A lead study on oxidative stress-mediated dehydroepiandrosterone formation in serum: The biochemical basis for a diagnosis of alzheimer's disease

Journal of Alzheimer's Disease

Volumn 24, Issue SUPPL. 2, 2011, Pages 5-16

  Rammouz, Georges ^a   Lecanu, Laurent ^a,b,c   Aisen, Paul ^c,d,e   Papadopoulos, Vassilios ^a,b,c  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; blood; DHEA; diagnosis; gas chromatography; mass spectrometry; mild cognitive impairment; oxidative stress

Indexed keywords

PRASTERONE;

ADULT; AGED; ALZHEIMER DISEASE; ANDROGEN BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 79955643509     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2011-101941     Document Type: Article

References (40)

1. Baulieu EE (1997) Neurosteroids: ofthe nervous system, By the nervous system, for the nervous system. Rec Progr Horm Res 52, 1-32.
2. Wojtal K, Trojnar MK, Czuczwar SJ (2006) Endogenous neuroprotective factors: neurosteroids. Pharmacol Rep 3, 335-340. (Pubitemid 44111068)
3. Qiu C, Kivipelto M, von SE (2009) Epidemiology of alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 2, 111-128.
4. Baulieu EE, Coprechot C, Dray F, Emiliozzi R, Lebeau MC, Mauvais JP, Robel P (1965) An adrenal-secreted "andro-gen": dehydroisoandrosterone sulfate. Its metabolism and a tentative generalization on the metabolism of other steroid conjugates in man. Recent Prog Horm Res 411-500.
5. Baulieu EE, Robel P (1998) Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci USA 8, 4089-4091. (Pubitemid 28207868)
6. Coprechot C, Robel P, Axelson M, Sjovall J, Baulieu EE (1981) Characterization and measurement of dehydroepi-androsterone sulfate in rat brain. Proc Natl Acad Sci USA 8, 4704-4707. (Pubitemid 12225548)
7. Parker CR, Jr. (1999) Dehydroepiandrosterone and dehy-droepiandrosterone sulfate production in the human adrenal during development and aging. Steroids 9, 640-647. (Pubitemid 29424103)
8. Roberts E, Bologa L, Flood JF, Smith GE (1987) Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice. Brain Res 1-2, 357-362. (Pubitemid 17048426)
9. Bastianetto S, Ramassamy C, Poirier J, Quirion R (1999) Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Brain Res Mol Brain Res 1-2, 35-41. (Pubitemid 29148331)
10. Alhaj HA, Massey AE, McAllister-Williams RH (2006) Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study. Psychopharmacology (Berl) 4, 541-551. (Pubitemid 46758956)
11. Cascio C, Prasad VV, Lin YY, Lieberman S, Papadopoulos V (1998) Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells. Proc Natl Acad Sci USA6, 2862-2867. (Pubitemid 28135820)
12. Prasad VV, Vegesna SR, Welch M, Lieberman S (1994) Pre-cursors of the neurosteroids. Proc Natl Acad Sci USA8, 3220-3223.
13. Le GC, Sananes N, Gouezou M, Takemori S, Kominami S, Baulieu EE, Robel P (1991) Immunoreactive cytochrome P-450(17 Alpha) in rat and guinea-pig gonads, adrenal glands and brain. J Reprod Fertil 2, 609-622.
14. Cascio C, Brown RC, Liu Y, Han Z, Hales DB, Papadopoulos V (2000) Pathways of dehydroepiandrosterone formation in rat brain glia. J Steroid Biochem Mol Biol 2-3, 177-186. (Pubitemid 32168142)
15. Brown RC, Cascio C, Papadopoulos V (2000) Pathways of neurosteroid biosynthesis in cell lines from human brain: regulation of dehydroepiandrosterone formation by oxidative stress and beta-amyloid peptide. J Neurochem 2, 847-859. (Pubitemid 30053759)
16. Brown RC, Han Z, Cascio C, Papadopoulos V (2003) Oxi-dative stress-mediated DHEA formation in alzheimer's dis-ease pathology. Neurobiol Aging 1, 57-65. (Pubitemid 36001985)
17. Malloy PF, Cummings JL, Coffey CE, Duffy J, Fink M, Lauterbach EC, Lovell M, Royall D, Salloway S (1997) Cog-nitive screening instruments in neuropsychiatry: a report of the committee on research of the american neuropsychiatric association. JNeuropsychiatry Clin Neurosci 2, 189-197. (Pubitemid 27198795)
18. Markesbery WR (1997) Oxidative stress hypothesis in alzheimer's disease. Free Radic Biol Med 1, 134-147. (Pubitemid 27217017)
19. Coprechot C, Robel P, Axelson M, Sjovall J, Baulieu EE (1981) Characterization and measurement of dehy-droepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA8, 4704-4707. (Pubitemid 12225548)
20. Genazzani AR, Petraglia F, Bernardi F, Casarosa E, Salvestroni C, Tonetti A, Nappi RE, Luisi S, Palumbo M, Purdy RH, Luisi M (1998) Circulating levels of allopreg-nanolone in humans: gender, age, and endocrine influences. J Clin Endocrinol Metab 6, 2099-2103. (Pubitemid 28496343)
21. Lapcik O, Hampl R, Hill M, Bicikova M, Starka L (1998) Immunoassay of 7-hydroxysteroids: 1. radioimmunoassay of 7beta-hydroxy dehydroepiandrosterone. J Steroid Biochem Mol Biol 5-6, 439-445. (Pubitemid 29049417)
