Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners

Clinical and Experimental Rheumatology

Volumn 29, Issue 1, 2011, Pages 43-49

  Yokota, Kazuhiro ^a   Miyoshi, Fumihiko ^a   Sato, Kojiro ^a   Asanuma, Yu ^a   Akiyama, Yuji ^a   Mimura, Toshihide ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

3 hydroxy 3 methylglutaryl co enzyme A reductase inibitor; Fibroblast like synoviocytes; Monocyte chemoattractant protein 1; Pentraxin 3; Rheumatoid arthritis; Small G protein

Indexed keywords

FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; MESSENGER RNA; MEVALONIC ACID; MONOCYTE CHEMOTACTIC PROTEIN 1; PENTRAXIN 3; RHO KINASE; SIMVASTATIN; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMIDE; BENZAMIDE DERIVATIVE; C REACTIVE PROTEIN; GGTI 298; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID PHOSPHATE; PYRIDINE DERIVATIVE; SERUM AMYLOID P; SESQUITERPENE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNOVIAL FLUID LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; SYNOVIUM;

AMIDES; ARTHRITIS, RHEUMATOID; BENZAMIDES; C-REACTIVE PROTEIN; CELLS, CULTURED; CHEMOKINE CCL2; FIBROBLASTS; GENE EXPRESSION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; POLYISOPRENYL PHOSPHATES; PYRIDINES; RNA, MESSENGER; SERUM AMYLOID P-COMPONENT; SESQUITERPENES; SIMVASTATIN; SYNOVIAL MEMBRANE;

EID: 79955652163     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

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