Synthesis, evaluation and metabolic studies of radiotracers containing a 4-(4-[18F]-fluorobenzyl)piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2295-2309

  Labas, Romain ^a,b   Gilbert, Gwénaëlle ^a,b   Nicole, Olivier ^b   Dhilly, Martine ^a,b   Abbas, Ahmed ^b   Tirel, Olivier ^a,b   Buisson, Alain ^b   Henry, Joël ^b   Barré, Louisa ^a,b   Debruyne, Danièle ^a,b   Sobrio, Franck ^a,b  

^a DIF   (France)

^b UNIVERSITÉ DE CAEN   (France)

Author keywords

Antagonist; Fluorine 18; NMDA; NR2B; PET; Radiotracer

Indexed keywords

2 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]METHYL 5 NITROBENZIMIDAZOLE; 2 [4 [3 (1,3 DITHIAN 2 YL) 4 NITROBENZYL]PIPERIDIN 1 YLMETHYL] 5 METHOXYBENZIMIDAZOLE; 2 ACETAMIDO N (2 OXO 1,3 DIHYDROINDOL 5 YL)ACETIC ACID; 2 ACETAMIDO N (2 OXO 3H 1,3 BENZOTHIAZOL 6 YL)ACETIC ACID; 2 ACETAMIDO N (2 OXO 3H 1,3 BENZOXAZOL 6 YL)ACETIC ACID; 2 FLUORO 5 [1 (5 METHOXYBENZIMIDAZOL 2 YLMETHYL)PIPERIDIN 4 YLMETHYL] BENZALDEHYDE; 4 (4 FLUOROBENZYL)PIPERIDINYL 1 METHYL 2 BENZIMIDAZOL 5 OL; 4 (4 FLUOROBENZYL)PIPERIDINYL 1 METHYL 2 BENZIMIDAZOL 5 OL F 18; 4 [3 (1,3 DITHIAN 2 YL) 4 NITROBENZYL]PIPERIDINE HYDROCHLORIDE; 5 [1 (5 METHOXYBENZIMIDAZOL 2 YLMETHYL)PIPERIDIN 4 YLMETHYL] 2 NITROBENZALDEHYDE; [1 (5 METHOXYBENZIMIDAZOL 2 YLMETHYL)PIPERIDIN 4 YL] (4 NITROPHENYL)METHANONE; [1 (5 METHOXYBENZIMIDAZOL) 2 YLMETHYLPIPERIDIN 4 YL] (4 FLUOROPHENYL)METHANONE; IFENPRODIL; IONOTROPIC RECEPTOR ANTAGONIST; N [2 [[4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]METHYL]BENZIMIDAZOL 5 YL]METHANESULFONAMIDE; N [4 (4 FLUOROBENZOYL)PIPERIDIN 1 YL] N' (2 OXO 3H 1,3 BENZOXAZOL 6 YL)OXAMIDE; N [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL] N' (2 OXO 1,3 DIHYDROINDOL 5 YL)OXAMIDE; N [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL] N' (2 OXO 3H 1,3 BENZOTHIAZOL 6 YL)OXAMIDE; N [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL] N' (2 OXO 3H 1,3 BENZOXAZOL 6 YL)OXAMIDE; N [4 (4 ITROBENZOYL)PIPERIDIN 1 YL] N' (2 OXO 3H 1,3 BENZOXAZOL 6 YL)OXAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; RADIOPHARMACEUTICAL AGENT; RADIPRODIL; RADIPRODIL F 18; TERT BUTYL 1 [4 (3 FORMYL 4 FLUOROBENZYL)PIPERIDIN 1 YL]CARBOXYLATE; TERT BUTYL 1 [4 (4 NITROBENZOYL)PIPERIDIN 1 YL]CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; BONE; CARTILAGE; CONTROLLED STUDY; DRUG PENETRATION; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; IN VIVO STUDY; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY;

ANIMALS; FLUORINE RADIOISOTOPES; MALE; MOLECULAR STRUCTURE; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM;

EID: 79955599150     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.013     Document Type: Article

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