Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder

BMC Psychiatry

Volumn 11, Issue , 2011, Pages

  Morey, Rajendra A ^a,b,c   Hariri, Ahmad R ^b   Gold, Andrea L ^d   Hauser, Michael A ^a,c   Munger, Heidi J ^a,c   Dolcos, Florin ^e   McCarthy, Gregory ^c,d  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

^d YALE UNIVERSITY   (United States)

^e UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Amygdala; Cognitive control; Emotion processing; PTSDimaging genetics; Rs16965628; SLC6A4; Ventrolateral PFC; Working memory

Indexed keywords

CITALOPRAM; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; MIRTAZAPINE; PAROXETINE; SEROTONIN TRANSPORTER; SERTRALINE; SLC6A4 PROTEIN, HUMAN;

ADULT; ALLELE; AMYGDALOID NUCLEUS; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; EMOTION; EMOTIONAL DISORDER; EXECUTIVE FUNCTION; EXON; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUSIFORM GYRUS; GENE EXPRESSION; GENE STRUCTURE; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; MALE; MEMORY CONSOLIDATION; NERVE CELL; PHENOTYPE; POSTTRAUMATIC STRESS DISORDER; PROMOTER REGION; RACE; RESPONSE TIME; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE; VETERAN; VISUAL INFORMATION; WORKING MEMORY; CASE CONTROL STUDY; FUNCTIONAL NEUROIMAGING; GENETICS; INJURY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PREFRONTAL CORTEX; PSYCHOLOGICAL ASPECT; PSYCHOMOTOR PERFORMANCE; SHORT TERM MEMORY; TERRORISM;

AMYGDALA; CASE-CONTROL STUDIES; COGNITION; EMOTIONS; FUNCTIONAL NEUROIMAGING; HUMANS; MAGNETIC RESONANCE IMAGING; MEMORY, SHORT-TERM; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; PROMOTER REGIONS, GENETIC; PSYCHOMOTOR PERFORMANCE; SEPTEMBER 11 TERRORIST ATTACKS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS DISORDERS, POST-TRAUMATIC; VETERANS; WOUNDS AND INJURIES;

EID: 79955563536     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-11-76     Document Type: Article

References (97)

