.2    Hakova, H.3
  • 16
    • 0025102171 scopus 로고
    • Prevention by silymarin of membrane alterations in acute CCl4 liver damage
    • Muriel P, Mourelle M. Prevention by silymarin of membrane alterations in acute CCl4 liver damage. J Appl Toxicol 1990; 10(4): 275-279.
    • (1990) J Appl Toxicol , vol.10 , Issue.4 , pp. 275-279
    • Muriel, P.1    Mourelle, M.2
  • 17
    • 0030772332 scopus 로고    scopus 로고
    • Silymarin mediated differential modulation of toxicity induced by carbon tetra-chloride, paracetamol and D-galactosamine in freshly isolated rat hepatocytes
    • Chrungoo VJ, Singh K, Singh J. Silymarin mediated differential modulation of toxicity induced by carbon tetra-chloride, paracetamol and D-galactosamine in freshly isolated rat hepatocytes. Indian J Exp Biol 1997; 35(6): 611-617.
    • (1997) Indian J Exp Biol , vol.35 , Issue.6 , pp. 611-617
    • Chrungoo, V.J.1    Singh, K.2    Singh, J.3
  • 18
    • 0027101799 scopus 로고
    • Protective activity of silipide on liver damage in rodents
    • Conti M, Malandrino S, Magistretti MJ. Protective activity of silipide on liver damage in rodents. Jpn J Pharmacol 1992; 60(4): 315-320.
    • (1992) Jpn J Pharmacol , vol.60 , Issue.4 , pp. 315-320
    • Conti, M.1    Malandrino, S.2    Magistretti, M.J.3
  • 19
    • 34250202901 scopus 로고    scopus 로고
    • The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver
    • Wong MC, Portmann B, Sherwood R, Niemela O, Koivisto H, et al. The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver. Metabolism 2007; 56(7): 865-875.
    • (2007) Metabolism , vol.56 , Issue.7 , pp. 865-875
    • Wong, M.C.1    Portmann, B.2    Sherwood, R.3    Niemela, O.4    Koivisto, H.5
  • 20
    • 0027732935 scopus 로고
    • Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration
    • Dabeva MD, Shafritz DA. Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration. Am J Pathol 1993; 143(6): 1606-1620.
    • (1993) Am J Pathol , vol.143 , Issue.6 , pp. 1606-1620
    • Dabeva, M.D.1    Shafritz, D.A.2
  • 21
    • 0027415060 scopus 로고
    • Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts
    • Peterson TC. Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts. Hepatolosy 1993; 17(3): 486-493.
    • (1993) Hepatolosy , vol.17 , Issue.3 , pp. 486-493
    • Peterson, T.C.1
  • 22
    • 0017891683 scopus 로고
    • Nature of inhibition of rat testicular alkaline phosphatase by isatin
    • Kumar P, Nagpaul JP, Singh B, Bansal RC, Sharma R. Nature of inhibition of rat testicular alkaline phosphatase by isatin. Experientia 1978; 34(4): 434-435.
    • (1978) Experientia , vol.34 , Issue.4 , pp. 434-435
    • Kumar, P.1    Nagpaul, J.P.2    Singh, B.3    Bansal, R.C.4    Sharma, R.5
  • 23
    • 33646188823 scopus 로고    scopus 로고
    • Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or acetaminophen
    • Abdel SOM, Baiuomy AR, El-Shenawy SM, Hassan NS. Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or acetaminophen. Pharmacol Rep. Sep-Oct 2005; 57(5): 596-603.
    • (2005) Pharmacol Rep , vol.57 , Issue.5 , pp. 596-603
    • Abdel, S.O.M.1    Baiuomy, A.R.2    El-Shenawy, S.M.3    Hassan, N.S.4
  • 24
    • 0018765817 scopus 로고
    • Liver injury and lipid metabolism: Sex differences in the fatty liver induced by d-galactosamine
    • Kattermann R, Sirowej H. Liver injury and lipid metabolism: sex differences in the fatty liver induced by d-galactosamine. Acta Hepatosastroenterol (Stutts) 1979; 2(26): 112-126.
