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Volumn 7, Issue 5, 2011, Pages 272-281

Induction of immune tolerance in the treatment of rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; ANTIRHEUMATIC AGENT; ATACICEPT; B CELL ACTIVATING FACTOR; BELIMUMAB; CANAKINUMAB; COLLAGEN TYPE 2; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ETANERCEPT; GLYCOPROTEIN GP 39; GOLIMUMAB; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 60; HYDROXYCHLOROQUINE; INFLIXIMAB; METHOTREXATE; PLACEBO; PROTEIN DNAJP1; RITUXIMAB; RUXOLITINIB; SECUKINUMAB; STEROID; T LYMPHOCYTE RECEPTOR; TASOCITINIB; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VX 702;

EID: 79955623932     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2011.36     Document Type: Review
Times cited : (29)

References (96)
  • 1
    • 77952493476 scopus 로고    scopus 로고
    • ACR70-disease activity score remission achievement from switches between all the available biological agents in rheumatoid arthritis: A systematic review of the literature
    • Alivernini, S., Laria, A., Gremese, E., Zoli, A. & Ferraccioli, G. ACR70-disease activity score remission achievement from switches between all the available biological agents in rheumatoid arthritis: a systematic review of the literature. Arthritis Res. Ther. 11, R163 (2009).
    • (2009) Arthritis Res. Ther. , vol.11
    • Alivernini, S.1    Laria, A.2    Gremese, E.3    Zoli, A.4    Ferraccioli, G.5
  • 2
    • 77953694972 scopus 로고    scopus 로고
    • Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: A systematic literature review informing the EULAR recommendations for the management of RA
    • Nam, J. L. et al. Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA. Ann. Rheum. Dis. 69, 976-986 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 976-986
    • Nam, J.L.1
  • 3
  • 4
    • 78049508184 scopus 로고    scopus 로고
    • The Japanese experience with biologic therapies for rheumatoid arthritis
    • Takeuchi, T. & Kameda, H. The Japanese experience with biologic therapies for rheumatoid arthritis. Nat. Rev. Rheumatol. 6, 644-652 (2010).
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 644-652
    • Takeuchi, T.1    Kameda, H.2
  • 5
    • 69949186313 scopus 로고    scopus 로고
    • Alterations in cytokine profile and dendritic cells subsets in peripheral blood of rheumatoid arthritis patients before and after biologic therapy
    • Marti, L. et al. Alterations in cytokine profile and dendritic cells subsets in peripheral blood of rheumatoid arthritis patients before and after biologic therapy. Ann. NY Acad. Sci. 1173, 334-342 (2009).
    • (2009) Ann. NY Acad. Sci. , vol.1173 , pp. 334-342
    • Marti, L.1
  • 6
    • 77956634447 scopus 로고    scopus 로고
    • New and future agents in the treatment of rheumatoid arthritis
    • van Vollenhoven, R. F. New and future agents in the treatment of rheumatoid arthritis. Discov. Med. 9, 319-327 (2010).
    • (2010) Discov. Med. , vol.9 , pp. 319-327
    • Van Vollenhoven, R.F.1
  • 7
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994). (Pubitemid 24140436)
    • (1994) Annual Review of Immunology , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 8
    • 3042722266 scopus 로고    scopus 로고
    • Immunotherapy: Bewitched, bothered, and bewildered no more
    • DOI 10.1126/science.1099688
    • Steinman, R. M. & Mellman, I. Immunotherapy: bewitched, bothered, and bewildered no more. Science 305, 197-200 (2004). (Pubitemid 38886724)
    • (2004) Science , vol.305 , Issue.5681 , pp. 197-200
    • Steinman, R.M.1    Mellman, I.2
  • 9
    • 3042847542 scopus 로고    scopus 로고
    • Immune therapy for autoimmune diseases
    • DOI 10.1126/science.1099896
    • Steinman, L. Immune therapy for autoimmune diseases. Science 305, 212-216 (2004). (Pubitemid 38886728)
    • (2004) Science , vol.305 , Issue.5681 , pp. 212-216
    • Steinman, L.1
  • 10
    • 20444490383 scopus 로고    scopus 로고
    • Regulation of immunity by self-reactive T cells
    • DOI 10.1038/nature03725
    • Kronenberg, M. & Rudensky, A. Regulation of immunity by self-reactive T cells. Nature 435, 598-604 (2005). (Pubitemid 40825499)
    • (2005) Nature , vol.435 , Issue.7042 , pp. 598-604
    • Kronenberg, M.1    Rudensky, A.2
  • 11
    • 61349096538 scopus 로고    scopus 로고
    • Modulation of T-cell co-stimulation in rheumatoid arthritis: Clinical experience with abatacept
    • Laganà, B., Vinciguerra, M. & D'Amelio, R. Modulation of T-cell co-stimulation in rheumatoid arthritis: clinical experience with abatacept. Clin. Drug Investig. 29, 185-202 (2009).
