Astaxanthin can alter CYP1A-dependent activities via two different mechanisms: Induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer

Food and Chemical Toxicology

Volumn 49, Issue 6, 2011, Pages 1285-1291

  Ohno, Marumi ^a   Darwish, Wageh S ^a,c   Ikenaka, Yoshinori ^a   Miki, Wataru ^b   Ishizuka, Mayumi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

^c Zagazig University   (Egypt)

Author keywords

Astaxanthin; Benzo a pyrene; Conjugating enzyme; Cytochrome P450 1A; Metabolic activation; NADPH P450 reductase

Indexed keywords

ASTAXANTHIN; BENZO[A]PYRENE; CYTOCHROME P450 1A; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE;

AMES TEST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DETOXIFICATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME INHIBITION; LIVER MICROSOME; MALE; METABOLIC ACTIVATION; MUTAGENICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

ANIMALS; ANTIMUTAGENIC AGENTS; BENZO(A)PYRENE; CYTOCHROME P-450 CYP1A1; ELECTRON TRANSPORT; ENZYME INHIBITORS; FIBRINOLYTIC AGENTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; LIVER; MALE; MUTAGENS; NADPH-FERRIHEMOPROTEIN REDUCTASE; RATS; RATS, WISTAR; RNA, MESSENGER; XANTHOPHYLLS;

RATTUS; RATTUS NORVEGICUS;

EID: 79955651826     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2011.03.009     Document Type: Article

References (30)

1. Albanes D., Heinonen O.P., Taylor P.R., Virtamo J., Edwards B.K., Rautalahti M., Hartman A.M., Palmgren J., Freedman L.S., Haapakoski J., Barrett M.J., Pietinen P., Malila N., Tala E., Liippo K., Salomaa E.R., Tangrea J.A., Teppo L., Askin F.B., Taskinen E., Erozan Y., Greenwald P., Huttunen J.K. Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J. Natl. Cancer Inst. 1996, 88:1513-1515.
2. Ames B.N., Mccann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 1975, 31:347-364.
3. Burton G.W., Ingold K.U. Beta-carotene: an unusual type of lipid antioxidant. Science 1984, 224:569-573.
4. Cantrell A., McGarvey D.J., Truscott T.G., Rancan F., Böhm F. Singlet oxygen quenching by dietary carotenoids in a model membrane environment. Arch. Biochem. Biophys. 2003, 412:47-54.
5. Clark R.M., Yao L., She Li., Furr H.C. A comparison of lycopene and astaxanthin absorption from corn oil and olive oil emulsions. Lipids 2000, 35:803-806.
6. Crespi C.L., Miller V.P., Penman B.W. Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450. Anal. Biochem. 1997, 248:188-190.
7. Deming D.M., Erdman J.W. Mammalian carotenoid absorption and metabolism. Pure Appl. Chem. 1999, 71:2213-2223.
8. Goto S., Kogure K., Abe K., Kimata Y., Kitahama K., Yamashita E., Terada H. Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochim. Biophys. Acta 2001, 1512:251-258.
9. Gradelet S., Astorg P., Leclerc J., Chevalier J., Vernevaut M.F., Siess M.H. Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat. Xenobiotica 1996, 26:49-63.
10. Ikeuchi M., Koyama T., Takahashi J., Yazawa K. Effects of astaxanthin in obese mice fed a high-fat diet. Biosci. Biotechnol. Biochem. 2007, 71:893-899.
11. Jeong T.C., Gu H.K., Chun Y.J., Yun C.H., Han S.S., Roh J.K. Effects of beta-ionone on the expression of cytochrome P450s and NADPH-cytochrome P450 reductase in Sprague-Dawley rats. Chem. Biol. Interact. 1998, 114:97-107.
12. Jewell C., O'Brien N.M. Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. Br. J. Nutr. 1999, 81:235-242.
13. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
14. Lennard P.R. Dealing with data. Nature 1990, 347:104-106.
15. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
16. 2 and ethanol as entrainer. Ind. Eng. Chem. Res. 2006, 45:3652-3657.
17. McLemore T.L., Adelberg S., Liu M.C., McMahon N.A., Yu S.J., Hubbard W.C., Czerwinski M., Wood T.G., Storeng R., Lubet R.A., et al. Expression of CYP1A1 gene in patients with lung cancer; evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. J. Natl. Cancer Inst. 1990, 82:1333-1339.
18. Muto S., Fujita K., Yamazaki Y., Kamataki T. Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450. Mutat. Res. 2001, 479:197-206.
19. Nakagawa K., Kang S.D., Park D.K., Handelman G.J., Miyazawa T. Inhibition of beta-carotene and astaxanthin of NADPH-dependent microsomal phospholipid peroxidation. J. Nutr. Sci. Vitaminol. (Tokyo) 1997, 43:345-355.
20. Nebert D.W. Role of genetics and drug metabolism in human cancer risk. Mutat. Res. 1991, 247:267-281.
21. Omenn G.S., Goodman G.E., Thornquist M.D., Balmes J., Cullen M.R., Glass A., Keogh J.P., Meyskens F.L., Valanis B., Williams J.H., Barnhart S., Cherniack M.G., Brodkin C.A., Hammar S. Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. J. Natl. Cancer Inst. 1996, 88:1550-1559.
22. Omura T., Takesue S. A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes. J. Biochem. 1970, 67:249-257.
23. Petri D., Lundebye A.K. Tissue distribution of astaxanthin in rats following exposure to graded levels in the feed. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2007, 145:202-209.
24. Santocono M., Zurria M., Berrettini M., Fedeli D., Falcioni G. Lutein, zeaxanthin and astaxanthin protect against DNA damage in SK-N-SH human neuroblastoma cells induced by reactive nitrogen species. J. Photochem. Photobiol. B 2007, 88:1-10.
25. Sivaraman L., Leatham M.P., Yee J., Wilkens L.R., Lau A.F., Le Marchand L. CYP1A1 genetic polymorphisms and in situ colorectal cancer. Cancer Res. 1994, 54:3692-3695.
26. Socaciu C., Jessel R., Diehl H.A. Carotenoid incorporation into microsomes: yields, stability and membrane dynamics. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2000, 56:2799-2809.
27. Takahashi K., Watanabe M., Takimoto T., Akiba Y. Uptake and distribution of astaxanthin in several tissues and plasma lipoproteins in male broiler chickens fed a yeast (Phaffia rhodozyma) with a high concentration of astaxanthin. Br. Poult. Sci. 2004, 45:133-138.
28. van Helden Y.G., Keijer J., Knaapen A.M., Heil S.G., Briedé J.J., van Schooten F.J., Godschalk R.W. Beta-carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells. Free Radic. Biol. Med. 2009, 46:299-304.
29. Wolz E., Liechti H., Notter B., Oesterhelt G., Kistler A. Characterization of metabolites of astaxanthin in primary cultures of rat hepatocytes. Drug Metab. Dispos. 1999, 27:456-462.
30. Yao H.T., Chang Y.W., Lan S.J., Yeh T.K. The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes. Food Chem. Toxicol. 2008, 46:645-653.