Gene therapy for head and neck squamous cell carcinoma using KITENIN (KAI1 COOH-terminal interacting tetraspanin)-antisense therapy

Yonsei Medical Journal

Volumn 52, Issue 3, 2011, Pages 463-468

  Lee, Joon Kyoo ^a   Lee, Dong Hoon ^a   Sun, Eun Gene ^a   Bae, Jeong A ^a   Lim, Sang Chul ^a   Min, Jeong Joon ^a   Sung, Myung Whun ^b   Kim, Kyung Keun ^a  

^a Chonnam National University Medical School   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Gene therapy; Head and neck cancer; KITENIN protein; Small interfering RNA (siRNA); Squamous cell carcinoma

Indexed keywords

BETA ACTIN; DNA; SMALL INTERFERING RNA;

ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA; KAI1 CARBOXYL TERMINAL INTERACTING TETRASPANIN ANTISENSE THERAPY; PROTEIN EXPRESSION;

CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; GENE THERAPY; HEAD AND NECK NEOPLASMS; HUMANS; MEMBRANE PROTEINS; RNA, SMALL INTERFERING;

EID: 79955582346     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2011.52.3.463     Document Type: Article

References (31)

1. Howell GM, Grandis JR. Molecular mediators of metastasis in head and neck squamous cell carcinoma. Head Neck 2005;27:710-7.
2. Woodhouse EC, Chuaqui RF, Liotta LA. General mechanisms of metastasis. Cancer 1997;80:1529-37.
3. Yamaguchi H, Wyckoff J, Condeelis J. Cell migration in tumors. Curr Opin Cell Biol 2005;17:559-64.
4. Jackson P, Marreiros A, Russell PJ. KAI1 tetraspanin and metastasis suppressor. Int J Biochem Cell Biol 2005;37:530-4.
5. Takaoka A, Hinoda Y, Satoh S, Adachi Y, Itoh F, Adachi M, et al. Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene. Oncogene 1998;16:1443-53.
6. Yang JL, Jackson P, Yu Y, Yoshie O, Ham JM, Russell PJ, et al. Invasion and metastasis correlate with down-regulation of KAI1 expression in human colon cancer cell lines. GI Cancer 2001;3:313-22.
7. Yang X, Wei LL, Tang C, Slack R, Mueller S, Lippman ME. Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells. Cancer Res 2001;61:5284-8.
8. Jee B, Jin K, Hahn JH, Song HG, Lee H. Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway. Exp Mol Med 2003;35:30-7.
9. Lee JH, Seo YW, Park SR, Kim YJ, Kim KK. Expression of a splice variant of KAI1, a tumor metastasis suppressor gene, influences tumor invasion and progression. Cancer Res 2003;63:7247-55.
10. Lee JH, Park SR, Chay KO, Seo YW, Kook H, Ahn KY, et al. KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer. Cancer Res 2004;64:4235-43.
11. Yagyu R, Hamamoto R, Furukawa Y, Okabe H, Yamamura T, Nakamura Y. Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma. Int J Oncol 2002;20:1173-8.
12. Lee JH, Cho ES, Kim MY, Seo YW, Kho DH, Chung IJ, et al. Suppression of progression and metastasis of established colon tumors in mice by intravenous delivery of short interfering RNA targeting KITENIN, a metastasis-enhancing protein. Cancer Res 2005;65:8993-9003.
13. Lee JK, Bae JA, Sun EG, Kim HD, Yoon TM, Kim K, et al. KITENIN increases invasion and migration of mouse squamous cancer cells and promotes pulmonary metastasis in a mouse squamous tumor model. FEBS Lett 2009;583:711-7.
14. Lee JK, Lim SC, Kim HD, Yoon TM, Kim K, Nam JH, et al. KITENIN represents a more aggressive phenotype in a murine model of oral cavity squamous carcinoma. Otolaryngol Head Neck Surg 2010;142:747-52.
15. Lee JK, Yoon TM, Seo DJ, Sun EG, Bae JA, Lim SC, et al. KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer. Laryngoscope 2010;120:953-8.
16. Sioud M. Therapeutic siRNAs. Trends Pharmacol Sci 2004;25:22-8.
17. Kim SG, Hong JW, Boo SH, Kim MG, Lee KD, Ahn JC, et al. Combination treatment of Cetuximab and photodynamic therapy in SNU-1041 squamous cancer cell line. Oncol Rep 2009;22:701-8.
18. Koh TY, Park SW, Park KH, Lee SG, Seol JG, Lee DW, et al. Inhibitory effect of p27KIP1 gene transfer on head and neck squamous cell carcinoma cell lines. Head Neck 2003;25:44-9.
19. Sung MW, Roh JL, Park BJ, Park SW, Kwon TK, Lee SJ, et al. Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. Laryngoscope 2003;113:1059-63.
20. Martinez LA, Naguibneva I, Lehrmann H, Vervisch A, Tchénio T, Lozano G, et al. Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways. Proc Natl Acad Sci U S A 2002;99:14849-54.
21. Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002;2:243-7.
22. Scherr M, Battmer K, Winkler T, Heidenreich O, Ganser A, Eder M. Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood 2003;101:1566-9.
23. Wilda M, Fuchs U, Wössmann W, Borkhardt A. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene 2002;21:5716-24.
24. Zhang L, Yang N, Mohamed-Hadley A, Rubin SC, Coukos G. Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer. Biochem Biophys Res Commun 2003;303:1169-78.
25. Holen T, Amarzguioui M, Wiiger MT, Babaie E, Prydz H. Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor. Nucleic Acids Res 2002;30:1757-66.
26. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002;296:550-3.
27. Miyagishi M, Taira K. U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol 2002;20:497-500.
28. Lee NS, Dohjima T, Bauer G, Li H, Li MJ, Ehsani A, et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol 2002;20:500-5.
29. Xia H, Mao Q, Paulson HL, Davidson BL. siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol 2002;20:1006-10.
30. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003;33:401-6.
31. Shen C, Buck AK, Liu X, Winkler M, Reske SN. Gene silencing by adenovirus-delivered siRNA. FEBS Lett 2003;539:111-4.