22. Lapcik O, Hampl R, Hill M, Starka L (1999) Immunoassay of 7-hydroxysteroids: 2. radioimmunoassay of 7alpha-hydroxydehydroepiandrosterone. J Steroid Biochem Mol Biol 5-6, 231-237.
23. Pearson Murphy BE, Allison CM (2000) Determination of progesterone and some of its neuroactive ring a-reduced metabolites in human serum. J Steroid Biochem Mol Biol 3, 137-142.
24. Attal-Khemis S, Dalmeyda V, Michot JL, Roudier M, Morfin R (1998) Increased total 7 alpha-hydroxy-dehydro-epiandrosterone in serum of patients with Alzheimer's dis-ease. J Gerontol A Biol Sci Med Sci 2, B125-B132. (Pubitemid 28136140)
25. Diallo S, Lecanu L, Greeson J, Papadopoulos V (2004) A capillary gas chromatography/mass spectrometric method for the quantification of hydroxysteroids in human plasma. Anal Biochem 1, 123-130. (Pubitemid 37491132)
26. Hill M, Havlikova H, Vrbikova J, Kancheva R, Kancheva L, Pouzar V, Cerny I, Starka L (2005) The identification and simultaneous quantification of 7-hydroxylated metabolites of pregnenolone, dehydroepiandrosterone, 3beta, 17beta-androstenediol, and testosterone in human serum using gas chromatography-mass spectrometry. J Steroid Biochem Mol Biol2, 187-200. (Pubitemid 41096680)
27. Jung HJ, Lee WY, Chung BC, Choi MH (2009) Mass spec-trometric profiling of saturated fatty acid esters of steroids separated by high-temperature gas chromatography. J Chro-matogr A 9, 1463-1468.
28. Kim YS, Zhang H, Kim HY (2000) Profiling neurosteroids in cerebrospinal fluids and plasma by gas chromatog-raphy/electron capture negative chemical ionization mass spectrometry. Anal Biochem 2, 187-195. (Pubitemid 30055866)
29. Wang Y, Griffiths WJ (2008) Capillary liquid chromatography combined with tandem mass spectrometry for the study of neurosteroids and oxysterols in brain. Neurochem Int 4-5, 506-521.
30. Hill M, Lapcik O, Havlikova H, Morfin R, Hampl R (2001) 7-Hydroxydehydroepiandrosterone epimers in human serum and saliva. comparison of gas chromatography-mass spec-trometry and radioimmunoassay. J Chromatogr A 1-2, 297-307. (Pubitemid 33044653)
31. Kancheva L, Hill M, Vcelakova H, Vrbikova J, Pelikanova T, Starka L (2007) The identification and simultaneous quantification of neuroactive androstane steroids and their polar conjugates in the serum of adult men, using gas chromatography-mass spectrometry. Steroids 11-12, 792-801. (Pubitemid 47320710)
32. Mitamura K, Nagaoka Y, Shimada K, Honma S, Namiki M, Koh E, Mizokami A (2003) Simultaneous determination of androstenediol 3-sulfate and dehydroepiandrosterone sulfate in human serum using isotope diluted liquid chromatography-electrospray ionization-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 1, 121-130. (Pubitemid 38352716)
33. Magnisali P, Dracopoulou M, Mataragas M, Dacou-Voutetakis A, Moutsatsou P (2008) Routine method for the simultaneous quantification of 17alpha-hydroxyproges-terone, testosterone, dehydroepiandrosterone, androstene-dione, cortisol, and pregnenolone in human serum of neonates using gas chromatography-mass spectrometry. J Chromatogr A 2, 166-177.
34. Naylor JC, Hulette CM, Steffens DC, Shampine LJ, Ervin JF, Payne VM, Massing MW, Kilts JD, Strauss JL, Calhoun PS, Calnaido RP, Blazer DG, Lieberman JA, Madison RD, Marx CE (2008) Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, ele-vated in alzheimer's disease, and related to neuropathological disease stage. J Clin Endocrinol Metab 8, 3173-3178.
35. Segura J, Ventura R, Jurado C (1998) Derivatization procedures for gas chromatographic-mass spectrometric determination of xenobiotics in biological samples, with special attention to drugs of abuse and doping agents. J Chro-matogr B Biomed Sci Appl 1, 61-90. (Pubitemid 28346480)
36. Armanini D, Vecchio F, Basso A, Milone FF, Simoncini M, Fiore C, Mattarello MJ, Sartorato P, Karbowiak I (2003) Alzheimer's disease: pathophysiological implications of mea-surement ofplasma cortisol, plasma dehydroepiandrosterone sulfate, and lymphocytic corticosteroid receptors. Endocrine 2, 113-118. (Pubitemid 38019117)
37. Carlson LE, Sherwin BB, Chertkow HM (1999) Relationships between dehydroepiandrosterone sulfate (DHEAS) and corti-sol (CRT) plasma levels and everyday memory in Alzheimer's disease patients compared to healthy controls. Horm Behav 3, 254-263. (Pubitemid 29287841)
38. Mariani E, Monastero R, Mecocci P (2007) Mild cognitive impairment: a systematic review. J Alzheimers Dis 1, 23-35. (Pubitemid 47396302)
39. Qi Z, Wu X, Wang Z, Zhang N, Dong H, Yao L, Li K (2010) Impairment and compensation coexist in amnestic MCI default mode network. Neuroimage 1, 48-55.
40. Burns A, Iliffe S (2009) Alzheimer'sdisease.BMJ338, B158.