1. Meyer-Lindenberg A, Weinberger DR. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience 2006, 7(10):818-827. 10.1038/nrn1993, 16988657.
2. Bigos K, Weinberger DA. Imaging Genetics - Days of Future Past. Neuroimage 2010,
3. Scharinger C, Rabl U, Sitte H, Pezawas L. Imaging genetics of mood disorders. NeuroImage 2010,
4. Domschke K, Dannlowski U. Imaging genetics of anxiety disorders. NeuroImage 2010,
5. Furmark T, Tillfors M, Garpenstrand H, Marteinsdottir I, Langstrom B, Oreland L, Fredrikson M. Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neuroscience Letters 2004, 362(3):189-92. 10.1016/j.neulet.2004.02.070, 15158011.
6. Domschke K, Braun M, Ohrmann P, Suslow T, Kugel H, Bauer J, Hohoff C, Kersting A, Engelien A, Arolt V, Heindel W, Deckert J. Association of the functional -1019C/G 5-HT1A polymorphism with prefrontal cortex and amygdala activation measured with 3 T fMRI in panic disorder. International Journal of Neuropsychopharmacology 2006, 9(3):349-55. 10.1017/S1461145705005869, 16316476.
7. Meyer-Lindenberg A, Olsen R, Kohn P, Brown T, Egan M, Weinberger D, Berman K. Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. 2005,
8. Potkin S, Guffanti G, Lakatos A, Turner J, Kruggel F, Fallon J, Saykin A, Orro A, Lupoli S, Salvi E, Weiner M, Macciardi F, . A.s.D.N. Initiative Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. 2009, A.s.D.N. Initiative.
9. Potkin S, Turner J, JA F, Lakatos A, DB K, Guffanti G, Macciardi F. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. 2009,
10. Hariri AR, Drabant EM, Weinberger DR. Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biological Psychiatry 2006, 59(10):888-97. 10.1016/j.biopsych.2005.11.005, 16442081.
11. Lee HJ, Lee MS, Kang RH, Kim H, Kim SD, Kee BS, Kim YH, Kim YK, Kim JB, Yeon BK, Oh KS, Oh BH, Yoon JS, Lee C, Jung HY, Chee IS, Paik IH. Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depression and Anxiety 2005, 21(3):135-139. 10.1002/da.20064, 15965993.
12. Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, Roitzsch J, Boyle J, Gelernter J. The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. American Journal of Psychiatry 2007, 164(11):1693-9. 10.1176/appi.ajp.2007.06122007, 17974934.
13. Koenen KC, Aiello AE, Bakshis E, Amstadter AB, Ruggiero KJ, Acierno R, Kilpatrick DG, Gelernter J, Galea S. Modification of the Association Between Serotonin Transporter Genotype and Risk of Posttraumatic Stress Disorder in Adults by County-Level Social Environment. American Journal of Epidemiology 2009, 169(6):704-711. 10.1093/aje/kwn397, 2727213, 19228812.
14. Kolassa I-T, Ertl V, Eckart C, Glockner F, Kolassa S, Papassotiropoulos A, de Quervain DJ, Elbert T. Association study of trauma load and SLC6A4 promoter polymorphism in posttraumatic stress disorder: Evidence from survivors of the Rwandan Genocide. Journal of Clinical Psychiatry 2010,
15. Xie PX, Kranzler HR, Poling J, Stein MB, Anton RF, Brady K, Weiss RD, Farrer L, Gelernter J. Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations. Archives of General Psychiatry 2009, 66(11):1201-1209. 10.1001/archgenpsychiatry.2009.153, 2867334, 19884608.
16. Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, Tang Y, Gillespie CF, Heim CM, Nemeroff CB, Schwartz AC, Cubells JF, Ressler KJ. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008, 299(11):1291-305. 10.1001/jama.299.11.1291, 2441757, 18349090.
17. Xie P, Kranzler HR, Poling J, Stein MB, Anton RF, Farrer LA, Gelernter J. Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder. Neuropsychopharmacology 2010,
18. Radant A, Tsuang D, Peskind ER, McFall ME, Rasking W. Biological markers and diagnostic accuracy in the genetics of posttraumatic stress disorder. Psychiatry Research 2001, 102(3):203-215. 10.1016/S0165-1781(01)00252-9, 11440771.
19. Sack WH, Clarke GN, Seeley J. Posttraumatic stress disorder across two generations of Cambodian refugees. Journal of the American Academy of Child & Adolescent Psychiatry 1995, 34(9):1160-6. 10.1097/00004583-199509000-00013, 21539491.
