Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios

Modern Rheumatology

Volumn 17, Issue 5, 2007, Pages 364-368

  Kanda, Hiroko ^a   Yokota, Kazuhiro ^b   Kohno, Chieko ^b   Sawada, Tetsuji ^a   Sato, Kojiro ^c   Yamaguchi, Masao ^a   Komagata, Yoshinori ^a   Shimada, Kota ^d   Yamamoto, Kazuhiko ^a   Mimura, Toshihide ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c Tokyo Medical and Dental University ^*  (Japan)

^d NATIONAL HOSPITAL ORGANIZATION   (Japan)

Author keywords

CD4 CD8; Inflammatory; Rheumatoid arthritis; Simvastatin; Statin; Th1 Th2

Indexed keywords

AURANOFIN; BUCILLAMINE; C REACTIVE PROTEIN; CORTICOSTEROID; METHOTREXATE; MIZORIBINE; RHEUMATOID FACTOR; SALAZOSULFAPYRIDINE; SIMVASTATIN;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4 CD8 RATIO; CLINICAL ARTICLE; CLINICAL TRIAL; DISEASE ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GRIP STRENGTH; HUMAN; HYPERCHOLESTEROLEMIA; IMMUNOMODULATION; JOINT SWELLING; LOW DRUG DOSE; MALE; MORNING STIFFNESS; PAIN ASSESSMENT; PRIORITY JOURNAL; QUESTIONNAIRE; RHEUMATOID ARTHRITIS; TH1 CELL; TH2 CELL; VISUAL ANALOG SCALE;

AGED; AGED, 80 AND OVER; ANTIGENS, CD4; ANTIGENS, CD8; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; MALE; MIDDLE AGED; RHEUMATOID FACTOR; SIMVASTATIN; TH1 CELLS; TH2 CELLS; TREATMENT OUTCOME;

EID: 35348874745     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-007-0589-4     Document Type: Article

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