Characterization of metabolites of astaxanthin in primary cultures of rat hepatocytes

Drug Metabolism and Disposition

Volumn 27, Issue 4, 1999, Pages 456-462

  Wolz, Erich ^a   Liechti, Hans ^a   Notter, Brigitte ^a   Oesterhelt, Gottfried ^a   Kistler, Andreas ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4 OXO 7,8 DIHYDRO BETA IONONE; 3 HYDROXY 4 OXO BETA IONONE; ASTAXANTHIN; BETA GLUCURONIDASE; DRUG METABOLITE; SULFATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER METABOLISM; LIVER MICROSOME; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BETA CAROTENE; CARBON RADIOISOTOPES; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A1; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; XANTHOPHYLLS; XENOBIOTICS;

ANIMALIA;

EID: 0032918033     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Albanes D and Heinonen (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330:1029-1035.
2. Astorg P, Gradelet S, Leclerc J, Canivenc MC and Siess HM (1994) Effects of β-carotene and canthaxanthin on liver xenobiotic-metabolizing enzymes in the rat. Food Chem Toxicol 32:735-742.
3. Brubacher GB and Weiser H (1985) The vitamin A activity of β-carotene. Int J Vitam Nutr Res 55:5-15.
4. Burke MD and Mayer G (1974) Ethoxyresorufin: Direct fluorometric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methycholanthrene. Drug Metab Dispos 2:583-588.
5. Ganguly J and Sastry PS (1985) Mechanism of conversion of β-carotene into vitamin A - Central cleavage versus random cleavage World Rev Nutr Diet 45:198-220.
6. Goodman DS and Huang HS (1965) Biosynthesis of vitamin A with rat intestinal enzymes. Science (Wash) 149:879-880.
7. Goodman DS, Blomsrand F, Werner B, Huang HS and Shiratori T (1966) The intestinal absorption and metabolism of vitamin A and β-carotene in man. J Clin Invest 45:1615-1623.
8. Gradelet S, Astorg P, Leclerc J, Chevalier J, Vernevaut MF and Siess MH (1996a) Effects of cantnaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat. Xenobiotica 26:49-63.
9. Gradelet S, Leclerc J, Siess MH and Astorg PO (1996b) β-Apo-8′-carotenal, but not β-carotene is a strong inducer of liver cytochromes P45012 A1 and 1A2 in rat. Xenobiotica 26:909-919.
10. Khachik F, Spangler CJ, Smith JC, Canfield LM, Steck A and Pfander H (1997) Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal Chem 69:1873-1881.
11. Lowry OH, Rosebrough NJ, Farr, AL and Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
12. Lu AYH, Kuntzman R, West S, Jacobso, M and Conney AH (1972) Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations. J Biol Chem 247:1727-1734.
13. Matsuno T, Nagata S and Kitamura K (1976) New carotenoids, parasiloxanthin and 7,8-dihydroparasiloxanthin. Tetrahedron Lett 50:4601-4604.
14. Olson JA and Hayaishi O (1965) The enzymatic cleavage of β-carotene into vitamin A by soluble enzymes of rat liver and intestine. Proc Nat Acad Sci USA 54:1364-1370.
15. Schüep W and Schierle J (1995) Determination of stabilized, added astaxanthin in fish feeds and pre-mixes, in Carotenoids, vol. 1A: Isolation and Analysis (Britton G, Liaaen-Jensen S and Pfander H eds) pp 273-276, Birkhäuser, Basel.
16. Seglen PO (1976) Preparation of rat liver cells. Methods Cell Biol 13:29-83.