    • (2009) Clin. Drug Investig. , vol.29 , pp. 185-202
    • Laganà, B.1    Vinciguerra, M.2    D'Amelio, R.3
  • 12
    • 32444447885 scopus 로고    scopus 로고
    • Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis
    • DOI 10.1002/art.21617
    • Leandro, M. J., Cambridge, G., Ehrenstein, M. R. & Edwards, J. C. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum. 54, 613-620 (2006). (Pubitemid 43228639)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.2 , pp. 613-620
    • Leandro, M.J.1    Cambridge, G.2    Ehrenstein, M.R.3    Edwards, J.C.W.4
  • 14
    • 46049109710 scopus 로고    scopus 로고
    • Therapeutic effects of antibodies to tumor necrosis factor-Á, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis
    • Matsumoto, I. et al. Therapeutic effects of antibodies to tumor necrosis factor-á, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis. Arthritis Res. Ther. 10, R66 (2008).
    • (2008) Arthritis Res. Ther. , vol.10
    • Matsumoto, I.1
  • 15
    • 77956410939 scopus 로고    scopus 로고
    • Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells
    • Platt, A. M. et al. Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells. J. Immunol. 185, 1558-1567 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1558-1567
    • Platt, A.M.1
  • 16
    • 51849108540 scopus 로고    scopus 로고
    • The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation
    • Bluestone, J. A. et al. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am. J. Transplant. 8, 2086-2096 (2008).
    • (2008) Am. J. Transplant. , vol.8 , pp. 2086-2096
    • Bluestone, J.A.1
  • 17
    • 76849086881 scopus 로고    scopus 로고
    • Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers
    • Dörner, T., Kinnman, N. & Tak, P. P. Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers. Pharmacol. Ther. 125, 464-475 (2010).
    • (2010) Pharmacol. Ther. , vol.125 , pp. 464-475
    • Dörner, T.1    Kinnman, N.2    Tak, P.P.3
  • 18
    • 33646362290 scopus 로고    scopus 로고
    • B-cell targeting in rheumatoid arthritis and other autoimmune diseases
    • Edwards, J. C. & Cambridge, G. B-cell targeting in rheumatoid arthritis and other autoimmune diseases. Nat. Rev. Immunol. 6, 394-403 (2006).
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 394-403
    • Edwards, J.C.1    Cambridge, G.2
  • 19
    • 79952697696 scopus 로고    scopus 로고
    • B-lymphocyte effector functions in health and disease
    • doi:10.1007/s12026-010-8189-8183
    • DiLillo, D. J., Horikawa, M. & Tedder, T. F. B-lymphocyte effector functions in health and disease. Immunol. Res. doi:10.1007/s12026-010-8189-8183.
    • Immunol. Res.
    • Dilillo, D.J.1    Horikawa, M.2    Tedder, T.F.3
  • 20
    • 75749087574 scopus 로고    scopus 로고
    • B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer
    • DiLillo, D. J., Matsushita, T. & Tedder, T. F. B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann. NY Acad. Sci. 1183, 38-57 (2010).
    • (2010) Ann. NY Acad. Sci. , vol.1183 , pp. 38-57
    • Dilillo, D.J.1    Matsushita, T.2    Tedder, T.F.3
  • 21
    • 79953711736 scopus 로고    scopus 로고
    • B-cell activation biomarkers as predictive factors of the response to rituximab in rheumatoid arthritis
    • doi:10.1002/art.30233
    • Sellam, J. et al. B-cell activation biomarkers as predictive factors of the response to rituximab in rheumatoid arthritis. Arthritis Rheum. doi:10.1002/art.30233.
    • Arthritis Rheum.
