Pan-DR-binding Hsp60 self epitopes induce an interleukin-10-mediated immune response in rheumatoid arthritis

Arthritis and Rheumatism

Volumn 60, Issue 7, 2009, Pages 1966-1976

  De Jong, Huib ^a   Lafeber, Floris F P ^a   De Jager, Wilco ^a   Haverkamp, Margje H ^a   Kuis, Wietse ^a   Bijlsma, Johannes W J ^a   Prakken, Berent J ^a,b   Albani, Salvatore ^b,c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b EUREKA Institute for Translational Medicine   (Italy)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD3 ANTIGEN; CD4 ANTIGEN; EPITOPE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 60; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOTHERAPY; IN VITRO STUDY; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MALE; OSTEOARTHRITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RHEUMATOID ARTHRITIS; STAINING; SYNOVIAL FLUID; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHAPERONIN 60; EPITOPES, T-LYMPHOCYTE; FEMALE; HLA-D ANTIGENS; HUMANS; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA;

EID: 67650079430     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24656     Document Type: Article

References (50)

1. Feldmann M, Brennan FM, Maini RN. Rheumatoid arthritis. Cell 1996;85:307-10.
2. Sewell KL, Trentham DE. Pathogenesis of rheumatoid arthritis. Lancet 1993;341:283-6.
3. Arend WP. The pathophysiology and treatment of rheumatoid arthritis. Arthritis Rheum 1997;40:595-7.
4. Firestein GS. The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis. J Clin Invest 2004;114:471-4.
5. Firestein GS, Zvaifler NJ. How important are T cells in chronic rheumatoid synovitis? II. T cell-independent mechanisms from beginning to end. Arthritis Rheum 2002;46:298-308.
6. Sioud M, Kjeldsen-Kragh J, Quayle AJ, Wiker HG, Sorskaar D, Natvig JB, et al. Immune responses to 18.6 and 30-kDa mycobacterial antigens in rheumatoid patients, and Vβ usage by specific synovial T-cell lines and fresh T cells. Scand J Immunol 1991;34:803-12.
7. Yang H, Rittner H, Weyand CM, Goronzy JJ. Aberrations in the primary T-cell receptor repertoire as a predisposition for synovial inflammation in rheumatoid arthritis. J Investig Med 1999;47:236-45.
8. Weyand CM, Goronzy JJ. HLA polymorphisms and T cells in rheumatoid arthritis. Int Rev Immunol 1999;18:37-59.
9. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
10. Albani S, Carson DA. A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis. Immunol Today 1996;17:466-70.
11. Prakken BJ, Carson DA, Albani S. T cell repertoire formation and molecular mimicry in rheumatoid arthritis. Curr Dir Autoimmun 2001;3:51-63.
12. Cope AP, Schulze-Koops H, Aringer M. The central role of T cells in rheumatoid arthritis. Clin Exp Rheumatol 2007;25(5 Suppl 46):S4-11.
13. Isaacs JD. Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future. Rheumatology (Oxford) 2008;47:1461-8.
14. Glant T, Csongor J, Szucs T. Immunopathologic role of proteoglycan antigens in rheumatoid joint disease. Scand J Immunol 1980;11:247-52.
15. Guerassimov A, Zhang Y, Banerjee S, Cartman A, Leroux JY, Rosenberg LC, et al. Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate. Arthritis Rheum 1998;41:1019-25.
16. Londei M, Savill CM, Verhoef A, Brennan F, Leech ZA, Duance V, et al. Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Proc Natl Acad Sci U S A 1989;86:636-40.
17. Verheijden GF, Rijnders AW, Bos E, Coenen-de Roo CJ, van Staveren CJ, Miltenburg AM, et al. Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis. Arthritis Rheum 1997;40:1115-25.
18. Blass S, Schumann F, Hain NA, Engel JM, Stuhlmuller B, Burmester GR. p205 is a major target of autoreactive T cells in rheumatoid arthritis. Arthritis Rheum 1999;42:971-80.
19. Snir O, Widhe M, von Spee C, Lindberg J, Padyukov L, Lundberg K, et al. Multiple antibody reactivities to citrullinated antigens in sera from rheumatoid arthritis patients: association with HLADRB1 alleles. Ann Rheum Dis 2008. E-pub ahead of print.
20. Cope AP, Sonderstrup G. Evaluating candidate autoantigens in rheumatoid arthritis. Springer Semin Immunopathol 1998;20:23-39.
21. Albani S, Prakken B. T cell epitope-specific immune therapy for rheumatic diseases. Arthritis Rheum 2006;54:19-25.
22. Albani S, Keystone EC, Nelson JL, Ollier WE, La Cava A, Montemayor AC, et al. Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nat Med 1995;1:448-52.
