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Volumn 9, Issue 5, 2011, Pages 585-598

Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide

Author keywords

Chloroplast biotechnology; Diabetes; Molecular farming; Plant made pharmaceuticals

Indexed keywords

C PEPTIDE; INSULIN; PROINSULIN; RECOMBINANT PROTEIN;

EID: 79955647602     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/j.1467-7652.2010.00582.x     Document Type: Article
Times cited : (137)

References (61)
  • 1
    • 0034752386 scopus 로고    scopus 로고
    • Current status of the oral delivery of insulin
    • October
    • Agarwal, V. and Khan, M. (2001) Current status of the oral delivery of insulin. Pharm. Technol., October, 76-90.
    • (2001) Pharm. Technol. , pp. 76-90
    • Agarwal, V.1    Khan, M.2
  • 2
    • 43449108812 scopus 로고    scopus 로고
    • Economic costs of diabetes in the U.S. in 2007
    • American Diabetes Association .
    • American Diabetes Association (2008) Economic costs of diabetes in the U.S. in 2007. Diabetes Care, 31, 596-615.
    • (2008) Diabetes Care , vol.31 , pp. 596-615
  • 3
    • 0031762753 scopus 로고    scopus 로고
    • A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes
    • Arakawa, T., Yu, J., Chong, D.K., Hough, J., Engen, P.C. and Langridge, W.H. (1998) A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes. Nat. Biotechnol., 16, 934-938.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 934-938
    • Arakawa, T.1    Yu, J.2    Chong, D.K.3    Hough, J.4    Engen, P.C.5    Langridge, W.H.6
  • 5
    • 48849104676 scopus 로고    scopus 로고
    • Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts
    • Arlen, P.A., Singleton, M., Adamovicz, J.J., Ding, Y., Davoodi-Semiromi, A. and Daniell, H. (2008) Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts. Infect. Immun., 76, 3640-3650.
    • (2008) Infect. Immun. , vol.76 , pp. 3640-3650
    • Arlen, P.A.1    Singleton, M.2    Adamovicz, J.J.3    Ding, Y.4    Davoodi-Semiromi, A.5    Daniell, H.6
  • 6
    • 36849027691 scopus 로고    scopus 로고
    • Both the stroma and thylakoid lumen of tobacco chloroplasts are competent for the formation of disulphide bonds in recombinant proteins
    • Bally, J., Paget, E., Droux, M., Job, C., Job, D. and Dubald, M. (2008) Both the stroma and thylakoid lumen of tobacco chloroplasts are competent for the formation of disulphide bonds in recombinant proteins. Plant Biotechnol. J., 6, 46-61.
    • (2008) Plant Biotechnol. J. , vol.6 , pp. 46-61
    • Bally, J.1    Paget, E.2    Droux, M.3    Job, C.4    Job, D.5    Dubald, M.6
  • 8
    • 79955653226 scopus 로고    scopus 로고
    • National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2007
    • Centers for Disease Control and Prevention ., GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.
    • Centers for Disease Control and Prevention (2008) National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2007. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.
    • (2008) Atlanta
  • 9
    • 34249852223 scopus 로고    scopus 로고
    • Transgene containment by maternal inheritance: effective or elusive?
    • Daniell, H. (2007) Transgene containment by maternal inheritance: effective or elusive? Proc. Natl Acad. Sci. USA, 104, 6879-6880.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6879-6880
    • Daniell, H.1
  • 10
    • 0035979785 scopus 로고    scopus 로고
    • Expression of the Native Cholera Toxin B Subunit Gene and Assembly as Functional Oligomers in Transgenic Tobacco Chloroplasts
    • Daniell, H., Lee, S.-B., Panchal, T. and Wiebe, P.O. (2001) Expression of the Native Cholera Toxin B Subunit Gene and Assembly as Functional Oligomers in Transgenic Tobacco Chloroplasts. J. Mol. Biol., 311, 1001-1009.
