An efficient route to 2,3-disubstituted indoles via reductive alkylation using H2 as reductant

Tetrahedron Letters

Volumn 52, Issue 22, 2011, Pages 2837-2839

  Cao, Liang Liang ^a   Wang, Duo Sheng ^b   Jiang, Guo Fang ^a   Zhou, Yong Gui ^b  

^a HUNAN UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

2,3 Disubstituted indoles; Pd C H2; Reductive alkylation

Indexed keywords

HYDROGEN; INDOLE DERIVATIVE; REDUCING AGENT;

ALKYLATION; ARTICLE; ATMOSPHERIC PRESSURE;

EID: 79955560491     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.03.099     Document Type: Article

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30. 2 (1 atm, hydrogen balloon) atmosphere for 12 h, then the product was purified by flash chromatography on silica gel using EtOAc/hexanes (1:5) as eluent.
31. 2 (1 atm, hydrogen balloon) atmosphere. The mixture was stirred at 0 °C and monitored by TLC until completed (4-8 h). After evaporation of the solvent under reduced pressure, the product was purified by flash chromatography on silica gel using EtOAc/hexanes (1:5) as eluent.