23. Prakken BJ, Samodal R, Le TD, Giannoni F, Yung GP, Scavulli J, et al. Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc Natl Acad Sci U S A 2004;101:4228-33.
24. Van Eden W, van der Zee R, Prakken B. Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 2005;5:318-30.
25. Van Eden W, Waksman BH. Immune regulation in adjuvant-induced arthritis: possible implications for innovative therapeutic strategies in arthritis. Arthritis Rheum 2003;48:1788-96.
26. Van Roon JA, van Eden W, van Roy JL, Lafeber FJ, Bijlsma JW. Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis. J Clin Invest 1997;100:459-63.
27. Graeff-Meeder ER, van der Zee R, Rijkers GT, Schuurman HJ, Kuis W, Bijlsma JW, et al. Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis. Lancet 1991;337:1368-72.
28. Prakken AB, van Eden W, Rijkers GT, Kuis W, Toebes EA, Graeff-Meeder ER, et al. Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis. Arthritis Rheum 1996;39:1826-32.
29. De Kleer IM, Kamphuis SM, Rijkers GT, Scholtens L, Gordon G, De Jager W, et al. The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10. Arthritis Rheum 2003;48:2001-10.
30. Van Eden W, van der Zee R, Paul AG, Prakken BJ, Wendling U, Anderton SM, et al. Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases? Immunol Today 1998;19:303-7.
31. Kamphuis S, Kuis W, De Jager W, Teklenburg G, Massa M, Gordon G, et al. Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet 2005;366:50-6.
32. Lehman TJ. Juvenile idiopathic arthritis and HSP60 vaccination: selective down-regulation? Lancet 2005;366:9-10.
33. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
34. Southwood S, Sidney J, Kondo A, del Guercio MF, Appella E, Hoffman S, et al. Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol 1998;160:3363-73.
35. Van der Zee R, Anderton SM, Buskens C, Alonso de Valasco E, Van Eden W. Heat shock protein T cell epitopes as immunogenic carriers in subunit vaccines. In: Peptides: 1994 Proceedings of the Twenty-Third European Peptide Symposium, ESCOM. Maya HLS, editor. Leiden, The Netherlands; 1995. p. 841-2.
36. Carson RT, Vignali DA. Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay. J Immunol Methods 1999;227:41-52.
37. Khan SS, Smith MS, Reda D, Suffredini AF, McCoy JP Jr. Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers. Cytometry B Clin Cytom 2004;61:35-9.
38. De Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003;10:133-9.
39. Graeff-Meeder ER, van Eden W, Rijkers GT, Prakken BJ, Kuis W, Voorhorst-Ogink MM, et al. Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis. J Clin Invest 1995;95:934-40.
40. Anderton SM, van der Zee R, Prakken B, Noordzij A, van Eden W. Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis. J Exp Med 1995;181:943-52.
41. Olsen NJ, Stein CM. New drugs for rheumatoid arthritis. N Engl J Med 2004;350:2167-79.
42. Bluestone JA. Regulatory T-cell therapy: is it ready for the clinic? Nat Rev Immunol 2005;5:343-9.
43. Koffeman E, Genovese M, Schiff M, Albani S. Epitope-specific immune therapy in rheumatoid arthritis: results of a phase 2 double-blind randomized clinical trial. Clinical Immunol 2006;119(Suppl 1):S4.
44. Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 2001;358:1749-53.
45. MacHt LM, Elson CJ, Kirwan JR, Gaston JS, Lamont AG, Thompson JM, et al. Relationship between disease severity and responses by blood mononuclear cells from patients with rheumatoid arthritis to human heat-shock protein 60. Immunology 2000;99:208-14.
46. Ramage JM, Young JL, Goodall JC, Gaston JS. T cell responses to heat-shock protein 60: differential responses by CD4+ T cell subsets according to their expression of CD45 isotypes. J Immunol 1999;162:704-10.
47. Zou J, Rudwaleit M, Thiel A, Lauster R, Braun J, Sieper J. T cell response to human HSP60 and yersinia 19 kDa in ankylosing spondylitis and rheumatoid arthritis: no evidence for a causal role of these antigens in the pathogenesis. Ann Rheum Dis 2002;61:473-4.
48. Ramage JM, Gaston JS. Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60. Rheumatology (Oxford) 1999;38:631-5.
49. Huurman VA, van der Meide PE, Duinkerken G, Willemen S, Cohen IR, Elias D, et al. Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes. Clin Exp Immunol 2008;152:488-97.
50. Massa M, Passalia M, Manzoni SM, Campanelli R, Ciardelli L, Yung GP, et al. Differential recognition of heat-shock protein dnaJ-derived epitopes by effector and Treg cells leads to modulation of inflammation in juvenile idiopathic arthritis. Arthritis Rheum 2007;56:1648-57.