Association study of trauma load and SLC6A4 promoter polymorphism in posttraumatic stress disorder: Evidence from survivors of the Rwandan genocide

Journal of Clinical Psychiatry

Volumn 71, Issue 5, 2010, Pages 543-547

  Kolassa, Iris Tatjana ^a   Ertl, Verena ^a   Eckart, Cindy ^a   Glöckner, Franka ^a   Kolassa, Stephan ^a,b   Papassotiropoulos, Andreas ^c   De Quervain, Dominique J F ^d   Elbert, Thomas ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b Analysis and Forecasting AG   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

ADOLESCENT; ADULT; AGED; ALLELE; ANTIBODY TITER; ARTICLE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE PREDISPOSITION; DNA POLYMORPHISM; DOSE RESPONSE; EMOTION; ENVIRONMENTAL FACTOR; EXPOSURE; FEMALE; GENETIC ASSOCIATION; GENETIC CODE; GENOCIDE; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HEREDITY; HIGH RISK POPULATION; HOMOZYGOSITY; HUMAN; LIFESPAN; MAJOR CLINICAL STUDY; MALE; POSTTRAUMATIC STRESS DISORDER; PREVALENCE; PRIORITY JOURNAL; PROMOTER REGION; REFUGEE; STRESS; SURVIVOR;

ADOLESCENT; ADULT; AGED; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMICIDE; HOMOZYGOTE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; RWANDA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; SURVIVORS; YOUNG ADULT;

EID: 77952609522     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.08m04787blu     Document Type: Article

References (40)