    • Sellam, J.1
  • 22
    • 78751692218 scopus 로고    scopus 로고
    • Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival
    • Moura, R. A. et al. Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival. Rheumatology (Oxford) 50, 278-282 (2011).
    • (2011) Rheumatology (Oxford) , vol.50 , pp. 278-282
    • Moura, R.A.1
  • 23
    • 77955895130 scopus 로고    scopus 로고
    • B-cell targeted therapies in human autoimmune diseases: An updated perspective
    • Townsend, M. J., Monroe, J. G. & Chan, A. C. B-cell targeted therapies in human autoimmune diseases: an updated perspective. Immunol. Rev. 237, 264-283 (2010).
    • (2010) Immunol. Rev. , vol.237 , pp. 264-283
    • Townsend, M.J.1    Monroe, J.G.2    Chan, A.C.3
  • 24
    • 33750209982 scopus 로고    scopus 로고
    • Targeting BAFF: Immunomodulation for autoimmune diseases and lymphomas
    • DOI 10.1016/j.pharmthera.2006.06.002, PII S016372580600115X
    • Sutherland, A. P., Mackay, F. & Mackay, C. R. Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas. Pharmacol. Ther. 112, 774-786 (2006). (Pubitemid 44604415)
    • (2006) Pharmacology and Therapeutics , vol.112 , Issue.3 , pp. 774-786
    • Sutherland, A.P.R.1    Mackay, F.2    Mackay, C.R.3
  • 25
    • 38149114077 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study
    • Tak, P. P. et al. Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study. Arthritis Rheum. 58, 61-72 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 61-72
    • Tak, P.P.1
  • 26
    • 67650388093 scopus 로고    scopus 로고
    • Atacicept a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis
    • Bracewell, C., Isaacs, J. D., Emery, P. & Ng, W. F. Atacicept, a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis. Expert Opin. Biol. Ther. 9, 909-919 (2009).
    • (2009) Expert Opin. Biol. Ther. , vol.9 , pp. 909-919
    • Bracewell, C.1    Isaacs, J.D.2    Emery, P.3    Ng, W.F.4
  • 27
    • 33644914684 scopus 로고    scopus 로고
    • Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: Relationships with B cell depletion, circulating antibodies, and clinical relapse
    • Cambridge, G. et al. Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse. Arthritis Rheum. 54, 723-732 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 723-732
    • Cambridge, G.1
  • 28
    • 77950487586 scopus 로고    scopus 로고
    • Kinase inhibitors attract attention as oral rheumatoid arthritis drugs
    • Opar, A. Kinase inhibitors attract attention as oral rheumatoid arthritis drugs. Nat. Rev. Drug Discov. 9, 257-258 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 257-258
    • Opar, A.1
  • 29
    • 77953245981 scopus 로고    scopus 로고
    • A multitude of kinases-which are the best targets in treating rheumatoid arthritis?
    • Lindstrom, T. M. & Robinson, W. H. A multitude of kinases-which are the best targets in treating rheumatoid arthritis? Rheum. Dis. Clin. North Am. 36, 367-383 (2010).
    • (2010) Rheum. Dis. Clin. North Am. , vol.36 , pp. 367-383
    • Lindstrom, T.M.1    Robinson, W.H.2
  • 30
    • 78249269177 scopus 로고    scopus 로고
    • Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: Does variable inhibition of interleukin-6 production limit effectiveness in vivo?
    • Page, T. H., Brown, A., Timms, E. M., Foxwell, B. M. & Ray, K. P. Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: does variable inhibition of interleukin-6 production limit effectiveness in vivo? Arthritis Rheum. 62, 3221-3231 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 3221-3231
    • Page, T.H.1    Brown, A.2    Timms, E.M.3    Foxwell, B.M.4    Ray, K.P.5
  • 31
    • 77956165442 scopus 로고    scopus 로고
    • Inhibition of JAK kinases in patients with rheumatoid arthritis: Scientific rationale and clinical outcomes
    • Riese, R. J., Krishnaswami, S. & Kremer, J. Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes. Best Pract. Res. Clin. Rheumatol. 24, 513-526 (2010).
