Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 2925-2929

  Zheng, Xiaofan ^a   Hudyma, Thomas W ^a   Martin, Scott W ^a   Bergstrom, Carl ^a   Ding, Min ^a   He, Feng ^a   Romine, Jeffrey ^a   Poss, Michael A ^a   Kadow, John F ^a   Chang, Chong Hwan ^a   Wan, John ^a   Witmer, Mark R ^a   Morin, Paul ^a   Camac, Daniel M ^a   Sheriff, Steven ^a   Beno, Brett R ^a   Rigat, Karen L ^a   Wang, Ying Kai ^a   Fridell, Robert ^a   Lemm, Julie ^a   Qiu, Dike ^a   Liu, Mengping ^a   Voss, Stacey ^a   Pelosi, Lenore ^a   Roberts, Susan B ^a   Gao, Min ^a   Knipe, Jay ^a   Gentles, Robert G ^a   more..

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

HCV; Indolo fused heterocyclic inhibitors; NS5B

Indexed keywords

13 CYCLOHEXYL 6 OXO 6,7 DIHYDRO 5H INDOLO[2,1 D][1,4]BENZODIAZEPINE 10 CARBOXYLIC ACID; INDOLE; NONSTRUCTURAL PROTEIN 5B; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG CLEARANCE; HEPATITIS C VIRUS; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; ENZYME ACTIVATION; HEPACIVIRUS; HETEROCYCLIC COMPOUNDS; INDOLES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 79955562226     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.067     Document Type: Article

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