A New Method for Determining the Status of p53 in Tumor Cell Lines of Different Origin

Oncology Research

Volumn 13, Issue 6-10, 2002, Pages 405-408

  Gartel, Andrei L ^a   Feliciano, Claudine ^a   Tyner, Angela L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Mutations; p53; Retrovirus; Transcription; Galactosidase

Indexed keywords

BETA GALACTOSIDASE; PROTEIN P21; PROTEIN P53;

APOPTOSIS; BREAST CARCINOMA; CANCER INHIBITION; CELL CYCLE; COLON CARCINOMA; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TUMOR CELL; TUMOR SUPPRESSOR GENE; WILD TYPE; ARTICLE; BIOASSAY; BREAST TUMOR; CELL CULTURE; CHEMISTRY; COLON TUMOR; GENETICS; METHODOLOGY; PHYSIOLOGY; RETROVIRUS;

BETA-GALACTOSIDASE; BIOLOGICAL ASSAY; BREAST NEOPLASMS; COLONIC NEOPLASMS; GENES, P53; HUMANS; RETROVIRIDAE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0038499524     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504003108748429     Document Type: Conference Paper

References (18)

1. Woods, D. B.; Vousden, K. H. Regulation of p53 function. Exp. Cell Res. 264:56-66; 2001.
2. Vogelstein, B.; Lane, D.; Levine, A. J. Surfing the p53 network. Nature 408:307-310; 2000.
3. Hainaut, P. TP53 tumor suppressor gene: 20 years (and ten thousand mutations. Bull. Cancer 87:11-18; 2000.
4. Oliner, J. D.; Kinzler, K. W.; Meltzer, P. S.; George, D. L.; Vogelstein, B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83; 1992.
5. Kim, I. S.; Kim, D. H.; Han, S. M.; Chin, M. U.; Nam, H. J.; Cho, H. P.; Choi, S. Y.; Song, B. J.; Kim, E. R.; Bae, Y. S.; Moon, Y. H. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. J. Biol. Chem. 275:23139-23145; 2000.
6. Vousden, K. H. Regulation of the cell cycle by viral oncoproteins. Semin. Cancer Biol. 6:109-116; 1995.
7. Chappuis, P. O.; Estreicher, A.; Dieterich, B.; Bonnefoi, H.; Otter, M.; Sappino, A. P.; Iggo, R. Prognostic significance of p53 mutation in breast cancer: Frequent detection of non-missense mutations by yeast functional assay. Int. J. Cancer 84:587-593; 1999.
8. Wang-Gohrke, S.; Hees, S.; Pochon, A.; Wen, W. H.; Reles, A.; Press, M. F.; Kreienberg, R.; Runnebaum, I. B. Genomic semi-automated cycle sequencing as a sensitive screening technique for p53 mutations in frozen tumor samples. Oncol. Rep. 5:65-68; 1998.
9. Grompe, M. The rapid detection of unknown mutations in nucleic acids. Nat. Genet. 5:111-117; 1993.
10. Moyret, C.; Theillet, C.; Puig, P. L.; Moles, J. P.; Thomas, G.; Hamelin, R. Relative efficiency of denaturing gradient gel electrophoresis and single strand conformation polymorphism in the detection of mutations in exons 5 to 8 of the p53 gene. Oncogene 9:1739-1743; 1994.
11. Lane, D. P. On the expression of the p53 protein in human cancer. Mol. Biol. Rep. 19:23-29; 1994.
12. Flaman, J. M.; Frebourg, T.; Moreau, V.; Charbonnier, F.; Martin, C.; Chappuis, P.; Sappino, A. P.; Limacher, I. M.; Bron, L.; Benhattar, J.; et al. A simple p53 functional assay for screening cell lines, blood, and tumors. Proc. Natl. Acad. Sci. USA 92:3963-3967; 1995.
13. Camplejohn, R. S.; Rutherford, J. p53 functional assays: Detecting p53 mutations in both the germline and in sporadic tumours. Cell Prolif. 34:1-14; 2001.
14. Bunz, F.; Hwang, P. M.; Torrance, C.; Waldman, T.; Zhang, Y.; Dillehay, L.; Williams, J.; Lengauer, C.; Kinzler, K. W.; Vogelstein, B. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J. Clin. Invest. 104:263-269; 1999.
15. Gartel, A. L.; Serfas, M. S.; Gartel, M.; Goufman, E.; Wu, G. S.; el-Deiry, W. S.; Tyner, A. L. p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line. Exp. Cell Res. 227:171-181; 1996.
16. Agapova, L. S.; Turovets, N. A.; Ivanov, A. V.; Il'inskaia, G. V.; Chumakov, P. M. Induction of hyperdiploidy and chromosome breaks in LIM1215 cells expressing the exogenous mutant p53. Genetika 32:1080-1087; 1996.
17. Gupta, M.; Fan, S.; Zhan, Q.; Kohn, K. W.; O'Connor, P. M.; Pommier, Y. Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells. Clin. Cancer Res. 3:1653-1660; 1997.
18. Parker, L. P.; Wolf, J. K.; Price, J. E. Adenoviral-mediated gene therapy with Ad5CMVp53 and Ad5CMVp21 in combination with standard therapies in human breast cancer cell lines. Ann. Clin. Lab. Sci. 30:395-405; 2000.