    • (2001) J. Mol. Biol. , vol.311 , pp. 1001-1009
    • Daniell, H.1    Lee, S.-B.2    Panchal, T.3    Wiebe, P.O.4
  • 12
    • 65549122095 scopus 로고    scopus 로고
    • Optimization of codon composition and regulatory elements for expression of human insulin like growth factor-1 in transgenic chloroplasts and evaluation of structural identity and function
    • Daniell, H., Ruiz, G., Denes, B., Sandberg, L. and Langridge, W. (2009b) Optimization of codon composition and regulatory elements for expression of human insulin like growth factor-1 in transgenic chloroplasts and evaluation of structural identity and function. BMC Biotechnol., 9, 33.
    • (2009) BMC Biotechnol. , vol.9 , pp. 33
    • Daniell, H.1    Ruiz, G.2    Denes, B.3    Sandberg, L.4    Langridge, W.5
  • 13
    • 70349538837 scopus 로고    scopus 로고
    • The green vaccine: a global strategy to combat infectious and autoimmune diseases
    • Davoodi-Semiromi, A., Samson, N. and Daniell, H. et al. (2009) The green vaccine: a global strategy to combat infectious and autoimmune diseases. Hum. Vaccin., 5, 488-493.
    • (2009) Hum. Vaccin. , vol.5 , pp. 488-493
    • Davoodi-Semiromi, A.1    Samson, N.2    Daniell, H.3
  • 15
    • 0031903613 scopus 로고    scopus 로고
    • The affinity of cholera toxin for Ni2+ ion
    • Dertzbaugh, M.T. and Cox, L. (1998) The affinity of cholera toxin for Ni2+ ion. Protein Eng., 11, 577-581.
    • (1998) Protein Eng. , vol.11 , pp. 577-581
    • Dertzbaugh, M.T.1    Cox, L.2
  • 16
    • 0037321440 scopus 로고    scopus 로고
    • Amelioration of sensory nerve dysfunction by C-Peptide in patients with type 1 diabetes
    • Ekberg, K., Brismar, T., Johansson, B.L., Jonsson, B., Lindström, P. and Wahren, J. (2003) Amelioration of sensory nerve dysfunction by C-Peptide in patients with type 1 diabetes. Diabetes, 52, 536-541.
    • (2003) Diabetes , vol.52 , pp. 536-541
    • Ekberg, K.1    Brismar, T.2    Johansson, B.L.3    Jonsson, B.4    Lindström, P.5    Wahren, J.6
  • 17
    • 85169106486 scopus 로고    scopus 로고
    • A chloroplast genetic approach to hyper-express and purify human serum albumin, a protein highly susceptible to proteolytic degradation
    • Fernandez-San Millan, A., Minego-Castel, A., Mingo-Castel, A., Miller, M. and Daniell, H. (2003) A chloroplast genetic approach to hyper-express and purify human serum albumin, a protein highly susceptible to proteolytic degradation. Plant Biotechnol. J., 1, 71-79.
    • (2003) Plant Biotechnol. J. , vol.1 , pp. 71-79
    • Fernandez-San Millan, A.1    Minego-Castel, A.2    Mingo-Castel, A.3    Miller, M.4    Daniell, H.5
  • 19
    • 73349104925 scopus 로고    scopus 로고
    • Technology and the issue of cost/benefit in diabetes
    • Giannini, C., Mohn, A. and Chiarelli, F. et al. (2009) Technology and the issue of cost/benefit in diabetes. Diabetes Metab. Res. Rev., 25(Suppl 1), S34-44.
    • (2009) Diabetes Metab. Res. Rev. , vol.25 , Issue.SUPPL. 1
    • Giannini, C.1    Mohn, A.2    Chiarelli, F.3
  • 20
    • 0028064783 scopus 로고
    • Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin
    • Groskreutz, D.J., Sliwkowski, M. and Gorman, C.M. (1994) Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J. Biol. Chem., 269, 6241-6245.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6241-6245
    • Groskreutz, D.J.1    Sliwkowski, M.2    Gorman, C.M.3
  • 21
    • 77955820301 scopus 로고    scopus 로고
    • Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus
    • Gupta, S., Chattopadhyay, T., Singh, M.P. and Surolia, A. (2010) Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus. Proc. Natl Acad. Sci. USA, 107, 13246-13251.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 13246-13251
    • Gupta, S.1    Chattopadhyay, T.2    Singh, M.P.3    Surolia, A.4
  • 22
    • 0031842147 scopus 로고    scopus 로고
    • The role of ADP-ribosylation and GM1-binding activity in the mucosal immunogenicity and adjuvanticity of the Escherichia coli heat-labile enterotoxin and Vibrio cholerae cholera toxin
    • de Haan, L., Verweij, W., Agsteribbe, E. and Wilschut, J. (1998) The role of ADP-ribosylation and GM1-binding activity in the mucosal immunogenicity and adjuvanticity of the Escherichia coli heat-labile enterotoxin and Vibrio cholerae cholera toxin. Immunol. Cell Biol., 76, 270-279.