    • (2010) Best Pract. Res. Clin. Rheumatol. , vol.24 , pp. 513-526
    • Riese, R.J.1    Krishnaswami, S.2    Kremer, J.3
  • 32
    • 75749092187 scopus 로고    scopus 로고
    • "Go upstream, young man": Lessons learned from the p38 saga
    • Hammaker, D. & Firestein G. S. "Go upstream, young man": lessons learned from the p38 saga. Ann. Rheum. Dis. 69 (Suppl. 1), i77-i82 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , Issue.SUPPL. 1
    • Hammaker, D.1    Firestein, G.S.2
  • 33
    • 78650294662 scopus 로고    scopus 로고
    • An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
    • Genovese, M. C. et al. An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents. Arthritis Rheum. 63, 337-345 (2011).
    • (2011) Arthritis Rheum. , vol.63 , pp. 337-345
    • Genovese, M.C.1
  • 34
    • 79955578517 scopus 로고    scopus 로고
    • Phase 3 study of oral JAK inhibitor tasocitinib (CP-690, 550) monotherapy in patients with active rheumatoid arthritis
    • Fleischmann, R. et al. Phase 3 study of oral JAK inhibitor tasocitinib (CP-690, 550) monotherapy in patients with active rheumatoid arthritis. Presented at the 74th Annual Scientific Meeting of the American College of Rheumatology.
    • 74th Annual Scientific Meeting of the American College of Rheumatology
    • Fleischmann, R.1
  • 35
    • 84988032309 scopus 로고    scopus 로고
    • Initial efficacy of INCB018424, a selective Janus kinase1 & 2 (JAK1 & 2) inhibitor in rheumatoid arthritis (RA)
    • Annual Scientific Congress
    • Williams, W. V. et al. Initial efficacy of INCB018424, a selective Janus kinase1 & 2 (JAK1 & 2) inhibitor in rheumatoid arthritis (RA). Presented at EULAR 2008, Annual Scientific Congress.
    • EULAR 2008
    • Williams, W.V.1
  • 36
    • 66049086274 scopus 로고    scopus 로고
    • Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies
    • Damjanov, N., Kauffman, R. S. & Spencer-Green, G. T. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 60, 1232-1241 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 1232-1241
    • Damjanov, N.1    Kauffman, R.S.2    Spencer-Green, G.T.3
  • 37
    • 77952776343 scopus 로고    scopus 로고
    • Evaluation of disease activity assessments in patients with rheumatoid arthritis and an inadequate response to anti-TNF therapy: Analyses of abatacept clinical trial data
    • Dougados, M. et al. Evaluation of disease activity assessments in patients with rheumatoid arthritis and an inadequate response to anti-TNF therapy: analyses of abatacept clinical trial data. Clin. Exp. Rheumatol. 28, 259-260 (2010).
    • (2010) Clin. Exp. Rheumatol. , vol.28 , pp. 259-260
    • Dougados, M.1
  • 38
    • 70349967965 scopus 로고    scopus 로고
    • Anti-TNF biologic agents: Still the therapy of choice for rheumatoid arthritis
    • Taylor, P. C. & Feldmann, M. Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat. Rev. Rheumatol. 5, 578-582 (2009).
    • (2009) Nat. Rev. Rheumatol. , vol.5 , pp. 578-582
    • Taylor, P.C.1    Feldmann, M.2
  • 40
    • 79551618947 scopus 로고    scopus 로고
    • Humanization and characterization of an anti-human TNF-Á murine monoclonal antibody
    • Chiu, W. C., Lai, Y. P. & Chou, M. Y. Humanization and characterization of an anti-human TNF-á murine monoclonal antibody. PLoS ONE 6, e16373 (2011).
    • (2011) PLoS ONE , vol.6
    • Chiu, W.C.1    Lai, Y.P.2    Chou, M.Y.3
  • 41
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec, P., Korn, T. & Kuchroo, V. K. Interleukin-17 and type 17 helper T cells. N. Engl. J. Med. 361, 888-898 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 42
    • 68949158362 scopus 로고    scopus 로고
    • Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: Synergy with tumour necrosis factor-Á, Oncostatin M and response to biologic therapies
    • Moran, E. M. et al. Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-á, Oncostatin M and response to biologic therapies. Arthritis Res. Ther. 11, R113 (2009).
    • (2009) Arthritis Res. Ther. , vol.11
    • Moran, E.M.1
  • 43
    • 78549271154 scopus 로고    scopus 로고
    • Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression
    • Aerts, N. E. et al. Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression. Rheumatology (Oxford) 49, 2264-2272 (2010).