20. Yehuda R, Halligan SL, Grossman R. Childhood trauma and risk for PTSD: relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion. Development & Psychopathology 2001, 13(3):733-53. 10.1017/S0954579401003170, 21548135.
21. True WR, Rice J, Eisen SA, Heath AC. A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Archives of General Psychiatry 1993, 50(4):257-265.
22. Seedat S, Lockhat R, Kaminer D, Zungu-Dirwayi N, Stein DJ. An open trial of citalopram in adolescents with post-traumatic stress disorder. International Clinical Psychopharmacology 2001, 16(1):21-5. 10.1097/00004850-200101000-00002, 11195256.
23. Koenen KC, Amstadter AB, Nugent NR. Gene-environment interaction in posttraumatic stress disorder: An update. Journal of Traumatic Stress 2009, 22(5):416-426. 10.1002/jts.20435, 2889033, 19743189.
24. Iles MM. What can genome-wide association studies tell us about the genetics of common disease. PLoS Genetics 2008, 4(2):e33. 10.1371/journal.pgen.0040033, 2323402, 18454206.
25. Hariri AR, Weinberger DR. Imaging genomics. British Medical Bulletin 2003, 65:259-70. 10.1093/bmb/65.1.259, 12697630.
26. Caspi A, Moffitt TE. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nature Reviews Neuroscience 2006, 7(7):583-90.
27. Green AE, Munafo MR, DeYoung CG, Fossella JA, Fan J, Gray JR. Using genetic data in cognitive neuroscience: from growing pains to genuine insights. Nature Reviews Neuroscience 2008, 9(9):710-720. 10.1038/nrn2461, 19143051.
28. Canli T, Omura K, Haas BW, Fallgatter A, Constable RT, Lesch KP. Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(34):12224-9. 10.1073/pnas.0503880102, 1189322, 16093315.
29. Dannlowski U, Ohrmann P, Bauer J, Deckert J, Hohoff C, Kugel H, Arolt V, Heindel W, Kersting A, Baune BT, Suslow T. 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology 2008, 33(2):418-24. 10.1038/sj.npp.1301411, 17406646.
30. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002, 297:400-403. 10.1126/science.1071829, 12130784.
31. Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR. A Susceptibility Gene for Affective Disorders and the Response of the Human Amygdala. Archives of General Psychiatry 2005, 62(2):146-152. 10.1001/archpsyc.62.2.146, 15699291.
32. Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D, Klein S, Grusser SM, Flor H, Schumann G, Mann K, Buchel C. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience 2005, 8(1):20-1. 10.1038/nn1366, 15592465.
33. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience 2005, 8(6):828-34. [see comment], 10.1038/nn1463, 15880108.
34. Surguladze SA, Elkin A, Ecker C, Kalidindi S, Corsico A, Giampietro V, Lawrence N, Deeley Q, Murphy DGM, Kucharska-Pietura K, Russell TA, McGuffin P, Murray R, Phillips ML. Genetic variation in the serotonin transporter modulates neural system-wide response to fearful faces. Genes, Brain & Behavior 2008, 7(5):543-55. 10.1111/j.1601-183X.2008.00390.x, 21548129.
35. Munafo MR, Brown SM, Hariri AR. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biological Psychiatry 2008, 63(9):852-7. 10.1016/j.biopsych.2007.08.016, 2755289, 17949693.
36. LeDoux J. Fear and the brain: Where have we been, and where are we going?. Biological Psychiatry 1998, 44(12):1229-1238. 10.1016/S0006-3223(98)00282-0, 9861466.
37. Morey RA, Dolcos F, Petty CM, Cooper DA, Hayes JP, LaBar KS, McCarthy G. The role of trauma-related distractors on neural systems for working memory and emotion processing in posttraumatic stress disorder. Journal of Psychiatric Research 2009, 43(8):809-817. 10.1016/j.jpsychires.2008.10.014, 2684984, 19091328.
38. Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Archives of General Psychiatry 2005, 62(3):273-81. 10.1001/archpsyc.62.3.273, 15753240.
39. Hayes Pannu J, LaBar KS, Petty C, McCarthy G, Morey RA. Alterations in the neural circuitry for emotion and attention associated with possttraumatic stress symptomatology. Psychiatry Research: Neuroimaging 2009, 172(1):7-15. 10.1016/j.pscychresns.2008.05.005, 2692949, 19237269.
40. Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS. Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. American Journal of Psychiatry 1999, 156(11):1787-95.
