Sodium pyruvate modulates cell death pathways in HaCaT keratinocytes exposed to half-mustard gas

International Journal of Toxicology

Volumn 30, Issue 2, 2011, Pages 197-206

  Paromov, Victor ^a   Brannon, Marianne ^a   Kumari, Sudha ^a   Samala, Mallikarjun ^a   Qui, Min ^b   Smith, Milton ^c   Stone, William L ^a  

^a East Tennessee State University   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c Amaox Ltd   (United States)

Author keywords

apoptosis; CEES; keratinocyte; necrosis; pyruvate; sulfur mustard

Indexed keywords

BIOLOGICAL MARKER; LIPOSOME; MUSTARD GAS DERIVATIVE; PYRUVATE SODIUM; SCAVENGER;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; KERATINOCYTE; NECROSIS; OXIDATIVE STRESS; SKIN INFLAMMATION; SKIN INJURY;

ANTIOXIDANTS; APOPTOSIS; BIOLOGICAL MARKERS; CELLS, CULTURED; DNA DAMAGE; DRUG COMBINATIONS; HUMANS; INFLAMMATION; KERATINOCYTES; LIPOSOMES; MUSTARD GAS; NECROSIS; OXIDATIVE STRESS; PYRUVATES; SKIN;

ANIMALIA;

EID: 79955611683     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581810390824     Document Type: Article

References (50)