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 2264-2272
    • Aerts, N.E.1
  • 44
    • 77949842566 scopus 로고    scopus 로고
    • Is interleukin-6 receptor blockade the Holy Grail for inflammatory diseases?
    • Febbraio, M. A., Rose-John, S. & Pedersen, B. K. Is interleukin-6 receptor blockade the Holy Grail for inflammatory diseases? Clin. Pharmacol. Ther. 87, 396-398 (2010).
    • (2010) Clin. Pharmacol. Ther. , vol.87 , pp. 396-398
    • Febbraio, M.A.1    Rose-John, S.2    Pedersen, B.K.3
  • 45
    • 77951192680 scopus 로고    scopus 로고
    • Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells
    • Yoshida, H., Hashizume, M., Suzuki, M. & Mihara, M. Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells. Eur. J. Pharmacol. 634, 178-183 (2010).
    • (2010) Eur. J. Pharmacol. , vol.634 , pp. 178-183
    • Yoshida, H.1    Hashizume, M.2    Suzuki, M.3    Mihara, M.4
  • 46
    • 76949092129 scopus 로고    scopus 로고
    • The addition of tocilizumab to DMARD therapy for rheumatoid arthritis: A meta-analysis of randomized controlled trials
    • An, M. M. et al. The addition of tocilizumab to DMARD therapy for rheumatoid arthritis: a meta-analysis of randomized controlled trials. Eur. J. Clin. Pharmacol. 66, 49-59 (2010).
    • (2010) Eur. J. Clin. Pharmacol. , vol.66 , pp. 49-59
    • An, M.M.1
  • 47
    • 73849131345 scopus 로고    scopus 로고
    • Will treatment of rheumatoid arthritis with an IL-6R inhibitor help facilitate the 'age of remission'?
    • Moots, R. J., Ostör, A. J. & Isaacs, J. D. Will treatment of rheumatoid arthritis with an IL-6R inhibitor help facilitate the 'age of remission'? Expert Opin. Investig. Drugs 18, 1687-1699 (2009).
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 1687-1699
    • Moots, R.J.1    Ostör, A.J.2    Isaacs, J.D.3
  • 48
    • 73449118587 scopus 로고    scopus 로고
    • Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
    • Jones, G. et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann. Rheum. Dis. 69, 88-96 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 88-96
    • Jones, G.1
  • 49
    • 77955503774 scopus 로고    scopus 로고
    • Tocilizumab for rheumatoid arthritis
    • doi:10.1002/14651858.CD008331.pub2 Art. No.: CD008331.
    • Singh, J. A., Beg, S. & Lopez-Olivo, M. A. Tocilizumab for rheumatoid arthritis. Cochrane Database of Systematic Reviews, Issue 7. Art. No.: CD008331. doi:10.1002/14651858.CD008331.pub2 (2010).
    • (2010) Cochrane Database of Systematic Reviews , Issue.7
    • Singh, J.A.1    Beg, S.2    Lopez-Olivo, M.A.3
  • 50
    • 62849085138 scopus 로고    scopus 로고
    • Is tocilizumab in combination with traditional DMARDs safe and effective for patients with active RA?
    • Feist, E. & Burmester, G. R. Is tocilizumab in combination with traditional DMARDs safe and effective for patients with active RA? Nat. Clin. Pract. Rheumatol. 5, 128-129 (2009).
    • (2009) Nat. Clin. Pract. Rheumatol. , vol.5 , pp. 128-129
    • Feist, E.1    Burmester, G.R.2
  • 51
    • 79955604960 scopus 로고    scopus 로고
    • Safety, tolerability and efficacy of ACZ885 (canakinumab) in patients with active rheumatoid arthritis identifier: NCT00784628
    • Safety, tolerability and efficacy of ACZ885 (canakinumab) in patients with active rheumatoid arthritis identifier: NCT00784628. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT00784628 (2010).
    • (2010) ClinicalTrials.gov
  • 52
    • 79955621927 scopus 로고    scopus 로고
    • Secukinumab (AIN457), a novel monoclonal antibody targeting IL-17A demonstrates efficacy in active rheumatoid arthritis patients despite stable methotrexate treatment: Results of a phase IIb study
    • Genovese, M. et al. Secukinumab (AIN457), a novel monoclonal antibody targeting IL-17A demonstrates efficacy in active rheumatoid arthritis patients despite stable methotrexate treatment: results of a phase IIb study. Presented at the 74th Annual Scientific Meeting of the American College of Rheumatology.