41. Bremner JD, Staib LH, Kaloupek D, Southwick SM, Soufer R, Charney DS. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biological Psychiatry 1999, 45(7):806-16. 10.1016/S0006-3223(98)00297-2, 10202567.
42. Dolcos F, Kragel P, Wang L, McCarthy G. Role of the inferior frontal cortex in coping with distracting emotions. Neuroreport 2006, 17(15):1591-4. 10.1097/01.wnr.0000236860.24081.be, 17001274.
43. Yamasaki H, LaBar KS, McCarthy G. Dissociable prefrontal brain systems for attention and emotion. Proceedings of the National Academy of Sciences of the United States of America 2002, 99(17):11447-51. 10.1073/pnas.182176499, 123276, 12177452.
44. Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends in Cognitive Sciences 2004, 8(4):170-7. 10.1016/j.tics.2004.02.010, 15050513.
45. Dolcos F, McCarthy G. Brain systems mediating cognitive interference by emotional distraction. Journal of Neuroscience 2006, 26(7):2072-9. 10.1523/JNEUROSCI.5042-05.2006, 16481440.
46. Ochsner KN, Gross JJ. The cognitive control of emotion. Trends in Cognitive Sciences 2005, 9(5):242-249. 10.1016/j.tics.2005.03.010, 15866151.
47. Gray JR, Braver TS, Raichle ME. Integration of emotion and cognition in the lateral prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America 2002, 99(6):4115-20. 10.1073/pnas.062381899, 122657, 11904454.
48. Garpenstrand H, Annas P, Ekblom J, Oreland L, Fredrikson M. Human fear conditioning is related to dopaminergic and serotonergic biological markers. Behavioral Neuroscience 2001, 115(2):358-364.
49. Rauch SL, Shin LM, Phelps EA. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future. Biological Psychiatry 2006, 60(4):376-82. 10.1016/j.biopsych.2006.06.004, 16919525.
50. Amstadter AB, Nugent NR, Koenen KC. Genetics of PTSD: Fear Conditioning as a Model for Future Research. Psychiatric Annals 2009, 39(6):358-+. 10.3928/00485713-20090526-01, 2749314, 19779593.
51. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implication for Studying Complex Diseases and Traits. American Journal of Psychiatry 2010, 167(May):509-527. 2943341, 20231323.
52. Strug LJ, Suresh R, Fyer AJ, Talati A, Adams PB, Li W, Hodge SE, Gilliam TC, Weissman MM. Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Molecular Psychiatry 2008, 1-11.
53. Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Timpano KR, Murphy DL. A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Human Molecular Genetics 2008, 17(5):717-723.
54. Hu X-Z, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. American Journal of Human Genetics 2006, 78(5):815-26. 10.1086/503850, 1474042, 16642437.
55. Parsey R, Hastings R, Oquendo M, Hu X, Goldman D, Huang Y, Simpson N, Arcement J, Huang Y, Ogden R, Van Heertum R, Arango V, Mann J. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. 2006,
56. Martin J, Cleak J, Willis-Owen SAG, Flint J, Shifman S. Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. [Erratum appears in Mol Psychiatry. 2007 Sep;12(9):881]. Molecular Psychiatry 2007, 12(5):421-2. 10.1038/sj.mp.4001952, 17453058.
57. Hayes JP, Labar KS, Petty CM, McCarthy G, Morey RA. Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology. Psychiatry Research-Neuroimaging 2009, 172(1):7-15.
58. Morey RA, Petty CM, Cooper DA, LaBar KS, McCarthy G. Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans. Psychiatry Research: Neuroimaging 2008, 162(1):59-72. 10.1016/j.pscychresns.2007.07.007, 2254508, 18093809.
59. McDonald SD, Beckham JC, Morey RA, Calhoun PS. The validity and diagnostic efficiency of the Davidson Trauma Scale in military veterans who have served since September 11th, 2001. Journal of Anxiety Disorders 2009, 23(2):247-255. 10.1016/j.janxdis.2008.07.007, 2709769, 18783913.
60. International HapMap C, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, Pasternak S, Wheeler DA, Willis TD, F Y, Yang H, Zeng C, Gao Y, Hu H, Hu W, Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q, et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007, 449(7164):851-61. 10.1038/nature06258, 2689609, 17943122.
61. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. American Journal of Human Genetics 2004, 74(1):106-20. 10.1086/381000, 1181897, 14681826.