    • (1998) Immunol. Cell Biol. , vol.76 , pp. 270-279
    • de Haan, L.1    Verweij, W.2    Agsteribbe, E.3    Wilschut, J.4
  • 23
    • 65549115158 scopus 로고    scopus 로고
    • Cellular and physiological effects of C-peptide
    • Hills, C.E. and Brunskill, N. (2009) Cellular and physiological effects of C-peptide. Clin. Sci. (Lond), 116, 565-574.
    • (2009) Clin. Sci. (Lond) , vol.116 , pp. 565-574
    • Hills, C.E.1    Brunskill, N.2
  • 24
    • 75649094914 scopus 로고    scopus 로고
    • Oral insulin - a review of current status
    • Iyer, H., Khedkar, A. and Verma, M. (2010) Oral insulin - a review of current status. Diabetes Obes. Metab., 12, 179-185.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 179-185
    • Iyer, H.1    Khedkar, A.2    Verma, M.3
  • 25
    • 0034700138 scopus 로고    scopus 로고
    • Activation of Rubisco regulates photosynthesis at high temperature and CO2
    • Jensen, R. (2000) Activation of Rubisco regulates photosynthesis at high temperature and CO2. Proc. Natl Acad. Sci., 97, 12937-12938.
    • (2000) Proc. Natl Acad. Sci. , vol.97 , pp. 12937-12938
    • Jensen, R.1
  • 26
    • 0003453248 scopus 로고    scopus 로고
    • Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus
    • Johansson, B.L., Borg, K., Fernqvist-Forbes, E., Kernell, A., Odergren, T. and Wahren, J. (2000) Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus. Diabet. Med., 1, 181-189.
    • (2000) Diabet. Med. , vol.1 , pp. 181-189
    • Johansson, B.L.1    Borg, K.2    Fernqvist-Forbes, E.3    Kernell, A.4    Odergren, T.5    Wahren, J.6
  • 27
    • 0033807177 scopus 로고    scopus 로고
    • Yeast secretory expression of insulin precursors
    • Kjeldsen, T. (2000) Yeast secretory expression of insulin precursors. Appl. Microbiol. Biotechnol., 54, 277-286.
    • (2000) Appl. Microbiol. Biotechnol. , vol.54 , pp. 277-286
    • Kjeldsen, T.1
  • 28
    • 28444439874 scopus 로고    scopus 로고
    • Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge
    • Koya, V., Moayeri, M., Leppla, S.H. and Daniell, H. (2005) Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect. Immun., 73, 8266-8274.
    • (2005) Infect. Immun. , vol.73 , pp. 8266-8274
    • Koya, V.1    Moayeri, M.2    Leppla, S.H.3    Daniell, H.4
  • 29
    • 70549101152 scopus 로고    scopus 로고
    • A rapid method for depletion of Rubisco from soybean (Glycine max) leaf for proteomic analysis of lower abundance proteins
    • Krishnan, H.B. and Natarajan, S. (2009) A rapid method for depletion of Rubisco from soybean (Glycine max) leaf for proteomic analysis of lower abundance proteins. Phytochemistry, 70, 1958-1964.
    • (2009) Phytochemistry , vol.70 , pp. 1958-1964
    • Krishnan, H.B.1    Natarajan, S.2
  • 30
    • 4644241217 scopus 로고    scopus 로고
    • Engineering the chloroplast genome for hyperexpression of human therapeutic proteins and vaccine antigens
    • Kumar, S. and Daniell, H. (2004) Engineering the chloroplast genome for hyperexpression of human therapeutic proteins and vaccine antigens. Methods Mol. Biol., 267, 365-383.
