Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 3066-3069

  Chahrour, Osama ^a   Abdalla, Ashraf ^a   Lam, Frankie ^a   Midgley, Carol ^b   Wang, Shudong ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b OPEN UNIVERSITY   (United Kingdom)

Author keywords

Anticancer therapy; Mitotic inhibitor; Polo like kinase; Serine threonine kinase

Indexed keywords

2 METHOXY 5 [(2,4,6 TRIMETHOXYSTYRYLSULFINYL)METHYL]ANILINE; ANTINEOPLASTIC AGENT; BENZYLSTYRYLSULFINE DERIVATIVE; BENZYLSTYRYLSULFONE DERIVATIVE; BENZYLSULFONYL N PHENYLACETAMIDE DERIVATIVE; ON 01910; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE PHASE; CELL PROLIFERATION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG FIBROBLAST; STRUCTURE ACTIVITY RELATION;

ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; STYRENES; SULFINIC ACIDS;

EID: 79955561056     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.041     Document Type: Article

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19. R = 2.4 min, purity >99%.