62. Howie BN, Carlson CS, Rieder MJ, Nickerson DA. Efficient selection of tagging single-nucleotide polymorphisms in multiple populations. Human Genetics 2006, 120(1):58-68. 10.1007/s00439-006-0182-5, 16680432.
63. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004, 23(Suppl 1):S208-19.
64. Jenkinson M, Smith S. A global optimisation method for robust affine registration of brain images. Medical Image Analysis 2001, 5(2):143-56. 10.1016/S1361-8415(01)00036-6, 11516708.
65. Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory-II. 1996, Psychological Corp: San Antonio, TX.
66. Lund M, Foy D, Sipprelle C, Strachan A. The Combat Exposure Scale: a systematic assessment of trauma in the Vietnam War. Journal of Clinical Psychology 1984, 40(6):1323-8. 10.1002/1097-4679(198411)40:6<1323::AID-JCLP2270400607>3.0.CO;2-I, 6511942.
67. Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. American Journal of Human Genetics 2004, 74(4):765-9. 10.1086/383251, 1181954, 14997420.
68. Fichtenholtz HM, Dean HL, Dillon DG, Yamasaki H, McCarthy G, LaBar KS. Emotion-attention network interactions during a visual oddball task. Cognitive Brain Research 2004, 20(1):67-80. 10.1016/j.cogbrainres.2004.01.006, 15130591.
69. Wang L, McCarthy G, Song AW, Labar KS. Amygdala activation to sad pictures during high-field (4 tesla) functional magnetic resonance imaging. Emotion 2005, 5(1):12-22.
70. Beevers CG, Pacheco J, Clasen P, McGeary JE, Schnyer D. Prefrontal morphology, 5-HTTLPR polymorphism and biased attention for emotional stimuli. Genes Brain and Behavior 2010, 9(2):224-233.
71. David SP, Murthy NV, Rabiner EA, Munafo MR, Johnstone EC, Jacob R, Walton RT, Grasby PM. A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. Journal of Neuroscience 2005, 25(10):2586-2590. 10.1523/JNEUROSCI.3769-04.2005, 1942077, 15758168.
72. Canli T, Lesch KP. Long story short: the serotonin transporter in emotion regulation and social cognition. Nature Neuroscience 2007, 10(9):1103-1109. 10.1038/nn1964, 17726476.
73. Shin L, Rauch S, Pitman R. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Meeting on Psychobiology of Post-Traumatic Stress Disorder 2006, 67-79. New York Acad Sci: New York, NY, Yehuda R.
74. Gillihan SJ, Rao H, Wang J, Detre J, Breland J, Sankoorikal GMV, Brodkin ES, Farah MJ. Serotonin transporter genotype modulates amygdala activity during mood regulation. Social Affective and Cognitive Neuroscience 2010,
75. Rauch SL, van der Kolk BA, Fisler RE, Alpert NM, Orr SP, Savage CR, Fischman AJ, Jenike MA, Pitman RK. A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Archives of General Psychiatry 1996, 53(5):380-7.
76. Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM, Metzger LJ, Lasko NB, Orr SP, Pitman RK. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. American Journal of Psychiatry 1999, 156(4):575-84.
77. Liberzon I, Taylor SF, Amdur R, Jung TD, Chamberlain KR, Minoshima S, Koeppe RA, Fig LM. Brain activation in PTSD in response to trauma-related stimuli. Biological Psychiatry 1999, 45(7):817-26. 10.1016/S0006-3223(98)00246-7, 10202568.
78. Protopopescu X, Pan H, Tuescher O, Cloitre M, Goldstein M, Engelien W, Epstein J, Yang Y, Gorman J, LeDoux J, Silbersweig D, Stern E. Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects. Biological Psychiatry 2005, 57(5):464-73. 10.1016/j.biopsych.2004.12.026, 15737660.
79. Rauch SL, Whalen PJ, Shin LM, McInerney SC, Macklin ML, Lasko NB, Orr SP, Pitman RK. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biological Psychiatry 2000, 47(9):769-76. 10.1016/S0006-3223(00)00828-3, 10812035.
80. Hendler T, Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich A. Sensing the invisible: differential sensitivity of visual cortex and amygdala to traumatic context. Neuroimage 2003, 19(3):587-600. 10.1016/S1053-8119(03)00141-1, 12880790.
81. Williams LM, Kemp AH, Felmingham K, Barton M, Olivieri G, Peduto A, Gordon E, Bryant RA. Trauma modulates amygdala and medial prefrontal responses to consciously attended fear. Neuroimage 2006, 29(2):347-57. 10.1016/j.neuroimage.2005.03.047, 16216534.