1. Neuner F, Schauer M, Karunakara U, et al. Psychological trauma and evidence for enhanced vulnerability for posttraumatic stress disorder through previous trauma among West Nile refugees. BMC Psychiatry. 2004;4(1):34. (Pubitemid 40177135)
2. Kolassa I-T, Elbert T. Structural and functional neuroplasticity in relation to traumatic stress. Curr Dir Psychol Sci. 2007;16(6):321-325.
3. Kilpatrick DG, Koenen KC, Ruggiero KJ, et al. The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. Am J Psychiatry. 2007;164(11):1693-1699.
4. Stein MB, Jang KL, Taylor S, et al. Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study. Am J Psychiatry. 2002;159(10):1675-1681.
5. Caspi A, Moffitt TE. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci. 2006;7(7):583-590. (Pubitemid 43995433)
6. Broekman BF, Olff M, Boer F. The genetic background to PTSD. Neurosci Biobehav Rev. 2007;31(3):348-362.
7. de Quervain DJ-F, Kolassa I-T, Ertl V, et al. A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nat Neurosci. 2007;10(9):1137-1139. (Pubitemid 47339945)
8. Koenen KC. Genetics of posttraumatic stress disorder: Review and recommendations for future studies. J Trauma Stress. 2007;20(5):737-750. (Pubitemid 350144881)
9. Lee HJ, Lee MS, Kang RH, et al. Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress Anxiety. 2005;21(3):135-139. (Pubitemid 41040636)
10. Nakamura M, Ueno S, Sano A, et al. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry. 2000;5(1):32-38. (Pubitemid 30088450)
11. Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet. 1997;101(2):243-246. (Pubitemid 28014742)
12. Greenberg BD, Tolliver TJ, Huang SJ, et al. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet. 1999;88(1):83-87.
13. Murphy DL, Lerner A, Rudnick G, et al. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol Interv. 2004;4(2):109-123. (Pubitemid 38584973)
14. Garpenstrand H, Annas P, Ekblom J, et al. Human fear conditioning is related to dopaminergic and serotonergic biological markers. Behav Neurosci. 2001;115(2):358-364. (Pubitemid 32378165)
15. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386-389. (Pubitemid 36877077)
16. Grabe HJ, Lange M, Wolff B, et al. Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Mol Psychiatry. 2005;10(2):220-224. (Pubitemid 40188517)
17. Kendler KS, Kuhn JW, Vittum J, et al. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry. 2005;62(5):529-535. (Pubitemid 40628882)
18. Wilhelm K, Mitchell PB, Niven H, et al. Life events, first depression onset and the serotonin transporter gene. Br J Psychiatry. 2006;188(3):210-215.
19. Foa EB, Cashman L, Jaycox L, et al. The validation of a self-report measure of posttraumatic stress disorder: The Posttraumatic Diagnostic Scale. Psychol Assess. 1997;9(4):445-451. (Pubitemid 28137200)
20. Odenwald M, Lingenfelder B, Schauer M, et al. Screening for Posttraumatic Stress Disorder among Somali ex-combatants: a validation study. Confl Health. 2007;1(1):10.
21. Ertl V. Validierung westlicher Konzepte zur Erfassung psychischen Leids in Afrika. Reliabilität und Validität der Erfassung posttraumatischer Belastungsstörung in einer ostafrikanischen Flüchtlingssiedlung. Saarbrücken, Saarland, Germany: VDM Verlag Dr Müller; 2008.
22. Spitzer RL, Williams JBW, Gibbon M, et al. Structured Clinical Interview for DSM-III-R-patient ed. Washington, DC: American Psychiatric Press; 1990.
23. Onyut LP, Neuner F, Schauer E, et al. The Nakivale Camp Mental Health Project: building local competency for psychological assistance to traumatised refugees. Intervention. 2004;2(2):90-107.
24. Neuner F, Onyut PL, Ertl V, et al. Treatment of posttraumatic stress disorder by trained lay counselors in an African refugee settlement: a randomized controlled trial. J Consult Clin Psychol. 2008;76(4):686-694.
25. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994.
26. Lotrich FE, Pollock BG, Ferrell RE. Serotonin transporter promoter polymorphism in African Americans: allele frequencies and implications for treatment. Am J Pharmacogenomics. 2003;3(2):145-147.
27. Holm SA. Simple sequentially rejective multiple test procedure. Scand J Stat. 1979;6:65-70.
28. Harrell FE. Hmisc: Harrell Miscellaneous R Package version 3.4-3; 2007. http://www.r-project.org. Accessed Mar 5, 2010.
29. Harrell FE. Design: Design R Package version 2.1-1; 2007. http://www.r-project.org. Accessed Mar 5, 2010.
30. R Development Core Team. R: A Language and Environment for Statistical Computing version 2.7.0; 2008. http://www.r-project.org. Accessed Mar 5, 2010.
31. Harrell FE. Regression Modeling Strategies. New York, NY: Springer; 2001.
32. Burnham KP, Anderson DR. Model Selection and Multi-Model Inference: A Practical Information-Theoretic Approach. New York, NY: Springer; 2002.
33. Good PI. Permutation, Parametric, and Bootstrap Tests of Hypotheses. New York, NY: Springer; 2005.
34. Rhodes RA, Murthy NV, Dresner MA, et al. Human 5-HT transporter availability predicts amygdala reactivity in vivo. J Neurosci. 2007;27(34):9233-9237.
35. Munafò MR, Brown SM, Hariri AR. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry. 2008;63(9):852-857.
36. Hariri AR, Mattay VS, Tessitore A, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science. 2002;297(5580):400- 403. (Pubitemid 34790769)
37. Lotrich FE, Pollock BG, Ferrell RE. Polymorphism of the serotonin transporter: implications for the use of selective serotonin reuptake inhibitors. Am J Pharmacogenomics. 2001;1(3):153-164.
38. Rausch JL, Johnson ME, Fei YJ, et al. Initial conditions of serotonin transporter kinetics and genotype: influence on SSRI treatment trial outcome. Biol Psychiatry. 2002;51(9):723-732.
39. True WR, Rice J, Eisen SA, et al. A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Arch Gen Psychiatry. 1993;50(4):257-264. (Pubitemid 23115368)
40. Segman RH, Shalev AY. Genetics of posttraumatic stress disorder. CNS Spectr. 2003;8(9):693-698.