    • (2004) Methods Mol. Biol. , vol.267 , pp. 365-383
    • Kumar, S.1    Daniell, H.2
  • 31
    • 78650067828 scopus 로고    scopus 로고
    • Expression and characterization of antimicrobial peptides Retrocyclin-101 and Protegrin-1 in chloroplasts to control viral and bacterial infections
    • doi:10.1111/j.1467-7652.2010.00538.x
    • Lee, S.B., Li, B., Jin, S. and Daniell, H. (2011) Expression and characterization of antimicrobial peptides Retrocyclin-101 and Protegrin-1 in chloroplasts to control viral and bacterial infections. Plant Biotechnol. J. doi:10.1111/j.1467-7652.2010.00538.x
    • (2011) Plant Biotechnol. J.
    • Lee, S.B.1    Li, B.2    Jin, S.3    Daniell, H.4
  • 32
    • 0038577974 scopus 로고    scopus 로고
    • Eighty years of insulin therapy: 1922-2002
    • Levinson, P.D. (2003) Eighty years of insulin therapy: 1922-2002. Med. Health R. I., 86, 101-106.
    • (2003) Med. Health R. I. , vol.86 , pp. 101-106
    • Levinson, P.D.1
  • 33
    • 33645996068 scopus 로고    scopus 로고
    • Expression of cholera toxin B subunit and the B chain of human insulin as a fusion protein in transgenic tobacco plants
    • Li, D., O'Leary, J., Huang, Y., Huner, N.P., Jevnikar, A.M. and Ma, S. (2006) Expression of cholera toxin B subunit and the B chain of human insulin as a fusion protein in transgenic tobacco plants. Plant Cell Rep., 25, 417-424.
    • (2006) Plant Cell Rep. , vol.25 , pp. 417-424
    • Li, D.1    O'Leary, J.2    Huang, Y.3    Huner, N.P.4    Jevnikar, A.M.5    Ma, S.6
  • 34
    • 0345055329 scopus 로고    scopus 로고
    • Fusions to the cholera toxin B subunit: influence on pentamerization and GM1 binding
    • Liljeqvist, S., Stahl, S., Andréoni, C., Binz, H., Uhlén, M. and Murby, M. (1997) Fusions to the cholera toxin B subunit: influence on pentamerization and GM1 binding. J. Immunol. Methods, 210, 125-135.
    • (1997) J. Immunol. Methods , vol.210 , pp. 125-135
    • Liljeqvist, S.1    Stahl, S.2    Andréoni, C.3    Binz, H.4    Uhlén, M.5    Murby, M.6
  • 35
    • 33845650824 scopus 로고    scopus 로고
    • Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system
    • Limaye, A., Koya, V., Samsam, M. and Daniell, H. (2006) Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J., 20, E37-E46.
    • (2006) FASEB J. , vol.20
    • Limaye, A.1    Koya, V.2    Samsam, M.3    Daniell, H.4
  • 36
    • 0007613844 scopus 로고
    • The role of protein synthesis in the senescence of leaves: I. The formation of protease
    • Martin, C. and Thimann, K. (1972) The role of protein synthesis in the senescence of leaves: I. The formation of protease. Plant Physiol., 49, 64-71.
    • (1972) Plant Physiol. , vol.49 , pp. 64-71
    • Martin, C.1    Thimann, K.2
  • 37
    • 66149136008 scopus 로고    scopus 로고
    • Plastid production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins
    • Oey, M., Lohse, M., Scharff, L.B., Kreikemeyer, B. and Bock, R. (2009) Plastid production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins. Proc. Natl Acad. Sci. USA, 106, 6579-6584.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 6579-6584
    • Oey, M.1    Lohse, M.2    Scharff, L.B.3    Kreikemeyer, B.4    Bock, R.5
  • 38
    • 0015522139 scopus 로고
    • Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH
    • Pekar, A.H. and Frank, B. (1972) Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH. Biochemistry, 11, 4013-4016.
    • (1972) Biochemistry , vol.11 , pp. 4013-4016
    • Pekar, A.H.1    Frank, B.2
  • 39
    • 73349138601 scopus 로고    scopus 로고
    • Review of clinical trials: update on oral insulin spray formulation
    • Pozzilli, P., Raskin, P. and Parkin, C.G. (2010) Review of clinical trials: update on oral insulin spray formulation. Diabetes Obes. Metab., 12, 91-96.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 91-96
    • Pozzilli, P.1    Raskin, P.2    Parkin, C.G.3
  • 40
    • 27244432790 scopus 로고    scopus 로고
    • Characterization of heterologous multigene operons in transgenic chloroplasts: transcription, processing, and translation
    • Quesada-Vargas, T., Ruiz, O. and Daniell, H. (2005) Characterization of heterologous multigene operons in transgenic chloroplasts: transcription, processing, and translation. Plant Physiol., 138, 1746-1762.