    • 74th Annual Scientific Meeting of the American College of Rheumatology
    • Genovese, M.1
  • 53
    • 0032705844 scopus 로고    scopus 로고
    • Autologous stem cell transplantation: A possible treatment for refractory juvenile chronic arthritis?
    • DOI 10.1093/rheumatology/38.8.764
    • Wulffraat, N. M. & Kuis, W. Autologous stem cell transplantation: a possible treatment for refractory juvenile chronic arthritis? Rheumatology (Oxford) 38, 764-766 (1999). (Pubitemid 29507399)
    • (1999) Rheumatology , vol.38 , Issue.8 , pp. 764-766
    • Wulffraat, N.M.1    Kuis, W.2
  • 55
    • 55149100214 scopus 로고    scopus 로고
    • Current perspectives of autologous stem cell transplantation for severe juvenile idiopathic arthritis
    • Wulffraat, N. M. et al. Current perspectives of autologous stem cell transplantation for severe juvenile idiopathic arthritis. Autoimmunity 41, 632-638 (2008).
    • (2008) Autoimmunity , vol.41 , pp. 632-638
    • Wulffraat, N.M.1
  • 57
    • 31044440026 scopus 로고    scopus 로고
    • T cell epitope-specific immune therapy for rheumatic diseases
    • DOI 10.1002/art.21520
    • Albani, S. & Prakken, B. T cell epitope-specific immune therapy for rheumatic diseases. Arthritis Rheum. 54, 19-25 (2006). (Pubitemid 43122182)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.1 , pp. 19-25
    • Albani, S.1    Prakken, B.2
  • 58
    • 0035838981 scopus 로고    scopus 로고
    • Regulation of T cell immunity by dendritic cells
    • DOI 10.1016/S0092-8674(01)00455-X
    • Lanzavecchia, A. & Sallusto, F. Regulation of T cell immunity by dendritic cells. Cell 106, 263-266 (2001). (Pubitemid 32772609)
    • (2001) Cell , vol.106 , Issue.3 , pp. 263-266
    • Lanzavecchia, A.1    Sallusto, F.2
  • 59
    • 84925548986 scopus 로고    scopus 로고
    • The instructive role of dendritic cells on T-cell responses
    • Sallusto, F. & Lanzavecchia, A. The instructive role of dendritic cells on T-cell responses. Arthritis Res. 4 (Suppl. 3), S127-S132 (2002).
    • (2002) Arthritis Res. , vol.4 , Issue.SUPPL. 3
    • Sallusto, F.1    Lanzavecchia, A.2
  • 60
  • 63
    • 0345827684 scopus 로고    scopus 로고
    • Dendritic cells: Emerging pharmacological targets of immunosuppressive drugs
    • Hackstein, H. & Thomson, A. W. Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat. Rev. Immunol. 4, 24-34 (2004). (Pubitemid 38084129)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.1 , pp. 24-34
    • Hackstein, H.1    Thomson, A.W.2
  • 64
    • 77956395771 scopus 로고    scopus 로고
    • Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells
    • Kleijwegt, F. S. et al. Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells. J. Immunol. 185, 1412-1418 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1412-1418
    • Kleijwegt, F.S.1
  • 65
    • 78149487035 scopus 로고    scopus 로고
    • Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis
    • Harry, R. A., Anderson, A. E., Isaacs, J. D. & Hilkens, C. M. Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis. Ann. Rheum. Dis. 69, 2042-2050 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 2042-2050
    • Harry, R.A.1    Anderson, A.E.2    Isaacs, J.D.3    Hilkens, C.M.4
  • 66
    • 74249111385 scopus 로고    scopus 로고
    • The mechanism of action of glatiramer acetate treatment in multiple sclerosis
    • Racke, M. K., Lovett-Racke, A. E. & Karandikar, N. J. The mechanism of action of glatiramer acetate treatment in multiple sclerosis. Neurology 74 (Suppl. 1), S25-S30 (2010).