1. Balali-Mood M, Hefazi M. The pharmacology, toxicology, and medical treatment of sulphur mustard poisoning. Fundam Clin Pharmacol. 2005 ; 19 (3). 297-315 (Pubitemid 40769451)
2. Paromov V, Suntres Z, Smith M, Stone WL. Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy. J Burns Wounds. 2007 ; 7: e7
3. Noort D, Benschop HP, Black RM. Biomonitoring of exposure to chemical warfare agents: a review. Toxicol Appl Pharmacol. 2002 ; 184 (2). 116-126 (Pubitemid 35339395)
4. Berger NA. Poly(ADP-ribose) in the cellular response to DNA damage. Radiat Res. 1985 ; 101 (1). 4-15 (Pubitemid 15168488)
5. Bouchard VJ, Rouleau M, Poirier GG. PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol. 2003 ; 31 (6). 446-454 (Pubitemid 36793950)
6. Chiarugi A. Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited. Trends Pharmacol Sci. 2002 ; 23 (3). 122-129
7. Herceg Z, Wang ZQ. Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res. 2001 ; 477 (1-2). 97-110 (Pubitemid 32480193)
8. Hinshaw DB, Lodhi IJ, Hurley LL, Atkins KB, Dabrowska MI. Activation of poly [ADP-Ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustard-mediated vesication. Toxicol Appl Pharmacol. 1999 ; 156 (1). 17-29 (Pubitemid 29181695)
9. Kehe K, Raithel K, Kreppel H, Jochum M, Worek F, Thiermann H. Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells. Arch Toxicol. 2008 ; 82 (7). 461-470
10. Lim SC, Choi JE, Kim CH, et al. Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. Int J Mol Med. 2007 ; 20 (2). 187-192
11. Meier HL, Millard CB. Alterations in human lymphocyte DNA caused by sulfur mustard can be mitigated by selective inhibitors of poly(ADP-ribose) polymerase. Biochim Biophys Acta. 1998 ; 1404 (3). 367-376 (Pubitemid 28470538)
12. Qin JZ, Bacon PE, Chaturvedi V, Bonish B, Nickoloff BJ. Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparations. Exp Dermatol. 2002 ; 11 (6). 573-583 (Pubitemid 37009769)
13. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol. 1988 ; 106 (3). 761-771 (Pubitemid 18089976)
14. Boukamp P, Popp S, Bleuel K, Tomakidi E, Burkle A, Fusenig NE. Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature. Oncogene. 1999 ; 18 (41). 5638-5645 (Pubitemid 29497598)
15. Schoop VM, Mirancea N, Fusenig NE. Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts. J Invest Dermatol. 1999 ; 112 (3). 343-353 (Pubitemid 29125112)
16. Maas-Szabowski N, Starker A, Fusenig NE. Epidermal tissue regeneration and stromal interaction in HaCaT cells is initiated by TGF-alpha. J Cell Sci. 2003 ; 116 (pt 14). 2937-2948 (Pubitemid 36926983)
17. Hirsch T, von Peter S, Dubin G, et al. Adenoviral gene delivery to primary human cutaneous cells and burn wounds. Mol Med. 2006 ; 12 (9-10). 199-207 (Pubitemid 44925018)
18. Lewis DA, Hengeltraub SF, Gao FC, Leivant MA, Spandau DF. Aberrant NF-kappaB activity in HaCaT cells alters their response to UVB signaling. J Invest Dermatol. 2006 ; 126 (8). 1885-1892 (Pubitemid 44086524)
19. Kehe K, Balszuweit F, Steinritz D, Thiermann H. Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering. Toxicology. 2009 ; 263 (1). 12-19
20. Smith WJ. Therapeutic options to treat sulfur mustard poisoning - the road ahead. Toxicology. 2009 ; 263 (1). 70-73
21. Stone WL, Qui M, Smith M. Lipopolysaccharide enhances the cytotoxicity of 2-chloroethyl ethyl sulfide. BMC Cell Biol. 2003 ; 4 (1). 1
22. Bakondi E, Bai P, Szabo EE, et al. Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate. J Histochem Cytochem. 2002 ; 50 (1). 91-98 (Pubitemid 34074626)
23. Chang I, Cho N, Koh JY, Lee MS. Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes. Diabetologia. 2003 ; 46 (9). 1220-1227 (Pubitemid 37220053)
24. Mari M, Bai J, Cederbaum AI. Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria. Free Radic Biol Med. 2002 ; 32 (1). 73-83 (Pubitemid 34045139)
25. Rosenthal DS, Velena A, Chou FP, et al. Expression of dominant-negative Fas-associated death domain blocks human keratinocyte apoptosis and vesication induced by sulfur mustard. J Biol Chem. 2003 ; 278 (10). 8531-8540 (Pubitemid 36800606)
26. Rosenthal DS, Simbulan-Rosenthal CM, Iyer S, et al. Sulfur mustard induces markers of terminal differentiation and apoptosis in keratinocytes via a Ca2+-calmodulin and caspase-dependent pathway. J Invest Dermatol. 1998 ; 111 (1). 64-71 (Pubitemid 28309210)
27. Ray R, Hauck S, Kramer R, Benton B. A convenient fluorometric method to study sulfur mustard-induced apoptosis in human epidermal keratinocytes monolayer microplate culture. Drug Chem Toxicol. 2005 ; 28 (1). 105-116 (Pubitemid 40188960)
28. Blaha M, Kohl J, DuBose D, Bowers W, Walker J. Ultrastructural and histological effects of exposure to CEES or heat in a human epidermal model. In Vitr Mol Toxicol. 2001 ; 14 (1). 15-23 (Pubitemid 32622657)
29. Debiak M, Kehe K, Burkle A. Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity. Toxicology. 2009 ; 263 (1). 20-25
30. Patel VA, Lee DJ, Longacre-Antoni A, et al. Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: response pathways initiated in nearby viable cells. Autoimmunity. 2009 ; 42 (4). 317-321
31. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 2002 ; 418 (6894). 191-195 (Pubitemid 34773774)
32. Syntichaki P, Tavernarakis N. Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos?. EMBO Rep. 2002 ; 3 (7). 604-609
33. Zong WX, Thompson CB. Necrotic death as a cell fate. Genes Dev. 2006 ; 20 (1). 1-15 (Pubitemid 43042662)
34. Arroyo CM, Schafer RJ, Kurt EM, Broomfield CA, Carmichael AJ. Response of normal human keratinocytes to sulfur mustard: cytokine release. J Appl Toxicol. 2000 ; 20 (suppl 1). S63 - S72
35. Blaha M, Bowers W, Kohl J, et al. Effects of CEES on inflammatory mediators, heat shock protein 70A, histology and ultrastructure in two skin models. J Appl Toxicol. 2000 ; 20 (suppl 1). S101 - S108
36. Groves RW, Rauschmayr T, Nakamura K, Sarkar S, Williams IR, Kupper TS. Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease. J Clin Invest. 1996 ; 98 (2). 336-344 (Pubitemid 26255731)
37. Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev. 2004 ; 18 (11). 1272-1282 (Pubitemid 38720595)
38. Jog NR, Dinnall JA, Gallucci S, Madaio MP, Caricchio R. Poly (ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation. J Immunol. 2009 ; 182 (11). 7297-7306
39. Munoz LE, Janko C, Grossmayer GE, et al. Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus. Arthritis Rheum. 2009 ; 60 (6). 1733-1742
40. Dobsak P, Courderot-Masuyer C, Zeller M, et al. Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia. J Cardiovasc Pharmacol. 1999 ; 34 (5). 651-659 (Pubitemid 29491726)
41. Das UN. Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule. Med Sci Monit. 2006 ; 12 (5). RA79 - RA84
42. Mallet RT, Sun J, Knott EM, Sharma AB, Olivencia-Yurvati AH. Metabolic cardioprotection by pyruvate: recent progress. Exp Biol Med (Maywood). 2005 ; 230 (7). 435-443 (Pubitemid 40923420)
43. Hollenbach M, Hintersdorf A, Huse K, et al. Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors. Biochem Pharmacol. 2008 ; 76 (5). 631-644
44. Varma SD, Devamanoharan PS, Ali AH, et al. Half mustard (CEES) induced damage to rabbit cornea: attenuating effect of taurine-pyruvate-alpha- ketoglutarate-pantothenate mixture. J Ocul Pharmacol Ther. 1998 ; 14 (5). 423-428 (Pubitemid 28489684)
45. Shall S, de Murcia G. Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?. Mutat Res. 2000 ; 460 (1). 1-15 (Pubitemid 30365046)
46. Los M, Mozoluk M, Ferrari D, et al. Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell. 2002 ; 13 (3). 978-988 (Pubitemid 34250359)
47. Rosenthal DS, Simbulan-Rosenthal CM, Liu WF, et al. PARP determines the mode of cell death in skin fibroblasts, but not keratinocytes, exposed to sulfur mustard. J Invest Dermatol. 2001 ; 117 (6). 1566-1573 (Pubitemid 34032789)
48. Stone WL, Mukherjee S, Smith M, Das SK. Therapeutic uses of antioxidant liposomes. Methods Mol Biol. 2002 ; 199: 145-161
49. Stone WL, Smith M. Therapeutic uses of antioxidant liposomes. Mol Biotechnol. 2004 ; 27 (3). 217-230 (Pubitemid 41490590)
50. Chen CH, Liu DZ, Fang HW, Liang HJ, Yang TS, Lin SY. Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer. Biosci Biotechnol Biochem. 2008 ; 72 (6). 1586-1594