    • (2005) Plant Physiol. , vol.138 , pp. 1746-1762
    • Quesada-Vargas, T.1    Ruiz, O.2    Daniell, H.3
  • 41
    • 58149515759 scopus 로고    scopus 로고
    • Cost and availability of insulin and other diabetes supplies: IDF survey 2003-2003
    • Raab, R., Fezeu, L. and Mbanya, J.C. (2004) Cost and availability of insulin and other diabetes supplies: IDF survey 2003-2003. Diabetes Voice, 49, 24-29.
    • (2004) Diabetes Voice , vol.49 , pp. 24-29
    • Raab, R.1    Fezeu, L.2    Mbanya, J.C.3
  • 43
    • 34249820528 scopus 로고    scopus 로고
    • Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts--oral administration protects against development of insulitis in non-obese diabetic mice
    • Ruhlman, T., Ahangari, R., Devine, A., Samsam, M. and Daniell, H. (2007) Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts--oral administration protects against development of insulitis in non-obese diabetic mice. Plant Biotechnol. J., 5, 495-510.
    • (2007) Plant Biotechnol. J. , vol.5 , pp. 495-510
    • Ruhlman, T.1    Ahangari, R.2    Devine, A.3    Samsam, M.4    Daniell, H.5
  • 44
    • 77950526756 scopus 로고    scopus 로고
    • The role of heterologous chloroplast sequence elements in transgene integration and expression
    • Ruhlman, T., Verma, D., Samson, N. and Daniell, H. (2010) The role of heterologous chloroplast sequence elements in transgene integration and expression. Plant Physiol., 152, 2088-2104.
    • (2010) Plant Physiol. , vol.152 , pp. 2088-2104
    • Ruhlman, T.1    Verma, D.2    Samson, N.3    Daniell, H.4
  • 45
    • 0036124978 scopus 로고    scopus 로고
    • Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo
    • Shaw, J.A.M., Delday, M., Hart, A.W., Docherty, H.M., Maltin, C.A. and Docherty, K. (2002) Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo. J. Endocrinol., 172, 653-672.
    • (2002) J. Endocrinol. , vol.172 , pp. 653-672
    • Shaw, J.A.M.1    Delday, M.2    Hart, A.W.3    Docherty, H.M.4    Maltin, C.A.5    Docherty, K.6
  • 46
    • 64549157603 scopus 로고    scopus 로고
    • Inhaled insulin--does it become reality?
    • Siekmeier, R. and Scheuch, G. (2008) Inhaled insulin--does it become reality? J. Physiol. Pharmacol., 59(Suppl 6), 81-113.
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.SUPPL. 6 , pp. 81-113
    • Siekmeier, R.1    Scheuch, G.2
  • 47
    • 17844388643 scopus 로고    scopus 로고
    • The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats
    • Sima, A.A.F. and Li, Z.-G. (2005) The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats. Diabetes, 54, 1497-1505.
    • (2005) Diabetes , vol.54 , pp. 1497-1505
    • Sima, A.A.F.1    Li, Z.-G.2
  • 48
    • 0031995477 scopus 로고    scopus 로고
    • The proprotein convertases
    • Steiner, D.F. (1998) The proprotein convertases. Curr. Opin. Chem. Biol., 2, 31-39.
    • (1998) Curr. Opin. Chem. Biol. , vol.2 , pp. 31-39
    • Steiner, D.F.1
  • 50
    • 0035313153 scopus 로고    scopus 로고
    • Advances in Escherichia coli production of therapeutic proteins
    • Swartz, J.R. (2001) Advances in Escherichia coli production of therapeutic proteins. Curr. Opin. Biotechnol., 12, 195-201.