    • (2010) Neurology , vol.74 , Issue.SUPPL. 1
    • Racke, M.K.1    Lovett-Racke, A.E.2    Karandikar, N.J.3
  • 67
    • 72649090947 scopus 로고    scopus 로고
    • Glatiramer acetate for the treatment of multiple sclerosis: Evidence for a dual anti-inflammatory and neuroprotective role
    • Liblau, R. Glatiramer acetate for the treatment of multiple sclerosis: evidence for a dual anti-inflammatory and neuroprotective role. J. Neurol. Sci. 287 (Suppl. 1), S17-S23 (2009).
    • (2009) J. Neurol. Sci. , vol.287 , Issue.SUPPL. 1
    • Liblau, R.1
  • 68
    • 0033792233 scopus 로고    scopus 로고
    • Oral tolerance, an active immunologic process mediated by multiple mechanisms
    • Weiner, H. L. Oral tolerance, an active immunologic process mediated by multiple mechanisms. J. Clin. Invest. 106, 935-937 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 935-937
    • Weiner, H.L.1
  • 69
    • 80055118474 scopus 로고    scopus 로고
    • Regulatory T cells: Therapeutic potential for treating transplant rejection and type I diabetes
    • Bluestone, J. A. Regulatory T cells: therapeutic potential for treating transplant rejection and type I diabetes. J. Vis. Exp. 7, 257 (2007).
    • (2007) J. Vis. Exp. , vol.7 , pp. 257
    • Bluestone, J.A.1
  • 70
    • 0027602686 scopus 로고
    • Current advances in gastrointestinal immunology
    • Mayer, L. Current advances in gastrointestinal immunology. Mt Sinai J. Med. 60, 178-179 (1993).
    • (1993) Mt Sinai J. Med. , vol.60 , pp. 178-179
    • Mayer, L.1
  • 71
    • 0034090082 scopus 로고    scopus 로고
    • Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/1 mice: Amelioration of clinical, histologic, and radiologic signs of type II collagen-induced arthritis
    • DOI 10.10 02/1529-01 31(2000 03)43:3<6 45::AID-AN R22>3.0.CO;2-O
    • Joosten, L. A. et al. Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/1 mice: amelioration of clinical, histologic, and radiologic signs of type II collagen-induced arthritis. Arthritis Rheum. 43, 645-655 (2000). (Pubitemid 30394957)
    • (2000) Arthritis and Rheumatism , vol.43 , Issue.3 , pp. 645-655
    • Joosten, L.A.B.1    Coenen-de Roo, C.J.J.2    Helsen, M.M.A.3    Lubberts, E.4    Boots, A.M.H.5    Van Den Berg, W.B.6    Miltenburg, A.M.M.7
  • 72
    • 0022615333 scopus 로고
    • Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats
    • Thompson, H. S. & Staines, N. A. Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats. Clin. Exp. Immunol. 64, 581-586 (1986). (Pubitemid 16122396)
    • (1986) Clinical and Experimental Immunology , vol.64 , Issue.3 , pp. 581-586
    • Thompson, H.S.G.1    Staines, N.A.2
  • 73
    • 0017657009 scopus 로고
    • Autoimmunity to type II collagen: An experimental model of arthritis
    • DOI 10.1084/jem.146.3.857
    • Trentham, D. E., Townes, A. S. & Kang, A. H. Autoimmunity to type II collagen an experimental model of arthritis. J. Exp. Med. 146, 857-868 (1977). (Pubitemid 8175993)
    • (1977) Journal of Experimental Medicine , vol.146 , Issue.3 , pp. 857-868
    • Trentham, D.E.1    Townes, A.S.2    Kang, A.H.3
  • 74
    • 0029962104 scopus 로고    scopus 로고
    • Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope
    • Staines, N. A. et al. Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope. Clin. Exp. Immunol. 103, 368-375 (1996). (Pubitemid 26089942)
    • (1996) Clinical and Experimental Immunology , vol.103 , Issue.3 , pp. 368-375
    • Staines, N.A.1    Harper, N.2    Ward, F.J.3    Malmstrom, V.4    Holmdahl, R.5    Bansal, S.6
  • 76
    • 1842682969 scopus 로고    scopus 로고
    • Type II collagen autoimmunity in rheumatoid arthritis
    • Kim, W. U. et al. Type II collagen autoimmunity in rheumatoid arthritis. Am. J. Med. Sci. 327, 202-211 (2004).