    • (1979) Acta Hepatosastroenterol (Stutts) , vol.2 , Issue.26 , pp. 112-126
    • Kattermann, R.1    Sirowej, H.2
  • 25
    • 33644875895 scopus 로고    scopus 로고
    • Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats
    • Di Sario A, Bendia E, Taffetani S, Omenetti A, Candelaresi C, Marzioni M, et al. Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats. Dis Liver Dis 2005; 37(11): 869-876.
    • (2005) Dis Liver Dis , vol.37 , Issue.11 , pp. 869-876
    • di Sario, A.1    Bendia, E.2    Taffetani, S.3    Omenetti, A.4    Candelaresi, C.5    Marzioni, M.6
  • 26
    • 67650519656 scopus 로고    scopus 로고
    • Role of ursodeoxycholic acid in prevention of hepatotoxicity caused by amoxicillin-clavulanic acid in rats
    • El-Sherbiny GA, Taye A, Abdel-Raheem IT. Role of ursodeoxycholic acid in prevention of hepatotoxicity caused by amoxicillin-clavulanic acid in rats. Ann Hepatol 2009; 8(2): 134-140.
    • (2009) Ann Hepatol , vol.8 , Issue.2 , pp. 134-140
    • El-Sherbiny, G.A.1    Taye, A.2    Abdel-Raheem, I.T.3
  • 27
    • 0141543868 scopus 로고    scopus 로고
    • Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR
    • Li X, Liu Y, Song L, Liu J. Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR. Toxicon 2003; 42(1): 85-89.
    • (2003) Toxicon , vol.42 , Issue.1 , pp. 85-89
    • Li, X.1    Liu, Y.2    Song, L.3    Liu, J.4
  • 28
    • 0025673837 scopus 로고
    • Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: The protective effect of allopurinol
    • Jaeschke H. Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. J Pharmacol Exp Ther 1990; 255(3): 935-941.
    • (1990) J Pharmacol Exp Ther , vol.255 , Issue.3 , pp. 935-941
    • Jaeschke, H.1
  • 30
    • 0026736019 scopus 로고
    • Changes in free radicals, trace elements, and neurophysiological function in rats with liver damage induced by D-galactosamine
    • Hu HL, Chen RD. Changes in free radicals, trace elements, and neurophysiological function in rats with liver damage induced by D-galactosamine. Biol Trace Elem Res 1992; 34(1): 19-25.
    • (1992) Biol Trace Elem Res , vol.34 , Issue.1 , pp. 19-25
    • Hu, H.L.1    Chen, R.D.2
  • 31
    • 0033607653 scopus 로고    scopus 로고
    • Glu-tathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells
    • De Bleser PJ, Xu G, Rombouts K, Rogiers V, Geerts A. Glu-tathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J Biol Chem 1999; 274(48): 33881-33887.
    • (1999) J Biol Chem , vol.274 , Issue.48 , pp. 33881-33887
    • de Bleser, P.J.1    Xu, G.2    Rombouts, K.3    Rogiers, V.4    Geerts, A.5
  • 32
    • 0030759735 scopus 로고    scopus 로고
    • Antioxidant enzyme status in biliary obstructed rats: Effects of N-acetylcysteine
    • Pastor A, Collado PS, Almar M, Gonzalez-Gallego J. Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine. J Hepatol 1997; 27(2): 363-370.
    • (1997) J Hepatol , vol.27 , Issue.2 , pp. 363-370
    • Pastor, A.1    Collado, P.S.2    Almar, M.3    Gonzalez-Gallego, J.4
  • 33
    • 0035830938 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxici-ty in HepG2 cells
    • Bai J, Cederbaum AI. Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxici-ty in HepG2 cells. J Biol Chem 2001; 276(6): 4315-4321.
