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Cancer Chemotherapy and Pharmacology

Volumn 65, Issue 1, 2009, Pages 177-186

Preclinical pharmacokinetics and in vitro activity of on 01910.Na, a novel anti-cancer agent

(4) Chun, Amy W a Cosenza, Stephen C b Taft, David R a Maniar, Manoj c

a LONG ISLAND UNIVERSITY (United States)

b TEMPLE UNIVERSITY SCHOOL OF MEDICINE (United States)

c Onconova Therapeutics Inc (United States)

Author keywords

Cytotoxicity; ON 01910.Na; Pharmacokinetics; Plasma binding

Indexed keywords

ANTINEOPLASTIC AGENT; ON 01910NA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CANCER CELL CULTURE; CONTINUOUS INFUSION; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY; LIVER; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RAT; TISSUE DISTRIBUTION; URINARY EXCRETION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GLYCINE; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; KIDNEY; LIVER; MALE; MICE; PROSTATIC NEOPLASMS; PROTEIN BINDING; RATS; SPECIES SPECIFICITY; SULFONES; TISSUE DISTRIBUTION;

EID: 70349610068 PISSN: 03445704 EISSN: None Source Type: Journal
DOI: 10.1007/s00280-009-1022-9 Document Type: Article

Times cited : (27)

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