    • (2004) Am. J. Med. Sci. , vol.327 , pp. 202-211
    • Kim, W.U.1
  • 79
    • 0030042970 scopus 로고    scopus 로고
    • Oral type II collagen treatment in early rheumatoid arthritis. A double-blind, placebo-controlled, randomized trial
    • Sieper, J. et al. Oral type II collagen treatment in early rheumatoid arthritis. A double-blind, placebo-controlled, randomized trial. Arthritis Rheum. 39, 41-51 (1996).
    • (1996) Arthritis Rheum. , vol.39 , pp. 41-51
    • Sieper, J.1
  • 82
    • 0029923071 scopus 로고    scopus 로고
    • A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis
    • DOI 10.1002/art.1780390413
    • Barnett, M. L., Combitchi, D. & Trentham, D. E. A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum. 39, 623-628 (1996). (Pubitemid 26118041)
    • (1996) Arthritis and Rheumatism , vol.39 , Issue.4 , pp. 623-628
    • Barnett, M.L.1    Combitchi, D.2    Trentham, D.E.3
  • 84
    • 70350521825 scopus 로고    scopus 로고
    • Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial
    • Koffeman, E. C. et al. Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial. Arthritis Rheum. 60, 3207-3216 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 3207-3216
    • Koffeman, E.C.1
  • 85
    • 85012430068 scopus 로고    scopus 로고
    • Heat shock proteins in health and disease: Therapeutic targets or therapeutic agents?
    • Pockley, A. G. Heat shock proteins in health and disease: therapeutic targets or therapeutic agents? Expert Rev. Mol. Med. 3, 1-21 (2001).
    • (2001) Expert Rev. Mol. Med. , vol.3 , pp. 1-21
    • Pockley, A.G.1
  • 86
    • 54949136480 scopus 로고    scopus 로고
    • Modulation of T cell function by combination of epitope specific and low dose anticytokine therapy controls autoimmune arthritis
    • Roord, S. T. et al. Modulation of T cell function by combination of epitope specific and low dose anticytokine therapy controls autoimmune arthritis. PLoS ONE 1, e87 (2006).
    • (2006) PLoS ONE , vol.1
    • Roord, S.T.1
  • 87
    • 67650079430 scopus 로고    scopus 로고
    • Pan-DR-binding Hsp60 self epitopes induce an interleukin-10-mediated immune response in rheumatoid arthritis
    • de Jong, H. et al. Pan-DR-binding Hsp60 self epitopes induce an interleukin-10-mediated immune response in rheumatoid arthritis. Arthritis Rheum. 60, 1966-1976 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 1966-1976
    • De Jong, H.1
  • 91
    • 0030271825 scopus 로고    scopus 로고
    • A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis
    • Albani, S. & Carson, D. A. A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis. Immunol. Today 17, 466-470 (1996).
    • (1996) Immunol. Today , vol.17 , pp. 466-470
    • Albani, S.1    Carson, D.A.2
  • 92
    • 0029078361 scopus 로고
    • Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis
    • Albani, S. et al. Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nat. Med. 1, 448-452 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 448-452
    • Albani, S.1
  • 93
    • 0026503670 scopus 로고
    • The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule
    • Albani, S., Tuckwell, J. E., Esparza, L., Carson, D. A. & Roudier, J. The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule. J. Clin. Invest. 89, 327-331 (1992).
    • (1992) J. Clin. Invest. , vol.89 , pp. 327-331
    • Albani, S.1    Tuckwell, J.E.2    Esparza, L.3    Carson, D.A.4    Roudier, J.5
  • 95
    • 79751531096 scopus 로고    scopus 로고
    • The HSP60 immune system network
    • Quintana, F. J. & Cohen, I. R. The HSP60 immune system network. Trends Immunol. 32, 89-95 (2011).
    • (2011) Trends Immunol. , vol.32 , pp. 89-95
    • Quintana, F.J.1    Cohen, I.R.2
  • 96
    • 78751703180 scopus 로고    scopus 로고
    • Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: Exploratory analyses from the BeSt study
    • Klarenbeek, N. B. et al. Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: exploratory analyses from the BeSt study. Ann. Rheum. Dis. 70, 315-319 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 315-319
    • Klarenbeek, N.B.1


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