82. Jovanovic T, Ressler KJ. How the Neurocircuitry and Genetics of Fear Inhibition May Inform Our Understanding of PTSD. American Journal of Psychiatry 2010, 167(6):648-662. 10.1176/appi.ajp.2009.09071074, 20231322.
83. Dannlowski U, Konrad C, Kugel H, Zwitserlood P, Domschke K, Schoning S, Ohrmann P, Bauer J, Pyka M, Hohoff C, Zhang WQ, Baune BT, Heindel W, Arolt V, Suslow T. Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype. Neuroimage 2010, 53(3):893-898. 10.1016/j.neuroimage.2009.11.073, 19962442.
84. Roiser JP, de Martino B, Tan GCY, Kumaran D, Seymour B, Wood NW, Dolan RJ. A genetically mediated bias in decision making driven by failure of amygdala control. Journal of Neuroscience 2009, 29(18):5985-91. 10.1523/JNEUROSCI.0407-09.2009, 2686091, 19420264.
85. Banich MT, Mackiewicz KL, Depue BE, Whitmer AJ, Miller GA, Heller W. Cognitive control mechanisms, emotion and memory: a neural perspective with implications for psychopathology. Neuroscience & Biobehavioral Reviews 2009, 33(5):613-30. 10.1016/j.neubiorev.2008.09.010, 21547950.
86. Cutting GR. Modifier genetics: Cystic fibrosis. Annual Review of Genomics and Human Genetics 2005, 6:237-260. 10.1146/annurev.genom.6.080604.162254, 16124861.
87. Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo C, Colombo JL, Debray D, Fernandez A, Lacaille F, Macek M, Rowland M, Salvatore F, Taylor CJ, Wainwright C, Wilschanski M, Zemkova D, Hannah WB, Phillips MJ, Corey M, Zielenski J, Dorfman R, Wang Y, Zou F, Silverman LM, Drumm ML, et al. Genetic modifiers of liver disease in cystic fibrosis. JAMA 2009, 302(10):1076-83. 10.1001/jama.2009.1295, 19738092.
88. Drumm ML, Konstan MW, Schluchter MD, Handler A, Pace R, Zou F, Zariwala M, Fargo D, Xu A, Dunn JM, Darrah RJ, Dorfman R, Sandford AJ, Corey M, Zielenski J, Durie P, Goddard K, Yankaskas JR, Wright FA, Knowles MR, Gene Modifier Study G. Genetic modifiers of lung disease in cystic fibrosis. New England Journal of Medicine 2005, 353(14):1443-53. 10.1056/NEJMoa051469, 16207846.
89. Breslau N, Davis GC, Peterson EL, Schultz LR. A second look at comorbidity in victims of trauma: The posttraumatic stress disorder-major depression connection. Biological Psychiatry 2000, 48(9):902-909. 10.1016/S0006-3223(00)00933-1, 11074228.
90. Suslow T, Konrad C, Kugel H, Rumstadt D, Zwitserlood P, Schoning S, Ohrmann P, Bauer J, Pyka M, Kersting A, Arolt V, Heindel W, Dannlowski U. Automatic Mood-Congruent Amygdala Responses to Masked Facial Expressions in Major Depression. Biological Psychiatry 2010, 67(2):155-160. 10.1016/j.biopsych.2009.07.023, 19748075.
91. Etkin A, Wager TD. Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry 2007, 164(10):1476-1488. 10.1176/appi.ajp.2007.07030504, 17898336.
92. Shin LM, Orr SP, Carson MA, Rauch SL, Macklin ML, Lasko NB, Peters PM, Metzger LJ, Dougherty DD, Cannistraro PA, Alpert NM, Fischman AJ, Pitman RK. Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Archives of General Psychiatry 2004, 61(2):168-76. 10.1001/archpsyc.61.2.168, 14757593.
93. Phan KL, Britton JC, Taylor SF, Fig LM, Liberzon I. Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. Archives of General Psychiatry 2006, 63(2):184-92. 10.1001/archpsyc.63.2.184, 16461862.
94. Fitzgerald PB, Laird AR, Maller J, Daskalakis ZJ. A meta-analytic study of changes in brain activation in depression. Human Brain Mapping 2008, 29(6):683-695. 10.1002/hbm.20426, 2873772, 17598168.
95. Koenen KC, Fu QJ, Ertel K, Lyons MJ, Eisen SA, True WR, Goldberg J, Tsuang MT. Common genetic liability to major depression and posttraumatic stress disorder in men. Journal of Affective Disorders 2008, 105(1-3):109-115. 10.1016/j.jad.2007.04.021, 2254223, 17540456.
96. Kolassa I-T, Kolassa S, Ertl V, Papassotiropoulos A, De Quervain DJF. The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism. Biological Psychiatry 2010, 67(4):304-308. 10.1016/j.biopsych.2009.10.009, 19944409.
97. American Psychiatric Association Proposed Revision | APA DSM-5: 309.81 Posttraumatic Stress Disorder. 2010, Date accessed: 2010 Mar 21, American Psychiatric Association., http://www.dsm5.org/ProposedRevisions/Pages/proposedrevision.aspx?rid=165