Targeting the role of a key conserved motif for substrate selection and catalysis by 3-Deoxy- D - Manno -octulosonate 8-Phosphate synthase

Biochemistry

Volumn 50, Issue 18, 2011, Pages 3686-3695

  Allison, Timothy M ^b   Hutton, Richard D ^b   Cochrane, Fiona C ^a   Yeoman, Jeffrey A ^a   Jameson, Geoffrey B ^a   Parker, Emily J ^b  

^a MASSEY UNIVERSITY   (New Zealand)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDITHIOBACILLUS FERROOXIDANS; ACTIVE SITE; BACTERIAL CELLS; BIOSYNTHETIC PATHWAY; CATALYTIC ACTIVITY; CATALYTIC FUNCTIONS; D-ARABINOSE; D-ERYTHROSE; DIVALENT METAL ION; LIPOPOLYSACCHARIDES; MENINGITIDIS; MUTANT PROTEINS; NEISSERIA MENINGITIDIS; PHOSPHOENOLPYRUVATES; SHIKIMATE PATHWAY; SUBSTRATE SELECTION; SUBSTRATE SELECTIVITY; SUBSTRATE SPECIFICITY; SYNTHASES; X-RAY STRUCTURE;

CATALYSIS; CATALYST ACTIVITY; CELL MEMBRANES; ENZYMES; METAL IONS; REACTION INTERMEDIATES;

METALS;

3 DEOXY DEXTRO MANNOOCTULOSONATE 8 PHOSPHATE SYNTHASE; MUTANT PROTEIN; SYNTHETASE; UNCLASSIFIED DRUG;

ACIDITHIOBACILLUS FERROOXIDANS; ARTICLE; BINDING SITE; CATALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF;

ALDEHYDE-LYASES; AMINO ACID MOTIFS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FLUOROMETRY; HYDROGEN BONDING; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

ACIDITHIOBACILLUS FERROOXIDANS; BACTERIA (MICROORGANISMS); NEGIBACTERIA; NEISSERIA MENINGITIDIS;

EID: 79955617645     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200251f     Document Type: Article

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