Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 16, 2004, Pages 4237-4240

  Wang, Shudong ^a   Wood, Gavin ^a   Meades, Christopher ^a   Griffiths, Gary ^a   Midgley, Carol ^a   McNae, Iain ^b   McInnes, Campbell ^a   Anderson, Sian ^a   Jackson, Wayne ^a   Mezna, Mokdad ^a   Yuill, Rhoda ^a   Walkinshaw, Malcolm ^b   Fischer, Peter M ^a  

^a CYCLACEL LTD   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

CDKs; Crystal structures; Inhibitors; SAR

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR;

ARTICLE; CELL PROLIFERATION; DRUG SCREENING; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3142764557     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.012     Document Type: Article

References (13)

1. Hartwell L.H., Kastan M.B. Science. 266:1994;1821-1828
2. Webster K.R., Kimball S.D. Emerg. Drugs. 5:2000;45-59
3. Toogood P.L. Med. Res. Rev. 21:2001;487-498
4. Sherr C.J. Science. 274:1996;1672-1677
5. Senderowicz A.M. Oncogene. 22:2003;6609-6620
6. Wu S.Y., McNae I., Kontopidis G., McClue S.J., McInnes C., Stewart K.J., Wang S., Zheleva D.I., Marriage H., Lane D.P., Taylor P., Fischer P.M., Walkinshaw M.D. Structure. 11:2003;399-410
7. Wang, S.; Anderson, S.; Clarke, R.; Duncan, K.; Eland, S.; Jackson, W.; Lyon, C.; McClue, S.; Meades, C.; Osnowski, A.; Perry, A.; Renachowski, S.; Stuart, I.; Thomas, M.; Westwood, B.; Wood, G.; Yuill, R.; Lane, D.; Jackson, R.; Fischer, P. Proc. Am. Assoc. Cancer Res. 2003, 44, Abs. 3974
8. Wang S., Meades C., Wood G., Osnowski A., Anderson S., Yuill R., Thomas M., Mezna M., Jackson W., Midgley C., Griffiths G., Fleming I., Green S., McNae I., Wu S.-Y., McInnes C., Zheleva D., Walkinshaw M.D., Fischer P.M. J. Med. Chem. 47:2004;1662-1675
9. Cheng L.J., Lightner D.A. Synthesis. 1999;46-48
10. Fischer, P. M.; Wang, S.; Wood, G. In PCT Intl. Patent Appl. Publ. WO 02/079193; Cyclacel Limited, UK, 2002
11. Haselsberger K., Peterson D.C., Thomas D.G., Darling J.L. Anti-Cancer Drugs. 7:1996;331-338
12. Ortega S., Malumbres M., Barbacid M. Curr. Genomics. 3:2002;245-263
13. +