    • (2001) J Biol Chem , vol.276 , Issue.6 , pp. 4315-4321
    • Bai, J.1    Cederbaum, A.I.2
  • 35
    • 0032943930 scopus 로고    scopus 로고
    • Hepatoprotective effect of Picrorr-hiza kurroa on tissue defence system in-galactosamine-in-duced hepatitis in rats
    • Anandan R, Devaki, T. Hepatoprotective effect of Picrorr-hiza kurroa on tissue defence system in-galactosamine-in-duced hepatitis in rats. Fitoterapia 1999; 70(1): 54-57.
    • (1999) Fitoterapia , vol.70 , Issue.1 , pp. 54-57
    • Anandan, R.1    Devaki, T.2
  • 36
    • 77954576713 scopus 로고    scopus 로고
    • Antihepatotoxic potential of Sargassum polycystum (Phaeophyceae) on antioxidant defense status in Dgalac-tosamine-induced hepatitis in rats
    • Meena B, Anbin ER, Rajesh R, Sheik HA, Ganesan B, Anandan R. Antihepatotoxic potential of Sargassum polycystum (Phaeophyceae) on antioxidant defense status in Dgalac-tosamine-induced hepatitis in rats. Afr J Biochem Res 2008; 2(2): 51-55.
    • (2008) Afr J Biochem Res , vol.2 , Issue.2 , pp. 51-55
    • Meena, B.1    Anbin, E.R.2    Rajesh, R.3    Sheik, H.A.4    Ganesan, B.5    Anandan, R.6
  • 37
    • 0347753590 scopus 로고    scopus 로고
    • Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats
    • Vimal V, Devaki T. Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats. J Ethnopharmacol 2004; 90(1): 151-154.
    • (2004) J Ethnopharmacol , vol.90 , Issue.1 , pp. 151-154
    • Vimal, V.1    Devaki, T.2
  • 38
    • 0346147023 scopus 로고    scopus 로고
    • Protection by sildenafil and theophylline of lead acetate-induced oxidative stress in rat sub-mandibular gland and saliva
    • Abdollahi M, Fooladian F, Emami B, Zafari K, Bahreini-Moghadam A. Protection by sildenafil and theophylline of lead acetate-induced oxidative stress in rat sub-mandibular gland and saliva. Hum Exp Toxicol 2003; 22(11): 587-592.
    • (2003) Hum Exp Toxicol , vol.22 , Issue.11 , pp. 587-592
    • Abdollahi, M.1    Fooladian, F.2    Emami, B.3    Zafari, K.4    Bahreini-Moghadam, A.5
  • 39
    • 0032575363 scopus 로고    scopus 로고
    • Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury
    • Demir S, Inal-Erden M. Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury. Clin Chim Acta 1998; 275(2): 127-135.
    • (1998) Clin Chim Acta , vol.275 , Issue.2 , pp. 127-135
    • Demir, S.1    Inal-Erden, M.2
  • 40
    • 0036258072 scopus 로고    scopus 로고
    • Pentoxify-lline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits
    • Savas S, Delibas N, Savas C, Sutcu R, Cindas A. Pentoxify-lline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits. Spinal Cord 2002; 40(5): 224-229.
    • (2002) Spinal Cord , vol.40 , Issue.5 , pp. 224-229
    • Savas, S.1    Delibas, N.2    Savas, C.3    Sutcu, R.4    Cindas, A.5
  • 41
    • 0035110655 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice
    • Sass G, Koerber K, Bang R, Guehring H, Tiegs G. Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest 2001; 107(4): 439-447.
    • (2001) J Clin Invest , vol.107 , Issue.4 , pp. 439-447
    • Sass, G.1    Koerber, K.2    Bang, R.3    Guehring, H.4    Tiegs, G.5
  • 42
    • 0033012214 scopus 로고    scopus 로고
    • Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver
    • Li J, Billiar TR. Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver. Am J Physiol 1999; 276(5 Pt 1): G1069-G1073.
    • (1999) Am J Physiol , vol.276 , Issue.5 PT 1
    • Li, J.1    Billiar, T.R.2


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