    • (2001) Curr. Opin. Biotechnol. , vol.12 , pp. 195-201
    • Swartz, J.R.1
  • 52
    • 0038461962 scopus 로고    scopus 로고
    • Curbing activation: proprotein convertases in homeostasis and pathology
    • Taylor, N.A., Van De Ven, W. and Creemers, J.W. (2003) Curbing activation: proprotein convertases in homeostasis and pathology. FASEB J., 17, 1215-1227.
    • (2003) FASEB J. , vol.17 , pp. 1215-1227
    • Taylor, N.A.1    Van De Ven, W.2    Creemers, J.W.3
  • 53
    • 0036791359 scopus 로고    scopus 로고
    • Furin at the cutting edge: from protein traffic to embryogenesis and disease
    • Thomas, G. (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat. Rev., 3, 753-766.
    • (2002) Nat. Rev. , vol.3 , pp. 753-766
    • Thomas, G.1
  • 54
    • 0028826127 scopus 로고
    • Monomer of the B Subunit of Heat-Labile Enterotoxin from Enterotoxigenic Escherichia coli Has Little Ability to Bind to GM1 Ganglioside Compared to Its Coligenoid
    • Tsuji, T., Watanabe, K. and Miyama, A. (1995) Monomer of the B Subunit of Heat-Labile Enterotoxin from Enterotoxigenic Escherichia coli Has Little Ability to Bind to GM1 Ganglioside Compared to Its Coligenoid. Microbiol. Immunol., 39, 817-819.
    • (1995) Microbiol. Immunol. , vol.39 , pp. 817-819
    • Tsuji, T.1    Watanabe, K.2    Miyama, A.3
  • 55
    • 37249014420 scopus 로고    scopus 로고
    • Chloroplast Vector Systems for Biotechnology Applications
    • Verma, D. and Daniell, H. (2007) Chloroplast Vector Systems for Biotechnology Applications. Plant Physiol., 145, 1129-1143.
    • (2007) Plant Physiol. , vol.145 , pp. 1129-1143
    • Verma, D.1    Daniell, H.2
  • 56
    • 42049111811 scopus 로고    scopus 로고
    • A protocol for expression of foreign genes in chloroplasts
    • Verma, D., Samson, N., Koya, V. and Daniell, H. (2008) A protocol for expression of foreign genes in chloroplasts. Nat. Protoc., 3, 739-758.
    • (2008) Nat. Protoc. , vol.3 , pp. 739-758
    • Verma, D.1    Samson, N.2    Koya, V.3    Daniell, H.4
  • 57
    • 77951055907 scopus 로고    scopus 로고
    • Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice
    • Verma, D., Moghimi, B., LoDuca, P.A., Singh, H.D., Hoffman, B.E., Herzog, R.W. and Daniell, H. (2010) Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice. Proc. Natl Acad. Sci. USA, 107, 7101-7106.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 7101-7106
    • Verma, D.1    Moghimi, B.2    LoDuca, P.A.3    Singh, H.D.4    Hoffman, B.E.5    Herzog, R.W.6    Daniell, H.7
  • 59
    • 4143154030 scopus 로고    scopus 로고
    • "C-peptide: new findings and therapeutic implications in diabetes
    • Wahren, J. (2004) "C-peptide: new findings and therapeutic implications in diabetes. Clin. Physiol. Funct. Imaging, 24, 180-189.
    • (2004) Clin. Physiol. Funct. Imaging , vol.24 , pp. 180-189
    • Wahren, J.1
  • 60
    • 33846847381 scopus 로고    scopus 로고
    • C-peptide is a bioactive peptide
    • Wahren, J., Ekberg, K. and Jörnvall, H. (2007) C-peptide is a bioactive peptide. Diabetologia, 50, 503-509.
    • (2007) Diabetologia , vol.50 , pp. 503-509
    • Wahren, J.1    Ekberg, K.2    Jörnvall, H.3
  • 61
    • 0020036666 scopus 로고
    • Cytoplasmic inclusion bodies in Escherichia coli producing biosynthetic human insulin proteins
    • Williams, D.C., Van Frank, R.M., Muth, W.L. and Burnett, J.P. (1982) Cytoplasmic inclusion bodies in Escherichia coli producing biosynthetic human insulin proteins. Science, 215, 687-689.
    • (1982) Science , vol.215 , pp. 687-689
    • Williams, D.C.1    Van Frank, R.M.2    Muth, W.L.3    Burnett, J.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.